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The map label for this gene is hemY [H]

Identifier: 158316930

GI number: 158316930

Start: 6208899

End: 6210311

Strand: Reverse

Name: hemY [H]

Synonym: Franean1_5174

Alternate gene names: 158316930

Gene position: 6210311-6208899 (Counterclockwise)

Preceding gene: 158316931

Following gene: 158316929

Centisome position: 69.14

GC content: 77.35

Gene sequence:

>1413_bases
GTGCGGGTTGTGATCATTGGAGCGGGTATCGCAGGGCTGTCCGCCGCGAGCGCGCTGACGGGCAGGGCCGAGGTCACCGT
GGTCGAGGCCGGTGACCGCATCGGCGGCAAGCTGCGCACCACCCCGATCGAGGGGCTGGCGGTGGAGGAGGGCGCGGAGG
CCTTCCTCGTCCGCGTGCCGGAGGCGCTCCGGCTGGCCCGGCACGTCGGGCTCGGGCACGACATCGTGCATCCGACGACG
ACCAAGGCCTCGCTGTGGGTGGGCGGGCGGCGCCGTCCCATCCCGCCCAACACGATGCTGGGGGTCCCGACCGACGTGCT
CGGCCTGGTGCGCTCCCGGGTGCTCTCGCCCTTCGGGCTGCTGCGCGCCGCGGCCGACCTGGTGCTCCCGCGCACGACCC
TGCCGACGGACCCGACGGTCGGCGGGTACGTCGGCGCCCGCGTCGGGCGGGAGATCGTGGACCGGCTGGTGGACCCGCTG
CTCGGCGGCGTCTACGCCGGGCGGGCCGACGCGCTCTCGCTGCAGGCGACCGTCCCCCAGCTCACCCCGATCGCGACCGA
GGACCGCTCGCTGCTGCTCGGCGCGCACCGCGTCCGGGCCCGGACCGGACCGGCCCCGGCGCAGACGCCCGTGTTCGCCT
CGCTGCGCGGCGGCCTGGGCTCGTTCGCGGAGAAGGTGGCCAGCACCAGCGGTGCCACGGTGCGGACCGGGCTGATGGCC
CGGGAGCTGCGCCGGGTCGAGGGCGGCTGGCAGGTGCGCTGCGACCCGGTGGGCGGCGGTGAGGTGCCCCCGCCCCTGGT
CGCCGACGCGGTGATCCTCGCGGTTCCCGCCGGCGCCGCGCGTGATCTCCTCTCCCCGATCGCCCCGCACGCGGCCGCGC
CCCTCGCGGGGGTGCCATACGCGTCGGTGGGCCTGGTCACACTGCTCTACCGGGGAGCTGTGCCGCCGCCCGGCAGCGGC
CTGCTCGTCCCCGCGCGGGCCGGCCTGTCGATCAAGGCGGTGACCTACCTGTCGGTGAAATGGCCGCACATCGCCCGCGG
TGGCGACCTGACGGTCGTGCGGGCCAGCGTGGGCCGTGCCGGCGCCGACGACGACCTGCGGCGCGGCGATGTCGAGCTCG
CCGGCGTCGCCGCCGCCGAGGTCGCCCAGGTCACCGGGATCAGCGCCCGTCCGATCGCCAACCGGGTCAGCCGCTGGGGC
GGGGCGCTCCCGCAGTACCTGCCGGGGCACCTAGGTCGGATCGCGGCCGTCCGGCGCGCGCTGCCGGCGGGCATCGCGCT
CGCCGGCGCCGGCTACGACGGTGTGGGCATCCCGGCGTGCATCCGTTCCGGCGAGGCGGCCGCGGCGTCGGTGGTGGGCC
AGCTGCGGCCGGACGGGACGCAGGCGGCGGAGTCCGAGCCGGCGGGGGCCTGA

Upstream 100 bases:

>100_bases
ACTCGGGCCGGTCCGGCCGTGAGGTCGGTGGCGCCGTGGGCCCAGGGCCCCGATCCGGGGGCGGCCACACGGGGACGGCG
TGAAGGGGCTGGGAGAAGAC

Downstream 100 bases:

>100_bases
GCCGGCGGGAGGGCTGAGTCCCGCCCGTGCCGCGCGGTGGTGTGCCCCGGCTGGGTCGCAGACCGGCGGCCGGGGTGGAC
AATGGTGGCATGTCAACTGG

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MRVVIIGAGIAGLSAASALTGRAEVTVVEAGDRIGGKLRTTPIEGLAVEEGAEAFLVRVPEALRLARHVGLGHDIVHPTT
TKASLWVGGRRRPIPPNTMLGVPTDVLGLVRSRVLSPFGLLRAAADLVLPRTTLPTDPTVGGYVGARVGREIVDRLVDPL
LGGVYAGRADALSLQATVPQLTPIATEDRSLLLGAHRVRARTGPAPAQTPVFASLRGGLGSFAEKVASTSGATVRTGLMA
RELRRVEGGWQVRCDPVGGGEVPPPLVADAVILAVPAGAARDLLSPIAPHAAAPLAGVPYASVGLVTLLYRGAVPPPGSG
LLVPARAGLSIKAVTYLSVKWPHIARGGDLTVVRASVGRAGADDDLRRGDVELAGVAAAEVAQVTGISARPIANRVSRWG
GALPQYLPGHLGRIAAVRRALPAGIALAGAGYDGVGIPACIRSGEAAAASVVGQLRPDGTQAAESEPAGA

Sequences:

>Translated_470_residues
MRVVIIGAGIAGLSAASALTGRAEVTVVEAGDRIGGKLRTTPIEGLAVEEGAEAFLVRVPEALRLARHVGLGHDIVHPTT
TKASLWVGGRRRPIPPNTMLGVPTDVLGLVRSRVLSPFGLLRAAADLVLPRTTLPTDPTVGGYVGARVGREIVDRLVDPL
LGGVYAGRADALSLQATVPQLTPIATEDRSLLLGAHRVRARTGPAPAQTPVFASLRGGLGSFAEKVASTSGATVRTGLMA
RELRRVEGGWQVRCDPVGGGEVPPPLVADAVILAVPAGAARDLLSPIAPHAAAPLAGVPYASVGLVTLLYRGAVPPPGSG
LLVPARAGLSIKAVTYLSVKWPHIARGGDLTVVRASVGRAGADDDLRRGDVELAGVAAAEVAQVTGISARPIANRVSRWG
GALPQYLPGHLGRIAAVRRALPAGIALAGAGYDGVGIPACIRSGEAAAASVVGQLRPDGTQAAESEPAGA
>Mature_470_residues
MRVVIIGAGIAGLSAASALTGRAEVTVVEAGDRIGGKLRTTPIEGLAVEEGAEAFLVRVPEALRLARHVGLGHDIVHPTT
TKASLWVGGRRRPIPPNTMLGVPTDVLGLVRSRVLSPFGLLRAAADLVLPRTTLPTDPTVGGYVGARVGREIVDRLVDPL
LGGVYAGRADALSLQATVPQLTPIATEDRSLLLGAHRVRARTGPAPAQTPVFASLRGGLGSFAEKVASTSGATVRTGLMA
RELRRVEGGWQVRCDPVGGGEVPPPLVADAVILAVPAGAARDLLSPIAPHAAAPLAGVPYASVGLVTLLYRGAVPPPGSG
LLVPARAGLSIKAVTYLSVKWPHIARGGDLTVVRASVGRAGADDDLRRGDVELAGVAAAEVAQVTGISARPIANRVSRWG
GALPQYLPGHLGRIAAVRRALPAGIALAGAGYDGVGIPACIRSGEAAAASVVGQLRPDGTQAAESEPAGA

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=497, Percent_Identity=30.9859154929577, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI4506001, Length=497, Percent_Identity=30.9859154929577, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24649745, Length=341, Percent_Identity=23.7536656891496, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 47723; Mature: 47723

Theoretical pI: Translated: 10.77; Mature: 10.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVIIGAGIAGLSAASALTGRAEVTVVEAGDRIGGKLRTTPIEGLAVEEGAEAFLVRVP
CEEEEEECCHHHHHHHHHHCCCEEEEEEECCCCCCCEEECCCCCCEEECCCCCEEEEECH
EALRLARHVGLGHDIVHPTTTKASLWVGGRRRPIPPNTMLGVPTDVLGLVRSRVLSPFGL
HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHH
LRAAADLVLPRTTLPTDPTVGGYVGARVGREIVDRLVDPLLGGVYAGRADALSLQATVPQ
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
LTPIATEDRSLLLGAHRVRARTGPAPAQTPVFASLRGGLGSFAEKVASTSGATVRTGLMA
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCHHHHHHHH
RELRRVEGGWQVRCDPVGGGEVPPPLVADAVILAVPAGAARDLLSPIAPHAAAPLAGVPY
HHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHEEECCCHHHHHHHHHCCHHCCCCCCCCH
ASVGLVTLLYRGAVPPPGSGLLVPARAGLSIKAVTYLSVKWPHIARGGDLTVVRASVGRA
HHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEEEEEEEECCCEECCCCEEEEEECCCCC
GADDDLRRGDVELAGVAAAEVAQVTGISARPIANRVSRWGGALPQYLPGHLGRIAAVRRA
CCCCCHHCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHH
LPAGIALAGAGYDGVGIPACIRSGEAAAASVVGQLRPDGTQAAESEPAGA
HCCCEEEECCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRVVIIGAGIAGLSAASALTGRAEVTVVEAGDRIGGKLRTTPIEGLAVEEGAEAFLVRVP
CEEEEEECCHHHHHHHHHHCCCEEEEEEECCCCCCCEEECCCCCCEEECCCCCEEEEECH
EALRLARHVGLGHDIVHPTTTKASLWVGGRRRPIPPNTMLGVPTDVLGLVRSRVLSPFGL
HHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHH
LRAAADLVLPRTTLPTDPTVGGYVGARVGREIVDRLVDPLLGGVYAGRADALSLQATVPQ
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
LTPIATEDRSLLLGAHRVRARTGPAPAQTPVFASLRGGLGSFAEKVASTSGATVRTGLMA
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCCHHHHHHHH
RELRRVEGGWQVRCDPVGGGEVPPPLVADAVILAVPAGAARDLLSPIAPHAAAPLAGVPY
HHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHEEECCCHHHHHHHHHCCHHCCCCCCCCH
ASVGLVTLLYRGAVPPPGSGLLVPARAGLSIKAVTYLSVKWPHIARGGDLTVVRASVGRA
HHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEEEEEEEECCCEECCCCEEEEEECCCCC
GADDDLRRGDVELAGVAAAEVAQVTGISARPIANRVSRWGGALPQYLPGHLGRIAAVRRA
CCCCCHHCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHH
LPAGIALAGAGYDGVGIPACIRSGEAAAASVVGQLRPDGTQAAESEPAGA
HCCCEEEECCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]