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The map label for this gene is ltrA [H]

Identifier: 158316143

GI number: 158316143

Start: 5210372

End: 5212153

Strand: Reverse

Name: ltrA [H]

Synonym: Franean1_4361

Alternate gene names: 158316143

Gene position: 5212153-5210372 (Counterclockwise)

Preceding gene: 158316144

Following gene: 158316141

Centisome position: 58.03

GC content: 62.85

Gene sequence:

>1782_bases
ATGCAGAGCGCCGCAACGGTGCTGGGTGTCCTGCGTGAACGCGGCAAACGAGGGCTGCCGTGCGACGAACTGTACCGGCA
ACTGTTCAACCCACAGATGTATCTGCTGGCCTACGGGCGTATCTACACCAACCATGGTGCGATGACACCCGGAGTCACAC
AGGAAACCGTGGACGGCATGTCCCAGGAGAGGATCGGTCGCATCATCGATGCGATGCGCCACGAACGCTACCGATTCCAC
CCCGTCCGGCGAGTCCACATCCCGAAAAAGAATGGGAAGACCCGCCCGTTGGGGCTACCGACCTGGTCGGACAAGCTCGT
CGGGGAAGTTGTACGCCTGCTCCTGGAGGCCTACTACGAACCGACGTTCTCCGACCGGTCCCACGGGTTCCGGCCACGGC
GAGGCTGCCACACCGCTCTGCGGGAGATAGCCAACACCTGGACCGGAACAGCCTGGTTCATCGAAGGAGACATCACCGAC
TGTTTCGGGTCTCTCAATCACGACCTGATGATCGGAATCCTGTCGGAGAGGGTCCGCGATAACCGGTTCCTGAGGCTGGT
GCGTAACATGCTACGAGCCGGATACCTGGAGGACTGGAGGTGGGGGGCGACTCTGTCGGGGGCTCCCCAAGGGGGCGTGG
CCTCGCCGATCCTGTCCTCGATCTACCTGCACAAGCTGGACGAGTTCGTCGAGAAGATTCTGATTCCGGAGTACACCCGA
GGGGGCCGCAGGGCGCGTAACCCTGCTTACCTCGTTCTGCAGAACGAGCTGGCCAAGGCACGCCGACGTGGTGACCGGGG
CCAAGCCCGGATACTACGACGGCGAATGGTCAGCCTGCCCAGCTCCGATCCCGATGATCCGGGATATCGGCGGCTGCGTT
ACTGCAGATATGCGGATGACCATCTACTCGGGTTCACCGGACCGAAGGCCGAAGCCGAGGAAATCAGACAGCGGCTGGCG
GAGTTCCTGCGTGACGACCTCAAGTTGGAACTGTCCGCCGACAAGACGCTGATAACCCACGCCCGTACCGGCGCGGCCCG
TTTCCTCGGCTACGAGATCACTGTCCAGCACAACAGCAGCAAGACCACCCGGCGCCGTCGATCGGTCAACGGGCAGGTCG
CGCTACGGGTGCCACGCGATGTGATCAAAGCTAAAAGTGTCCCCTACCTGCACCGCGGAAAACCCGCTAAGCAGAAGGCC
CTGACCAACGGTAACGACTACACCATCGTCGCCACCTACGGGGCCATCTACCGGGGCATCGTCCAGTACTACCTGCTGGC
CGGAGACGTCCACCGACTTCACCGGCTGCGCTGGGTCATGGAGACATCCATGCTCAAGACCCTGGCAGGCAAGCACCGCT
CGTCGGTGTCGAAGATGGCAGCCAAACACAAGGCCAAAATCCAGACACCGCACGGGCCACGCACCTGCTTCGAGGCACGC
ATCGAACGCGACAGCAGAAAACCACTGGTCGCACGGTTCGGTGACATCCCACTCCGCCGGCAGAAAACAGCGACGGTCTC
TGACCGTCAGCCGACCCGGGTGGACTATCCGCACAAGGAACTCCTCACCAGGCTCCTCGCGGATATCTGCGAAGTCTGCC
AGCGCACGGGCAACGTTGAAGTTCACCACGTCCGCGCGCTCAAAGACCTCGCGGCACCCGGCCCTCTGCCGCCCCCGTGG
GTCACAGCCATGGCAAACCGCAGACGCAAGACACTCGTGGTCTGCGCTACCTGCCACGGCCAGATCCACAAGGGGCGGCC
CGCCACACCGCTCACGCAGTAG

Upstream 100 bases:

>100_bases
TAGTCGCCGGAGTCACGACCGGCCAGGGAGGGCGGGAAAGCCGCCTACAGGGCGAAGGGGGCCAGGTGATCGGACACCCA
AGACTCGGGAGGTATGCGTA

Downstream 100 bases:

>100_bases
TCACCGGAGAGCCGGATGATCGGGAAACCATCACGTCCGGTTCGGCGGGAGGCCGCGCGGAAAAGGACCAGCCCTCGGGC
TGGCACCTCGCTGCGCGGCC

Product: RNA-directed DNA polymerase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MQSAATVLGVLRERGKRGLPCDELYRQLFNPQMYLLAYGRIYTNHGAMTPGVTQETVDGMSQERIGRIIDAMRHERYRFH
PVRRVHIPKKNGKTRPLGLPTWSDKLVGEVVRLLLEAYYEPTFSDRSHGFRPRRGCHTALREIANTWTGTAWFIEGDITD
CFGSLNHDLMIGILSERVRDNRFLRLVRNMLRAGYLEDWRWGATLSGAPQGGVASPILSSIYLHKLDEFVEKILIPEYTR
GGRRARNPAYLVLQNELAKARRRGDRGQARILRRRMVSLPSSDPDDPGYRRLRYCRYADDHLLGFTGPKAEAEEIRQRLA
EFLRDDLKLELSADKTLITHARTGAARFLGYEITVQHNSSKTTRRRRSVNGQVALRVPRDVIKAKSVPYLHRGKPAKQKA
LTNGNDYTIVATYGAIYRGIVQYYLLAGDVHRLHRLRWVMETSMLKTLAGKHRSSVSKMAAKHKAKIQTPHGPRTCFEAR
IERDSRKPLVARFGDIPLRRQKTATVSDRQPTRVDYPHKELLTRLLADICEVCQRTGNVEVHHVRALKDLAAPGPLPPPW
VTAMANRRRKTLVVCATCHGQIHKGRPATPLTQ

Sequences:

>Translated_593_residues
MQSAATVLGVLRERGKRGLPCDELYRQLFNPQMYLLAYGRIYTNHGAMTPGVTQETVDGMSQERIGRIIDAMRHERYRFH
PVRRVHIPKKNGKTRPLGLPTWSDKLVGEVVRLLLEAYYEPTFSDRSHGFRPRRGCHTALREIANTWTGTAWFIEGDITD
CFGSLNHDLMIGILSERVRDNRFLRLVRNMLRAGYLEDWRWGATLSGAPQGGVASPILSSIYLHKLDEFVEKILIPEYTR
GGRRARNPAYLVLQNELAKARRRGDRGQARILRRRMVSLPSSDPDDPGYRRLRYCRYADDHLLGFTGPKAEAEEIRQRLA
EFLRDDLKLELSADKTLITHARTGAARFLGYEITVQHNSSKTTRRRRSVNGQVALRVPRDVIKAKSVPYLHRGKPAKQKA
LTNGNDYTIVATYGAIYRGIVQYYLLAGDVHRLHRLRWVMETSMLKTLAGKHRSSVSKMAAKHKAKIQTPHGPRTCFEAR
IERDSRKPLVARFGDIPLRRQKTATVSDRQPTRVDYPHKELLTRLLADICEVCQRTGNVEVHHVRALKDLAAPGPLPPPW
VTAMANRRRKTLVVCATCHGQIHKGRPATPLTQ
>Mature_593_residues
MQSAATVLGVLRERGKRGLPCDELYRQLFNPQMYLLAYGRIYTNHGAMTPGVTQETVDGMSQERIGRIIDAMRHERYRFH
PVRRVHIPKKNGKTRPLGLPTWSDKLVGEVVRLLLEAYYEPTFSDRSHGFRPRRGCHTALREIANTWTGTAWFIEGDITD
CFGSLNHDLMIGILSERVRDNRFLRLVRNMLRAGYLEDWRWGATLSGAPQGGVASPILSSIYLHKLDEFVEKILIPEYTR
GGRRARNPAYLVLQNELAKARRRGDRGQARILRRRMVSLPSSDPDDPGYRRLRYCRYADDHLLGFTGPKAEAEEIRQRLA
EFLRDDLKLELSADKTLITHARTGAARFLGYEITVQHNSSKTTRRRRSVNGQVALRVPRDVIKAKSVPYLHRGKPAKQKA
LTNGNDYTIVATYGAIYRGIVQYYLLAGDVHRLHRLRWVMETSMLKTLAGKHRSSVSKMAAKHKAKIQTPHGPRTCFEAR
IERDSRKPLVARFGDIPLRRQKTATVSDRQPTRVDYPHKELLTRLLADICEVCQRTGNVEVHHVRALKDLAAPGPLPPPW
VTAMANRRRKTLVVCATCHGQIHKGRPATPLTQ

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226521, Length=585, Percent_Identity=30.4273504273504, Blast_Score=280, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6226520, Length=589, Percent_Identity=32.76740237691, Blast_Score=276, Evalue=8e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 67649; Mature: 67649

Theoretical pI: Translated: 10.90; Mature: 10.90

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSAATVLGVLRERGKRGLPCDELYRQLFNPQMYLLAYGRIYTNHGAMTPGVTQETVDGM
CCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEECCEEECCCCCCCCCCHHHHCCC
SQERIGRIIDAMRHERYRFHPVRRVHIPKKNGKTRPLGLPTWSDKLVGEVVRLLLEAYYE
CHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
PTFSDRSHGFRPRRGCHTALREIANTWTGTAWFIEGDITDCFGSLNHDLMIGILSERVRD
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCCHHHHHHHHHHHHHH
NRFLRLVRNMLRAGYLEDWRWGATLSGAPQGGVASPILSSIYLHKLDEFVEKILIPEYTR
HHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGRRARNPAYLVLQNELAKARRRGDRGQARILRRRMVSLPSSDPDDPGYRRLRYCRYADD
CCCCCCCCEEEEECHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
HLLGFTGPKAEAEEIRQRLAEFLRDDLKLELSADKTLITHARTGAARFLGYEITVQHNSS
CEECCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCEEEHHCCCCHHHHEEEEEEEEECCC
KTTRRRRSVNGQVALRVPRDVIKAKSVPYLHRGKPAKQKALTNGNDYTIVATYGAIYRGI
HHHHHHHCCCCEEEEECCHHHHHHCCCCCHHCCCCHHHHHCCCCCCEEEEEEHHHHHHHH
VQYYLLAGDVHRLHRLRWVMETSMLKTLAGKHRSSVSKMAAKHKAKIQTPHGPRTCFEAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
IERDSRKPLVARFGDIPLRRQKTATVSDRQPTRVDYPHKELLTRLLADICEVCQRTGNVE
HHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
VHHVRALKDLAAPGPLPPPWVTAMANRRRKTLVVCATCHGQIHKGRPATPLTQ
EEHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQSAATVLGVLRERGKRGLPCDELYRQLFNPQMYLLAYGRIYTNHGAMTPGVTQETVDGM
CCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEECCEEECCCCCCCCCCHHHHCCC
SQERIGRIIDAMRHERYRFHPVRRVHIPKKNGKTRPLGLPTWSDKLVGEVVRLLLEAYYE
CHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
PTFSDRSHGFRPRRGCHTALREIANTWTGTAWFIEGDITDCFGSLNHDLMIGILSERVRD
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCCHHHHHHHHHHHHHH
NRFLRLVRNMLRAGYLEDWRWGATLSGAPQGGVASPILSSIYLHKLDEFVEKILIPEYTR
HHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
GGRRARNPAYLVLQNELAKARRRGDRGQARILRRRMVSLPSSDPDDPGYRRLRYCRYADD
CCCCCCCCEEEEECHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCC
HLLGFTGPKAEAEEIRQRLAEFLRDDLKLELSADKTLITHARTGAARFLGYEITVQHNSS
CEECCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCEEEHHCCCCHHHHEEEEEEEEECCC
KTTRRRRSVNGQVALRVPRDVIKAKSVPYLHRGKPAKQKALTNGNDYTIVATYGAIYRGI
HHHHHHHCCCCEEEEECCHHHHHHCCCCCHHCCCCHHHHHCCCCCCEEEEEEHHHHHHHH
VQYYLLAGDVHRLHRLRWVMETSMLKTLAGKHRSSVSKMAAKHKAKIQTPHGPRTCFEAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
IERDSRKPLVARFGDIPLRRQKTATVSDRQPTRVDYPHKELLTRLLADICEVCQRTGNVE
HHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
VHHVRALKDLAAPGPLPPPWVTAMANRRRKTLVVCATCHGQIHKGRPATPLTQ
EEHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]