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The map label for this gene is gmd [H]

Identifier: 158317251

GI number: 158317251

Start: 6656776

End: 6657765

Strand: Direct

Name: gmd [H]

Synonym: Franean1_5498

Alternate gene names: 158317251

Gene position: 6656776-6657765 (Clockwise)

Preceding gene: 158317250

Following gene: 158317252

Centisome position: 74.11

GC content: 65.86

Gene sequence:

>990_bases
GTGCCTCGCGCGCTGATTACGGGAATCACCGGCCAGGACGGGTTGTATCTGGGGGAGTTGCTGGTTGGGCGGGGTTATGA
GGTGTTCGGGCTGGTGCGCGGGCAGTCGAACCCGAAGGTGGCGACCGTGGAGCGGCTGGTGCCGGGGGTCGTGTTGTTGG
AGGGTGATCTGACGGATCTTCCGTCGTTGATCGGCGCGGTGGAGATCTCCCAGCCCGACGAGGTGTACAACCTGGGCGCG
ATCTCGTTCGTCGGACTCTCCTGGAAGCAGGCGGAGCTGACCGGGGAGACGACGGGTATGGGGGTGCTGCGGGTTCTGGA
GGCGCTGCGGATCGCGGGCGGTAACGACCTGTCCCGGGTGCGTTTCTACCAGGCGTCGTCGTCGGAGATGTTCGGAAAGG
TGCGGGAGACGCCACAGCGAGAGACGACGCCGTTTCATCCACGTTCCCCGTACGGGGTGGCGAAGACGTTCGGGCATTAC
CTGACGGTGAATTACCGCGAGTCGTACGGGTTGTTCGCGTGTTCGGGGATGCTGTTCAATCACGAGTCGCCGCGGCGGGG
GATCGAGTTCGTGACGCGGAAGATTTCGCGGGCGGTGGCGCGGATTTCACTCGGTCTACAGGACTCGGTGTCCCTGGGGA
ATCTCGAGTCGCGGCGCGACTGGGGTTTCGCGGGGGACTATGTGGACGCGATGTGGCGGATGCTCCAGCAGGACACCCCG
GACGACTTCGTGGTGGCGACCGGCGAGACCCACAGCATTCGTGAGTTGTTGGACGTCGCCTTCGCCCGGGTGGGCATCGA
GGACTGGTCCGGCTATGTCCGCTCCGACCCGCGGTTCTTCCGCCCGGCCGAGGTGGATGTCCTCGTGGGCGACGCGTCGA
AGGCTCGTGAGGTGCTGGGGTGGAAGCCCCGGATCGGCTTCCACGAGCTGGTGGAGATGATGGTCGACGCCGACCTCGCC
ACCGAGGCCGCTGCGGCGGACAGACACTGA

Upstream 100 bases:

>100_bases
CGTGGTGCCGACGGGCCGGCCCCGGCACCCGAGTGACCCGGCCGCTTTACCTGACGCTAACCTTCCGCAGCAGTACTCCA
CGGGCCACAGGAGGATGATC

Downstream 100 bases:

>100_bases
CCAACCGGTGACCGACGTTCCCCGGGTGCCCGCCACCGAGCCCGCACGACTGGCGCGGGCCGCACCACCCGCGCCGAGAC
CTGGCGTGGGTGAATACACA

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MPRALITGITGQDGLYLGELLVGRGYEVFGLVRGQSNPKVATVERLVPGVVLLEGDLTDLPSLIGAVEISQPDEVYNLGA
ISFVGLSWKQAELTGETTGMGVLRVLEALRIAGGNDLSRVRFYQASSSEMFGKVRETPQRETTPFHPRSPYGVAKTFGHY
LTVNYRESYGLFACSGMLFNHESPRRGIEFVTRKISRAVARISLGLQDSVSLGNLESRRDWGFAGDYVDAMWRMLQQDTP
DDFVVATGETHSIRELLDVAFARVGIEDWSGYVRSDPRFFRPAEVDVLVGDASKAREVLGWKPRIGFHELVEMMVDADLA
TEAAAADRH

Sequences:

>Translated_329_residues
MPRALITGITGQDGLYLGELLVGRGYEVFGLVRGQSNPKVATVERLVPGVVLLEGDLTDLPSLIGAVEISQPDEVYNLGA
ISFVGLSWKQAELTGETTGMGVLRVLEALRIAGGNDLSRVRFYQASSSEMFGKVRETPQRETTPFHPRSPYGVAKTFGHY
LTVNYRESYGLFACSGMLFNHESPRRGIEFVTRKISRAVARISLGLQDSVSLGNLESRRDWGFAGDYVDAMWRMLQQDTP
DDFVVATGETHSIRELLDVAFARVGIEDWSGYVRSDPRFFRPAEVDVLVGDASKAREVLGWKPRIGFHELVEMMVDADLA
TEAAAADRH
>Mature_328_residues
PRALITGITGQDGLYLGELLVGRGYEVFGLVRGQSNPKVATVERLVPGVVLLEGDLTDLPSLIGAVEISQPDEVYNLGAI
SFVGLSWKQAELTGETTGMGVLRVLEALRIAGGNDLSRVRFYQASSSEMFGKVRETPQRETTPFHPRSPYGVAKTFGHYL
TVNYRESYGLFACSGMLFNHESPRRGIEFVTRKISRAVARISLGLQDSVSLGNLESRRDWGFAGDYVDAMWRMLQQDTPD
DFVVATGETHSIRELLDVAFARVGIEDWSGYVRSDPRFFRPAEVDVLVGDASKAREVLGWKPRIGFHELVEMMVDADLAT
EAAAADRH

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=344, Percent_Identity=50.5813953488372, Blast_Score=346, Evalue=2e-95,
Organism=Escherichia coli, GI1788366, Length=359, Percent_Identity=49.025069637883, Blast_Score=339, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17507723, Length=341, Percent_Identity=49.8533724340176, Blast_Score=343, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI133901790, Length=340, Percent_Identity=48.8235294117647, Blast_Score=342, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI133901786, Length=340, Percent_Identity=48.8235294117647, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17539424, Length=340, Percent_Identity=48.8235294117647, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17539422, Length=340, Percent_Identity=48.8235294117647, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI133901788, Length=340, Percent_Identity=48.8235294117647, Blast_Score=341, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24158427, Length=340, Percent_Identity=49.4117647058824, Blast_Score=342, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 36320; Mature: 36188

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRALITGITGQDGLYLGELLVGRGYEVFGLVRGQSNPKVATVERLVPGVVLLEGDLTDL
CCCCEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCEEEEECCHHHH
PSLIGAVEISQPDEVYNLGAISFVGLSWKQAELTGETTGMGVLRVLEALRIAGGNDLSRV
HHHHCEEECCCCCHHHCCCCEEEECCCCEEHCCCCCCCCHHHHHHHHHHHHCCCCCHHHE
RFYQASSSEMFGKVRETPQRETTPFHPRSPYGVAKTFGHYLTVNYRESYGLFACSGMLFN
EEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCEEEEEECCCCCEEEECCEEEC
HESPRRGIEFVTRKISRAVARISLGLQDSVSLGNLESRRDWGFAGDYVDAMWRMLQQDTP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
DDFVVATGETHSIRELLDVAFARVGIEDWSGYVRSDPRFFRPAEVDVLVGDASKAREVLG
CCEEEECCCCHHHHHHHHHHHHHHCHHHHCCCCCCCCCEECCCCEEEEECCHHHHHHHHC
WKPRIGFHELVEMMVDADLATEAAAADRH
CCCCCCHHHHHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure 
PRALITGITGQDGLYLGELLVGRGYEVFGLVRGQSNPKVATVERLVPGVVLLEGDLTDL
CCCEEECCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCEEEEECCHHHH
PSLIGAVEISQPDEVYNLGAISFVGLSWKQAELTGETTGMGVLRVLEALRIAGGNDLSRV
HHHHCEEECCCCCHHHCCCCEEEECCCCEEHCCCCCCCCHHHHHHHHHHHHCCCCCHHHE
RFYQASSSEMFGKVRETPQRETTPFHPRSPYGVAKTFGHYLTVNYRESYGLFACSGMLFN
EEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCEEEEEECCCCCEEEECCEEEC
HESPRRGIEFVTRKISRAVARISLGLQDSVSLGNLESRRDWGFAGDYVDAMWRMLQQDTP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
DDFVVATGETHSIRELLDVAFARVGIEDWSGYVRSDPRFFRPAEVDVLVGDASKAREVLG
CCEEEECCCCHHHHHHHHHHHHHHCHHHHCCCCCCCCCEECCCCEEEEECCHHHHHHHHC
WKPRIGFHELVEMMVDADLATEAAAADRH
CCCCCCHHHHHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]