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The map label for this gene is devS [H]

Identifier: 158316421

GI number: 158316421

Start: 5554002

End: 5555609

Strand: Reverse

Name: devS [H]

Synonym: Franean1_4655

Alternate gene names: 158316421

Gene position: 5555609-5554002 (Counterclockwise)

Preceding gene: 158316424

Following gene: 158316420

Centisome position: 61.85

GC content: 71.77

Gene sequence:

>1608_bases
ATGACGTCTGCTTCGAGGGGGGCCACGCGGCGCCAGGGTCCGTGCCGGACCGGGGCGGGCCACGGTGGGGATACGGCCGG
CTGTTGCGATGCCGGGGATCTGCTGGACTCGTTGGGCGAGGTGGTGTTCCGGACCGACGCGGAGGGTTGTTGGACGTATC
TGAACCGGGCGTGGACGACCCTGACCGGCTTCGATGTCGTGGCCAGCCTGGGTGCCCAGTTCCTGGACTATGTTCACCCG
GACGAGGTGGAGGCCACGGTCGCGTTGTTCATGGGTGTCGTCGCGGGGGGTGCCGATCACTGTCACCACGAGACCCGCTA
CCGCACCCGGGACGGCAGCTACCGGCGGGTCCAGATCAGGGCGACCGTCCTGCGGGACGCGGCGGGCGTGGTGGTCGGCA
ACACCGGGACGATCCTGGACGTCACCGCCGCCCGCCGTGACGCGCAGACCGTCGGGGAACACGCCGCGCTGCTGGAGTTG
GTGTCCGCAGGGGTACCCGCCGGCGAGCTGCCGGTTGGGGTGGCGGTGTATGACGCCGACCTGCGGCTGTGGCGTGGTTC
ACCGGTCCTGGACCAGATCGCTCGTGTGCCCCAGCGTGTGGGGGATCGTCTTGCCCAGCTGGCCGAACGGCTCTCGCCGG
CGGCCGGGCCGCGGCAGCGCTCGCTGGGTGGCGAGTGGGGCATGATCGCGGCTGCGCTGCGTACCCACCACGCCCAGGTC
GGTGATCTCGACCTCGTGGGGGAGCGCGGTACCGGCCGGTCGATGCGGGTCACAGTGATCCCATACGTACGGGGCGGTGA
GGAGATGCTCGCGCTCGTCTTCACCGACATCACCGACCTGCGCCGCGCCGAGCGCGAGCTGCGCCGGCTCTACGAGCAGG
CGGAACGGAGCCGGGCCTGGCTGGCGGCGAGCACCGAGATCACGACCAGCGTGCTGGCCGCCCCGGATCCATGCGAGGCT
CTCGGTCGCGTCGCGCGGATGGGCCGGCGGATGGCCGCCGCGGACCTGTCCCTGGTCGCCGTGCCCGACGAGCACGGCAC
CCTGGTCGTGACCGCCGCCTCCGTAGCCCCCGACCTTCCCGCCGACGCCGACGCCCTACCAGGGCTGACCGTCACTCTCC
GCGCCGCGCCAGGAGCCGGCGTGCTCAACGCAGGCCACGCCGTTGTCCTGGACGGCCTACAGCTGCGGGGGAACCGGGTC
GTCCACGCGCCGACGCTGCCCCTCGCCGCGGCGCTGGCCGTGCCGCTACGAATCGCCGGGCATCAGGCGGCGATCCTTCT
CCTCGCCCACCGGAGCAGCACGGCTCGCCTTCCGGCGCGCGACATCGAACTGGTCGAGGGCTTCGCCGCCGACGCCGCGC
TCGCCCTCGAACTAGCCCAGGCACACCAGGAACGTGCCCGCCTGGCGGTCTTCGAGGACCGCGACCGCATCGCCCGCGAC
CTCCATGACCTGGTCCTCCAACGGCTGTTCGCCATCGGCCTGCACCTGCAGTCCCTAGCCCGCGCCGCCGGCGACATGAT
CGGCGCACGACTCACCGCGGCCATCGACGCCCTCGACCAGACCATCGAGGAAATCCGCCGCACAATCCTGCAGGTACAAC
CCTCATGA

Upstream 100 bases:

>100_bases
GCTGCTCGGCCGGTTCCATCGGCCAGAGACGCCCCTAGGGTCGTGCCGGCCCGCTACGGCAGGTGGAGGATCCGCTGTCG
CGAGGGAAGGGGGGCCGTCG

Downstream 100 bases:

>100_bases
ACCGGGCAGCGCCCGTCCCACTTGCCGGCGGCGTAACTGGTCACCGTTGTCGGCGCAGGCGCGGAAGAGCGGGCTGGCGA
TGCCGCGGCTGCCGTTTGCC

Product: putative PAS/PAC sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTSASRGATRRQGPCRTGAGHGGDTAGCCDAGDLLDSLGEVVFRTDAEGCWTYLNRAWTTLTGFDVVASLGAQFLDYVHP
DEVEATVALFMGVVAGGADHCHHETRYRTRDGSYRRVQIRATVLRDAAGVVVGNTGTILDVTAARRDAQTVGEHAALLEL
VSAGVPAGELPVGVAVYDADLRLWRGSPVLDQIARVPQRVGDRLAQLAERLSPAAGPRQRSLGGEWGMIAAALRTHHAQV
GDLDLVGERGTGRSMRVTVIPYVRGGEEMLALVFTDITDLRRAERELRRLYEQAERSRAWLAASTEITTSVLAAPDPCEA
LGRVARMGRRMAAADLSLVAVPDEHGTLVVTAASVAPDLPADADALPGLTVTLRAAPGAGVLNAGHAVVLDGLQLRGNRV
VHAPTLPLAAALAVPLRIAGHQAAILLLAHRSSTARLPARDIELVEGFAADAALALELAQAHQERARLAVFEDRDRIARD
LHDLVLQRLFAIGLHLQSLARAAGDMIGARLTAAIDALDQTIEEIRRTILQVQPS

Sequences:

>Translated_535_residues
MTSASRGATRRQGPCRTGAGHGGDTAGCCDAGDLLDSLGEVVFRTDAEGCWTYLNRAWTTLTGFDVVASLGAQFLDYVHP
DEVEATVALFMGVVAGGADHCHHETRYRTRDGSYRRVQIRATVLRDAAGVVVGNTGTILDVTAARRDAQTVGEHAALLEL
VSAGVPAGELPVGVAVYDADLRLWRGSPVLDQIARVPQRVGDRLAQLAERLSPAAGPRQRSLGGEWGMIAAALRTHHAQV
GDLDLVGERGTGRSMRVTVIPYVRGGEEMLALVFTDITDLRRAERELRRLYEQAERSRAWLAASTEITTSVLAAPDPCEA
LGRVARMGRRMAAADLSLVAVPDEHGTLVVTAASVAPDLPADADALPGLTVTLRAAPGAGVLNAGHAVVLDGLQLRGNRV
VHAPTLPLAAALAVPLRIAGHQAAILLLAHRSSTARLPARDIELVEGFAADAALALELAQAHQERARLAVFEDRDRIARD
LHDLVLQRLFAIGLHLQSLARAAGDMIGARLTAAIDALDQTIEEIRRTILQVQPS
>Mature_534_residues
TSASRGATRRQGPCRTGAGHGGDTAGCCDAGDLLDSLGEVVFRTDAEGCWTYLNRAWTTLTGFDVVASLGAQFLDYVHPD
EVEATVALFMGVVAGGADHCHHETRYRTRDGSYRRVQIRATVLRDAAGVVVGNTGTILDVTAARRDAQTVGEHAALLELV
SAGVPAGELPVGVAVYDADLRLWRGSPVLDQIARVPQRVGDRLAQLAERLSPAAGPRQRSLGGEWGMIAAALRTHHAQVG
DLDLVGERGTGRSMRVTVIPYVRGGEEMLALVFTDITDLRRAERELRRLYEQAERSRAWLAASTEITTSVLAAPDPCEAL
GRVARMGRRMAAADLSLVAVPDEHGTLVVTAASVAPDLPADADALPGLTVTLRAAPGAGVLNAGHAVVLDGLQLRGNRVV
HAPTLPLAAALAVPLRIAGHQAAILLLAHRSSTARLPARDIELVEGFAADAALALELAQAHQERARLAVFEDRDRIARDL
HDLVLQRLFAIGLHLQSLARAAGDMIGARLTAAIDALDQTIEEIRRTILQVQPS

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaer

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016030
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56846; Mature: 56715

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50112 PAS ; PS50113 PAC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSASRGATRRQGPCRTGAGHGGDTAGCCDAGDLLDSLGEVVFRTDAEGCWTYLNRAWTT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHH
LTGFDVVASLGAQFLDYVHPDEVEATVALFMGVVAGGADHCHHETRYRTRDGSYRRVQIR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCEEEEEEE
ATVLRDAAGVVVGNTGTILDVTAARRDAQTVGEHAALLELVSAGVPAGELPVGVAVYDAD
EEEHHCCCCEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
LRLWRGSPVLDQIARVPQRVGDRLAQLAERLSPAAGPRQRSLGGEWGMIAAALRTHHAQV
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHCCCC
GDLDLVGERGTGRSMRVTVIPYVRGGEEMLALVFTDITDLRRAERELRRLYEQAERSRAW
CCEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
LAASTEITTSVLAAPDPCEALGRVARMGRRMAAADLSLVAVPDEHGTLVVTAASVAPDLP
EEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCC
ADADALPGLTVTLRAAPGAGVLNAGHAVVLDGLQLRGNRVVHAPTLPLAAALAVPLRIAG
CCCCCCCCCEEEEEECCCCCCCCCCCEEEEECEEECCCEEEECCCHHHHHHHHHHHHCCC
HQAAILLLAHRSSTARLPARDIELVEGFAADAALALELAQAHQERARLAVFEDRDRIARD
CCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHH
LHDLVLQRLFAIGLHLQSLARAAGDMIGARLTAAIDALDQTIEEIRRTILQVQPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSASRGATRRQGPCRTGAGHGGDTAGCCDAGDLLDSLGEVVFRTDAEGCWTYLNRAWTT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCHHHHHHHHHHHHH
LTGFDVVASLGAQFLDYVHPDEVEATVALFMGVVAGGADHCHHETRYRTRDGSYRRVQIR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCEEEEEEE
ATVLRDAAGVVVGNTGTILDVTAARRDAQTVGEHAALLELVSAGVPAGELPVGVAVYDAD
EEEHHCCCCEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
LRLWRGSPVLDQIARVPQRVGDRLAQLAERLSPAAGPRQRSLGGEWGMIAAALRTHHAQV
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHCCCC
GDLDLVGERGTGRSMRVTVIPYVRGGEEMLALVFTDITDLRRAERELRRLYEQAERSRAW
CCEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
LAASTEITTSVLAAPDPCEALGRVARMGRRMAAADLSLVAVPDEHGTLVVTAASVAPDLP
EEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCC
ADADALPGLTVTLRAAPGAGVLNAGHAVVLDGLQLRGNRVVHAPTLPLAAALAVPLRIAG
CCCCCCCCCEEEEEECCCCCCCCCCCEEEEECEEECCCEEEECCCHHHHHHHHHHHHCCC
HQAAILLLAHRSSTARLPARDIELVEGFAADAALALELAQAHQERARLAVFEDRDRIARD
CCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHH
LHDLVLQRLFAIGLHLQSLARAAGDMIGARLTAAIDALDQTIEEIRRTILQVQPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]