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The map label for this gene is mmr [H]

Identifier: 158315900

GI number: 158315900

Start: 4898328

End: 4899734

Strand: Reverse

Name: mmr [H]

Synonym: Franean1_4115

Alternate gene names: 158315900

Gene position: 4899734-4898328 (Counterclockwise)

Preceding gene: 158315903

Following gene: 158315899

Centisome position: 54.55

GC content: 73.85

Gene sequence:

>1407_bases
ATGATGGACCGGGGCGTCTCGCCCCCACGACGCCGCGAGGCGTCCGGACGCGAGGTTCTGCTGATCGTCTGCAGTGGCGT
GATCCTGGCGAGCCTCGACCTGTTCATCGTCAACGTCGCGCTGCCGCAGATCGCCCACGATCTCGGCGAGACCGACCTGA
GCCGGCTGTCGTGGGTGCTCAACGGCTACGCGGTCGTCTACGCGGCGCTGCTCGTCTTCTTCGGACGGCTCGCCGACCGG
TACCGCCGCGACCTCGGCTTCCTGCTCGGCGTCGCGGTGTTCACGCTCGCGTCGGCGGCCTGCGCGGCGGCCACCACCGT
CGACATGCTGATCGGCTTCCGGCTCGTGCAGGCCGCCGGGGCCGCGCTGGTGACACCCACCTCACTGGGCCTGGTGCTCG
CGGCCCACGAACCCGAGCGCCGTCAGGGCGCCGTGCGCACCTGGACCGCCGTCGGCGGGATGTCGGCGGCGATCGGCCCG
GTCGTCGGCGGGCTGCTCGTCGCCGCCAGCTGGCGCTGGGCGTTCCTCGTCAACGTCCCGGTCGGCCTCGCGGCCCTCGT
CGTCGGCTGGCGTCGGCTGCCGCGCCTGGCCGGCCAGCCGACCGAGCGGCCCGACGCCGTCGGCGTGCTGCTGGCCACCG
GCGGGGTCGGCCTGCTGACCGCCGGGCTGGTCCGGGGGCCGGACTGGGGCTGGTCCTCGGCGGCGCTGGTGGGATCCCTC
GGCGGCGGGGTCGGCCTGCTCGTCCTGTTCGCCGTCCACTGCGCCACCAGCCGGAACCCGCTCGTGCACCCGTCCCTGTT
CACCTCCCGGCACTTCACCGGCGCCTCGATCGTCGCGCTGTTCTTCTCCGCCTCCTTCGGCGCGATGCTGCTGTCGATCG
TGCTCTGGGAGCAGGGCCAGTGGGGATGGTCCGCGCTGCAGGCCGGCCTGGCCATGGCGCCTGGGCCGCTCATGGTCCCG
CTCGTCTCGTTCGGCATCACCGGCAGGCTGATCACCCGCTACGGGCCGGCGATCGTCATCGGGCTGGGCAGTGTCATCTT
CGGCGGCGGGGTCGCCTGGTGGGCGCTCGCGATCACCACGGAGCCGGACTACGTCTCCGGCGTGCTCGGCGGCATGGCCC
TCACCGGGATCGGCGTCGGCCTGACCCTGCCCACCATGATGTCCACGGCCGCCGCGTCGCTGCCCCCGCAGTCGTTCGCG
ACCGGCTCCGCGGTCGTCAACATGGTGCGCCAGACCGGCATCGCCCTGGGCGTCGCCGTCACCATCGCGGTGCTCGGCGA
GTCGTCGGTGGCCAGCGGCATCCCGCTGCACCTGTTCGCCCGGGTCTGGTGGGTCACCGCCGCCCTGTCGTTCGCCGGAA
TCGTGCCCGCCGTGGCCCTCCTGCGCCGCCCCGCCCGCACGGCTTGA

Upstream 100 bases:

>100_bases
GCAGTTCATGTCCGCGAAGCTCTTGCGCTCCATGACCGGCACGCTAGTCAGTTGCGTGATGGAACGCCAGCGCCCTAAGT
TCAGTTGCATGACAGAACTG

Downstream 100 bases:

>100_bases
GCACCCGACCGGCGACGTTGTCGACCGGTGGCGTTCGGGGCCGCGAACCGGTTGACTTTAGGCCGCCGGGCCGGTGTGGG
CCCGGTGCCGGCGGTGGTCC

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: MMR peptide [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MMDRGVSPPRRREASGREVLLIVCSGVILASLDLFIVNVALPQIAHDLGETDLSRLSWVLNGYAVVYAALLVFFGRLADR
YRRDLGFLLGVAVFTLASAACAAATTVDMLIGFRLVQAAGAALVTPTSLGLVLAAHEPERRQGAVRTWTAVGGMSAAIGP
VVGGLLVAASWRWAFLVNVPVGLAALVVGWRRLPRLAGQPTERPDAVGVLLATGGVGLLTAGLVRGPDWGWSSAALVGSL
GGGVGLLVLFAVHCATSRNPLVHPSLFTSRHFTGASIVALFFSASFGAMLLSIVLWEQGQWGWSALQAGLAMAPGPLMVP
LVSFGITGRLITRYGPAIVIGLGSVIFGGGVAWWALAITTEPDYVSGVLGGMALTGIGVGLTLPTMMSTAAASLPPQSFA
TGSAVVNMVRQTGIALGVAVTIAVLGESSVASGIPLHLFARVWWVTAALSFAGIVPAVALLRRPARTA

Sequences:

>Translated_468_residues
MMDRGVSPPRRREASGREVLLIVCSGVILASLDLFIVNVALPQIAHDLGETDLSRLSWVLNGYAVVYAALLVFFGRLADR
YRRDLGFLLGVAVFTLASAACAAATTVDMLIGFRLVQAAGAALVTPTSLGLVLAAHEPERRQGAVRTWTAVGGMSAAIGP
VVGGLLVAASWRWAFLVNVPVGLAALVVGWRRLPRLAGQPTERPDAVGVLLATGGVGLLTAGLVRGPDWGWSSAALVGSL
GGGVGLLVLFAVHCATSRNPLVHPSLFTSRHFTGASIVALFFSASFGAMLLSIVLWEQGQWGWSALQAGLAMAPGPLMVP
LVSFGITGRLITRYGPAIVIGLGSVIFGGGVAWWALAITTEPDYVSGVLGGMALTGIGVGLTLPTMMSTAAASLPPQSFA
TGSAVVNMVRQTGIALGVAVTIAVLGESSVASGIPLHLFARVWWVTAALSFAGIVPAVALLRRPARTA
>Mature_468_residues
MMDRGVSPPRRREASGREVLLIVCSGVILASLDLFIVNVALPQIAHDLGETDLSRLSWVLNGYAVVYAALLVFFGRLADR
YRRDLGFLLGVAVFTLASAACAAATTVDMLIGFRLVQAAGAALVTPTSLGLVLAAHEPERRQGAVRTWTAVGGMSAAIGP
VVGGLLVAASWRWAFLVNVPVGLAALVVGWRRLPRLAGQPTERPDAVGVLLATGGVGLLTAGLVRGPDWGWSSAALVGSL
GGGVGLLVLFAVHCATSRNPLVHPSLFTSRHFTGASIVALFFSASFGAMLLSIVLWEQGQWGWSALQAGLAMAPGPLMVP
LVSFGITGRLITRYGPAIVIGLGSVIFGGGVAWWALAITTEPDYVSGVLGGMALTGIGVGLTLPTMMSTAAASLPPQSFA
TGSAVVNMVRQTGIALGVAVTIAVLGESSVASGIPLHLFARVWWVTAALSFAGIVPAVALLRRPARTA

Specific function: Resistance to the epoxide antibiotic methylenomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=411, Percent_Identity=31.1435523114355, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1790195, Length=431, Percent_Identity=29.4663573085847, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789042, Length=420, Percent_Identity=29.0476190476191, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87081983, Length=432, Percent_Identity=28.2407407407407, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788392, Length=473, Percent_Identity=29.5983086680761, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321663, Length=151, Percent_Identity=26.4900662251656, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319770, Length=398, Percent_Identity=23.8693467336683, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=246, Percent_Identity=25.2032520325203, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48278; Mature: 48278

Theoretical pI: Translated: 11.20; Mature: 11.20

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDRGVSPPRRREASGREVLLIVCSGVILASLDLFIVNVALPQIAHDLGETDLSRLSWVL
CCCCCCCCCHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
NGYAVVYAALLVFFGRLADRYRRDLGFLLGVAVFTLASAACAAATTVDMLIGFRLVQAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AALVTPTSLGLVLAAHEPERRQGAVRTWTAVGGMSAAIGPVVGGLLVAASWRWAFLVNVP
CEEECCCCCCEEEEECCCHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECH
VGLAALVVGWRRLPRLAGQPTERPDAVGVLLATGGVGLLTAGLVRGPDWGWSSAALVGSL
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHC
GGGVGLLVLFAVHCATSRNPLVHPSLFTSRHFTGASIVALFFSASFGAMLLSIVLWEQGQ
CCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
WGWSALQAGLAMAPGPLMVPLVSFGITGRLITRYGPAIVIGLGSVIFGGGVAWWALAITT
CCHHHHHCCHHCCCCCHHHHHHHHCCCHHHHHHCCCEEEEEHHHHHHCCCHHHEEEEEEC
EPDYVSGVLGGMALTGIGVGLTLPTMMSTAAASLPPQSFATGSAVVNMVRQTGIALGVAV
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHH
TIAVLGESSVASGIPLHLFARVWWVTAALSFAGIVPAVALLRRPARTA
HHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MMDRGVSPPRRREASGREVLLIVCSGVILASLDLFIVNVALPQIAHDLGETDLSRLSWVL
CCCCCCCCCHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
NGYAVVYAALLVFFGRLADRYRRDLGFLLGVAVFTLASAACAAATTVDMLIGFRLVQAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AALVTPTSLGLVLAAHEPERRQGAVRTWTAVGGMSAAIGPVVGGLLVAASWRWAFLVNVP
CEEECCCCCCEEEEECCCHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECH
VGLAALVVGWRRLPRLAGQPTERPDAVGVLLATGGVGLLTAGLVRGPDWGWSSAALVGSL
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHC
GGGVGLLVLFAVHCATSRNPLVHPSLFTSRHFTGASIVALFFSASFGAMLLSIVLWEQGQ
CCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
WGWSALQAGLAMAPGPLMVPLVSFGITGRLITRYGPAIVIGLGSVIFGGGVAWWALAITT
CCHHHHHCCHHCCCCCHHHHHHHHCCCHHHHHHCCCEEEEEHHHHHHCCCHHHEEEEEEC
EPDYVSGVLGGMALTGIGVGLTLPTMMSTAAASLPPQSFATGSAVVNMVRQTGIALGVAV
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHH
TIAVLGESSVASGIPLHLFARVWWVTAALSFAGIVPAVALLRRPARTA
HHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1379177; 9384377 [H]