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The map label for this gene is serS2 [H]

Identifier: 158317501

GI number: 158317501

Start: 6991286

End: 6992578

Strand: Reverse

Name: serS2 [H]

Synonym: Franean1_5753

Alternate gene names: 158317501

Gene position: 6992578-6991286 (Counterclockwise)

Preceding gene: 158317502

Following gene: 158317499

Centisome position: 77.85

GC content: 71.77

Gene sequence:

>1293_bases
GTGCACGACGTCCGTGAGTTGCTGGACCTGAGCACGAAAGCGACGGCCGCGTTGGCCCGCCGAGGATTCGACATCTCCCT
CGACGAGCTCGCCGCGGCCCACCGTCGCCGTACCGACCGCGAAGACCGGGTCGCTCGGCTGCGAGCCGACCTGAAACGGG
CAGCGGCGGCAGGCGCCCGGCGGACAGCGACCGGTTCGGCCGACGCGGCGGACCGGGACAGCGCACGGCGACTGCGCGAA
GCGGTCCGGGCGGCGGAGGCTGACGCCCGGTCGGCCAGCGAAGAACTGACCGAGCTGCTGCTGGCGATCCCGAACCTGCC
GTCGGAGGAGGCGCCGGACGGGCGAAGTGAGACCGAAGCCGTCGAGGTGCGCACGGGAGGGCCACCGCCGGTGCCCGCCG
ACGACGCCCGGCACCACGCGACGGTGGGCACCGCCACGGGGGTGTTCGACGCCGCCGCGGCGGCGAAGCTGTCGGGGGCT
CGGTTCAGCGTCGCGCGCGGGGCCGGCGCGAGACTCGAGCGAGCGCTCGTGGAGTTCTTGCTGGACCTGCACACCGGGGA
GCACGGCTACGTCGAGTACTCCGTGCCGTACCTGGTCACCCGCAAGACCATGACGGGTACCGGGCAGCTACCCAAGTTCG
AGGCGGACTTGTTCGCCACCCAGGTAGGCGACCGTGAGATGTTCCTGATCCCGACCGCGGAGGTTCCGCTCACGAACCTG
TTCGCCGGCGAGGTCGTGAGCCCCCGGCAGTTGCCGCTCGCGCTCACCGCCCGGTCGGCGTGTTTTCGCGCCGAGGCCGG
CAGCTACGGCAAGGACACTCGCGGCGTCCTGCGGCTCCACCAGTTCGAGAAGGTCGAACTGGTGCGCATCTGCCTGCTTG
ACGAGACCCGCGACGAACTCGACGTCATGGTCGGGCACGTGGAGGAGTGCTTGCGGCGGCTGGGCCTCACCTACCGGGTG
ATGCTGCTGGCGGCCGGCGACCTGGGCTTCTCCGCCCGGTTGACCTTCGACGTCGAAGTGTGGCTGCCAGGCTCCGGGGC
GTTCCGGGAAATCTCCTCGGTGTCCGACTGCGGGGCTTTCCAGGCGCGGCGCGCCGGCATCCGCGTACAAGGCCGTGACG
GCCGCCGGGTTCCCGCGGCGACGCTCAACGGTTCCGCGTTGCCCGTCGGCCGGACCTTGGCGGCCCTGCTCGAACAGGGC
CGCCAAGCCGACGGCTCGGTCCTCCTGCCGGAGGCGCTCGTGCCCTACGCCGGTTTCCGTCGGATCAGGCCCGGTGGCAC
CACGTCCGACTGA

Upstream 100 bases:

>100_bases
GCCAGAACGCGGTGCTCGCGATCGCCAAGGCGTGAGGTCGCGCGCGTGAACCGCGGCGGCGAGCCGCGCGGGCGTCGACG
ACGCAGGAGGGAGTTCGGCC

Downstream 100 bases:

>100_bases
TCCCTAGTGCAACGAGGAAGCCTGGTTGAGGATCTCCTGGAAGCGTTCCTTGAGTTGGACGGACGGTTCCATGCCGAGTT
CGCGGTCCAGGCGTCGGCGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase 2; SerRS 2; Seryl-tRNA(Ser/Sec) synthetase 2 [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MHDVRELLDLSTKATAALARRGFDISLDELAAAHRRRTDREDRVARLRADLKRAAAAGARRTATGSADAADRDSARRLRE
AVRAAEADARSASEELTELLLAIPNLPSEEAPDGRSETEAVEVRTGGPPPVPADDARHHATVGTATGVFDAAAAAKLSGA
RFSVARGAGARLERALVEFLLDLHTGEHGYVEYSVPYLVTRKTMTGTGQLPKFEADLFATQVGDREMFLIPTAEVPLTNL
FAGEVVSPRQLPLALTARSACFRAEAGSYGKDTRGVLRLHQFEKVELVRICLLDETRDELDVMVGHVEECLRRLGLTYRV
MLLAAGDLGFSARLTFDVEVWLPGSGAFREISSVSDCGAFQARRAGIRVQGRDGRRVPAATLNGSALPVGRTLAALLEQG
RQADGSVLLPEALVPYAGFRRIRPGGTTSD

Sequences:

>Translated_430_residues
MHDVRELLDLSTKATAALARRGFDISLDELAAAHRRRTDREDRVARLRADLKRAAAAGARRTATGSADAADRDSARRLRE
AVRAAEADARSASEELTELLLAIPNLPSEEAPDGRSETEAVEVRTGGPPPVPADDARHHATVGTATGVFDAAAAAKLSGA
RFSVARGAGARLERALVEFLLDLHTGEHGYVEYSVPYLVTRKTMTGTGQLPKFEADLFATQVGDREMFLIPTAEVPLTNL
FAGEVVSPRQLPLALTARSACFRAEAGSYGKDTRGVLRLHQFEKVELVRICLLDETRDELDVMVGHVEECLRRLGLTYRV
MLLAAGDLGFSARLTFDVEVWLPGSGAFREISSVSDCGAFQARRAGIRVQGRDGRRVPAATLNGSALPVGRTLAALLEQG
RQADGSVLLPEALVPYAGFRRIRPGGTTSD
>Mature_430_residues
MHDVRELLDLSTKATAALARRGFDISLDELAAAHRRRTDREDRVARLRADLKRAAAAGARRTATGSADAADRDSARRLRE
AVRAAEADARSASEELTELLLAIPNLPSEEAPDGRSETEAVEVRTGGPPPVPADDARHHATVGTATGVFDAAAAAKLSGA
RFSVARGAGARLERALVEFLLDLHTGEHGYVEYSVPYLVTRKTMTGTGQLPKFEADLFATQVGDREMFLIPTAEVPLTNL
FAGEVVSPRQLPLALTARSACFRAEAGSYGKDTRGVLRLHQFEKVELVRICLLDETRDELDVMVGHVEECLRRLGLTYRV
MLLAAGDLGFSARLTFDVEVWLPGSGAFREISSVSDCGAFQARRAGIRVQGRDGRRVPAATLNGSALPVGRTLAALLEQG
RQADGSVLLPEALVPYAGFRRIRPGGTTSD

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=330, Percent_Identity=34.2424242424242, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI225579074, Length=330, Percent_Identity=34.2424242424242, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI16306548, Length=303, Percent_Identity=32.013201320132, Blast_Score=159, Evalue=4e-39,
Organism=Escherichia coli, GI1787120, Length=407, Percent_Identity=44.963144963145, Blast_Score=348, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI17539260, Length=344, Percent_Identity=29.6511627906977, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17542084, Length=333, Percent_Identity=30.6306306306306, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320226, Length=285, Percent_Identity=32.280701754386, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6321799, Length=359, Percent_Identity=30.08356545961, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24581334, Length=283, Percent_Identity=33.5689045936396, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI17737985, Length=287, Percent_Identity=32.7526132404181, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 46271; Mature: 46271

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDVRELLDLSTKATAALARRGFDISLDELAAAHRRRTDREDRVARLRADLKRAAAAGAR
CCHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
RTATGSADAADRDSARRLREAVRAAEADARSASEELTELLLAIPNLPSEEAPDGRSETEA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
VEVRTGGPPPVPADDARHHATVGTATGVFDAAAAAKLSGARFSVARGAGARLERALVEFL
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHH
LDLHTGEHGYVEYSVPYLVTRKTMTGTGQLPKFEADLFATQVGDREMFLIPTAEVPLTNL
HHHCCCCCCEEEEECCEEEEECEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHH
FAGEVVSPRQLPLALTARSACFRAEAGSYGKDTRGVLRLHQFEKVELVRICLLDETRDEL
HHCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DVMVGHVEECLRRLGLTYRVMLLAAGDLGFSARLTFDVEVWLPGSGAFREISSVSDCGAF
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEEEEEEECCCCHHHHHHHHHHCCHH
QARRAGIRVQGRDGRRVPAATLNGSALPVGRTLAALLEQGRQADGSVLLPEALVPYAGFR
HHHHCCCEEECCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCEECHHHHCCHHCCE
RIRPGGTTSD
EECCCCCCCC
>Mature Secondary Structure
MHDVRELLDLSTKATAALARRGFDISLDELAAAHRRRTDREDRVARLRADLKRAAAAGAR
CCHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
RTATGSADAADRDSARRLREAVRAAEADARSASEELTELLLAIPNLPSEEAPDGRSETEA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
VEVRTGGPPPVPADDARHHATVGTATGVFDAAAAAKLSGARFSVARGAGARLERALVEFL
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHH
LDLHTGEHGYVEYSVPYLVTRKTMTGTGQLPKFEADLFATQVGDREMFLIPTAEVPLTNL
HHHCCCCCCEEEEECCEEEEECEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHH
FAGEVVSPRQLPLALTARSACFRAEAGSYGKDTRGVLRLHQFEKVELVRICLLDETRDEL
HHCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
DVMVGHVEECLRRLGLTYRVMLLAAGDLGFSARLTFDVEVWLPGSGAFREISSVSDCGAF
HHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEEEEEEECCCCHHHHHHHHHHCCHH
QARRAGIRVQGRDGRRVPAATLNGSALPVGRTLAALLEQGRQADGSVLLPEALVPYAGFR
HHHHCCCEEECCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCEECHHHHCCHHCCE
RIRPGGTTSD
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]