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The map label for this gene is fadA [H]

Identifier: 158316935

GI number: 158316935

Start: 6215526

End: 6216743

Strand: Direct

Name: fadA [H]

Synonym: Franean1_5179

Alternate gene names: 158316935

Gene position: 6215526-6216743 (Clockwise)

Preceding gene: 158316934

Following gene: 158316936

Centisome position: 69.2

GC content: 72.58

Gene sequence:

>1218_bases
GTGTTCGTCAGCGCGCAGGGTTCGATCCGTGACGTGGTGTTCGTCGACGGTGTACGCACTCCCTTCGGCAAGGCCAAGGG
CGTCTACGCCGAGACCCGGGCCGACGACCTGGTGGTCCGGGTCATCCGCGAGCTGATGCGGCGCAATCCCGCGCTGCCGC
CCGAGCGGGTCGACGAGGTCGCGATCGCGGCGACGACCCAGATCGGCGATCAGGGCCTGACCATCGGCCGGGTCGCCGGC
ATCCTGGCCGGGCTGCCCGAGTCGGTGCCCGGCTACGCCATCGACCGGATGTGCGCGGGCGCGGTGACGGCGGTGACCAC
CACCGCGTCCGCGATCGCCGTCGGCGCCTACGACATCGCCATCGCCGGCGGCGTCGAGCACATGGGGCGCCATCCGATGG
GCGAGGGCGTGGACCCGAACCCGCGGTTCGTCTCCGAGCGTCTCGTCGATCCCTCCGCGCTGGTCATGGGCATGACCGCG
GAGAACGTGCACGACCGGTTCCCGGGGATCACCCGGGCCCGGGCGGACGCGTACGCCGCCGCGTCGCAGGCGAAGGCCGC
CAAGGCGTACGCGGACGGCAGGATCCAGCCCGACCTCGTCCCCGTCGCCGCGCGGCACGTCGACAGCGGCTGGGAGCTGG
TCACCGCGGACGAGCCGCCCCGGCCCGGCACCACCGTCGAGGGCCTCGCCGGGCTGCGGACACCGTTCCGGCCGCACGGG
CGGGTCACCGCGGGCAACGCCGCGGGCATCAACGACGGCGCCACCGGCTGCGTGCTCGCCGCCGCGGACGTCGCCGCCGA
GCTCGGCCTGACCCGGAAGATGTCGCTGGTCGGGTTCGGGTTCGCCGGTGTGGCGCCCGAGGTCATGGGTGTCGGGCCGA
TCCCGTCCACGGAGAAGGCGCTGGCCCGCACCGGCCTGAGCATCGACGACATCGGCCTGTTCGAGCTGAACGAGGCCTTC
GCCGTGCAGGTGATCGCCTTCCTGGAACACTTCGGCCTCGCCGACGACGACCCGCGGGTCAACCCCTACGGCGGCGCCAT
CGCGTACGGGCACCCGCTCGCCTCCAGCGGAGTGCGACTGATGACCCAGCTGGCCCGCCAGTTCGAGGAGCATCCCGAGG
TCCGCTACGGGATGACCGCGATGTGCGTGGGCTTCGGCATGGGAGCGACGACGATCTGGGAGAACCCGCACTTCGGCCGA
ACGGGAGAAGGAGCATGA

Upstream 100 bases:

>100_bases
TCCCGTCGCGGTCCGGCGCCACTGCGGGCAGCCGGCCCGACACCGTCTGCCGTGGGCCGCGCACGTGCCGCCCACGGGTG
AGGCGTCGAGGAGGCCGGTG

Downstream 100 bases:

>100_bases
GCAGCGCCGCGATGACCCTGGAGCACCCGGACGAGGTCGTCACGCAGGCCCATGTCCGGTACGCACAACTGTCCGGCGTG
AGCGGCCCGGTCGCGCTCAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MFVSAQGSIRDVVFVDGVRTPFGKAKGVYAETRADDLVVRVIRELMRRNPALPPERVDEVAIAATTQIGDQGLTIGRVAG
ILAGLPESVPGYAIDRMCAGAVTAVTTTASAIAVGAYDIAIAGGVEHMGRHPMGEGVDPNPRFVSERLVDPSALVMGMTA
ENVHDRFPGITRARADAYAAASQAKAAKAYADGRIQPDLVPVAARHVDSGWELVTADEPPRPGTTVEGLAGLRTPFRPHG
RVTAGNAAGINDGATGCVLAAADVAAELGLTRKMSLVGFGFAGVAPEVMGVGPIPSTEKALARTGLSIDDIGLFELNEAF
AVQVIAFLEHFGLADDDPRVNPYGGAIAYGHPLASSGVRLMTQLARQFEEHPEVRYGMTAMCVGFGMGATTIWENPHFGR
TGEGA

Sequences:

>Translated_405_residues
MFVSAQGSIRDVVFVDGVRTPFGKAKGVYAETRADDLVVRVIRELMRRNPALPPERVDEVAIAATTQIGDQGLTIGRVAG
ILAGLPESVPGYAIDRMCAGAVTAVTTTASAIAVGAYDIAIAGGVEHMGRHPMGEGVDPNPRFVSERLVDPSALVMGMTA
ENVHDRFPGITRARADAYAAASQAKAAKAYADGRIQPDLVPVAARHVDSGWELVTADEPPRPGTTVEGLAGLRTPFRPHG
RVTAGNAAGINDGATGCVLAAADVAAELGLTRKMSLVGFGFAGVAPEVMGVGPIPSTEKALARTGLSIDDIGLFELNEAF
AVQVIAFLEHFGLADDDPRVNPYGGAIAYGHPLASSGVRLMTQLARQFEEHPEVRYGMTAMCVGFGMGATTIWENPHFGR
TGEGA
>Mature_405_residues
MFVSAQGSIRDVVFVDGVRTPFGKAKGVYAETRADDLVVRVIRELMRRNPALPPERVDEVAIAATTQIGDQGLTIGRVAG
ILAGLPESVPGYAIDRMCAGAVTAVTTTASAIAVGAYDIAIAGGVEHMGRHPMGEGVDPNPRFVSERLVDPSALVMGMTA
ENVHDRFPGITRARADAYAAASQAKAAKAYADGRIQPDLVPVAARHVDSGWELVTADEPPRPGTTVEGLAGLRTPFRPHG
RVTAGNAAGINDGATGCVLAAADVAAELGLTRKMSLVGFGFAGVAPEVMGVGPIPSTEKALARTGLSIDDIGLFELNEAF
AVQVIAFLEHFGLADDDPRVNPYGGAIAYGHPLASSGVRLMTQLARQFEEHPEVRYGMTAMCVGFGMGATTIWENPHFGR
TGEGA

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=37.8787878787879, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=35.2185089974293, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI167614485, Length=398, Percent_Identity=31.1557788944724, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4557237, Length=389, Percent_Identity=30.3341902313625, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI4504327, Length=437, Percent_Identity=29.2906178489703, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI194353979, Length=245, Percent_Identity=34.2857142857143, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=42.0398009950249, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI48994986, Length=389, Percent_Identity=39.3316195372751, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=35.1758793969849, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI87082165, Length=400, Percent_Identity=35.75, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1788683, Length=406, Percent_Identity=30.5418719211823, Blast_Score=148, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=397, Percent_Identity=34.0050377833753, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=31.8877551020408, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17535921, Length=390, Percent_Identity=31.025641025641, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17551802, Length=434, Percent_Identity=27.6497695852535, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17535917, Length=386, Percent_Identity=25.6476683937824, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=36.9620253164557, Blast_Score=218, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=30.4785894206549, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=36.1538461538462, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI17648125, Length=358, Percent_Identity=34.6368715083799, Blast_Score=204, Evalue=8e-53,
Organism=Drosophila melanogaster, GI17137578, Length=433, Percent_Identity=29.3302540415704, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=30.9823677581864, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42267; Mature: 42267

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVSAQGSIRDVVFVDGVRTPFGKAKGVYAETRADDLVVRVIRELMRRNPALPPERVDEV
CEECCCCCCEEEEEECCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
AIAATTQIGDQGLTIGRVAGILAGLPESVPGYAIDRMCAGAVTAVTTTASAIAVGAYDIA
HEEEEHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCEE
IAGGVEHMGRHPMGEGVDPNPRFVSERLVDPSALVMGMTAENVHDRFPGITRARADAYAA
EECCHHHHCCCCCCCCCCCCHHHHHHHHCCCHHEEEECCHHHHHHHCCCCHHHHHHHHHH
ASQAKAAKAYADGRIQPDLVPVAARHVDSGWELVTADEPPRPGTTVEGLAGLRTPFRPHG
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCCCC
RVTAGNAAGINDGATGCVLAAADVAAELGLTRKMSLVGFGFAGVAPEVMGVGPIPSTEKA
CEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCHHHCCHHHHCCCCCCCHHHH
LARTGLSIDDIGLFELNEAFAVQVIAFLEHFGLADDDPRVNPYGGAIAYGHPLASSGVRL
HHHCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHH
MTQLARQFEEHPEVRYGMTAMCVGFGMGATTIWENPHFGRTGEGA
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MFVSAQGSIRDVVFVDGVRTPFGKAKGVYAETRADDLVVRVIRELMRRNPALPPERVDEV
CEECCCCCCEEEEEECCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHH
AIAATTQIGDQGLTIGRVAGILAGLPESVPGYAIDRMCAGAVTAVTTTASAIAVGAYDIA
HEEEEHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCEE
IAGGVEHMGRHPMGEGVDPNPRFVSERLVDPSALVMGMTAENVHDRFPGITRARADAYAA
EECCHHHHCCCCCCCCCCCCHHHHHHHHCCCHHEEEECCHHHHHHHCCCCHHHHHHHHHH
ASQAKAAKAYADGRIQPDLVPVAARHVDSGWELVTADEPPRPGTTVEGLAGLRTPFRPHG
HHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCCCC
RVTAGNAAGINDGATGCVLAAADVAAELGLTRKMSLVGFGFAGVAPEVMGVGPIPSTEKA
CEECCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCHHHCCHHHHCCCCCCCHHHH
LARTGLSIDDIGLFELNEAFAVQVIAFLEHFGLADDDPRVNPYGGAIAYGHPLASSGVRL
HHHCCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHH
MTQLARQFEEHPEVRYGMTAMCVGFGMGATTIWENPHFGRTGEGA
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA