| Definition | Frankia sp. EAN1pec chromosome, complete genome. |
|---|---|
| Accession | NC_009921 |
| Length | 8,982,042 |
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The map label for this gene is fabG [C]
Identifier: 158316255
GI number: 158316255
Start: 5345640
End: 5346557
Strand: Reverse
Name: fabG [C]
Synonym: Franean1_4480
Alternate gene names: 158316255
Gene position: 5346557-5345640 (Counterclockwise)
Preceding gene: 158316256
Following gene: 158316254
Centisome position: 59.52
GC content: 65.36
Gene sequence:
>918_bases ATGGCCGAGTTTCGTTTTGGCAACCGGGTTGCCCTGGTGACCGGTGCGGGGGGCGGTCTCGGACTGCAGCACGCGAAGCT CCTGGCGTCGCGCGGCGCCCGCGTGGTTGTCAATGACCTCGGTGGAACCGTCGCTGGTCAGGATGCCGACGGCGGCGCCG CCCACCGCGCCGCCGACGAGATCAAAGAAGCCGGCGGGGAAGCGGTGGCTGACACGCGCTCGGTATCCACCCCGGACGGC GCGGCCGCCATGGTCCAGACCGCACTCGACACGTTCGGCCGTATCGACATCGTGGTCAACAACGCCGGAATTCTCCGGGA CAGATCGCTGACCAAACTCGAGCCGGCCGACTTCGACGCCGTGATCGACGTCCATCTGCGGGGTTCCTTCCTGGTCACCC AGGCAGCCTTTCCGCATCTGCGTGAGCAGCGCTACGGCCGCATAGTGAACACGACATCGCCAGCCGGCCTGTACGGCAAC TTCGGGCAGGCCAACTACTCGGCGGCGAAGGCCGGACTGATCGGCCTCACTCGGACGGTGGCGGTCGAGGGAGCGAAGTA CGGTGTTTCCTGCAATGCCGTCTCACCGGCCGCGCTGACCCGCATGACCGAAGAAATCATGGGACAGCTCTTCGTCGACC CGGACGGAGCTGCCCGCCTCGACGCGGCCAAGGTCTCTCCGGTTGTGGCCTGGCTGTGTCACGAGCAGTGCGCACTGACC GGTCAGGTCTTCGGTGTGGCCGGTGGACTGGTCACCAAGATAATCATCGCGGAGACCCGTGGCTTCTTCGATCCGGACCT GACCATCGAGACGGTGGCGGAACGTGTCGATGCTATCCAGAACATGGCGGACCTCGCGGTTCCGGGCAGCGTCGGCGACA GTATGTCCCTGCTCTTCGATCATTACGCCAAACCTTGA
Upstream 100 bases:
>100_bases TCCTCAAAAGAGAGCTTCGCGGCCGGTTCAGCTGAACCCGAGTTGGCACGTAGACCCAACCATGATGCAGGCATCGTGGT GAAATCATGGAGGAACGCTC
Downstream 100 bases:
>100_bases CACCACCGGCTTGATGAACCGCGAACGGAGATACATGCCGCGGCGAAAGCAGGTCAGGGTGAGATCCGAAGGCTCCGCAC CGAGGGGCAGATTCCTGGTG
Product: short-chain dehydrogenase/reductase SDR
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 305; Mature: 304
Protein sequence:
>305_residues MAEFRFGNRVALVTGAGGGLGLQHAKLLASRGARVVVNDLGGTVAGQDADGGAAHRAADEIKEAGGEAVADTRSVSTPDG AAAMVQTALDTFGRIDIVVNNAGILRDRSLTKLEPADFDAVIDVHLRGSFLVTQAAFPHLREQRYGRIVNTTSPAGLYGN FGQANYSAAKAGLIGLTRTVAVEGAKYGVSCNAVSPAALTRMTEEIMGQLFVDPDGAARLDAAKVSPVVAWLCHEQCALT GQVFGVAGGLVTKIIIAETRGFFDPDLTIETVAERVDAIQNMADLAVPGSVGDSMSLLFDHYAKP
Sequences:
>Translated_305_residues MAEFRFGNRVALVTGAGGGLGLQHAKLLASRGARVVVNDLGGTVAGQDADGGAAHRAADEIKEAGGEAVADTRSVSTPDG AAAMVQTALDTFGRIDIVVNNAGILRDRSLTKLEPADFDAVIDVHLRGSFLVTQAAFPHLREQRYGRIVNTTSPAGLYGN FGQANYSAAKAGLIGLTRTVAVEGAKYGVSCNAVSPAALTRMTEEIMGQLFVDPDGAARLDAAKVSPVVAWLCHEQCALT GQVFGVAGGLVTKIIIAETRGFFDPDLTIETVAERVDAIQNMADLAVPGSVGDSMSLLFDHYAKP >Mature_304_residues AEFRFGNRVALVTGAGGGLGLQHAKLLASRGARVVVNDLGGTVAGQDADGGAAHRAADEIKEAGGEAVADTRSVSTPDGA AAMVQTALDTFGRIDIVVNNAGILRDRSLTKLEPADFDAVIDVHLRGSFLVTQAAFPHLREQRYGRIVNTTSPAGLYGNF GQANYSAAKAGLIGLTRTVAVEGAKYGVSCNAVSPAALTRMTEEIMGQLFVDPDGAARLDAAKVSPVVAWLCHEQCALTG QVFGVAGGLVTKIIIAETRGFFDPDLTIETVAERVDAIQNMADLAVPGSVGDSMSLLFDHYAKP
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI4504505, Length=305, Percent_Identity=44.9180327868852, Blast_Score=253, Evalue=2e-67, Organism=Homo sapiens, GI15277342, Length=263, Percent_Identity=37.6425855513308, Blast_Score=110, Evalue=2e-24, Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=31.4285714285714, Blast_Score=92, Evalue=4e-19, Organism=Homo sapiens, GI4758504, Length=261, Percent_Identity=30.2681992337165, Blast_Score=80, Evalue=3e-15, Organism=Homo sapiens, GI32483357, Length=262, Percent_Identity=27.0992366412214, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI59889578, Length=195, Percent_Identity=29.2307692307692, Blast_Score=76, Evalue=4e-14, Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=30.46875, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI40254986, Length=194, Percent_Identity=28.3505154639175, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI19923817, Length=266, Percent_Identity=28.1954887218045, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI66933014, Length=104, Percent_Identity=32.6923076923077, Blast_Score=71, Evalue=2e-12, Organism=Homo sapiens, GI31542939, Length=212, Percent_Identity=30.188679245283, Blast_Score=69, Evalue=6e-12, Organism=Homo sapiens, GI40807363, Length=192, Percent_Identity=28.125, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI10190704, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=5e-11, Organism=Homo sapiens, GI5031737, Length=193, Percent_Identity=29.0155440414508, Blast_Score=65, Evalue=9e-11, Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=34.1176470588235, Blast_Score=123, Evalue=2e-29, Organism=Escherichia coli, GI87082100, Length=226, Percent_Identity=31.858407079646, Blast_Score=105, Evalue=5e-24, Organism=Escherichia coli, GI1789208, Length=209, Percent_Identity=30.1435406698565, Blast_Score=96, Evalue=4e-21, Organism=Escherichia coli, GI1790717, Length=229, Percent_Identity=28.3842794759825, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI1787905, Length=266, Percent_Identity=27.0676691729323, Blast_Score=82, Evalue=5e-17, Organism=Escherichia coli, GI1789057, Length=228, Percent_Identity=30.2631578947368, Blast_Score=81, Evalue=8e-17, Organism=Escherichia coli, GI1788459, Length=253, Percent_Identity=30.4347826086957, Blast_Score=81, Evalue=1e-16, Organism=Escherichia coli, GI87082160, Length=197, Percent_Identity=29.9492385786802, Blast_Score=80, Evalue=1e-16, Organism=Escherichia coli, GI1786812, Length=191, Percent_Identity=32.9842931937173, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI2367175, Length=257, Percent_Identity=28.0155642023346, Blast_Score=62, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17568967, Length=302, Percent_Identity=43.7086092715232, Blast_Score=245, Evalue=2e-65, Organism=Caenorhabditis elegans, GI25147288, Length=204, Percent_Identity=37.2549019607843, Blast_Score=104, Evalue=6e-23, Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=31.8897637795276, Blast_Score=91, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17559104, Length=201, Percent_Identity=34.3283582089552, Blast_Score=90, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17531453, Length=218, Percent_Identity=33.0275229357798, Blast_Score=90, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17562908, Length=221, Percent_Identity=32.579185520362, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17562906, Length=219, Percent_Identity=31.9634703196347, Blast_Score=89, Evalue=4e-18, Organism=Caenorhabditis elegans, GI71982365, Length=194, Percent_Identity=29.3814432989691, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17560332, Length=231, Percent_Identity=31.6017316017316, Blast_Score=85, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17560676, Length=264, Percent_Identity=26.5151515151515, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI193204405, Length=250, Percent_Identity=30, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI17560220, Length=247, Percent_Identity=29.9595141700405, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17538486, Length=203, Percent_Identity=33.4975369458128, Blast_Score=82, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17508895, Length=191, Percent_Identity=29.8429319371728, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17562910, Length=207, Percent_Identity=31.8840579710145, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17544670, Length=204, Percent_Identity=28.921568627451, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17538182, Length=225, Percent_Identity=30.2222222222222, Blast_Score=79, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17561402, Length=273, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17558628, Length=196, Percent_Identity=31.1224489795918, Blast_Score=78, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17560150, Length=204, Percent_Identity=31.8627450980392, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17564282, Length=191, Percent_Identity=29.3193717277487, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17562904, Length=255, Percent_Identity=29.0196078431373, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17538480, Length=233, Percent_Identity=30.0429184549356, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI72000259, Length=217, Percent_Identity=29.9539170506912, Blast_Score=76, Evalue=3e-14, Organism=Caenorhabditis elegans, GI71994600, Length=257, Percent_Identity=27.6264591439689, Blast_Score=74, Evalue=8e-14, Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=27.0588235294118, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17551412, Length=200, Percent_Identity=31.5, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17562990, Length=204, Percent_Identity=30.8823529411765, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17565030, Length=247, Percent_Identity=30.3643724696356, Blast_Score=70, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17563726, Length=196, Percent_Identity=29.0816326530612, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI193203115, Length=190, Percent_Identity=28.4210526315789, Blast_Score=67, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=283, Percent_Identity=45.2296819787986, Blast_Score=252, Evalue=6e-68, Organism=Saccharomyces cerevisiae, GI6324126, Length=201, Percent_Identity=26.865671641791, Blast_Score=63, Evalue=7e-11, Organism=Drosophila melanogaster, GI18859837, Length=307, Percent_Identity=47.8827361563518, Blast_Score=269, Evalue=2e-72, Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=35.6589147286822, Blast_Score=114, Evalue=1e-25, Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=35.5731225296443, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI21357673, Length=271, Percent_Identity=27.6752767527675, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI21357041, Length=198, Percent_Identity=33.8383838383838, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI17737361, Length=266, Percent_Identity=30.8270676691729, Blast_Score=86, Evalue=4e-17, Organism=Drosophila melanogaster, GI28571526, Length=247, Percent_Identity=29.5546558704453, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI21355319, Length=266, Percent_Identity=25.5639097744361, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI24649181, Length=178, Percent_Identity=30.3370786516854, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI24643142, Length=195, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI24644339, Length=201, Percent_Identity=27.363184079602, Blast_Score=74, Evalue=9e-14, Organism=Drosophila melanogaster, GI281364892, Length=175, Percent_Identity=29.7142857142857, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24665243, Length=215, Percent_Identity=31.6279069767442, Blast_Score=73, Evalue=3e-13, Organism=Drosophila melanogaster, GI221331218, Length=212, Percent_Identity=32.0754716981132, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI24640492, Length=171, Percent_Identity=28.6549707602339, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI24665247, Length=216, Percent_Identity=31.9444444444444, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI221331216, Length=213, Percent_Identity=32.3943661971831, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI21355631, Length=176, Percent_Identity=28.4090909090909, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI21356301, Length=192, Percent_Identity=27.6041666666667, Blast_Score=65, Evalue=7e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 31695; Mature: 31564
Theoretical pI: Translated: 5.14; Mature: 5.14
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.0 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAEFRFGNRVALVTGAGGGLGLQHAKLLASRGARVVVNDLGGTVAGQDADGGAAHRAADE CCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCEECCCCCCCCHHHHHHHH IKEAGGEAVADTRSVSTPDGAAAMVQTALDTFGRIDIVVNNAGILRDRSLTKLEPADFDA HHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCEEECCCCCCCCCCCCCE VIDVHLRGSFLVTQAAFPHLREQRYGRIVNTTSPAGLYGNFGQANYSAAKAGLIGLTRTV EEEEEECCCEEEEHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHEEEE AVEGAKYGVSCNAVSPAALTRMTEEIMGQLFVDPDGAARLDAAKVSPVVAWLCHEQCALT EECCCCCCEECCCCCHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH GQVFGVAGGLVTKIIIAETRGFFDPDLTIETVAERVDAIQNMADLAVPGSVGDSMSLLFD HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH HYAKP HHCCC >Mature Secondary Structure AEFRFGNRVALVTGAGGGLGLQHAKLLASRGARVVVNDLGGTVAGQDADGGAAHRAADE CCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCEECCCCCCCCHHHHHHHH IKEAGGEAVADTRSVSTPDGAAAMVQTALDTFGRIDIVVNNAGILRDRSLTKLEPADFDA HHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCEEECCCCCCCCCCCCCE VIDVHLRGSFLVTQAAFPHLREQRYGRIVNTTSPAGLYGNFGQANYSAAKAGLIGLTRTV EEEEEECCCEEEEHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHEEEE AVEGAKYGVSCNAVSPAALTRMTEEIMGQLFVDPDGAARLDAAKVSPVVAWLCHEQCALT EECCCCCCEECCCCCHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH GQVFGVAGGLVTKIIIAETRGFFDPDLTIETVAERVDAIQNMADLAVPGSVGDSMSLLFD HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH HYAKP HHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9634230 [H]