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The map label for this gene is ispH2 [H]

Identifier: 158317460

GI number: 158317460

Start: 6930669

End: 6932642

Strand: Reverse

Name: ispH2 [H]

Synonym: Franean1_5712

Alternate gene names: 158317460

Gene position: 6932642-6930669 (Counterclockwise)

Preceding gene: 158317461

Following gene: 158317459

Centisome position: 77.18

GC content: 76.04

Gene sequence:

>1974_bases
ATGAGCATCCCGGCAACAGACAACGGGGGCGACGCCGACCACGGCGGTTCGCCCACCGTTACCCCGCGCGACGCCACGGC
GCCGAGCCTCGGACCGCCGGGCTTCGGCCCGGCCGCCGTGCGGCCCGCGTCGCCCGTCGCGCCCGCGTCGCCGGTCGTGC
CTGTGGTGCCGGCGGCACCGGTGGTGCCCGCAGGTGCCGCGGTGCCCGCGGGCGCGGTGCCGAGGGCGGCCATCCCCGAG
CAGGCCGGCGCGGTGCCGCCGGCCGGCGGGCCGTCGCGGGCCGGTTCGGCGCTGCCGTCGGTCGGGTCGCGGCGGGGGGC
GGCTTCGGCCGCGAGCCCGCTGGTGACCCGGGCGGTGCCTGCGGCGGTGAGCCCGGCCCCGAACGGGGCCGCGGCCCGGG
CACGCACGGTGAGCGCGAAGGGGTCGCCGGTCCAGCCGGCGCCCCGCACCCCGCGTCTCGTCGTCGCCGCCCCGCTGCGT
CTCGAGGGATTCGCGATCGGCCGGGCCGACCTGCCGCCCGGCACCGTGATCGTGCGGACCGGGATGGGCCCGGACAAGGC
GCACCGCGCGAACCGCGTGGTCCGCGATGCCCGGCCGGACGCGGTGGCCGTCGTCGGTCTCGCCGGTGGGCTCACCGTCG
AGACGAAGCCCGGCGACGTGGTCGTCGCGAGCGAGGTGCGCCTCGCCGACGGCACGGTGACGGGGACCTGCCCGACCGCC
CCGCTGCTGGCCGGCGAACTGCGCCGTGCCGGCCTCCGGGTGCACGTCGGACCGGTCGTGTCGGTAGCCCAGGTGGCGGT
CGGATCGGCCCGCGCCGAGCTGGCCGCGACCGGTGCCATCGCCGTGGACATGGAGTCCGCTGCCCTCGCCCCCGGTGCTG
GCACCCGCCCGTTCGCGGTGATCCGGGTGATCGTGGACACCCCCGACCAGCCGCTGGGCCGGATTGACCTGGTCCGGCGC
GGGGTGGCCGGGCTGCGCACGATCAACCAGCTCGGCCCGGCGATCCGCGCGTGGGTGGAGGCGGTCAGCAGCCGTCGGCT
GCTCCTCGCCGAGCCGCGCGCCTTCTGTGCCGGGGTCGAGCGCGCCATCGAGGTGGTCGAACGGGCGCTGGAGATCCACG
GCGCACCGGTCTACGTCCGCAAGCAGATCGTGCACAACACCCACGTCGTGGCCGACCTGGCCAGCCGCGGCGCGGTCTTC
GTCGAGGAGTTGGACGAGGTCCCGCCCGGCGCGACCGTGGTCTTCTCCGCGCACGGGGTCGCCCCCGCGATCTGGGACGA
GGCGGGCGAGCGCGACCTGGCGGTCATCGACGCCACCTGCCCGCTGGTGGAGAAGGTGCATGCCGAGGCGCGGCGGTTCA
CCGCGCGTGGCGACACCGTCCTGCTCATCGGGCACTCCGGCCACGAGGAGGTGGACGGGACGCTCGGCGAGGCACCGGGG
CGGATCCAACTGGTCGAGTCCGCCGCCGCGGTCGAGGACATCGAGGTCGCCGACCCGGAGCGGGTCACCTACCTCATGCA
GACCACGCTCGCCGTGGACGAGGCCGAGGAGGTCGTCGACGCGCTGCGCGACCGCTTCCCGGCCGTCGTCGGCCCCGGCT
CGGCCGACATCTGCTACGCGACGTCCAACCGGCAGAACGCGGTTCGCCGGGTGGCCGCCGAGGCGGAGCTCGTCCTGGTC
GTCGGGTCGGAGAACAGCTCGAACTCGCGCCGGCTGGTCGAGGTCAGCGAGCGGGACGGCGTCGCCGCGCACCTTGTCGA
GAGCGTCGAGGACGTCCAGCTCGACTGGCTCAAGGGGGTGCGGACCGTCGGCATCTCCGCCGGGGCCTCCGCGCCGCCGC
TGCTCGTCGAGGAGCTGACGGCGGCACTGTCGGGGCTGGGGTCGGCGTCGGTGTCGGTCCGTTCCGTGGGCTCGGAGTCG
ATCTCCTTCCACCTGCCGAAGGAGGTCCGTCGACCGCTCTCCGAACGGAGATGA

Upstream 100 bases:

>100_bases
GCTTCCCCTGGGACTTCTCCATCAACTATCACCTGTACCGGCTGGTCTTTCCCGTGACGGCACTCGGTCGGTACGTGACC
CTCACCGGCAGGTCGACGTC

Downstream 100 bases:

>100_bases
CGCGCGGTCAGACAGGCACGCGTCAGTTCAGCGCCGGCGGCCCGGGTTCCGATGAACCCGGGCCGCCGGCGTTGTCGGCC
GGTTCCTGACATCGGGCGCG

Product: hydroxymethylbutenyl pyrophosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MSIPATDNGGDADHGGSPTVTPRDATAPSLGPPGFGPAAVRPASPVAPASPVVPVVPAAPVVPAGAAVPAGAVPRAAIPE
QAGAVPPAGGPSRAGSALPSVGSRRGAASAASPLVTRAVPAAVSPAPNGAAARARTVSAKGSPVQPAPRTPRLVVAAPLR
LEGFAIGRADLPPGTVIVRTGMGPDKAHRANRVVRDARPDAVAVVGLAGGLTVETKPGDVVVASEVRLADGTVTGTCPTA
PLLAGELRRAGLRVHVGPVVSVAQVAVGSARAELAATGAIAVDMESAALAPGAGTRPFAVIRVIVDTPDQPLGRIDLVRR
GVAGLRTINQLGPAIRAWVEAVSSRRLLLAEPRAFCAGVERAIEVVERALEIHGAPVYVRKQIVHNTHVVADLASRGAVF
VEELDEVPPGATVVFSAHGVAPAIWDEAGERDLAVIDATCPLVEKVHAEARRFTARGDTVLLIGHSGHEEVDGTLGEAPG
RIQLVESAAAVEDIEVADPERVTYLMQTTLAVDEAEEVVDALRDRFPAVVGPGSADICYATSNRQNAVRRVAAEAELVLV
VGSENSSNSRRLVEVSERDGVAAHLVESVEDVQLDWLKGVRTVGISAGASAPPLLVEELTAALSGLGSASVSVRSVGSES
ISFHLPKEVRRPLSERR

Sequences:

>Translated_657_residues
MSIPATDNGGDADHGGSPTVTPRDATAPSLGPPGFGPAAVRPASPVAPASPVVPVVPAAPVVPAGAAVPAGAVPRAAIPE
QAGAVPPAGGPSRAGSALPSVGSRRGAASAASPLVTRAVPAAVSPAPNGAAARARTVSAKGSPVQPAPRTPRLVVAAPLR
LEGFAIGRADLPPGTVIVRTGMGPDKAHRANRVVRDARPDAVAVVGLAGGLTVETKPGDVVVASEVRLADGTVTGTCPTA
PLLAGELRRAGLRVHVGPVVSVAQVAVGSARAELAATGAIAVDMESAALAPGAGTRPFAVIRVIVDTPDQPLGRIDLVRR
GVAGLRTINQLGPAIRAWVEAVSSRRLLLAEPRAFCAGVERAIEVVERALEIHGAPVYVRKQIVHNTHVVADLASRGAVF
VEELDEVPPGATVVFSAHGVAPAIWDEAGERDLAVIDATCPLVEKVHAEARRFTARGDTVLLIGHSGHEEVDGTLGEAPG
RIQLVESAAAVEDIEVADPERVTYLMQTTLAVDEAEEVVDALRDRFPAVVGPGSADICYATSNRQNAVRRVAAEAELVLV
VGSENSSNSRRLVEVSERDGVAAHLVESVEDVQLDWLKGVRTVGISAGASAPPLLVEELTAALSGLGSASVSVRSVGSES
ISFHLPKEVRRPLSERR
>Mature_656_residues
SIPATDNGGDADHGGSPTVTPRDATAPSLGPPGFGPAAVRPASPVAPASPVVPVVPAAPVVPAGAAVPAGAVPRAAIPEQ
AGAVPPAGGPSRAGSALPSVGSRRGAASAASPLVTRAVPAAVSPAPNGAAARARTVSAKGSPVQPAPRTPRLVVAAPLRL
EGFAIGRADLPPGTVIVRTGMGPDKAHRANRVVRDARPDAVAVVGLAGGLTVETKPGDVVVASEVRLADGTVTGTCPTAP
LLAGELRRAGLRVHVGPVVSVAQVAVGSARAELAATGAIAVDMESAALAPGAGTRPFAVIRVIVDTPDQPLGRIDLVRRG
VAGLRTINQLGPAIRAWVEAVSSRRLLLAEPRAFCAGVERAIEVVERALEIHGAPVYVRKQIVHNTHVVADLASRGAVFV
EELDEVPPGATVVFSAHGVAPAIWDEAGERDLAVIDATCPLVEKVHAEARRFTARGDTVLLIGHSGHEEVDGTLGEAPGR
IQLVESAAAVEDIEVADPERVTYLMQTTLAVDEAEEVVDALRDRFPAVVGPGSADICYATSNRQNAVRRVAAEAELVLVV
GSENSSNSRRLVEVSERDGVAAHLVESVEDVQLDWLKGVRTVGISAGASAPPLLVEELTAALSGLGSASVSVRSVGSESI
SFHLPKEVRRPLSERR

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=313, Percent_Identity=52.0766773162939, Blast_Score=332, Evalue=5e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 66966; Mature: 66835

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPATDNGGDADHGGSPTVTPRDATAPSLGPPGFGPAAVRPASPVAPASPVVPVVPAAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCC
VVPAGAAVPAGAVPRAAIPEQAGAVPPAGGPSRAGSALPSVGSRRGAASAASPLVTRAVP
CCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHCC
AAVSPAPNGAAARARTVSAKGSPVQPAPRTPRLVVAAPLRLEGFAIGRADLPPGTVIVRT
CCCCCCCCCCHHHEEEECCCCCCCCCCCCCCEEEEECCEEEEEEEECCCCCCCCEEEEEE
GMGPDKAHRANRVVRDARPDAVAVVGLAGGLTVETKPGDVVVASEVRLADGTVTGTCPTA
CCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCCCEEEEEEEEEECCEEECCCCCC
PLLAGELRRAGLRVHVGPVVSVAQVAVGSARAELAATGAIAVDMESAALAPGAGTRPFAV
HHHHHHHHHCCCEEEECHHHHHHHHHHCCHHHHHHCCCEEEEECCHHCCCCCCCCCCEEE
IRVIVDTPDQPLGRIDLVRRGVAGLRTINQLGPAIRAWVEAVSSRRLLLAEPRAFCAGVE
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHH
RAIEVVERALEIHGAPVYVRKQIVHNTHVVADLASRGAVFVEELDEVPPGATVVFSAHGV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEECCCC
APAIWDEAGERDLAVIDATCPLVEKVHAEARRFTARGDTVLLIGHSGHEEVDGTLGEAPG
CHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
RIQLVESAAAVEDIEVADPERVTYLMQTTLAVDEAEEVVDALRDRFPAVVGPGSADICYA
EEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEE
TSNRQNAVRRVAAEAELVLVVGSENSSNSRRLVEVSERDGVAAHLVESVEDVQLDWLKGV
ECCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RTVGISAGASAPPLLVEELTAALSGLGSASVSVRSVGSESISFHLPKEVRRPLSERR
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCHHHHHHHHHCC
>Mature Secondary Structure 
SIPATDNGGDADHGGSPTVTPRDATAPSLGPPGFGPAAVRPASPVAPASPVVPVVPAAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCC
VVPAGAAVPAGAVPRAAIPEQAGAVPPAGGPSRAGSALPSVGSRRGAASAASPLVTRAVP
CCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHCC
AAVSPAPNGAAARARTVSAKGSPVQPAPRTPRLVVAAPLRLEGFAIGRADLPPGTVIVRT
CCCCCCCCCCHHHEEEECCCCCCCCCCCCCCEEEEECCEEEEEEEECCCCCCCCEEEEEE
GMGPDKAHRANRVVRDARPDAVAVVGLAGGLTVETKPGDVVVASEVRLADGTVTGTCPTA
CCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEEECCCCCEEEEEEEEEECCEEECCCCCC
PLLAGELRRAGLRVHVGPVVSVAQVAVGSARAELAATGAIAVDMESAALAPGAGTRPFAV
HHHHHHHHHCCCEEEECHHHHHHHHHHCCHHHHHHCCCEEEEECCHHCCCCCCCCCCEEE
IRVIVDTPDQPLGRIDLVRRGVAGLRTINQLGPAIRAWVEAVSSRRLLLAEPRAFCAGVE
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHH
RAIEVVERALEIHGAPVYVRKQIVHNTHVVADLASRGAVFVEELDEVPPGATVVFSAHGV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEECCCC
APAIWDEAGERDLAVIDATCPLVEKVHAEARRFTARGDTVLLIGHSGHEEVDGTLGEAPG
CHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
RIQLVESAAAVEDIEVADPERVTYLMQTTLAVDEAEEVVDALRDRFPAVVGPGSADICYA
EEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEE
TSNRQNAVRRVAAEAELVLVVGSENSSNSRRLVEVSERDGVAAHLVESVEDVQLDWLKGV
ECCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RTVGISAGASAPPLLVEELTAALSGLGSASVSVRSVGSESISFHLPKEVRRPLSERR
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]