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The map label for this gene is fabG [C]

Identifier: 158315165

GI number: 158315165

Start: 3990170

End: 3991060

Strand: Direct

Name: fabG [C]

Synonym: Franean1_3365

Alternate gene names: 158315165

Gene position: 3990170-3991060 (Clockwise)

Preceding gene: 158315163

Following gene: 158315173

Centisome position: 44.42

GC content: 74.41

Gene sequence:

>891_bases
ATGGAGATGTTCTTGCCGCCCTACGCAGACCGGCCCGTCGCCGTCGTCACGGGCGCCAGCTCGGGGATAGGCCGGGCGAC
CGCCCGCACTCTCGCCGAGCAGGGCTGGCAGGTGATCGGCGTCGGCCGTGATCCGGTACGCAGCGCCGCCACCGAGGCCG
AGATCGCCGCGGCGGCGCGCAAGGACGGCGGCTTCACGATGCTGCGCGGCGACTTCACCCTCATGGCGGATGTCCGGCGC
GTCGCCGGCGAGATCCAGCACCTCACCCCGCGCCTCGACATCCTCATCAACAACGCCGGCGGCGTGCGGGACCGGCAGAT
CATCAGCGCGGAGGGTACCGAGGCGACCTTCGCCGTCAACCACCTCGCCCCGTTCCTGCTGACCCGGGAGCTCACGCCCC
TGCTGCGGGCGAGCGCGGCCAGCCTGCCCGCCGGGTCGACGCGGGTGATCGCCGTGTCGTCGAGCGGCCACCGCGCGGTC
GACGGGCTCGACTGGGACGACCTGCAGAGCCTCGGCGAGTTCCGTCCCGCCGTCGCCTACTGCCGGGCCAAGCTCGCCAA
CATCCTGTTCACCCGCGAGCTGGCCCGGCGGGCCGGGCCGGACGGGATCGTCGCCCAGGCCATGCATCCCGGCGTCGTGG
CCAGCAACTTCAGCGCGCACGGCGACGCGGCGATGCGGGCGCACATGGCCGCGGCCGACACGGTGCCACCCGACGAACCG
GCGGAGACGCTGGCCTGGCTGGCCACCGAGCCCGAAGGCGGCCGCACCGGCGGGCGCTACTTCCACCGCAGGGCGGAGGA
GCTACCCGCCGAAGCCGCGCGGGACGATGCCGCCGCCGCCCGCCTCTGGACCGAGAGCGAGCGGCTGCTGGACGGGCTCG
GCTTCCGCTGA

Upstream 100 bases:

>100_bases
ATCTACGCCCGCTGCGCGGACAAGGCCCCACTGTTCCGGGCCGCGGTGCGGCACGCCACCGTTCGCCTGCTCCGCGACGG
CCTCCGGCCCCGCCGACCTG

Downstream 100 bases:

>100_bases
TCCGTTTCCGCCTCCGTCGGTCCACCCTTGGCGGGCGGGCGCGGAAACCGTGGCGCTCCTGGAACGAAGATCAGAGCGTG
TTGCCGCACAGGCCCGGCTC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MEMFLPPYADRPVAVVTGASSGIGRATARTLAEQGWQVIGVGRDPVRSAATEAEIAAAARKDGGFTMLRGDFTLMADVRR
VAGEIQHLTPRLDILINNAGGVRDRQIISAEGTEATFAVNHLAPFLLTRELTPLLRASAASLPAGSTRVIAVSSSGHRAV
DGLDWDDLQSLGEFRPAVAYCRAKLANILFTRELARRAGPDGIVAQAMHPGVVASNFSAHGDAAMRAHMAAADTVPPDEP
AETLAWLATEPEGGRTGGRYFHRRAEELPAEAARDDAAAARLWTESERLLDGLGFR

Sequences:

>Translated_296_residues
MEMFLPPYADRPVAVVTGASSGIGRATARTLAEQGWQVIGVGRDPVRSAATEAEIAAAARKDGGFTMLRGDFTLMADVRR
VAGEIQHLTPRLDILINNAGGVRDRQIISAEGTEATFAVNHLAPFLLTRELTPLLRASAASLPAGSTRVIAVSSSGHRAV
DGLDWDDLQSLGEFRPAVAYCRAKLANILFTRELARRAGPDGIVAQAMHPGVVASNFSAHGDAAMRAHMAAADTVPPDEP
AETLAWLATEPEGGRTGGRYFHRRAEELPAEAARDDAAAARLWTESERLLDGLGFR
>Mature_296_residues
MEMFLPPYADRPVAVVTGASSGIGRATARTLAEQGWQVIGVGRDPVRSAATEAEIAAAARKDGGFTMLRGDFTLMADVRR
VAGEIQHLTPRLDILINNAGGVRDRQIISAEGTEATFAVNHLAPFLLTRELTPLLRASAASLPAGSTRVIAVSSSGHRAV
DGLDWDDLQSLGEFRPAVAYCRAKLANILFTRELARRAGPDGIVAQAMHPGVVASNFSAHGDAAMRAHMAAADTVPPDEP
AETLAWLATEPEGGRTGGRYFHRRAEELPAEAARDDAAAARLWTESERLLDGLGFR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI10190746, Length=294, Percent_Identity=35.0340136054422, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI225579078, Length=286, Percent_Identity=34.6153846153846, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI193804850, Length=291, Percent_Identity=32.9896907216495, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI7706523, Length=287, Percent_Identity=33.7979094076655, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI186928839, Length=279, Percent_Identity=35.1254480286738, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI19923931, Length=230, Percent_Identity=35.6521739130435, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI166795268, Length=281, Percent_Identity=32.7402135231317, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI146231950, Length=312, Percent_Identity=37.5, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17532791, Length=294, Percent_Identity=28.9115646258503, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193207620, Length=292, Percent_Identity=29.1095890410959, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17558006, Length=289, Percent_Identity=29.4117647058824, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17532805, Length=289, Percent_Identity=28.3737024221453, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17505416, Length=273, Percent_Identity=28.2051282051282, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533174, Length=285, Percent_Identity=27.719298245614, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI115533172, Length=285, Percent_Identity=27.719298245614, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71992402, Length=290, Percent_Identity=28.2758620689655, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535059, Length=294, Percent_Identity=26.530612244898, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI72001364, Length=217, Percent_Identity=29.4930875576037, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=29.4776119402985, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=261, Percent_Identity=26.4367816091954, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=27.1317829457364, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324820, Length=238, Percent_Identity=28.1512605042017, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI22024069, Length=284, Percent_Identity=33.4507042253521, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28573296, Length=284, Percent_Identity=34.1549295774648, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24647946, Length=281, Percent_Identity=32.0284697508897, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI45553409, Length=281, Percent_Identity=32.0284697508897, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24647948, Length=281, Percent_Identity=32.0284697508897, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI161076371, Length=285, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24586328, Length=284, Percent_Identity=31.6901408450704, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45554248, Length=287, Percent_Identity=34.1463414634146, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24640117, Length=287, Percent_Identity=34.1463414634146, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI20129347, Length=291, Percent_Identity=32.3024054982818, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI19921754, Length=284, Percent_Identity=30.6338028169014, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24656154, Length=281, Percent_Identity=28.8256227758007, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19922628, Length=281, Percent_Identity=28.8256227758007, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24647931, Length=312, Percent_Identity=27.2435897435897, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571526, Length=222, Percent_Identity=30.6306306306306, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644339, Length=211, Percent_Identity=28.9099526066351, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 31497; Mature: 31497

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMFLPPYADRPVAVVTGASSGIGRATARTLAEQGWQVIGVGRDPVRSAATEAEIAAAAR
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHH
KDGGFTMLRGDFTLMADVRRVAGEIQHLTPRLDILINNAGGVRDRQIISAEGTEATFAVN
CCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCEEEHH
HLAPFLLTRELTPLLRASAASLPAGSTRVIAVSSSGHRAVDGLDWDDLQSLGEFRPAVAY
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
CRAKLANILFTRELARRAGPDGIVAQAMHPGVVASNFSAHGDAAMRAHMAAADTVPPDEP
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCH
AETLAWLATEPEGGRTGGRYFHRRAEELPAEAARDDAAAARLWTESERLLDGLGFR
HHHHEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEMFLPPYADRPVAVVTGASSGIGRATARTLAEQGWQVIGVGRDPVRSAATEAEIAAAAR
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHH
KDGGFTMLRGDFTLMADVRRVAGEIQHLTPRLDILINNAGGVRDRQIISAEGTEATFAVN
CCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCEEEHH
HLAPFLLTRELTPLLRASAASLPAGSTRVIAVSSSGHRAVDGLDWDDLQSLGEFRPAVAY
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
CRAKLANILFTRELARRAGPDGIVAQAMHPGVVASNFSAHGDAAMRAHMAAADTVPPDEP
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCH
AETLAWLATEPEGGRTGGRYFHRRAEELPAEAARDDAAAARLWTESERLLDGLGFR
HHHHEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]