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The map label for this gene is hemH [H]

Identifier: 158314065

GI number: 158314065

Start: 2669519

End: 2670784

Strand: Direct

Name: hemH [H]

Synonym: Franean1_2232

Alternate gene names: 158314065

Gene position: 2669519-2670784 (Clockwise)

Preceding gene: 158314064

Following gene: 158314066

Centisome position: 29.72

GC content: 75.36

Gene sequence:

>1266_bases
ATGGAAGGGGACATGACGGTGCCGACGGACACCGCCGGCCACGGCCGCGGGATCGACGTGGACGCGCTGCTGCTCGTCTC
CTTCGGCGGTCCGGAGGGGCCGGAGGACGTCCTGCCGTTCCTGCGCAACGTGACCCGCGGCCGCGGGGTGCCCGAGGCGC
GGCTGGCCGAGGTCGCGGCGCACTACGACCGCTTCGGCGGGCGCAGCCCGATCAACGACCAGAACCGGGCGCTGCTCGCC
GCGCTGCGGGAGCGGCTGGCCCCGATGCCCGTGTACTGGGGCAACCGGAACTGGCAGCCGTACCTCGCCGACGCCGTGGC
GCGCATGCGGGCCGACGGCGTGCGCCGGGCGGCCTGCTTCGTGACGTCCGCGTTCGCGTCCTACTCGGGGTGCCGGCAGT
ACCGGGAGGATCTGGCGGCGGCCCTGGAGCAGGTCGGCCCGGGCGCCCCCGACCTGGTGAAGCTGCGGCTGTTCTTCGAC
CACCCGGGATTCGTCGAGCCGATGGTCGACCACTGCGTGCGGGCGCTCGCGTCGCTGCCGGCGGCGGTGCGCGACGAGGC
CCGGCTGGTGTTCACCGCCCATGCGCTGCCCCGCTCGCAGGCGGCCGCGAGCGGGCCGGACGGCGGAGCCTACGAGCGCC
AGCTCCGCGCGGCCGCCGGTGTGATCGCGCAGCGGGTCGCCGCGCGCGCCGGTACCCGGCACGAGTGGCAGGTCGCCTAC
TGCAGCCGCAGCGGCCCGCCGAGCGTGCCCTGGCTCGAACCGGACGTCAACGACGCCCTGGCGGCGCTCGCGGACGGCGG
CGCGCGCGCCGCGGTGATCGTGCCGGTCGGTTTCGTCAGCGACCACATGGAGGTCGTCTACGATCTCGACGTCGAGGCGG
TGCGCACCGCCTCGGAACGCGGTCTGGCGGTCGCCCGGGCGGGCACCGTCGGGACGGACCCGCGCTTCGTCGGGATGGTG
GCCGATCTGGTCGCCGAGCGCCGCTTCCCCGAGTGGGAGCGGCCCGCGCTGAGCGGCGAGGGGCCGTCCCACGACGTCTG
CCCGCTGCACTGCTGTGACCCGGGTGCCCGCCGCCCGGCGGCGGCCGGTGTTCCGGCGGATCTCTGCGCGCACGGCCCGG
CACGTTCCGGCGCGACGGCGTCACAGCCGGGCAGGCCGACGAACGCGGAGCGCTCCCGGGATGGTGAACCGCGCAACGAA
GCGACGATACTGGTGGATGAGCGGGCAGGTATCTCGCGGTCCGACTCTCACCCCGCAGGCGAATAA

Upstream 100 bases:

>100_bases
TCGACGAGATCCGGGGCCGGGTGCCGCGCTGACGGCGCGGGCCCGGCTGGCGGACGGGCGCGACGTACGACGGGGGCGAC
GTACGACGGGGGCGACGTAC

Downstream 100 bases:

>100_bases
GACGGAGCGATCCGAGACATGCAGCGATTTGTGTTCGACCCGCCGGAGCGGTTCGTGGTCGGGACCGTCGGGCAGCCCGG
TGACCGCGTGTTCTTCCTCC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MEGDMTVPTDTAGHGRGIDVDALLLVSFGGPEGPEDVLPFLRNVTRGRGVPEARLAEVAAHYDRFGGRSPINDQNRALLA
ALRERLAPMPVYWGNRNWQPYLADAVARMRADGVRRAACFVTSAFASYSGCRQYREDLAAALEQVGPGAPDLVKLRLFFD
HPGFVEPMVDHCVRALASLPAAVRDEARLVFTAHALPRSQAAASGPDGGAYERQLRAAAGVIAQRVAARAGTRHEWQVAY
CSRSGPPSVPWLEPDVNDALAALADGGARAAVIVPVGFVSDHMEVVYDLDVEAVRTASERGLAVARAGTVGTDPRFVGMV
ADLVAERRFPEWERPALSGEGPSHDVCPLHCCDPGARRPAAAGVPADLCAHGPARSGATASQPGRPTNAERSRDGEPRNE
ATILVDERAGISRSDSHPAGE

Sequences:

>Translated_421_residues
MEGDMTVPTDTAGHGRGIDVDALLLVSFGGPEGPEDVLPFLRNVTRGRGVPEARLAEVAAHYDRFGGRSPINDQNRALLA
ALRERLAPMPVYWGNRNWQPYLADAVARMRADGVRRAACFVTSAFASYSGCRQYREDLAAALEQVGPGAPDLVKLRLFFD
HPGFVEPMVDHCVRALASLPAAVRDEARLVFTAHALPRSQAAASGPDGGAYERQLRAAAGVIAQRVAARAGTRHEWQVAY
CSRSGPPSVPWLEPDVNDALAALADGGARAAVIVPVGFVSDHMEVVYDLDVEAVRTASERGLAVARAGTVGTDPRFVGMV
ADLVAERRFPEWERPALSGEGPSHDVCPLHCCDPGARRPAAAGVPADLCAHGPARSGATASQPGRPTNAERSRDGEPRNE
ATILVDERAGISRSDSHPAGE
>Mature_421_residues
MEGDMTVPTDTAGHGRGIDVDALLLVSFGGPEGPEDVLPFLRNVTRGRGVPEARLAEVAAHYDRFGGRSPINDQNRALLA
ALRERLAPMPVYWGNRNWQPYLADAVARMRADGVRRAACFVTSAFASYSGCRQYREDLAAALEQVGPGAPDLVKLRLFFD
HPGFVEPMVDHCVRALASLPAAVRDEARLVFTAHALPRSQAAASGPDGGAYERQLRAAAGVIAQRVAARAGTRHEWQVAY
CSRSGPPSVPWLEPDVNDALAALADGGARAAVIVPVGFVSDHMEVVYDLDVEAVRTASERGLAVARAGTVGTDPRFVGMV
ADLVAERRFPEWERPALSGEGPSHDVCPLHCCDPGARRPAAAGVPADLCAHGPARSGATASQPGRPTNAERSRDGEPRNE
ATILVDERAGISRSDSHPAGE

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=327, Percent_Identity=27.217125382263, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI60499025, Length=327, Percent_Identity=27.217125382263, Blast_Score=112, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6324750, Length=328, Percent_Identity=23.780487804878, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17864156, Length=330, Percent_Identity=24.5454545454545, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI45552018, Length=169, Percent_Identity=27.810650887574, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 44746; Mature: 44746

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGDMTVPTDTAGHGRGIDVDALLLVSFGGPEGPEDVLPFLRNVTRGRGVPEARLAEVAA
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
HYDRFGGRSPINDQNRALLAALRERLAPMPVYWGNRNWQPYLADAVARMRADGVRRAACF
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
VTSAFASYSGCRQYREDLAAALEQVGPGAPDLVKLRLFFDHPGFVEPMVDHCVRALASLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCC
AAVRDEARLVFTAHALPRSQAAASGPDGGAYERQLRAAAGVIAQRVAARAGTRHEWQVAY
HHHCCCCEEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
CSRSGPPSVPWLEPDVNDALAALADGGARAAVIVPVGFVSDHMEVVYDLDVEAVRTASER
ECCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECHHHHCHHEEECCCHHHHHHHHHC
GLAVARAGTVGTDPRFVGMVADLVAERRFPEWERPALSGEGPSHDVCPLHCCDPGARRPA
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
AAGVPADLCAHGPARSGATASQPGRPTNAERSRDGEPRNEATILVDERAGISRSDSHPAG
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
E
C
>Mature Secondary Structure
MEGDMTVPTDTAGHGRGIDVDALLLVSFGGPEGPEDVLPFLRNVTRGRGVPEARLAEVAA
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
HYDRFGGRSPINDQNRALLAALRERLAPMPVYWGNRNWQPYLADAVARMRADGVRRAACF
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
VTSAFASYSGCRQYREDLAAALEQVGPGAPDLVKLRLFFDHPGFVEPMVDHCVRALASLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCC
AAVRDEARLVFTAHALPRSQAAASGPDGGAYERQLRAAAGVIAQRVAARAGTRHEWQVAY
HHHCCCCEEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
CSRSGPPSVPWLEPDVNDALAALADGGARAAVIVPVGFVSDHMEVVYDLDVEAVRTASER
ECCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECHHHHCHHEEECCCHHHHHHHHHC
GLAVARAGTVGTDPRFVGMVADLVAERRFPEWERPALSGEGPSHDVCPLHCCDPGARRPA
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
AAGVPADLCAHGPARSGATASQPGRPTNAERSRDGEPRNEATILVDERAGISRSDSHPAG
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA