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The map label for this gene is mrpD [H]

Identifier: 158316968

GI number: 158316968

Start: 6255472

End: 6257043

Strand: Reverse

Name: mrpD [H]

Synonym: Franean1_5212

Alternate gene names: 158316968

Gene position: 6257043-6255472 (Counterclockwise)

Preceding gene: 158316969

Following gene: 158316967

Centisome position: 69.66

GC content: 72.33

Gene sequence:

>1572_bases
GTGAGCGTCCTGGCGGTTCTCCCGGTCGTGGTGCCCCTGCTCGCCGCCGGCGCCGTGCTCGTCCTGCGCGGCCGGGTGCG
GGCGCAGCGGATCCTCGCGCTCCTGGTGGTCGCGGGTGTCGTCGCCGACGCGGTGGCGATCGTCGTGATCGCCGACACCG
ACGGTCCGCTGGTCGCGAACCTGGGCGGATGGCCGGCGCCGATCGGCATCACGCTGGTCGCGGACCGGCTCTCCGGCCTG
CTGCTGCTCACCTCGGCCGTCGTCACCTTCGCGGTGCTCGCCTACGCGATCGGCCAGGGCGTCACGGAGGACACTCGCCG
CGGCAACAGCTCGATCTTCCAGTCGGTGTACCTGGTCCTGGTCGCCGGTGTGGCGCTCGCGTATCTCACCGGCGACCTGT
TCAACCTGTTCGTCGCGTTCGAGGTCATGCTGGTCTCGTCCTACGTGCTGATCACGCTCGACACCACCGCGGGGCGCATC
CGCGCCGGCATGACCTACGTGATCGTCAGCATGACGTCGTCCCTGCTGTTCCTCACGATGCTGGCGCTGGTCTACGCGGC
GACCGGGACGATGAACCTCGCCGACCTGTCGGGGCGGGTCGGCGAGCTGCCGGAGGGCCTGGCCGGGGCGCTCGGCCTGC
TGGCCCTGGTCGTCTTCGGTATCAAGGCGGCGGCCGTCCCGCTGCACTTCTGGCTGCCGGACAGCTACCCGACGGCACCG
GCACCGGTCACGGCCGTCCTCGCCGCCCTGCTGACCAAGGTCGGCGTGTACGCGCTGCTGCGGACGCACACCCTGGTGTT
CGCGCATGACGGGGTGTGGGTGCTGCTGCTGGTCGCCGCGGTGGTCACGCTGCTCGTCGGCGCCCTCGGCGCGCTCGCCC
AGGACAACCTGAACCGGATGCTGTCGTACCTGCTGGTGAGCCACATCGGCTACATGCTGTTCGGCCTGTCGCTGTTCACC
GTGATCGGCCTCACCGGCGTGATCATCTATATGGTGCACCACATCGTGGCGCAGGCCGCGCTGTTCCTGGCCAGCGGACT
GATCACCCGGTACGCCGGGACGTCGGTGCCGCGGCGCATGGGCGGGCTGGCGGCCGCCGTGCCGGCGACGGCGGTGCTCT
TCGCGCTGCCGGCGCTCAGCCTCGCGGGCATCCCCCCGTTCTCCGGCTTCGTCGCGAAGCTGACCCTGCTCGAGGCCGGG
TCCGGGGTCGGCACCTGGCCGGTTTACGCCGCGGTCGCCGCCGGCCTGGCCACCAGCCTGCTGACGCTCTACGCGATGGC
CCGGGTATGGACGCTGGCCTTCTGGGGATCGCGCCGGGCGAGCGTGCCCGATCCGGAGCCCGCGGACGACCTGGTGGTCG
GGACGGAGCGGGTGAACCGCCCGATGATCCTGGCGACCGGTGGGATCGTCGCCGTCGGGCTGGCCGCCGCGGTGTTCGCC
GGCCCGCTGGCCGCGCTGAGCCAGCGGGCCGCGGACGACCTGCTCGAGCCGTCGGGCTACGTGGAGTCCGTGCTTCCGGG
CGCCGTCCCGGTGGGGCTCCCGCGGGCCGTTCCGGCAGGGGCTGGCCGATGA

Upstream 100 bases:

>100_bases
CCGAACAGTCCGACCGGGAGGACCGGGAGCCGCCGCGCGAACCGGGTGAGCTCGCCGTGCCCGGCCTGCTCGAGCGGTGC
GACGCCTACGGACGGCACCC

Downstream 100 bases:

>100_bases
GCCGCCGGAGCGCCGGGCCCGAGCCGGCCACCCGCGTGTTCCGTCGGCCCGGCCGGTTGCTGTGGCTGTGGGCGGTGTGG
ATGCTGCTGTGGGGCCGGCC

Product: putative monovalent cation/H+ antiporter subunit D

Products: H2; oxidized ferredoxin [C]

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSVLAVLPVVVPLLAAGAVLVLRGRVRAQRILALLVVAGVVADAVAIVVIADTDGPLVANLGGWPAPIGITLVADRLSGL
LLLTSAVVTFAVLAYAIGQGVTEDTRRGNSSIFQSVYLVLVAGVALAYLTGDLFNLFVAFEVMLVSSYVLITLDTTAGRI
RAGMTYVIVSMTSSLLFLTMLALVYAATGTMNLADLSGRVGELPEGLAGALGLLALVVFGIKAAAVPLHFWLPDSYPTAP
APVTAVLAALLTKVGVYALLRTHTLVFAHDGVWVLLLVAAVVTLLVGALGALAQDNLNRMLSYLLVSHIGYMLFGLSLFT
VIGLTGVIIYMVHHIVAQAALFLASGLITRYAGTSVPRRMGGLAAAVPATAVLFALPALSLAGIPPFSGFVAKLTLLEAG
SGVGTWPVYAAVAAGLATSLLTLYAMARVWTLAFWGSRRASVPDPEPADDLVVGTERVNRPMILATGGIVAVGLAAAVFA
GPLAALSQRAADDLLEPSGYVESVLPGAVPVGLPRAVPAGAGR

Sequences:

>Translated_523_residues
MSVLAVLPVVVPLLAAGAVLVLRGRVRAQRILALLVVAGVVADAVAIVVIADTDGPLVANLGGWPAPIGITLVADRLSGL
LLLTSAVVTFAVLAYAIGQGVTEDTRRGNSSIFQSVYLVLVAGVALAYLTGDLFNLFVAFEVMLVSSYVLITLDTTAGRI
RAGMTYVIVSMTSSLLFLTMLALVYAATGTMNLADLSGRVGELPEGLAGALGLLALVVFGIKAAAVPLHFWLPDSYPTAP
APVTAVLAALLTKVGVYALLRTHTLVFAHDGVWVLLLVAAVVTLLVGALGALAQDNLNRMLSYLLVSHIGYMLFGLSLFT
VIGLTGVIIYMVHHIVAQAALFLASGLITRYAGTSVPRRMGGLAAAVPATAVLFALPALSLAGIPPFSGFVAKLTLLEAG
SGVGTWPVYAAVAAGLATSLLTLYAMARVWTLAFWGSRRASVPDPEPADDLVVGTERVNRPMILATGGIVAVGLAAAVFA
GPLAALSQRAADDLLEPSGYVESVLPGAVPVGLPRAVPAGAGR
>Mature_522_residues
SVLAVLPVVVPLLAAGAVLVLRGRVRAQRILALLVVAGVVADAVAIVVIADTDGPLVANLGGWPAPIGITLVADRLSGLL
LLTSAVVTFAVLAYAIGQGVTEDTRRGNSSIFQSVYLVLVAGVALAYLTGDLFNLFVAFEVMLVSSYVLITLDTTAGRIR
AGMTYVIVSMTSSLLFLTMLALVYAATGTMNLADLSGRVGELPEGLAGALGLLALVVFGIKAAAVPLHFWLPDSYPTAPA
PVTAVLAALLTKVGVYALLRTHTLVFAHDGVWVLLLVAAVVTLLVGALGALAQDNLNRMLSYLLVSHIGYMLFGLSLFTV
IGLTGVIIYMVHHIVAQAALFLASGLITRYAGTSVPRRMGGLAAAVPATAVLFALPALSLAGIPPFSGFVAKLTLLEAGS
GVGTWPVYAAVAAGLATSLLTLYAMARVWTLAFWGSRRASVPDPEPADDLVVGTERVNRPMILATGGIVAVGLAAAVFAG
PLAALSQRAADDLLEPSGYVESVLPGAVPVGLPRAVPAGAGR

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=209, Percent_Identity=29.1866028708134, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI251831116, Length=390, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788827, Length=290, Percent_Identity=31.7241379310345, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788829, Length=345, Percent_Identity=31.0144927536232, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1788613, Length=360, Percent_Identity=30, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788831, Length=348, Percent_Identity=28.448275862069, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI145693160, Length=363, Percent_Identity=30.3030303030303, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI2367154, Length=372, Percent_Identity=25, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788614, Length=417, Percent_Identity=28.0575539568345, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 53650; Mature: 53519

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLAVLPVVVPLLAAGAVLVLRGRVRAQRILALLVVAGVVADAVAIVVIADTDGPLVAN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEC
LGGWPAPIGITLVADRLSGLLLLTSAVVTFAVLAYAIGQGVTEDTRRGNSSIFQSVYLVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHH
VAGVALAYLTGDLFNLFVAFEVMLVSSYVLITLDTTAGRIRAGMTYVIVSMTSSLLFLTM
HHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LALVYAATGTMNLADLSGRVGELPEGLAGALGLLALVVFGIKAAAVPLHFWLPDSYPTAP
HHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCC
APVTAVLAALLTKVGVYALLRTHTLVFAHDGVWVLLLVAAVVTLLVGALGALAQDNLNRM
CCHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSYLLVSHIGYMLFGLSLFTVIGLTGVIIYMVHHIVAQAALFLASGLITRYAGTSVPRRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
GGLAAAVPATAVLFALPALSLAGIPPFSGFVAKLTLLEAGSGVGTWPVYAAVAAGLATSL
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LTLYAMARVWTLAFWGSRRASVPDPEPADDLVVGTERVNRPMILATGGIVAVGLAAAVFA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECHHHCCCCEEEECCHHHHHHHHHHHHH
GPLAALSQRAADDLLEPSGYVESVLPGAVPVGLPRAVPAGAGR
HHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVLAVLPVVVPLLAAGAVLVLRGRVRAQRILALLVVAGVVADAVAIVVIADTDGPLVAN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEEEC
LGGWPAPIGITLVADRLSGLLLLTSAVVTFAVLAYAIGQGVTEDTRRGNSSIFQSVYLVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHH
VAGVALAYLTGDLFNLFVAFEVMLVSSYVLITLDTTAGRIRAGMTYVIVSMTSSLLFLTM
HHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LALVYAATGTMNLADLSGRVGELPEGLAGALGLLALVVFGIKAAAVPLHFWLPDSYPTAP
HHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCC
APVTAVLAALLTKVGVYALLRTHTLVFAHDGVWVLLLVAAVVTLLVGALGALAQDNLNRM
CCHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSYLLVSHIGYMLFGLSLFTVIGLTGVIIYMVHHIVAQAALFLASGLITRYAGTSVPRRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
GGLAAAVPATAVLFALPALSLAGIPPFSGFVAKLTLLEAGSGVGTWPVYAAVAAGLATSL
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LTLYAMARVWTLAFWGSRRASVPDPEPADDLVVGTERVNRPMILATGGIVAVGLAAAVFA
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECHHHCCCCEEEECCHHHHHHHHHHHHH
GPLAALSQRAADDLLEPSGYVESVLPGAVPVGLPRAVPAGAGR
HHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton; reduced ferredoxin [C]

Specific reaction: Proton + reduced ferredoxin = H2 + oxidized ferredoxin [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]