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The map label for this gene is mutB [H]

Identifier: 158313779

GI number: 158313779

Start: 2335352

End: 2337574

Strand: Direct

Name: mutB [H]

Synonym: Franean1_1944

Alternate gene names: 158313779

Gene position: 2335352-2337574 (Clockwise)

Preceding gene: 158313778

Following gene: 158313780

Centisome position: 26.0

GC content: 70.9

Gene sequence:

>2223_bases
ATGTCATCGATCCCCGACTTCGCCGAGATCGCGCTCGGAGCACCCAGCGGCGCGGACGCCGACGAGGCCCAGTGGCGGGT
CGCGCTCGAGCAGGCCACCGGCAAGGACGCCGACGCGCTGACCTGGGACACCCCCGAGGGCATCGCGGTGAAGCCGCTGT
ACACCGCGGCCGACACGGCCGGCCTGGACTTCCTCGGCACCTACCCGGGCATCGCCCCCTACCTGCGCGGCCCGTACCCG
GCGATGTACGTGACCCAGCCGTGGACGATCCGCCAGTACGCGGGGTTCTCCACCGCGGCCGAGTCGAACGCCTTCTACCG
ACGCAACCTGGCCGCCGGCCAGAAGGGCCTCTCGGTGGCCTTCGACCTGCCGACCCACCGCGGGTACGACAGCGACCACC
CGCGGGTCACCGGCGACGTGGGCATGGCCGGCGTGGCCATCGACTCGATCTACGACATGCGCCAGCTCTTCGACGGCATC
CCGCTGGACCGGATGAGCGTGTCGATGACCATGAACGGCGCGGTGCTGCCGGTCCTGGCGCTGTACATCGTCGCCGCCGA
GGAACAGGGGGTGGCACCGGAGCAGCTCGCCGGCACCATCCAGAACGACATCCTCAAAGAGTTCATGGTCCGCAACACCT
ACATCTACCCGCCGCAGCCGTCGATGCAGATCATCTCGGACATCTTCGCGTACACGTCGAAGCGGATGCCGCGATTCAAC
TCGATCTCCATCTCCGGCTACCACATGCAGGAGGCGGGCGCGACCGCCGACCTGGAGCTCGCCTACACGCTGGCGGACGG
CGTCGAGTACATCCGGGCGGGTCTGGGTGCCGGCCTGGAGATCGACGCCTTCGCCCCCCGGCTGTCGTTCTTCTGGGCGA
TCGGCATGAACTTCTTCATGGAAGTCGCCAAGATGCGCGCGGCGCGCCTGCTGTGGGCGCGGTTGGTGAACCAGTTCGGC
CCGACCAGCGCCCGTTCGACGTCGCTGCGGACGCACTCGCAGACCTCCGGATGGTCGCTGACCGCCCAGGACGTCTTCAA
CAACGTCGTGCGCACCTGCGTCGAGGCGATGGCCGCCACCCAGGGGCACACCCAGTCGCTGCACACCAACGCCCTCGACG
AGGCGCTGGCGCTGCCCACCGACTTCTCCGCCCGCATCGCGCGCAACACCCAGCTGCTGCTCCAGCAGGAGTCCGGTACC
ACCCGGGTCGTCGACCCGTGGGGCGGCAGCCACTATGTCGAGCGGCTCACCTACGACCTGGCCCGCAAGGCCTGGGCGCA
CATCACCGAGGTCGAGTCGACCGGCGGGATGGCGCAGGCGATCGACGCCGGCATCCCGAAGATGCGCATCGAGGAGGCGG
CGGCGCGCACCCAGGCCCGCATCGACGCCGGACGCCAGCCGCTCGTCGGGGTCAACAAGTACCGGGTGGACGCGGATGAG
GCCATCGACGTCCTGAAGGTCGACAACTCGGCGGTCCGGGTCGGTCAGATCGAGAAGCTGCGCCGGCTGCGCGAGGAACG
TGACACCGCCGCCGTCGAGTCGGCGCTGCACGCGCTGACCGCCGCGGCCGACGCGGCCCGCGACGGCAGCCGGCCGTCCG
ACCTGGGGCACAACCTGCTCGCGCTGGCAGTCGACGCCGCCCGCGCCAAGGCGACCGTGGGTGAGATCTCCGACGCCCTG
GAGAAGGTGTACGGGCGGCACTCCGGTCAGATCCGTACGATCTCGGGTGTGTACCGGGATGAGGCCGGGCCAGCCGGCAA
CATCGTCGCCGCCCGCGAGGCCGCGGCGGCCTTCGAGCGGGCCGAGGGCCGGCGCCCACGGATCCTCGTCGCGAAGATGG
GGCAGGACGGGCACGACCGCGGCCAGAAGGTGATCGCCACGGCCTTCGCCGACATCGGCTTCGACGTGGACGTCGGCCCG
CTGTTCCAGACGCCGGCCGAGGTGGCCCGCCAGGCCGTCGAGGCGGACGTCCAGATCATCGGCGTGTCCTCGCTCGCCGC
CGGGCACCTCACGCTGGTCCCGGCGCTGAAGGAGGAGCTGGCGGCGCTCGAACGCGACGACATCCTCGTCGTCGTCGGCG
GGGTCATCCCGCCGCAGGACTTCGACGCGCTGCGCGCCGCCGGTGCCGCCGCGATCTTCCCGCCTGGCACGGTCATCGCG
GACGCGGCGATCGAGCTGCTGGCCACGCTGTCCGACCAGCTCGGCCACACCGCGGCGCCTTGA

Upstream 100 bases:

>100_bases
CGGAGACCGACGCCGCGGCGGGCGTGAGCGGGTACGTCTTCACCGGCTGCAACGCCGTCGAGGTGCTGCGGACGACCCTC
GCAGAGGCGGGAGTGGCCTG

Downstream 100 bases:

>100_bases
CCGCACTGGCCCGCCGGCCCGTCGACGTCGCCGCGTACGTCGACGGTGTCCTCGCGTCGTCGCGGATGTGGGTCGCGCGC
GCCATCACACTGGTCGAGTC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MSSIPDFAEIALGAPSGADADEAQWRVALEQATGKDADALTWDTPEGIAVKPLYTAADTAGLDFLGTYPGIAPYLRGPYP
AMYVTQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDHPRVTGDVGMAGVAIDSIYDMRQLFDGI
PLDRMSVSMTMNGAVLPVLALYIVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPQPSMQIISDIFAYTSKRMPRFN
SISISGYHMQEAGATADLELAYTLADGVEYIRAGLGAGLEIDAFAPRLSFFWAIGMNFFMEVAKMRAARLLWARLVNQFG
PTSARSTSLRTHSQTSGWSLTAQDVFNNVVRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGT
TRVVDPWGGSHYVERLTYDLARKAWAHITEVESTGGMAQAIDAGIPKMRIEEAAARTQARIDAGRQPLVGVNKYRVDADE
AIDVLKVDNSAVRVGQIEKLRRLREERDTAAVESALHALTAAADAARDGSRPSDLGHNLLALAVDAARAKATVGEISDAL
EKVYGRHSGQIRTISGVYRDEAGPAGNIVAAREAAAAFERAEGRRPRILVAKMGQDGHDRGQKVIATAFADIGFDVDVGP
LFQTPAEVARQAVEADVQIIGVSSLAAGHLTLVPALKEELAALERDDILVVVGGVIPPQDFDALRAAGAAAIFPPGTVIA
DAAIELLATLSDQLGHTAAP

Sequences:

>Translated_740_residues
MSSIPDFAEIALGAPSGADADEAQWRVALEQATGKDADALTWDTPEGIAVKPLYTAADTAGLDFLGTYPGIAPYLRGPYP
AMYVTQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDHPRVTGDVGMAGVAIDSIYDMRQLFDGI
PLDRMSVSMTMNGAVLPVLALYIVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPQPSMQIISDIFAYTSKRMPRFN
SISISGYHMQEAGATADLELAYTLADGVEYIRAGLGAGLEIDAFAPRLSFFWAIGMNFFMEVAKMRAARLLWARLVNQFG
PTSARSTSLRTHSQTSGWSLTAQDVFNNVVRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGT
TRVVDPWGGSHYVERLTYDLARKAWAHITEVESTGGMAQAIDAGIPKMRIEEAAARTQARIDAGRQPLVGVNKYRVDADE
AIDVLKVDNSAVRVGQIEKLRRLREERDTAAVESALHALTAAADAARDGSRPSDLGHNLLALAVDAARAKATVGEISDAL
EKVYGRHSGQIRTISGVYRDEAGPAGNIVAAREAAAAFERAEGRRPRILVAKMGQDGHDRGQKVIATAFADIGFDVDVGP
LFQTPAEVARQAVEADVQIIGVSSLAAGHLTLVPALKEELAALERDDILVVVGGVIPPQDFDALRAAGAAAIFPPGTVIA
DAAIELLATLSDQLGHTAAP
>Mature_739_residues
SSIPDFAEIALGAPSGADADEAQWRVALEQATGKDADALTWDTPEGIAVKPLYTAADTAGLDFLGTYPGIAPYLRGPYPA
MYVTQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDHPRVTGDVGMAGVAIDSIYDMRQLFDGIP
LDRMSVSMTMNGAVLPVLALYIVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPQPSMQIISDIFAYTSKRMPRFNS
ISISGYHMQEAGATADLELAYTLADGVEYIRAGLGAGLEIDAFAPRLSFFWAIGMNFFMEVAKMRAARLLWARLVNQFGP
TSARSTSLRTHSQTSGWSLTAQDVFNNVVRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTT
RVVDPWGGSHYVERLTYDLARKAWAHITEVESTGGMAQAIDAGIPKMRIEEAAARTQARIDAGRQPLVGVNKYRVDADEA
IDVLKVDNSAVRVGQIEKLRRLREERDTAAVESALHALTAAADAARDGSRPSDLGHNLLALAVDAARAKATVGEISDALE
KVYGRHSGQIRTISGVYRDEAGPAGNIVAAREAAAAFERAEGRRPRILVAKMGQDGHDRGQKVIATAFADIGFDVDVGPL
FQTPAEVARQAVEADVQIIGVSSLAAGHLTLVPALKEELAALERDDILVVVGGVIPPQDFDALRAAGAAAIFPPGTVIAD
AAIELLATLSDQLGHTAAP

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=709, Percent_Identity=63.0465444287729, Blast_Score=923, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=703, Percent_Identity=61.1664295874822, Blast_Score=843, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=724, Percent_Identity=61.6022099447514, Blast_Score=912, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 79272; Mature: 79141

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIPDFAEIALGAPSGADADEAQWRVALEQATGKDADALTWDTPEGIAVKPLYTAADTA
CCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCEEEEEEECCCCCC
GLDFLGTYPGIAPYLRGPYPAMYVTQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVA
CCCHHCCCCCCCHHHCCCCCEEEEECCEEEHHHCCCCCHHCCCCHHHHHHHCCCCCCEEE
FDLPTHRGYDSDHPRVTGDVGMAGVAIDSIYDMRQLFDGIPLDRMSVSMTMNGAVLPVLA
EECCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHH
LYIVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPQPSMQIISDIFAYTSKRMPRFN
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHCCCCCC
SISISGYHMQEAGATADLELAYTLADGVEYIRAGLGAGLEIDAFAPRLSFFWAIGMNFFM
EEEEECEEECCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHH
EVAKMRAARLLWARLVNQFGPTSARSTSLRTHSQTSGWSLTAQDVFNNVVRTCVEAMAAT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHC
QGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTTRVVDPWGGSHYVERLTYDL
CCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHH
ARKAWAHITEVESTGGMAQAIDAGIPKMRIEEAAARTQARIDAGRQPLVGVNKYRVDADE
HHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCHHH
AIDVLKVDNSAVRVGQIEKLRRLREERDTAAVESALHALTAAADAARDGSRPSDLGHNLL
HEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHH
ALAVDAARAKATVGEISDALEKVYGRHSGQIRTISGVYRDEAGPAGNIVAAREAAAAFER
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCCCCCCCEEHHHHHHHHHHH
AEGRRPRILVAKMGQDGHDRGQKVIATAFADIGFDVDVGPLFQTPAEVARQAVEADVQII
HCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHCCEEEE
GVSSLAAGHLTLVPALKEELAALERDDILVVVGGVIPPQDFDALRAAGAAAIFPPGTVIA
EEHHHCCCCEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCCEEECCCCHHHH
DAAIELLATLSDQLGHTAAP
HHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSIPDFAEIALGAPSGADADEAQWRVALEQATGKDADALTWDTPEGIAVKPLYTAADTA
CCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCEEEEEEECCCCCC
GLDFLGTYPGIAPYLRGPYPAMYVTQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVA
CCCHHCCCCCCCHHHCCCCCEEEEECCEEEHHHCCCCCHHCCCCHHHHHHHCCCCCCEEE
FDLPTHRGYDSDHPRVTGDVGMAGVAIDSIYDMRQLFDGIPLDRMSVSMTMNGAVLPVLA
EECCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHH
LYIVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPQPSMQIISDIFAYTSKRMPRFN
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHCCCCCC
SISISGYHMQEAGATADLELAYTLADGVEYIRAGLGAGLEIDAFAPRLSFFWAIGMNFFM
EEEEECEEECCCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHH
EVAKMRAARLLWARLVNQFGPTSARSTSLRTHSQTSGWSLTAQDVFNNVVRTCVEAMAAT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHC
QGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTTRVVDPWGGSHYVERLTYDL
CCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHH
ARKAWAHITEVESTGGMAQAIDAGIPKMRIEEAAARTQARIDAGRQPLVGVNKYRVDADE
HHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCHHH
AIDVLKVDNSAVRVGQIEKLRRLREERDTAAVESALHALTAAADAARDGSRPSDLGHNLL
HEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHH
ALAVDAARAKATVGEISDALEKVYGRHSGQIRTISGVYRDEAGPAGNIVAAREAAAAFER
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHCCCCCCCCEEHHHHHHHHHHH
AEGRRPRILVAKMGQDGHDRGQKVIATAFADIGFDVDVGPLFQTPAEVARQAVEADVQII
HCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHCCEEEE
GVSSLAAGHLTLVPALKEELAALERDDILVVVGGVIPPQDFDALRAAGAAAIFPPGTVIA
EEHHHCCCCEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCCEEECCCCHHHH
DAAIELLATLSDQLGHTAAP
HHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]