| Definition | Frankia sp. EAN1pec chromosome, complete genome. |
|---|---|
| Accession | NC_009921 |
| Length | 8,982,042 |
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The map label for this gene is yqhE [C]
Identifier: 158316316
GI number: 158316316
Start: 5419856
End: 5420743
Strand: Reverse
Name: yqhE [C]
Synonym: Franean1_4543
Alternate gene names: 158316316
Gene position: 5420743-5419856 (Counterclockwise)
Preceding gene: 158316317
Following gene: 158316314
Centisome position: 60.35
GC content: 66.78
Gene sequence:
>888_bases ATGTCCACCAGGACGCACATAACGCTGAACAACGGGGTCGAGATGCCCGCGCTCGGTCTCGGTGTCTTCCAGACCCCGCC GGAGGAGACCCGGTCGGCTGTTGAAACGGCGCTGTCGGCCGGTTACCGGCACATCGACACCGCGGCGGCCTACGGCAACG AGCGGCAGGTCGGCGAGGCCGTCCTCAAGTCCGGTGTCGACCGGACCGACGTCTTTCTGGAGACCAAGATCTGGATCAGC GACTACGGCTACGACCAGACCCTGCACGGCTTCGAGAAGAGCGCGCGCAAGCTCGGCGTCGACCAGATCGACCTGCTCAT CCTGCATCAGGCGCTGCCGTCGGAGTTCGACAGGACCCTGGAGGCCTACCGCGCCCTGGAGGCGCTGCTCGCCGACGGGA AGGTCCGCGCGATCGGGGTCAGCAACTTCATGGTCGAGCATCTCACCGCCCTGCTGGAGCGGGCGAGTGTCGTCCCCGCG GTGAACCAGATCGAGGTGCACCCCTACTTCACCCAGCGCGAGGTGCAGGCGATCGACACCAAGCACGGCATCCTCACCCA GGCATGGTCACCGATCGGTGGAATCACGTTCTACCGTGCCGGCAGCCACGGCAGCACCCTGCGGGACCCGGCGATCGGTG AGATCGCGCAAGCGCACGGCAGGACGCCGGCGCAGGTGATGCTGCGCTGGCACCTGCAGCAGGGCCGGTCGGCGATCCCG AAGTCGACGCGACCGGAGCGGATCGCGGAGAACTTCGACGTGTTCGACTTCGAGCTGACGGACAAGCAGCTCGCCGTGAT CGATGGCCTCGACACCGGCCGACGCGGCGGCCCGGAGCCCAGCGACATCACTCTTGCGACCTTCAGTAAAGCGATCCCTG AAGCCTGA
Upstream 100 bases:
>100_bases TGGGGCCCGAAGCGCTGAGCCTTCAGTTACCGTCGGGTCCTGCACCGCTGAGCACGCTCAGATCATCGTCTCCGATTTTC GACGGGAAGAGGAACGCCCC
Downstream 100 bases:
>100_bases TTACCCCACTTCATCCTGTGAGGCCCCAGAACTCGGATCGAAAATCACAGGAGGTTGACACGCCGCAGCCATGCGTCGAC GTCGGCGCCGGCTTGCGTGA
Product: 2,5-didehydrogluconate reductase
Products: morphinone; NADH; NADPH; H+
Alternate protein names: NA
Number of amino acids: Translated: 295; Mature: 294
Protein sequence:
>295_residues MSTRTHITLNNGVEMPALGLGVFQTPPEETRSAVETALSAGYRHIDTAAAYGNERQVGEAVLKSGVDRTDVFLETKIWIS DYGYDQTLHGFEKSARKLGVDQIDLLILHQALPSEFDRTLEAYRALEALLADGKVRAIGVSNFMVEHLTALLERASVVPA VNQIEVHPYFTQREVQAIDTKHGILTQAWSPIGGITFYRAGSHGSTLRDPAIGEIAQAHGRTPAQVMLRWHLQQGRSAIP KSTRPERIAENFDVFDFELTDKQLAVIDGLDTGRRGGPEPSDITLATFSKAIPEA
Sequences:
>Translated_295_residues MSTRTHITLNNGVEMPALGLGVFQTPPEETRSAVETALSAGYRHIDTAAAYGNERQVGEAVLKSGVDRTDVFLETKIWIS DYGYDQTLHGFEKSARKLGVDQIDLLILHQALPSEFDRTLEAYRALEALLADGKVRAIGVSNFMVEHLTALLERASVVPA VNQIEVHPYFTQREVQAIDTKHGILTQAWSPIGGITFYRAGSHGSTLRDPAIGEIAQAHGRTPAQVMLRWHLQQGRSAIP KSTRPERIAENFDVFDFELTDKQLAVIDGLDTGRRGGPEPSDITLATFSKAIPEA >Mature_294_residues STRTHITLNNGVEMPALGLGVFQTPPEETRSAVETALSAGYRHIDTAAAYGNERQVGEAVLKSGVDRTDVFLETKIWISD YGYDQTLHGFEKSARKLGVDQIDLLILHQALPSEFDRTLEAYRALEALLADGKVRAIGVSNFMVEHLTALLERASVVPAV NQIEVHPYFTQREVQAIDTKHGILTQAWSPIGGITFYRAGSHGSTLRDPAIGEIAQAHGRTPAQVMLRWHLQQGRSAIPK STRPERIAENFDVFDFELTDKQLAVIDGLDTGRRGGPEPSDITLATFSKAIPEA
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=294, Percent_Identity=34.6938775510204, Blast_Score=189, Evalue=3e-48, Organism=Homo sapiens, GI5174391, Length=294, Percent_Identity=34.6938775510204, Blast_Score=189, Evalue=3e-48, Organism=Homo sapiens, GI223468663, Length=296, Percent_Identity=35.8108108108108, Blast_Score=184, Evalue=8e-47, Organism=Homo sapiens, GI4502049, Length=300, Percent_Identity=36, Blast_Score=173, Evalue=1e-43, Organism=Homo sapiens, GI5174695, Length=307, Percent_Identity=32.5732899022801, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI310109922, Length=288, Percent_Identity=32.6388888888889, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI5453543, Length=302, Percent_Identity=31.7880794701987, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI93277124, Length=306, Percent_Identity=32.6797385620915, Blast_Score=159, Evalue=3e-39, Organism=Homo sapiens, GI291291012, Length=273, Percent_Identity=34.4322344322344, Blast_Score=158, Evalue=4e-39, Organism=Homo sapiens, GI310109920, Length=302, Percent_Identity=31.7880794701987, Blast_Score=158, Evalue=5e-39, Organism=Homo sapiens, GI45446745, Length=302, Percent_Identity=31.7880794701987, Blast_Score=158, Evalue=6e-39, Organism=Homo sapiens, GI4503285, Length=302, Percent_Identity=31.7880794701987, Blast_Score=158, Evalue=6e-39, Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=34.2281879194631, Blast_Score=157, Evalue=1e-38, Organism=Homo sapiens, GI24497583, Length=299, Percent_Identity=33.4448160535117, Blast_Score=157, Evalue=2e-38, Organism=Homo sapiens, GI300116273, Length=286, Percent_Identity=32.5174825174825, Blast_Score=144, Evalue=1e-34, Organism=Homo sapiens, GI300116271, Length=286, Percent_Identity=31.8181818181818, Blast_Score=139, Evalue=3e-33, Organism=Homo sapiens, GI310109924, Length=157, Percent_Identity=34.3949044585987, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI310109926, Length=110, Percent_Identity=34.5454545454545, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI207028673, Length=110, Percent_Identity=34.5454545454545, Blast_Score=75, Evalue=6e-14, Organism=Escherichia coli, GI87082198, Length=281, Percent_Identity=41.9928825622776, Blast_Score=232, Evalue=2e-62, Organism=Escherichia coli, GI1786400, Length=266, Percent_Identity=36.4661654135338, Blast_Score=163, Evalue=1e-41, Organism=Escherichia coli, GI1788081, Length=283, Percent_Identity=30.0353356890459, Blast_Score=104, Evalue=8e-24, Organism=Escherichia coli, GI87081735, Length=291, Percent_Identity=24.3986254295533, Blast_Score=68, Evalue=9e-13, Organism=Escherichia coli, GI1787674, Length=279, Percent_Identity=26.8817204301075, Blast_Score=61, Evalue=7e-11, Organism=Caenorhabditis elegans, GI17537077, Length=293, Percent_Identity=37.542662116041, Blast_Score=195, Evalue=2e-50, Organism=Caenorhabditis elegans, GI17537075, Length=301, Percent_Identity=37.2093023255814, Blast_Score=193, Evalue=1e-49, Organism=Caenorhabditis elegans, GI71998625, Length=281, Percent_Identity=36.2989323843416, Blast_Score=192, Evalue=2e-49, Organism=Caenorhabditis elegans, GI17561298, Length=281, Percent_Identity=35.5871886120996, Blast_Score=171, Evalue=4e-43, Organism=Caenorhabditis elegans, GI17564128, Length=297, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=7e-42, Organism=Caenorhabditis elegans, GI17550248, Length=299, Percent_Identity=33.4448160535117, Blast_Score=162, Evalue=3e-40, Organism=Caenorhabditis elegans, GI17566692, Length=293, Percent_Identity=31.740614334471, Blast_Score=161, Evalue=4e-40, Organism=Caenorhabditis elegans, GI17552492, Length=292, Percent_Identity=30.8219178082192, Blast_Score=154, Evalue=6e-38, Organism=Caenorhabditis elegans, GI17537079, Length=297, Percent_Identity=28.6195286195286, Blast_Score=150, Evalue=1e-36, Organism=Caenorhabditis elegans, GI17538386, Length=277, Percent_Identity=32.4909747292419, Blast_Score=149, Evalue=2e-36, Organism=Caenorhabditis elegans, GI17562292, Length=285, Percent_Identity=29.1228070175439, Blast_Score=129, Evalue=2e-30, Organism=Caenorhabditis elegans, GI17561300, Length=271, Percent_Identity=30.9963099630996, Blast_Score=127, Evalue=6e-30, Organism=Caenorhabditis elegans, GI17550246, Length=78, Percent_Identity=42.3076923076923, Blast_Score=67, Evalue=9e-12, Organism=Saccharomyces cerevisiae, GI6320576, Length=276, Percent_Identity=35.8695652173913, Blast_Score=178, Evalue=1e-45, Organism=Saccharomyces cerevisiae, GI6324694, Length=282, Percent_Identity=33.3333333333333, Blast_Score=176, Evalue=3e-45, Organism=Saccharomyces cerevisiae, GI6322556, Length=283, Percent_Identity=31.8021201413428, Blast_Score=167, Evalue=1e-42, Organism=Saccharomyces cerevisiae, GI6319625, Length=289, Percent_Identity=35.9861591695502, Blast_Score=165, Evalue=1e-41, Organism=Saccharomyces cerevisiae, GI6321896, Length=307, Percent_Identity=30.9446254071661, Blast_Score=152, Evalue=7e-38, Organism=Saccharomyces cerevisiae, GI6320079, Length=281, Percent_Identity=32.0284697508897, Blast_Score=128, Evalue=1e-30, Organism=Drosophila melanogaster, GI24644950, Length=308, Percent_Identity=38.3116883116883, Blast_Score=194, Evalue=5e-50, Organism=Drosophila melanogaster, GI221378297, Length=328, Percent_Identity=36.280487804878, Blast_Score=188, Evalue=4e-48, Organism=Drosophila melanogaster, GI24663317, Length=301, Percent_Identity=36.2126245847176, Blast_Score=187, Evalue=5e-48, Organism=Drosophila melanogaster, GI24657054, Length=295, Percent_Identity=34.5762711864407, Blast_Score=179, Evalue=3e-45, Organism=Drosophila melanogaster, GI24662789, Length=300, Percent_Identity=35.6666666666667, Blast_Score=171, Evalue=7e-43, Organism=Drosophila melanogaster, GI45553081, Length=291, Percent_Identity=34.3642611683849, Blast_Score=167, Evalue=7e-42, Organism=Drosophila melanogaster, GI21356425, Length=317, Percent_Identity=31.2302839116719, Blast_Score=165, Evalue=4e-41, Organism=Drosophila melanogaster, GI20129731, Length=294, Percent_Identity=34.6938775510204, Blast_Score=161, Evalue=5e-40, Organism=Drosophila melanogaster, GI24662781, Length=284, Percent_Identity=35.9154929577465, Blast_Score=154, Evalue=8e-38, Organism=Drosophila melanogaster, GI24662785, Length=279, Percent_Identity=36.2007168458781, Blast_Score=151, Evalue=4e-37, Organism=Drosophila melanogaster, GI281366140, Length=257, Percent_Identity=33.0739299610895, Blast_Score=137, Evalue=6e-33,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: 1.1.1.218
Molecular weight: Translated: 32398; Mature: 32267
Theoretical pI: Translated: 5.79; Mature: 5.79
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 1.4 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 1.0 %Met (Mature Protein) 1.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSTRTHITLNNGVEMPALGLGVFQTPPEETRSAVETALSAGYRHIDTAAAYGNERQVGEA CCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHH VLKSGVDRTDVFLETKIWISDYGYDQTLHGFEKSARKLGVDQIDLLILHQALPSEFDRTL HHHCCCCHHHEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH EAYRALEALLADGKVRAIGVSNFMVEHLTALLERASVVPAVNQIEVHPYFTQREVQAIDT HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHH KHGILTQAWSPIGGITFYRAGSHGSTLRDPAIGEIAQAHGRTPAQVMLRWHLQQGRSAIP HCCHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC KSTRPERIAENFDVFDFELTDKQLAVIDGLDTGRRGGPEPSDITLATFSKAIPEA CCCCHHHHHCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCEEHHHHHHHCCCC >Mature Secondary Structure STRTHITLNNGVEMPALGLGVFQTPPEETRSAVETALSAGYRHIDTAAAYGNERQVGEA CCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHH VLKSGVDRTDVFLETKIWISDYGYDQTLHGFEKSARKLGVDQIDLLILHQALPSEFDRTL HHHCCCCHHHEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH EAYRALEALLADGKVRAIGVSNFMVEHLTALLERASVVPAVNQIEVHPYFTQREVQAIDT HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHH KHGILTQAWSPIGGITFYRAGSHGSTLRDPAIGEIAQAHGRTPAQVMLRWHLQQGRSAIP HCCHHHHCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC KSTRPERIAENFDVFDFELTDKQLAVIDGLDTGRRGGPEPSDITLATFSKAIPEA CCCCHHHHHCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCEEHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: morphine; NAD+; NADP+
Specific reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA