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The map label for this gene is mutA [H]

Identifier: 158313778

GI number: 158313778

Start: 2333391

End: 2335352

Strand: Direct

Name: mutA [H]

Synonym: Franean1_1943

Alternate gene names: 158313778

Gene position: 2333391-2335352 (Clockwise)

Preceding gene: 158313777

Following gene: 158313779

Centisome position: 25.98

GC content: 76.2

Gene sequence:

>1962_bases
ATGACCGTTCCACCGGTGGAGCTGGCGCTCGCCGCCGATTTTCCGGACTCGACGAGGGACGACTGGCGGCGGCTGGTCCT
CGGGGTGCTGCGAAAGTCGGGGGTTGCGGGCGAGGACACCGCTCCGGGTGAGGCTGAGGAGCTGATCGCGACCTCGACCT
ACGAGGGCATCCGCATCCGTCCGCTCTACGACGCGGCGGACGCCGCCGGCGCGGCCGGCGCGGGCCTGCCGGGGCTGGCG
CCGTTCGTCCGCGGCGGCCGGCCACAGGGCGCCAACACCGACGGCTGGGACGTCCGTGCGCTGCACGCCCACCCCGGCCC
GAAGGCCGGCGGCCAGGCGGTGCTCGCCGACCTGGAGAACGGCGTCACCTCGCTGTGGCTGCGGCTCGGTCCGGCGGGCC
TGCCTCTCGACGGGCTCGCCGAGATCCTGCGGGATGTCTACCTCGACCTCGCTCCGGTCGTCCTGGACGCGGGCACGCTC
ACCGGGGAGGCGGTCGCCGCGTTCCTGGCGCTGGCCGACGAGCGGGGTGTTCCGGCGTCCCAGCTCACCGGCGTGCTCGG
CGCGGACCCGCTGGGGCTCGCGGCGCGCACCGGGGCGGCGCCGGACTTCAGCGTGGCCCGCGCGCTCGCCCCACGCGTCG
CCGCCGAGTACCCACGCCTGCGGACGCTGGTCGTCGACGCCCGGCCGTACCACGACGCCGGCGGGAGCGACGCCGAGGAG
CTCGGCGCCTCGTTGGCGACCGGTGTGGCCTACCTGCGCGAGCTGACCGACGCCGGGCTGGGCGTGGCCGAGGCCCTCGG
CCAGCTCGAGTTCCGCTACGCGGTGAGCGCCGACCAGTTCCTGTCGATCGCCAAGCTGCGGGCGGCGCGGCGGCTGTGGG
CCCGGGTGGCGGAGGTGTGCGGTGCCGCGCCCGCGGAGCGGGTGCAGCGTCAGCACGCGGTCACCTCGTCCGCGATGATG
TCCCGCCGTGACCCCTGGGTGAACATGCTCCGCACCACCGTGGCCTGCTTCGCGGCGGGGGTCGGCGGCGCGGACGCGGT
CACCGTGCTGCCCTTCGACGTCAGGCTCGGGCTCGCCGACGACTTCGCCCGTCGGATCGCGCGGAACACGCAGACGCTGC
TGCAGGAAGAGTCGAGCCTGATCCGGGTGATCGACCCGGCCGGGGGCTCCTGGTACGTCGAGTCGCTCACCGACTCCCTC
GCCGAGGCGGCGTGGGCGGTCTTCACTGAGATCGAGCGTGCCGGAGGGATCTCGGCCACGCTGGCGGACGGCTCGCTGCG
GGCCCGCCTCGCCGCGACCTGGGCGGCCCGTGCGGACGCGATCGCGCACCGGCGTGATCCGCTGACCGGCGTCAGCGAGT
TCCCCAACCTGGGTGAGAAGCTCCCCGAGCGGCCGCCCGCCCCGGCGGAGACCGGCCCGTCCGGCGCCACGGCCGCGACC
GGCACGACCGAGGCCGGCACGACGGCGACCGGAACGACCGGGGCCGGTGGCGGCCACGGGCTGCCGACCGTCACCTACGA
CCAGGATTACGAGGCGCTGCGCGCCCGGTCGGACGCGCACACCGCCGCCACCGGCGCCCGGCCCGCGGTCTTCCTGGCCA
CGATCGGCGGGGCCTCGGCGTTCACCGCCCGCGCGACCTTCGCCGCGAACCTGTTCCAGGCCGGCGGCCTGGCCACGCCC
GACTCGGGCCCGGGCACGGATCCGGCCTCGATCGCGGCCGCGTTCACCGCGTCCGGCGCGAAGGTCGCCTGCCTGTGCTC
GGGGGACAAGGTGTACGCCGAGTGGGTGGCCCCGGTGGCCGAGGCGCTGCACGCGGCGGGGGCCACGCGGGTCTGGCTGG
CCGGCAAGGCCGGCTCGCGCGCGGAGACCGACGCCGCGGCGGGCGTGAGCGGGTACGTCTTCACCGGCTGCAACGCCGTC
GAGGTGCTGCGGACGACCCTCGCAGAGGCGGGAGTGGCCTGA

Upstream 100 bases:

>100_bases
GTCACCGGATGGCTGGCAGCAGGCCCGTGACCGGCCCGGGAAGCTGTGACGGGAGGAACAATCCGGGCTCGTGGGGCCGC
GGGCCCCTACGATCCGTCCC

Downstream 100 bases:

>100_bases
TGTCATCGATCCCCGACTTCGCCGAGATCGCGCTCGGAGCACCCAGCGGCGCGGACGCCGACGAGGCCCAGTGGCGGGTC
GCGCTCGAGCAGGCCACCGG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MTVPPVELALAADFPDSTRDDWRRLVLGVLRKSGVAGEDTAPGEAEELIATSTYEGIRIRPLYDAADAAGAAGAGLPGLA
PFVRGGRPQGANTDGWDVRALHAHPGPKAGGQAVLADLENGVTSLWLRLGPAGLPLDGLAEILRDVYLDLAPVVLDAGTL
TGEAVAAFLALADERGVPASQLTGVLGADPLGLAARTGAAPDFSVARALAPRVAAEYPRLRTLVVDARPYHDAGGSDAEE
LGASLATGVAYLRELTDAGLGVAEALGQLEFRYAVSADQFLSIAKLRAARRLWARVAEVCGAAPAERVQRQHAVTSSAMM
SRRDPWVNMLRTTVACFAAGVGGADAVTVLPFDVRLGLADDFARRIARNTQTLLQEESSLIRVIDPAGGSWYVESLTDSL
AEAAWAVFTEIERAGGISATLADGSLRARLAATWAARADAIAHRRDPLTGVSEFPNLGEKLPERPPAPAETGPSGATAAT
GTTEAGTTATGTTGAGGGHGLPTVTYDQDYEALRARSDAHTAATGARPAVFLATIGGASAFTARATFAANLFQAGGLATP
DSGPGTDPASIAAAFTASGAKVACLCSGDKVYAEWVAPVAEALHAAGATRVWLAGKAGSRAETDAAAGVSGYVFTGCNAV
EVLRTTLAEAGVA

Sequences:

>Translated_653_residues
MTVPPVELALAADFPDSTRDDWRRLVLGVLRKSGVAGEDTAPGEAEELIATSTYEGIRIRPLYDAADAAGAAGAGLPGLA
PFVRGGRPQGANTDGWDVRALHAHPGPKAGGQAVLADLENGVTSLWLRLGPAGLPLDGLAEILRDVYLDLAPVVLDAGTL
TGEAVAAFLALADERGVPASQLTGVLGADPLGLAARTGAAPDFSVARALAPRVAAEYPRLRTLVVDARPYHDAGGSDAEE
LGASLATGVAYLRELTDAGLGVAEALGQLEFRYAVSADQFLSIAKLRAARRLWARVAEVCGAAPAERVQRQHAVTSSAMM
SRRDPWVNMLRTTVACFAAGVGGADAVTVLPFDVRLGLADDFARRIARNTQTLLQEESSLIRVIDPAGGSWYVESLTDSL
AEAAWAVFTEIERAGGISATLADGSLRARLAATWAARADAIAHRRDPLTGVSEFPNLGEKLPERPPAPAETGPSGATAAT
GTTEAGTTATGTTGAGGGHGLPTVTYDQDYEALRARSDAHTAATGARPAVFLATIGGASAFTARATFAANLFQAGGLATP
DSGPGTDPASIAAAFTASGAKVACLCSGDKVYAEWVAPVAEALHAAGATRVWLAGKAGSRAETDAAAGVSGYVFTGCNAV
EVLRTTLAEAGVA
>Mature_652_residues
TVPPVELALAADFPDSTRDDWRRLVLGVLRKSGVAGEDTAPGEAEELIATSTYEGIRIRPLYDAADAAGAAGAGLPGLAP
FVRGGRPQGANTDGWDVRALHAHPGPKAGGQAVLADLENGVTSLWLRLGPAGLPLDGLAEILRDVYLDLAPVVLDAGTLT
GEAVAAFLALADERGVPASQLTGVLGADPLGLAARTGAAPDFSVARALAPRVAAEYPRLRTLVVDARPYHDAGGSDAEEL
GASLATGVAYLRELTDAGLGVAEALGQLEFRYAVSADQFLSIAKLRAARRLWARVAEVCGAAPAERVQRQHAVTSSAMMS
RRDPWVNMLRTTVACFAAGVGGADAVTVLPFDVRLGLADDFARRIARNTQTLLQEESSLIRVIDPAGGSWYVESLTDSLA
EAAWAVFTEIERAGGISATLADGSLRARLAATWAARADAIAHRRDPLTGVSEFPNLGEKLPERPPAPAETGPSGATAATG
TTEAGTTATGTTGAGGGHGLPTVTYDQDYEALRARSDAHTAATGARPAVFLATIGGASAFTARATFAANLFQAGGLATPD
SGPGTDPASIAAAFTASGAKVACLCSGDKVYAEWVAPVAEALHAAGATRVWLAGKAGSRAETDAAAGVSGYVFTGCNAVE
VLRTTLAEAGVA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=441, Percent_Identity=30.3854875283447, Blast_Score=173, Evalue=5e-43,
Organism=Escherichia coli, GI1789284, Length=436, Percent_Identity=31.8807339449541, Blast_Score=193, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI25144500, Length=436, Percent_Identity=30.045871559633, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 66695; Mature: 66564

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPPVELALAADFPDSTRDDWRRLVLGVLRKSGVAGEDTAPGEAEELIATSTYEGIRIR
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEE
PLYDAADAAGAAGAGLPGLAPFVRGGRPQGANTDGWDVRALHAHPGPKAGGQAVLADLEN
ECCCCHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHC
GVTSLWLRLGPAGLPLDGLAEILRDVYLDLAPVVLDAGTLTGEAVAAFLALADERGVPAS
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHH
QLTGVLGADPLGLAARTGAAPDFSVARALAPRVAAEYPRLRTLVVDARPYHDAGGSDAEE
HHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHH
LGASLATGVAYLRELTDAGLGVAEALGQLEFRYAVSADQFLSIAKLRAARRLWARVAEVC
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
GAAPAERVQRQHAVTSSAMMSRRDPWVNMLRTTVACFAAGVGGADAVTVLPFDVRLGLAD
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCHH
DFARRIARNTQTLLQEESSLIRVIDPAGGSWYVESLTDSLAEAAWAVFTEIERAGGISAT
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LADGSLRARLAATWAARADAIAHRRDPLTGVSEFPNLGEKLPERPPAPAETGPSGATAAT
ECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCCCCC
GTTEAGTTATGTTGAGGGHGLPTVTYDQDYEALRARSDAHTAATGARPAVFLATIGGASA
CCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHCCCCHHHHCCCCCEEEEEECCCCHH
FTARATFAANLFQAGGLATPDSGPGTDPASIAAAFTASGAKVACLCSGDKVYAEWVAPVA
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
EALHAAGATRVWLAGKAGSRAETDAAAGVSGYVFTGCNAVEVLRTTLAEAGVA
HHHHHCCCCEEEEECCCCCCCCCHHHCCCCCEEEECCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TVPPVELALAADFPDSTRDDWRRLVLGVLRKSGVAGEDTAPGEAEELIATSTYEGIRIR
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEE
PLYDAADAAGAAGAGLPGLAPFVRGGRPQGANTDGWDVRALHAHPGPKAGGQAVLADLEN
ECCCCHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHC
GVTSLWLRLGPAGLPLDGLAEILRDVYLDLAPVVLDAGTLTGEAVAAFLALADERGVPAS
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHH
QLTGVLGADPLGLAARTGAAPDFSVARALAPRVAAEYPRLRTLVVDARPYHDAGGSDAEE
HHHHHHCCCCCCCHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHH
LGASLATGVAYLRELTDAGLGVAEALGQLEFRYAVSADQFLSIAKLRAARRLWARVAEVC
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
GAAPAERVQRQHAVTSSAMMSRRDPWVNMLRTTVACFAAGVGGADAVTVLPFDVRLGLAD
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCHH
DFARRIARNTQTLLQEESSLIRVIDPAGGSWYVESLTDSLAEAAWAVFTEIERAGGISAT
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LADGSLRARLAATWAARADAIAHRRDPLTGVSEFPNLGEKLPERPPAPAETGPSGATAAT
ECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCCCCC
GTTEAGTTATGTTGAGGGHGLPTVTYDQDYEALRARSDAHTAATGARPAVFLATIGGASA
CCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHCCCCHHHHCCCCCEEEEEECCCCHH
FTARATFAANLFQAGGLATPDSGPGTDPASIAAAFTASGAKVACLCSGDKVYAEWVAPVA
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
EALHAAGATRVWLAGKAGSRAETDAAAGVSGYVFTGCNAVEVLRTTLAEAGVA
HHHHHCCCCEEEEECCCCCCCCCHHHCCCCCEEEECCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]