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The map label for this gene is tcmR [H]

Identifier: 158315448

GI number: 158315448

Start: 4329034

End: 4329600

Strand: Reverse

Name: tcmR [H]

Synonym: Franean1_3652

Alternate gene names: 158315448

Gene position: 4329600-4329034 (Counterclockwise)

Preceding gene: 158315454

Following gene: 158315446

Centisome position: 48.2

GC content: 72.13

Gene sequence:

>567_bases
ATGGGGCGATGGGAGCCGAACGCGAGAGGCCGGCTCAGCGAGGCGGCGATGGAGCTCTACGTCGAGCGCGGCTTCGAGCA
GACGACCGTCGCCGAGATCGCCCAGCGGGCGGGGCTCACGGCCCGGACGTTCTTCCGCTACTTCGCAGACAAGCGCGAGG
TGCTCTTCGCCGGCTCGACCATCCTGGAGGAGCACCTGATCGCCGCGCTCGAGAGCACCCCCGCCTCCGCGTCGCCGATG
GAGGCCGTCGCGGCCGCCCTCGACGCGGCGGCGACGATGCTCGGCCAGCGGCGCGAGTTCTCCCGGCGGCGCCAGTCCGT
CATCGCCGCCAACGCGGAGCTGCGTGAACGCGAACTGATCAAAATGGCGTCGCTGTCCGGTGCCCTCGCCGCGGGTCTGC
GCCGGCGCGGCGTCGCCGACTCGGACGCCAGCCTGGCCGCGGAGGCGGGGATCGCCGTCTTCCGGGTGGCGTTCGAGCGT
TGGGTCGGCGAGCCGACCGACCGGGGCCTGACGACGATCATGCGCGAGTCGCTGGAACAGTTGAAGGCCCTCACAGCTGC
CAGCTGA

Upstream 100 bases:

>100_bases
GACCTCCAGAGGGCCGTCCGCCGCGGGGGCGGACGTGATGTCATTTGATGACATGACCCTAGCAGGTCATGTCAGCGTGT
GTCATCACTAGAATCGTCGC

Downstream 100 bases:

>100_bases
CGGGGCGAGGCACGGCCGGCGCCTCGCCGCGCTCACCCACCGTGATCTCGCTGCCAGGATTCCCGTTATTCCGGGGGCCG
GCGGTCACCGGCCCCGGTCA

Product: regulatory protein TetR

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MGRWEPNARGRLSEAAMELYVERGFEQTTVAEIAQRAGLTARTFFRYFADKREVLFAGSTILEEHLIAALESTPASASPM
EAVAAALDAAATMLGQRREFSRRRQSVIAANAELRERELIKMASLSGALAAGLRRRGVADSDASLAAEAGIAVFRVAFER
WVGEPTDRGLTTIMRESLEQLKALTAAS

Sequences:

>Translated_188_residues
MGRWEPNARGRLSEAAMELYVERGFEQTTVAEIAQRAGLTARTFFRYFADKREVLFAGSTILEEHLIAALESTPASASPM
EAVAAALDAAATMLGQRREFSRRRQSVIAANAELRERELIKMASLSGALAAGLRRRGVADSDASLAAEAGIAVFRVAFER
WVGEPTDRGLTTIMRESLEQLKALTAAS
>Mature_187_residues
GRWEPNARGRLSEAAMELYVERGFEQTTVAEIAQRAGLTARTFFRYFADKREVLFAGSTILEEHLIAALESTPASASPME
AVAAALDAAATMLGQRREFSRRRQSVIAANAELRERELIKMASLSGALAAGLRRRGVADSDASLAAEAGIAVFRVAFERW
VGEPTDRGLTTIMRESLEQLKALTAAS

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 20448; Mature: 20316

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRWEPNARGRLSEAAMELYVERGFEQTTVAEIAQRAGLTARTFFRYFADKREVLFAGST
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHH
ILEEHLIAALESTPASASPMEAVAAALDAAATMLGQRREFSRRRQSVIAANAELRERELI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMASLSGALAAGLRRRGVADSDASLAAEAGIAVFRVAFERWVGEPTDRGLTTIMRESLEQ
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LKALTAAS
HHHHHCCC
>Mature Secondary Structure 
GRWEPNARGRLSEAAMELYVERGFEQTTVAEIAQRAGLTARTFFRYFADKREVLFAGST
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHH
ILEEHLIAALESTPASASPMEAVAAALDAAATMLGQRREFSRRRQSVIAANAELRERELI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMASLSGALAAGLRRRGVADSDASLAAEAGIAVFRVAFERWVGEPTDRGLTTIMRESLEQ
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LKALTAAS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]