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The map label for this gene is adhC [C]

Identifier: 158316287

GI number: 158316287

Start: 5385319

End: 5386407

Strand: Reverse

Name: adhC [C]

Synonym: Franean1_4514

Alternate gene names: 158316287

Gene position: 5386407-5385319 (Counterclockwise)

Preceding gene: 158316288

Following gene: 158316286

Centisome position: 59.97

GC content: 69.97

Gene sequence:

>1089_bases
ATGTCGGTGCGTGCTCGGATAGCGGTGCTACCTCCCGGGACCCACATGCTCGAGTTTCGGGAGCTGACCATGCCGCCGCC
CGGCCCGTTCGAGGTCGTGGTCGAACAGAGCGCGTTCGGGGTGTGCCACAGCCAGCTCGACCGGATCTTCAGCCCGTCCC
GGACCGCCCCGATGCTGCTGGGCCACGAGTCGATCGGGACGGTTGTCGCCGTCGGTGCAGAGGTGACCTATGTGCGAGAG
GGCGACCAGGTGTGCATCACCTGGATCCCCCGCAGCCCCCGGGAGGGCCGTCCACCCTCGCCGTCCCGACTGACGTTCCC
CGACGGCGAGGTGGCCACGTCGCACAACTGCCACACCTGGGGGACCCACGCCCTGGTCGACGAGCAGTATGTCGTTCGGA
TGCCCGAGGGCACCGACCCCGACCTCGGGAGCATCATCGGCTGCGCGCTGATGACCGGCGCCGGCGCCGTGATGAACAGC
ATCGATCTCCGGGCCGGTCAGTCGGTCGCGGTCTGGGGCGCGGGTGGCGTGGGGCTGTGCGCCATCGCCGGCGCCGCGAT
TCTGGGCGCAGGACGGGTCATCGCCGTCGACGTGAGCGACGCGAAGCTCGCCCTGGCGGGGAAGTTCGGCGCCACCGACG
GCGTCAACGCCCGCGAGACCGACCCGGTGGAGGCGATCCGTCAGCTGACCCGGCACAACGACGGAACCGCGGGTGCCGAC
TACTGCCTGGACTGCACCGGCATCGGAAACAACATTCCGGTGAGCCTCGCGGCCGTGCGTCCGGGTATCCGCGGCGCGGG
AGTTCGCGGCGGTACCGATGTTCTCGTCGGCATTCCGCGCGAGCCGTTCAGCCTCGACAGTTTCGACCTGCTGAACGGTG
AGAAGAGCCTGGCTGGCTCGGTCGGGGGCGGCTGCGATCCGGTCCGGGATTTCGCGACCTTCGTGGACTGGACGAACGAC
GGCCGCTTCGATCCCGCCCTGCTGGTGACGGACCGGTTCGGGCTCGACCAGATCAACGAGGCTGTGGACGCCCTCCACCA
CGGTCGGGTCCGAGGCCGTGCCGTGGTCACCGTGCGCGACCCGGCGTGA

Upstream 100 bases:

>100_bases
TTCGGTATCGAGGAGTTCCTGGAGTACCAGTCGATCGGGTGAGCGAGCGGGCAGGCGACCAGCCGGGAACGCGATGGCGG
GGAAGAAGGGCGGAGAGGAC

Downstream 100 bases:

>100_bases
CCGCGGCCGTCACGGCAGGTGCTGCCAGCCCACATGGGTCGTCACCGGCTACACCCCATGTTCTCGGCCCTGCTGCTGTT
CGGCGGCACGCTGTCCGACC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSVRARIAVLPPGTHMLEFRELTMPPPGPFEVVVEQSAFGVCHSQLDRIFSPSRTAPMLLGHESIGTVVAVGAEVTYVRE
GDQVCITWIPRSPREGRPPSPSRLTFPDGEVATSHNCHTWGTHALVDEQYVVRMPEGTDPDLGSIIGCALMTGAGAVMNS
IDLRAGQSVAVWGAGGVGLCAIAGAAILGAGRVIAVDVSDAKLALAGKFGATDGVNARETDPVEAIRQLTRHNDGTAGAD
YCLDCTGIGNNIPVSLAAVRPGIRGAGVRGGTDVLVGIPREPFSLDSFDLLNGEKSLAGSVGGGCDPVRDFATFVDWTND
GRFDPALLVTDRFGLDQINEAVDALHHGRVRGRAVVTVRDPA

Sequences:

>Translated_362_residues
MSVRARIAVLPPGTHMLEFRELTMPPPGPFEVVVEQSAFGVCHSQLDRIFSPSRTAPMLLGHESIGTVVAVGAEVTYVRE
GDQVCITWIPRSPREGRPPSPSRLTFPDGEVATSHNCHTWGTHALVDEQYVVRMPEGTDPDLGSIIGCALMTGAGAVMNS
IDLRAGQSVAVWGAGGVGLCAIAGAAILGAGRVIAVDVSDAKLALAGKFGATDGVNARETDPVEAIRQLTRHNDGTAGAD
YCLDCTGIGNNIPVSLAAVRPGIRGAGVRGGTDVLVGIPREPFSLDSFDLLNGEKSLAGSVGGGCDPVRDFATFVDWTND
GRFDPALLVTDRFGLDQINEAVDALHHGRVRGRAVVTVRDPA
>Mature_361_residues
SVRARIAVLPPGTHMLEFRELTMPPPGPFEVVVEQSAFGVCHSQLDRIFSPSRTAPMLLGHESIGTVVAVGAEVTYVREG
DQVCITWIPRSPREGRPPSPSRLTFPDGEVATSHNCHTWGTHALVDEQYVVRMPEGTDPDLGSIIGCALMTGAGAVMNSI
DLRAGQSVAVWGAGGVGLCAIAGAAILGAGRVIAVDVSDAKLALAGKFGATDGVNARETDPVEAIRQLTRHNDGTAGADY
CLDCTGIGNNIPVSLAAVRPGIRGAGVRGGTDVLVGIPREPFSLDSFDLLNGEKSLAGSVGGGCDPVRDFATFVDWTNDG
RFDPALLVTDRFGLDQINEAVDALHHGRVRGRAVVTVRDPA

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=373, Percent_Identity=27.8820375335121, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=28.1501340482574, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI71565154, Length=371, Percent_Identity=28.8409703504043, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=26.8096514745308, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI71565152, Length=379, Percent_Identity=26.6490765171504, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI71743840, Length=373, Percent_Identity=26.8096514745308, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI262073058, Length=373, Percent_Identity=26.8096514745308, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI4501939, Length=373, Percent_Identity=27.3458445040214, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI156523966, Length=374, Percent_Identity=27.807486631016, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI156627571, Length=360, Percent_Identity=26.1111111111111, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=30.4, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI87082125, Length=376, Percent_Identity=26.8617021276596, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1788073, Length=363, Percent_Identity=25.6198347107438, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081918, Length=347, Percent_Identity=26.5129682997118, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786518, Length=362, Percent_Identity=28.7292817679558, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=26.9333333333333, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=26.2599469496021, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17565904, Length=342, Percent_Identity=26.9005847953216, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=23.8805970149254, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=374, Percent_Identity=27.0053475935829, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322619, Length=334, Percent_Identity=29.940119760479, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=350, Percent_Identity=29.4285714285714, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=329, Percent_Identity=27.0516717325228, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=348, Percent_Identity=28.1609195402299, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=348, Percent_Identity=26.1494252873563, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=349, Percent_Identity=28.6532951289398, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=303, Percent_Identity=25.0825082508251, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324486, Length=349, Percent_Identity=28.3667621776504, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=28.686327077748, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 37903; Mature: 37772

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00059 ADH_ZINC ; PS00289 PENTAXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRARIAVLPPGTHMLEFRELTMPPPGPFEVVVEQSAFGVCHSQLDRIFSPSRTAPMLL
CCCEEEEEEECCCCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCEEE
GHESIGTVVAVGAEVTYVREGDQVCITWIPRSPREGRPPSPSRLTFPDGEVATSHNCHTW
CCCCCCEEEEECCEEEEEECCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
GTHALVDEQYVVRMPEGTDPDLGSIIGCALMTGAGAVMNSIDLRAGQSVAVWGAGGVGLC
CCCEEECCCEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCHHHH
AIAGAAILGAGRVIAVDVSDAKLALAGKFGATDGVNARETDPVEAIRQLTRHNDGTAGAD
HHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
YCLDCTGIGNNIPVSLAAVRPGIRGAGVRGGTDVLVGIPREPFSLDSFDLLNGEKSLAGS
EEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCHHCCCCHHHCCC
VGGGCDPVRDFATFVDWTNDGRFDPALLVTDRFGLDQINEAVDALHHGRVRGRAVVTVRD
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEEC
PA
CC
>Mature Secondary Structure 
SVRARIAVLPPGTHMLEFRELTMPPPGPFEVVVEQSAFGVCHSQLDRIFSPSRTAPMLL
CCEEEEEEECCCCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCEEE
GHESIGTVVAVGAEVTYVREGDQVCITWIPRSPREGRPPSPSRLTFPDGEVATSHNCHTW
CCCCCCEEEEECCEEEEEECCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
GTHALVDEQYVVRMPEGTDPDLGSIIGCALMTGAGAVMNSIDLRAGQSVAVWGAGGVGLC
CCCEEECCCEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCHHHH
AIAGAAILGAGRVIAVDVSDAKLALAGKFGATDGVNARETDPVEAIRQLTRHNDGTAGAD
HHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
YCLDCTGIGNNIPVSLAAVRPGIRGAGVRGGTDVLVGIPREPFSLDSFDLLNGEKSLAGS
EEEEECCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCHHCCCCHHHCCC
VGGGCDPVRDFATFVDWTNDGRFDPALLVTDRFGLDQINEAVDALHHGRVRGRAVVTVRD
CCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEEC
PA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]