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The map label for this gene is tetR [H]

Identifier: 158314507

GI number: 158314507

Start: 3174184

End: 3174840

Strand: Direct

Name: tetR [H]

Synonym: Franean1_2683

Alternate gene names: 158314507

Gene position: 3174184-3174840 (Clockwise)

Preceding gene: 158314506

Following gene: 158314508

Centisome position: 35.34

GC content: 68.34

Gene sequence:

>657_bases
ATGGCCCGTGTCAGAACCCCTCCGATCAGCCGTTCCGACGTCATCGCGAAGGCACTCGAAATCATCGACCGGGATGGGCT
CGAAGGCTTCAGCATCCGGCGGCTGGGCGACGAGCTCGGCATCAACGGGACGTCGCTCTATTACCACTTCGAGGACAAGG
ACGCGATCCTGCACGGCGTCCGCATGCTCGTCCTGCGCGAAGGCCAGGTCGGCGCCGAGCCTCTCGAGTCGTTCACGTGG
CAGGAGCACCTGCGCACCGCGGTCATCCAGTATCGGGAGGTCCTGCTGCGCCACCCGAACACGGCGCCGCTGATGTCACC
GGCGGCGCTGCTGCGGCCACTCGGCCTCGCACACCGCGACCGGGTCGTCGCGAAGCTCGTCGACGAGGGAGTCCCCGCCG
AGCACGCCCACGCAGTCATCGACAGCGCCGAGACGCTCGCCTACGGGTCGGCACTGCTCAACCCACACCGGCTCAGCCCA
CAGGACTGGGTCGGCCTGCGGCCCGACGACGACACCCCAGCGCTCTCCCAGGCACTCGCGCGAACGACCGCGTCTCCCGA
CGAACTGTTCCACCAGCAGATCGACGCACTGCTCGACGGGTGGACACACCGTCTCTGCCCGCAGCCCGACGTCGGAGACC
GTGAGGCAGGCACATGA

Upstream 100 bases:

>100_bases
GCGTCGGGACCCCGCTCAACCCGCTGGCCGTCCGATGAGCCACGCACCAGCCGGGCATTCCCTGGCCACACGACGTCAGC
CGGACAACCAGGATGGACGG

Downstream 100 bases:

>100_bases
CACCAGGCAGCGAGGCTCCGGGCAAAGGCTCCCGCGCTCCACGGTTCGCCGGCCTCGACCCGCGGCACGCCCGCTACCCG
CTGCCCGGCGTCGAGGCCCT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MARVRTPPISRSDVIAKALEIIDRDGLEGFSIRRLGDELGINGTSLYYHFEDKDAILHGVRMLVLREGQVGAEPLESFTW
QEHLRTAVIQYREVLLRHPNTAPLMSPAALLRPLGLAHRDRVVAKLVDEGVPAEHAHAVIDSAETLAYGSALLNPHRLSP
QDWVGLRPDDDTPALSQALARTTASPDELFHQQIDALLDGWTHRLCPQPDVGDREAGT

Sequences:

>Translated_218_residues
MARVRTPPISRSDVIAKALEIIDRDGLEGFSIRRLGDELGINGTSLYYHFEDKDAILHGVRMLVLREGQVGAEPLESFTW
QEHLRTAVIQYREVLLRHPNTAPLMSPAALLRPLGLAHRDRVVAKLVDEGVPAEHAHAVIDSAETLAYGSALLNPHRLSP
QDWVGLRPDDDTPALSQALARTTASPDELFHQQIDALLDGWTHRLCPQPDVGDREAGT
>Mature_217_residues
ARVRTPPISRSDVIAKALEIIDRDGLEGFSIRRLGDELGINGTSLYYHFEDKDAILHGVRMLVLREGQVGAEPLESFTWQ
EHLRTAVIQYREVLLRHPNTAPLMSPAALLRPLGLAHRDRVVAKLVDEGVPAEHAHAVIDSAETLAYGSALLNPHRLSPQ
DWVGLRPDDDTPALSQALARTTASPDELFHQQIDALLDGWTHRLCPQPDVGDREAGT

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24104; Mature: 23972

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVRTPPISRSDVIAKALEIIDRDGLEGFSIRRLGDELGINGTSLYYHFEDKDAILHGV
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHH
RMLVLREGQVGAEPLESFTWQEHLRTAVIQYREVLLRHPNTAPLMSPAALLRPLGLAHRD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHH
RVVAKLVDEGVPAEHAHAVIDSAETLAYGSALLNPHRLSPQDWVGLRPDDDTPALSQALA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
RTTASPDELFHQQIDALLDGWTHRLCPQPDVGDREAGT
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARVRTPPISRSDVIAKALEIIDRDGLEGFSIRRLGDELGINGTSLYYHFEDKDAILHGV
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHH
RMLVLREGQVGAEPLESFTWQEHLRTAVIQYREVLLRHPNTAPLMSPAALLRPLGLAHRD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHH
RVVAKLVDEGVPAEHAHAVIDSAETLAYGSALLNPHRLSPQDWVGLRPDDDTPALSQALA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
RTTASPDELFHQQIDALLDGWTHRLCPQPDVGDREAGT
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3241623 [H]