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The map label for this gene is baeB [H]

Identifier: 158314097

GI number: 158314097

Start: 2707020

End: 2707730

Strand: Direct

Name: baeB [H]

Synonym: Franean1_2264

Alternate gene names: 158314097

Gene position: 2707020-2707730 (Clockwise)

Preceding gene: 158314095

Following gene: 158314098

Centisome position: 30.14

GC content: 72.15

Gene sequence:

>711_bases
GTGAGCGATCGCCTGTACTTCCGCCAGTTGCTGTCCGGCCGCGACTTCGCGGTGGGTGATCCCGCCGCGACCCAGATGGT
CAACTTCGTCTACCTCATCGGTGACCGGGGGACGGGCGAGGCCGTCGTGGTCGACCCCGCCTACCGGGTGGGCGACCTGC
TCGACGTGCTGGCCGCCGACGACATGCGGCTGACCGGGGCGCTGGTCACCCACCACCACGCCGACCATGTCGGCGGCACG
GCCTTCGGCATCGAGCTGGAGGGGATCCGCGAGCTGCTGGAGCGCACATCCGTCCCGATCCACCTGCAGCGGGATGAGGC
CGAGTGGGTGCGGCGCGGGACGGGCGTGGGGGCCGCCGAGCTCGTCGAGCACGGCGACGACGACGTGGTCACCGTCGGCG
CGGTGGACATCCGCCTGCTGCACACCCCCGGTCACACCCCGGGCAGCCAGTGCTTCCTCGTGGACGGGCGGCTCGTCGCC
GGGGACACTCTGTTCCTCGAGGGTTGCGGGCGGATGGACTTCCCGGGCGGGGACGCCGCGGCGATGTACGACAGCCTGCG
CCGCCTGGGCGCGCTGCCCGACGACGTCACCGTCTACCCGGGTCACCGGTACTCGGCGGAGTCCGCCGCGGAGCTCGGCG
TGGTGCGCAAGATGAACTACGTCTTCCGGCCGACCAGCTCCCGGCAGTGGCTGGCGATGCTCGGCGCCTGA

Upstream 100 bases:

>100_bases
CGGCCCACGCCGCCCCGCCCCGCGATGGCACGTGGTGGGTGACGGTCCGCCCGCTCCACCGGTTCTGGAGTGCGGGCCCG
GCGCTCCGTAGGCTCGCGGT

Downstream 100 bases:

>100_bases
CCGCCCGCGTGGTGGGTATGGACACGGCGGGGGTGAGCGCCGTGGACGCTGACGGCTCGGCCGGCACACGGCCCCGGGTC
GAGATCGAGTACTGCACCCG

Product: beta-lactamase domain-containing protein

Products: Reduced glutathione; H+; D-Lactate [C]

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSDRLYFRQLLSGRDFAVGDPAATQMVNFVYLIGDRGTGEAVVVDPAYRVGDLLDVLAADDMRLTGALVTHHHADHVGGT
AFGIELEGIRELLERTSVPIHLQRDEAEWVRRGTGVGAAELVEHGDDDVVTVGAVDIRLLHTPGHTPGSQCFLVDGRLVA
GDTLFLEGCGRMDFPGGDAAAMYDSLRRLGALPDDVTVYPGHRYSAESAAELGVVRKMNYVFRPTSSRQWLAMLGA

Sequences:

>Translated_236_residues
MSDRLYFRQLLSGRDFAVGDPAATQMVNFVYLIGDRGTGEAVVVDPAYRVGDLLDVLAADDMRLTGALVTHHHADHVGGT
AFGIELEGIRELLERTSVPIHLQRDEAEWVRRGTGVGAAELVEHGDDDVVTVGAVDIRLLHTPGHTPGSQCFLVDGRLVA
GDTLFLEGCGRMDFPGGDAAAMYDSLRRLGALPDDVTVYPGHRYSAESAAELGVVRKMNYVFRPTSSRQWLAMLGA
>Mature_235_residues
SDRLYFRQLLSGRDFAVGDPAATQMVNFVYLIGDRGTGEAVVVDPAYRVGDLLDVLAADDMRLTGALVTHHHADHVGGTA
FGIELEGIRELLERTSVPIHLQRDEAEWVRRGTGVGAAELVEHGDDDVVTVGAVDIRLLHTPGHTPGSQCFLVDGRLVAG
DTLFLEGCGRMDFPGGDAAAMYDSLRRLGALPDDVTVYPGHRYSAESAAELGVVRKMNYVFRPTSSRQWLAMLGA

Specific function: Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=200, Percent_Identity=32.5, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI21703352, Length=222, Percent_Identity=35.1351351351351, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI116642887, Length=222, Percent_Identity=35.1351351351351, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI46361987, Length=187, Percent_Identity=33.6898395721925, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI14150041, Length=187, Percent_Identity=33.6898395721925, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1786406, Length=181, Percent_Identity=33.1491712707182, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787158, Length=185, Percent_Identity=32.972972972973, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538952, Length=195, Percent_Identity=29.2307692307692, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356335, Length=191, Percent_Identity=32.9842931937173, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667703, Length=191, Percent_Identity=32.9842931937173, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667711, Length=191, Percent_Identity=32.9842931937173, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI221330176, Length=223, Percent_Identity=27.3542600896861, Blast_Score=87, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: 3.1.2.6 [C]

Molecular weight: Translated: 25533; Mature: 25402

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00743 BETA_LACTAMASE_B_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRLYFRQLLSGRDFAVGDPAATQMVNFVYLIGDRGTGEAVVVDPAYRVGDLLDVLAAD
CCCHHHHHHHHCCCCCCCCCHHHHHHEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHCC
DMRLTGALVTHHHADHVGGTAFGIELEGIRELLERTSVPIHLQRDEAEWVRRGTGVGAAE
CCEEHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCCEEEECCHHHHHHHCCCCCHHH
LVEHGDDDVVTVGAVDIRLLHTPGHTPGSQCFLVDGRLVAGDTLFLEGCGRMDFPGGDAA
HHHCCCCCEEEEEEEEEEEEECCCCCCCCEEEEECCEEEECCEEEEECCCCCCCCCCCHH
AMYDSLRRLGALPDDVTVYPGHRYSAESAAELGVVRKMNYVFRPTSSRQWLAMLGA
HHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHCCEEECCCCCCCHHEECCC
>Mature Secondary Structure 
SDRLYFRQLLSGRDFAVGDPAATQMVNFVYLIGDRGTGEAVVVDPAYRVGDLLDVLAAD
CCHHHHHHHHCCCCCCCCCHHHHHHEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHCC
DMRLTGALVTHHHADHVGGTAFGIELEGIRELLERTSVPIHLQRDEAEWVRRGTGVGAAE
CCEEHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCCEEEECCHHHHHHHCCCCCHHH
LVEHGDDDVVTVGAVDIRLLHTPGHTPGSQCFLVDGRLVAGDTLFLEGCGRMDFPGGDAA
HHHCCCCCEEEEEEEEEEEEECCCCCCCCEEEEECCEEEECCEEEEECCCCCCCCCCCHH
AMYDSLRRLGALPDDVTVYPGHRYSAESAAELGVVRKMNYVFRPTSSRQWLAMLGA
HHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHCCEEECCCCCCCHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; (R)-S-Lactoylglutathione [C]

Specific reaction: H2O + (R)-S-Lactoylglutathione --> Reduced glutathione + H+ + D-Lactate [C]

General reaction: Thioester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA