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The map label for this gene is relA [H]

Identifier: 158316895

GI number: 158316895

Start: 6158535

End: 6161174

Strand: Reverse

Name: relA [H]

Synonym: Franean1_5139

Alternate gene names: 158316895

Gene position: 6161174-6158535 (Counterclockwise)

Preceding gene: 158316896

Following gene: 158316894

Centisome position: 68.59

GC content: 72.23

Gene sequence:

>2640_bases
GTGCCTGAGGCGCCGCCGGTGACCACCGGATCCGTGCCGACGGCCGCGTCATCCGCCGGGGATACGCGGCCGGTCCAGGC
TGCCCTGTCCGCGACCGACCGCACGCCGTCCACCGCGGACCGTGCGCCGCTCGCAGCCGACCGCACGCCGTCCACCGCCG
ACCGCACGCCGCTCGCGGGCGGCCAGCTCCCGCGCACCGGGCCGTCGTCCGCCGCGCACGGCGGCCGTGACGGCGCCGAG
GGCGGGTCGGCGTCCTCGCCCGTCCCGGACGCCCCCGGAGAGGACGCCGAGAGCGGCTCGCCGGTGGTGCCGCGGCTGGG
GCACGAGTCGCCTCCGCTGCCTCGCCGGGTCCGCCGCTTCTCCCGGCTGGGGGCGCACCGCGCCACGCCGCCCTCGTCGC
TGGATCCGGTGCTGCGGGGGCTGGTCGCGAACCACCCGCGGATGGACATCGGGCCGGTGCAGCGGGCGTTCGAGGTGGCC
GACGCGGCCCACGCCGGGCAGGTCCGTTTCTCCGGGCACCCGTACATCACCCATCCGATCGCGGTCGCCAGCATCCTGGC
CGATCTCGGCATGGACATCCCGACGCTGTGCGCCGCGCTGCTGCACGACACCCTGGAGGAGACCGACCTCCCGCCGGAGA
CGATCGAGGCCGAGTTCGGCCCGCAGGTGCTGCAGATCGTCGACGCCGTCAGCAAGCTCAACCGGGTCAAGGTCGGCGAG
GCCGCGCAGACCGAGACCATCCGCCGGATGGTCGTCGCCATGGCGCGCGACCCGCGGGCCCTGGTGGTCAAGCTCGCTGA
CCGCCTGCACAACATGCGGACGCTGCGCTTCCTGCCCGAACACAAGCAGGAGCGCAAGGCGCGCGAGACGCTGGAGATCT
ACGCGCCGCTGGCCCACCGCCTCGGGATGAACTCCCTCAAGTGGGAGCTGGAGGACCTGGCCTTCGCGGCGCTGTTCCCC
AAGCGCTACGACGAGATCGTCCGCCTTGTGGCCGACCGGGCACCCAGCCGCGACGTCTACCTCACCGAGACGTCCACGCA
GGTGCAGACGCAGCTGGCCGAGGCGCGGATCAAGGCCGTGGTGACCGGCCGGCCGAAGCACTACTACTCGATCTACCAGA
AGATGGTCGTCCGCGGCCGGTCCTTCGAGGACATCTACGACCTCGTCGGCATCCGGGTGCTGGTCGACTCGGTGCGGGAC
TGCTACGCGGCGCTGGGCACCGTCCACGCGAACTGGAAGCCGATCCCGGGCCGGTTCAAGGACTACATCGCGATGCCCAA
GTACAACATGTACCAGTCGCTGCACACGACGGTCATCGGGCCCGAGGGCAAGCCGGTCGAGCTGCAGATCCGCACACACT
CGATGCACAACCGCGCCGAGTACGGCATCGCGGCGCACTGGAAGTACAAGGAGGACGGCTCCGGCGCGGGCTCCCGGTCC
GGCGGTTCCCGCTCGTCGGGCTCGTCGGCGTCGCGGCGGGCTGCCGCGAACAGCGGCGCCGGGGGCACCGACCCGAACCT
GCGCAACTGGCTGCGCCAGATCCTGGACTGGCAGCGCGAGACGGCCGACCCGGGGGAGTTCCTCGACAGCCTGCGCTTCG
ACATGGCCGACGACGAGGTCTTCGTCTTCACGCCGAAGGGCGACGTCATCCCGCTGCCGGTCGGGTCGACGCCGATCGAC
TTCGCCTACGCCGTACACACCGACATCGGCCACCAGTGCGTCGGCGCCCGGGTCAACGGCCGGCTCGCGGCGCTCGACAC
CGCGCTGGAGAACGGCGACACGGTCGAGGTCTTCACCTCGCGGGCCCACTCGGCCGGCCCGAGCGAGGACTGGCTGACCT
TCGTCCACTCGTCCCGCGCCCGGACGAAGATCCGCCAGTGGCACGCCCGGGAGCGCCGCGAGGACGCGATCGTCGCCGGC
CGGGACGCGATCGGCCGGGCGATGCGCCGCCACGGCCTCCCGCTGGCCCGCCTGATGACCGGCGACGCGCTGCTGACCCT
GGCGAAGGACATGCGCTACGCCGACGTCGCGGCGCTGTACGCGGCGGTCGGAGAGAAGAACATCAGCGCGCAGGCGGTGG
TGAACCGGCTGCTACAGGGGCTCGGCGGTCCCGAGGGCGCCGAGGAGGACGCGGCCGAGATCGAGCTGCCGATCCGGGCC
CTGCGCCGGGCCACCGGTGACGCCGGCGTGCTCGTCACCGGTTCCCCGGACGTGTGGGCCAAGCTGGCCCGCTGCTGCAC
GCCGATGCCCGGCGACGCCATCGCCGGCTTCGTCACCCGGGGCAAGGGCGTGTCGGTGCACCGCGCCGACTGCGTCAACC
TCGCCGGCCTGCGGGGCGGCCCGCACGACCGGACGGTCGAGGTGGAGTGGGCGCCGTCATCGGGCTCGGTCTTCCTGGTA
GTGATCCAGGTGGAGGCGCTGGACCGGACCCGACTGCTCTCCGATGTGACCAGGGTGCTGTCCGACCACCACGTCAACAT
CCTCTCCGCGTCGGTCACCACGACGCGCGAGCAGGTGGCGGTCAGCCGGTTCACCTTCGAGATGGGCGACGCCAAGCATC
TCGGTCACATCCTCGACGCCGTCAGATCCACCGACGGTGTGTACGACTGTTTCCGAGTCACCTCGGACGCACAGAGCTGA

Upstream 100 bases:

>100_bases
CGGGGTTGCGGAAGGCCCGGCGCCGCCGCAGCGTTAACCTCGACGTCAGGAGCCCTTCGCACATCCGTGCCACGGCTGAA
GTGCTAAGCAGGAGCGGCCT

Downstream 100 bases:

>100_bases
CTGCGAGGGGGCACGCCGTGAATGCTGAGGCCGCGGGAGCGGGTCTGCCGGCGGGCGGCGGCTTCTCGCCCGCACTGCCC
GCACTGTCCAGGGCGGACGG

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 879; Mature: 878

Protein sequence:

>879_residues
MPEAPPVTTGSVPTAASSAGDTRPVQAALSATDRTPSTADRAPLAADRTPSTADRTPLAGGQLPRTGPSSAAHGGRDGAE
GGSASSPVPDAPGEDAESGSPVVPRLGHESPPLPRRVRRFSRLGAHRATPPSSLDPVLRGLVANHPRMDIGPVQRAFEVA
DAAHAGQVRFSGHPYITHPIAVASILADLGMDIPTLCAALLHDTLEETDLPPETIEAEFGPQVLQIVDAVSKLNRVKVGE
AAQTETIRRMVVAMARDPRALVVKLADRLHNMRTLRFLPEHKQERKARETLEIYAPLAHRLGMNSLKWELEDLAFAALFP
KRYDEIVRLVADRAPSRDVYLTETSTQVQTQLAEARIKAVVTGRPKHYYSIYQKMVVRGRSFEDIYDLVGIRVLVDSVRD
CYAALGTVHANWKPIPGRFKDYIAMPKYNMYQSLHTTVIGPEGKPVELQIRTHSMHNRAEYGIAAHWKYKEDGSGAGSRS
GGSRSSGSSASRRAAANSGAGGTDPNLRNWLRQILDWQRETADPGEFLDSLRFDMADDEVFVFTPKGDVIPLPVGSTPID
FAYAVHTDIGHQCVGARVNGRLAALDTALENGDTVEVFTSRAHSAGPSEDWLTFVHSSRARTKIRQWHARERREDAIVAG
RDAIGRAMRRHGLPLARLMTGDALLTLAKDMRYADVAALYAAVGEKNISAQAVVNRLLQGLGGPEGAEEDAAEIELPIRA
LRRATGDAGVLVTGSPDVWAKLARCCTPMPGDAIAGFVTRGKGVSVHRADCVNLAGLRGGPHDRTVEVEWAPSSGSVFLV
VIQVEALDRTRLLSDVTRVLSDHHVNILSASVTTTREQVAVSRFTFEMGDAKHLGHILDAVRSTDGVYDCFRVTSDAQS

Sequences:

>Translated_879_residues
MPEAPPVTTGSVPTAASSAGDTRPVQAALSATDRTPSTADRAPLAADRTPSTADRTPLAGGQLPRTGPSSAAHGGRDGAE
GGSASSPVPDAPGEDAESGSPVVPRLGHESPPLPRRVRRFSRLGAHRATPPSSLDPVLRGLVANHPRMDIGPVQRAFEVA
DAAHAGQVRFSGHPYITHPIAVASILADLGMDIPTLCAALLHDTLEETDLPPETIEAEFGPQVLQIVDAVSKLNRVKVGE
AAQTETIRRMVVAMARDPRALVVKLADRLHNMRTLRFLPEHKQERKARETLEIYAPLAHRLGMNSLKWELEDLAFAALFP
KRYDEIVRLVADRAPSRDVYLTETSTQVQTQLAEARIKAVVTGRPKHYYSIYQKMVVRGRSFEDIYDLVGIRVLVDSVRD
CYAALGTVHANWKPIPGRFKDYIAMPKYNMYQSLHTTVIGPEGKPVELQIRTHSMHNRAEYGIAAHWKYKEDGSGAGSRS
GGSRSSGSSASRRAAANSGAGGTDPNLRNWLRQILDWQRETADPGEFLDSLRFDMADDEVFVFTPKGDVIPLPVGSTPID
FAYAVHTDIGHQCVGARVNGRLAALDTALENGDTVEVFTSRAHSAGPSEDWLTFVHSSRARTKIRQWHARERREDAIVAG
RDAIGRAMRRHGLPLARLMTGDALLTLAKDMRYADVAALYAAVGEKNISAQAVVNRLLQGLGGPEGAEEDAAEIELPIRA
LRRATGDAGVLVTGSPDVWAKLARCCTPMPGDAIAGFVTRGKGVSVHRADCVNLAGLRGGPHDRTVEVEWAPSSGSVFLV
VIQVEALDRTRLLSDVTRVLSDHHVNILSASVTTTREQVAVSRFTFEMGDAKHLGHILDAVRSTDGVYDCFRVTSDAQS
>Mature_878_residues
PEAPPVTTGSVPTAASSAGDTRPVQAALSATDRTPSTADRAPLAADRTPSTADRTPLAGGQLPRTGPSSAAHGGRDGAEG
GSASSPVPDAPGEDAESGSPVVPRLGHESPPLPRRVRRFSRLGAHRATPPSSLDPVLRGLVANHPRMDIGPVQRAFEVAD
AAHAGQVRFSGHPYITHPIAVASILADLGMDIPTLCAALLHDTLEETDLPPETIEAEFGPQVLQIVDAVSKLNRVKVGEA
AQTETIRRMVVAMARDPRALVVKLADRLHNMRTLRFLPEHKQERKARETLEIYAPLAHRLGMNSLKWELEDLAFAALFPK
RYDEIVRLVADRAPSRDVYLTETSTQVQTQLAEARIKAVVTGRPKHYYSIYQKMVVRGRSFEDIYDLVGIRVLVDSVRDC
YAALGTVHANWKPIPGRFKDYIAMPKYNMYQSLHTTVIGPEGKPVELQIRTHSMHNRAEYGIAAHWKYKEDGSGAGSRSG
GSRSSGSSASRRAAANSGAGGTDPNLRNWLRQILDWQRETADPGEFLDSLRFDMADDEVFVFTPKGDVIPLPVGSTPIDF
AYAVHTDIGHQCVGARVNGRLAALDTALENGDTVEVFTSRAHSAGPSEDWLTFVHSSRARTKIRQWHARERREDAIVAGR
DAIGRAMRRHGLPLARLMTGDALLTLAKDMRYADVAALYAAVGEKNISAQAVVNRLLQGLGGPEGAEEDAAEIELPIRAL
RRATGDAGVLVTGSPDVWAKLARCCTPMPGDAIAGFVTRGKGVSVHRADCVNLAGLRGGPHDRTVEVEWAPSSGSVFLVV
IQVEALDRTRLLSDVTRVLSDHHVNILSASVTTTREQVAVSRFTFEMGDAKHLGHILDAVRSTDGVYDCFRVTSDAQS

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=142, Percent_Identity=42.2535211267606, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1790082, Length=736, Percent_Identity=39.5380434782609, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1789147, Length=724, Percent_Identity=37.9834254143646, Blast_Score=505, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 95077; Mature: 94946

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAPPVTTGSVPTAASSAGDTRPVQAALSATDRTPSTADRAPLAADRTPSTADRTPLAG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GQLPRTGPSSAAHGGRDGAEGGSASSPVPDAPGEDAESGSPVVPRLGHESPPLPRRVRRF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
SRLGAHRATPPSSLDPVLRGLVANHPRMDIGPVQRAFEVADAAHAGQVRFSGHPYITHPI
HHHCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEHHH
AVASILADLGMDIPTLCAALLHDTLEETDLPPETIEAEFGPQVLQIVDAVSKLNRVKVGE
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
AAQTETIRRMVVAMARDPRALVVKLADRLHNMRTLRFLPEHKQERKARETLEIYAPLAHR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LGMNSLKWELEDLAFAALFPKRYDEIVRLVADRAPSRDVYLTETSTQVQTQLAEARIKAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHH
VTGRPKHYYSIYQKMVVRGRSFEDIYDLVGIRVLVDSVRDCYAALGTVHANWKPIPGRFK
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
DYIAMPKYNMYQSLHTTVIGPEGKPVELQIRTHSMHNRAEYGIAAHWKYKEDGSGAGSRS
HHHCCCCHHHHHHHHHEEECCCCCEEEEEEEECCCCCHHCCCEEEEEEECCCCCCCCCCC
GGSRSSGSSASRRAAANSGAGGTDPNLRNWLRQILDWQRETADPGEFLDSLRFDMADDEV
CCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCE
FVFTPKGDVIPLPVGSTPIDFAYAVHTDIGHQCVGARVNGRLAALDTALENGDTVEVFTS
EEECCCCCEEEECCCCCCCCEEEEEECCCCCHHHCCCCCCEEEEHHHHHCCCCEEEEEHH
RAHSAGPSEDWLTFVHSSRARTKIRQWHARERREDAIVAGRDAIGRAMRRHGLPLARLMT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHCCCCHHHHHC
GDALLTLAKDMRYADVAALYAAVGEKNISAQAVVNRLLQGLGGPEGAEEDAAEIELPIRA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LRRATGDAGVLVTGSPDVWAKLARCCTPMPGDAIAGFVTRGKGVSVHRADCVNLAGLRGG
HHHCCCCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHCCCCC
PHDRTVEVEWAPSSGSVFLVVIQVEALDRTRLLSDVTRVLSDHHVNILSASVTTTREQVA
CCCCEEEEEECCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHH
VSRFTFEMGDAKHLGHILDAVRSTDGVYDCFRVTSDAQS
HHHHHECCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
PEAPPVTTGSVPTAASSAGDTRPVQAALSATDRTPSTADRAPLAADRTPSTADRTPLAG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GQLPRTGPSSAAHGGRDGAEGGSASSPVPDAPGEDAESGSPVVPRLGHESPPLPRRVRRF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
SRLGAHRATPPSSLDPVLRGLVANHPRMDIGPVQRAFEVADAAHAGQVRFSGHPYITHPI
HHHCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCEEHHH
AVASILADLGMDIPTLCAALLHDTLEETDLPPETIEAEFGPQVLQIVDAVSKLNRVKVGE
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
AAQTETIRRMVVAMARDPRALVVKLADRLHNMRTLRFLPEHKQERKARETLEIYAPLAHR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LGMNSLKWELEDLAFAALFPKRYDEIVRLVADRAPSRDVYLTETSTQVQTQLAEARIKAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHH
VTGRPKHYYSIYQKMVVRGRSFEDIYDLVGIRVLVDSVRDCYAALGTVHANWKPIPGRFK
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
DYIAMPKYNMYQSLHTTVIGPEGKPVELQIRTHSMHNRAEYGIAAHWKYKEDGSGAGSRS
HHHCCCCHHHHHHHHHEEECCCCCEEEEEEEECCCCCHHCCCEEEEEEECCCCCCCCCCC
GGSRSSGSSASRRAAANSGAGGTDPNLRNWLRQILDWQRETADPGEFLDSLRFDMADDEV
CCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCE
FVFTPKGDVIPLPVGSTPIDFAYAVHTDIGHQCVGARVNGRLAALDTALENGDTVEVFTS
EEECCCCCEEEECCCCCCCCEEEEEECCCCCHHHCCCCCCEEEEHHHHHCCCCEEEEEHH
RAHSAGPSEDWLTFVHSSRARTKIRQWHARERREDAIVAGRDAIGRAMRRHGLPLARLMT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHCCCCHHHHHC
GDALLTLAKDMRYADVAALYAAVGEKNISAQAVVNRLLQGLGGPEGAEEDAAEIELPIRA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LRRATGDAGVLVTGSPDVWAKLARCCTPMPGDAIAGFVTRGKGVSVHRADCVNLAGLRGG
HHHCCCCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHCCCCC
PHDRTVEVEWAPSSGSVFLVVIQVEALDRTRLLSDVTRVLSDHHVNILSASVTTTREQVA
CCCCEEEEEECCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHH
VSRFTFEMGDAKHLGHILDAVRSTDGVYDCFRVTSDAQS
HHHHHECCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8825780; 8631867; 12000953 [H]