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The map label for this gene is dut [H]

Identifier: 158316952

GI number: 158316952

Start: 6237998

End: 6238693

Strand: Reverse

Name: dut [H]

Synonym: Franean1_5196

Alternate gene names: 158316952

Gene position: 6238693-6237998 (Counterclockwise)

Preceding gene: 158316954

Following gene: 158316951

Centisome position: 69.46

GC content: 72.27

Gene sequence:

>696_bases
ATGACCGCGACCACCCCCACGCCACCCGGCGCCCCGCTTCCTGTCGGCGCCCTGCGCGCCTACGTTCCACCAGCCGACGC
CGTGCCCGGTGATGGCGTGGCCGGCGACATCGTCCTCGGCGCGCAGCGCCCCGAGCCGCCGACCCGCCAGCCGACCGGTG
ATTCGGTGCCGCCGACCGGCCAGCAGGCCGCCGGCGCGGGCACGCTGGAGGTGCTGGTCCGCCGTCTGGACCCGGATCTC
CCGCTGCCCGCCTACGCCCAGCCCTCGGACGCCGGCGCCGACCTGGTGACCGCGCAGGACGTCACGCTGGCGCCCGGTGA
ACGGGCCATCGTCGGAACCGGCCTCTCCGTCGCGCTGCCCGAGGGTTATGCGGCTTTCGTGCATCCCCGCAGCGGACTGG
CCGCGCGACACGGTCTGTCCGTGGTCAACGCCCCCGGAACCGTCGATGCCGGTTACCGTGGAGAAGTCAAGGTGATACTT
ATAAACACCGATCGAAGTGAAGTCATCGCTCTCCGTCGTGGGGATCGGGTGGCTCAGCTCGTGGTCCAGCGGGTGGAGCA
CGCGGTCTTCCGCGAGGTCGACCTGCTCCCGGATTCCGTCCGGGGTGCGGGCGGCTTCGGGTCGACGGGCGGTTTCGGGC
GGTCCTCCGACGGTGGACCGCGAAGGGAGGGCCACGGTGTTCGGTCGGGGTCGTAG

Upstream 100 bases:

>100_bases
CGGGTCGTCCTCGTGTCGCCGGCATGTGCCGGCCGTCTCGTCACGGGGAGTCGTTAGTGTCGCGGACAGCCCGCCCGGGT
GAGGACGACCCAGGAGAATC

Downstream 100 bases:

>100_bases
GTCGTCGGCCGTCATGGCGGCCGACCCGAGGGCGGAGGAGCCGGACGACGTCGATCTGGTCGGCCCCTTCGACCTCGAGG
AGGCGCCCGACGACGACGTG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase Dut

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTATTPTPPGAPLPVGALRAYVPPADAVPGDGVAGDIVLGAQRPEPPTRQPTGDSVPPTGQQAAGAGTLEVLVRRLDPDL
PLPAYAQPSDAGADLVTAQDVTLAPGERAIVGTGLSVALPEGYAAFVHPRSGLAARHGLSVVNAPGTVDAGYRGEVKVIL
INTDRSEVIALRRGDRVAQLVVQRVEHAVFREVDLLPDSVRGAGGFGSTGGFGRSSDGGPRREGHGVRSGS

Sequences:

>Translated_231_residues
MTATTPTPPGAPLPVGALRAYVPPADAVPGDGVAGDIVLGAQRPEPPTRQPTGDSVPPTGQQAAGAGTLEVLVRRLDPDL
PLPAYAQPSDAGADLVTAQDVTLAPGERAIVGTGLSVALPEGYAAFVHPRSGLAARHGLSVVNAPGTVDAGYRGEVKVIL
INTDRSEVIALRRGDRVAQLVVQRVEHAVFREVDLLPDSVRGAGGFGSTGGFGRSSDGGPRREGHGVRSGS
>Mature_230_residues
TATTPTPPGAPLPVGALRAYVPPADAVPGDGVAGDIVLGAQRPEPPTRQPTGDSVPPTGQQAAGAGTLEVLVRRLDPDLP
LPAYAQPSDAGADLVTAQDVTLAPGERAIVGTGLSVALPEGYAAFVHPRSGLAARHGLSVVNAPGTVDAGYRGEVKVILI
NTDRSEVIALRRGDRVAQLVVQRVEHAVFREVDLLPDSVRGAGGFGSTGGFGRSSDGGPRREGHGVRSGS

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906441, Length=167, Percent_Identity=39.5209580838323, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI4503423, Length=164, Percent_Identity=39.0243902439024, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI70906444, Length=142, Percent_Identity=41.5492957746479, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1790071, Length=148, Percent_Identity=35.1351351351351, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71988561, Length=162, Percent_Identity=40.7407407407407, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319729, Length=130, Percent_Identity=41.5384615384615, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19921126, Length=121, Percent_Identity=43.801652892562, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583610, Length=121, Percent_Identity=43.801652892562, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 23461; Mature: 23329

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATTPTPPGAPLPVGALRAYVPPADAVPGDGVAGDIVLGAQRPEPPTRQPTGDSVPPTG
CCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
QQAAGAGTLEVLVRRLDPDLPLPAYAQPSDAGADLVTAQDVTLAPGERAIVGTGLSVALP
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCEEECCCCEEEEECCCEEECC
EGYAAFVHPRSGLAARHGLSVVNAPGTVDAGYRGEVKVILINTDRSEVIALRRGDRVAQL
CCEEEEEECCCCCHHHHCCEEEECCCCCCCCCCCCEEEEEEECCCHHEEEECCCCHHHHH
VVQRVEHAVFREVDLLPDSVRGAGGFGSTGGFGRSSDGGPRREGHGVRSGS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TATTPTPPGAPLPVGALRAYVPPADAVPGDGVAGDIVLGAQRPEPPTRQPTGDSVPPTG
CCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
QQAAGAGTLEVLVRRLDPDLPLPAYAQPSDAGADLVTAQDVTLAPGERAIVGTGLSVALP
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCEEECCCCEEEEECCCEEECC
EGYAAFVHPRSGLAARHGLSVVNAPGTVDAGYRGEVKVILINTDRSEVIALRRGDRVAQL
CCEEEEEECCCCCHHHHCCEEEECCCCCCCCCCCCEEEEEEECCCHHEEEECCCCHHHHH
VVQRVEHAVFREVDLLPDSVRGAGGFGSTGGFGRSSDGGPRREGHGVRSGS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA