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The map label for this gene is moaA [H]

Identifier: 158315007

GI number: 158315007

Start: 3779991

End: 3780986

Strand: Direct

Name: moaA [H]

Synonym: Franean1_3201

Alternate gene names: 158315007

Gene position: 3779991-3780986 (Clockwise)

Preceding gene: 158315006

Following gene: 158315014

Centisome position: 42.08

GC content: 70.68

Gene sequence:

>996_bases
ATGCAGCTCGCCGACTCGTACGGGCGAGTCGCGACCGACCTACGGGTGTCGCTGACCGACCGTTGCAACCTGCGTTGCAC
CTACTGCATGCCCGCCGAAGGCCTGGCCTGGCTGCCGCGGCCGGAAATCCTCACGGACAGTGAGGTGTTACGCCTGGTCG
CGATTGCGGTGACAAGGCTCGGGGTGACCGAGATCCGGTTGACCGGGGGCGAGCCCACACTGCGGCCGGGGCTGGTGTCC
CTGGTGCAGGCGATAACCGCCCTGGTACCGCGGCCGGAGGTGGCGCTGACGACGAACGGCCTGCTTCTGGGCGGCTCCGG
AGGGCTGGCCGGAGCACTGGCGGCGGCAGGCATGGACCGGGTGAACGTGTCGCTGGACACGCTGCGTCCGGACCGGTTTG
GTGAGATCACCCGCCGTCACCGCCTGGACGACGTGTTCGCGGGTCTGGAAGCCGCGGCACGGGCGGGATTCGCCCCGGTG
AAGGTGAACGCGGTGCTGATGCGGGGAGTCAACGACGACGAGGCCGTCCCGCTACTGCACTGGTGCCTGGACCGAGGCTA
CGAGCTGCGGTTCATCGAGCAGATGCCGCTCGACGCCCAGGGCGGCTGGCGACGGGAGCAGATGGTGACCGCGGCGGAGA
TCTTGGACCGGCTGGCCGCGGAGTTCACCCTCACCCCCGCACCCGGGCGCGGCAACGCGCCGGCCGAACTTTTCACGATC
GACGCGGGCCCCGGGCAGGTCGGGGTGATCGCCTCGGTGTCGGCGCCGTTCTGCGCGGCGTGTGACCGAGTCCGGCTCAC
AGCTGACGGGCAGGTACGCGACTGCCTGTTCGCCCGGACCGAGTCGGATCTGCGGACCCCCCTGAGGTCTGGGGCTGACG
ACGAGGAGATCGCGGCCCGGTGGGTGCGGGCGGTGCGGGCGAAACGGGCCGGGCACGGCATCGACGTCCCCGGATTCGTT
CAACCGGCTCGTCCCATGTCCGCCATCGGCGGGTGA

Upstream 100 bases:

>100_bases
ACCCGTTCGATAGAGTCCTGGTAGATGGATCTCGTGGATCTGCTCGAGTTGACGGAATCATCAGTGAAAATCGTGGGAAT
GGACACGTAGAATCATCCGA

Downstream 100 bases:

>100_bases
CGGTCACGGTGGCGACTCGGTGAAGTATCCCCGGAGTCCGCGCAGGGCTTCGTCGAGAATCTCCCCGATCGTCCTGTCCT
CGTGTTCCAGCCACTGTTCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MQLADSYGRVATDLRVSLTDRCNLRCTYCMPAEGLAWLPRPEILTDSEVLRLVAIAVTRLGVTEIRLTGGEPTLRPGLVS
LVQAITALVPRPEVALTTNGLLLGGSGGLAGALAAAGMDRVNVSLDTLRPDRFGEITRRHRLDDVFAGLEAAARAGFAPV
KVNAVLMRGVNDDEAVPLLHWCLDRGYELRFIEQMPLDAQGGWRREQMVTAAEILDRLAAEFTLTPAPGRGNAPAELFTI
DAGPGQVGVIASVSAPFCAACDRVRLTADGQVRDCLFARTESDLRTPLRSGADDEEIAARWVRAVRAKRAGHGIDVPGFV
QPARPMSAIGG

Sequences:

>Translated_331_residues
MQLADSYGRVATDLRVSLTDRCNLRCTYCMPAEGLAWLPRPEILTDSEVLRLVAIAVTRLGVTEIRLTGGEPTLRPGLVS
LVQAITALVPRPEVALTTNGLLLGGSGGLAGALAAAGMDRVNVSLDTLRPDRFGEITRRHRLDDVFAGLEAAARAGFAPV
KVNAVLMRGVNDDEAVPLLHWCLDRGYELRFIEQMPLDAQGGWRREQMVTAAEILDRLAAEFTLTPAPGRGNAPAELFTI
DAGPGQVGVIASVSAPFCAACDRVRLTADGQVRDCLFARTESDLRTPLRSGADDEEIAARWVRAVRAKRAGHGIDVPGFV
QPARPMSAIGG
>Mature_331_residues
MQLADSYGRVATDLRVSLTDRCNLRCTYCMPAEGLAWLPRPEILTDSEVLRLVAIAVTRLGVTEIRLTGGEPTLRPGLVS
LVQAITALVPRPEVALTTNGLLLGGSGGLAGALAAAGMDRVNVSLDTLRPDRFGEITRRHRLDDVFAGLEAAARAGFAPV
KVNAVLMRGVNDDEAVPLLHWCLDRGYELRFIEQMPLDAQGGWRREQMVTAAEILDRLAAEFTLTPAPGRGNAPAELFTI
DAGPGQVGVIASVSAPFCAACDRVRLTADGQVRDCLFARTESDLRTPLRSGADDEEIAARWVRAVRAKRAGHGIDVPGFV
QPARPMSAIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=330, Percent_Identity=39.6969696969697, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI22027536, Length=330, Percent_Identity=39.6969696969697, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI1786999, Length=334, Percent_Identity=34.4311377245509, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32566329, Length=335, Percent_Identity=38.2089552238806, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI32566331, Length=317, Percent_Identity=37.5394321766561, Blast_Score=223, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17561210, Length=335, Percent_Identity=38.2089552238806, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI28574488, Length=331, Percent_Identity=40.785498489426, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI28574490, Length=327, Percent_Identity=40.3669724770642, Blast_Score=231, Evalue=6e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35411; Mature: 35411

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLADSYGRVATDLRVSLTDRCNLRCTYCMPAEGLAWLPRPEILTDSEVLRLVAIAVTRL
CCCCCHHCCHHHHEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GVTEIRLTGGEPTLRPGLVSLVQAITALVPRPEVALTTNGLLLGGSGGLAGALAAAGMDR
CCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCHHHHHHHCCCCC
VNVSLDTLRPDRFGEITRRHRLDDVFAGLEAAARAGFAPVKVNAVLMRGVNDDEAVPLLH
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHH
WCLDRGYELRFIEQMPLDAQGGWRREQMVTAAEILDRLAAEFTLTPAPGRGNAPAELFTI
HHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEE
DAGPGQVGVIASVSAPFCAACDRVRLTADGQVRDCLFARTESDLRTPLRSGADDEEIAAR
ECCCCCEEEEEECCCCHHHHCCCEEEECCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHH
WVRAVRAKRAGHGIDVPGFVQPARPMSAIGG
HHHHHHHHHCCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MQLADSYGRVATDLRVSLTDRCNLRCTYCMPAEGLAWLPRPEILTDSEVLRLVAIAVTRL
CCCCCHHCCHHHHEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GVTEIRLTGGEPTLRPGLVSLVQAITALVPRPEVALTTNGLLLGGSGGLAGALAAAGMDR
CCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCHHHHHHHCCCCC
VNVSLDTLRPDRFGEITRRHRLDDVFAGLEAAARAGFAPVKVNAVLMRGVNDDEAVPLLH
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHH
WCLDRGYELRFIEQMPLDAQGGWRREQMVTAAEILDRLAAEFTLTPAPGRGNAPAELFTI
HHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEE
DAGPGQVGVIASVSAPFCAACDRVRLTADGQVRDCLFARTESDLRTPLRSGADDEEIAAR
ECCCCCEEEEEECCCCHHHHCCCEEEECCCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHH
WVRAVRAKRAGHGIDVPGFVQPARPMSAIGG
HHHHHHHHHCCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]