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The map label for this gene is gcvT

Identifier: 158313618

GI number: 158313618

Start: 2142064

End: 2143161

Strand: Direct

Name: gcvT

Synonym: Franean1_1782

Alternate gene names: 158313618

Gene position: 2142064-2143161 (Clockwise)

Preceding gene: 158313613

Following gene: 158313622

Centisome position: 23.85

GC content: 74.5

Gene sequence:

>1098_bases
ATGGGAGAGCTGCGTCGGTCCCCGCTACACGAACGGCACGTCGAGCTGGGCGCCAAGACGGCCGCCTTCGGCGGGTGGGA
GATGCCGATCGAGTACGCCGGCCGGGGCGTGCTCGCCGAGCACGCGGCCGTCCGCGGCGCGGTGGGGATCTTCGACGTCA
GCCACCTGGGCAAGGCCCGGGTCGCCGGCCCCGGCGCGGCCGAGTTCGTCAACACCTGCCTGACCAACGACCTGAGGCGG
GTCGGCCCCGGCCAGGCGCAGTACACGCTGTGCTGCGACGAGACCGGCGGCGTCGTCGACGACCTGATCGCTTACTACTA
CGCCGTCGACAACGTGTTCCTCGTGCCCAACGCGGCCAACACCGCCGAGGTCGTCCGGCGGCTCGCCGCGCAGGCGCCCG
CCGGCGTCGCCGTCACCGACCTGCACACCGAGTTCGCGGTGCTCGCAGTGCAGGGCCCTGCCGCGCCGGAGGTGCTGCGC
AAGCTCGGCCTGCCCGCCGACGGTGCCTACATGAGCTTCGCCGACGCCGAGTGGAAGGGGCGGCCCGTCATCGTCTGCCG
CTCCGGCTACACCGGCGAGGCGGGCTTCGAGCTCCTGCCGCGCTGGGCGGACGCGGTGCCGCTCTGGGACGAGCTGCTGA
CGGTGGTGACCGGCCTCGGTGGCCTGCCGTGCGGCCTCGGCGCCCGGGACACCCTGCGCACCGAGATGGGCTACCCGCTG
CACGGCCAGGATCTCTCCCTGTCCATCAGCCCGGTGCAGGCCCGGTCGGGGTGGGCCGTCGGCTGGGACAAGCCGGCGTT
CTGGGGCCGCGAGGCGCTGCTCGCCGAGCGCGCGGCGGGCCCGGCGCGGTCGCTGTGGGGGCTGCGCTCGAACGACCGCG
GCATCCCGCGCCCGCACATGCGGGTGAGTGGCCCGGATGGTGCCGAGCTCGGCGAGGTCACCAGCGGCACGTTCTCCCCG
ACCCTGCGGCAGGGCATCGGCCTTGCCCTGCTCGACCGCTCAGTGACCGCCGGCGACGAGGTGGCGGTGGACGTGCGCGG
CCGCGTCTCGACGATGACGGTCGTCCGCCCGCCGTTCGTCTCCGCCTCGCCCAGGTGA

Upstream 100 bases:

>100_bases
CCGTCACCGCGCCGTCATCCCGCCGGCCCGTGGCCACGTGGTCCTGTCCGGGCCGCTGCCGGCGTGCCGAAGTGACGTCC
CGGGCGGCTACGCTGCCGGC

Downstream 100 bases:

>100_bases
CGCCGGCGGCTCGCGTCAGCGGGTGACGGGCCGTGTCACCCGGTCACGCGTTCCGGCTCGGCGAAGTCCAGCAGGGCGGC
ACGGTCCTCGGGCAGGACGA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MGELRRSPLHERHVELGAKTAAFGGWEMPIEYAGRGVLAEHAAVRGAVGIFDVSHLGKARVAGPGAAEFVNTCLTNDLRR
VGPGQAQYTLCCDETGGVVDDLIAYYYAVDNVFLVPNAANTAEVVRRLAAQAPAGVAVTDLHTEFAVLAVQGPAAPEVLR
KLGLPADGAYMSFADAEWKGRPVIVCRSGYTGEAGFELLPRWADAVPLWDELLTVVTGLGGLPCGLGARDTLRTEMGYPL
HGQDLSLSISPVQARSGWAVGWDKPAFWGREALLAERAAGPARSLWGLRSNDRGIPRPHMRVSGPDGAELGEVTSGTFSP
TLRQGIGLALLDRSVTAGDEVAVDVRGRVSTMTVVRPPFVSASPR

Sequences:

>Translated_365_residues
MGELRRSPLHERHVELGAKTAAFGGWEMPIEYAGRGVLAEHAAVRGAVGIFDVSHLGKARVAGPGAAEFVNTCLTNDLRR
VGPGQAQYTLCCDETGGVVDDLIAYYYAVDNVFLVPNAANTAEVVRRLAAQAPAGVAVTDLHTEFAVLAVQGPAAPEVLR
KLGLPADGAYMSFADAEWKGRPVIVCRSGYTGEAGFELLPRWADAVPLWDELLTVVTGLGGLPCGLGARDTLRTEMGYPL
HGQDLSLSISPVQARSGWAVGWDKPAFWGREALLAERAAGPARSLWGLRSNDRGIPRPHMRVSGPDGAELGEVTSGTFSP
TLRQGIGLALLDRSVTAGDEVAVDVRGRVSTMTVVRPPFVSASPR
>Mature_364_residues
GELRRSPLHERHVELGAKTAAFGGWEMPIEYAGRGVLAEHAAVRGAVGIFDVSHLGKARVAGPGAAEFVNTCLTNDLRRV
GPGQAQYTLCCDETGGVVDDLIAYYYAVDNVFLVPNAANTAEVVRRLAAQAPAGVAVTDLHTEFAVLAVQGPAAPEVLRK
LGLPADGAYMSFADAEWKGRPVIVCRSGYTGEAGFELLPRWADAVPLWDELLTVVTGLGGLPCGLGARDTLRTEMGYPLH
GQDLSLSISPVQARSGWAVGWDKPAFWGREALLAERAAGPARSLWGLRSNDRGIPRPHMRVSGPDGAELGEVTSGTFSPT
LRQGIGLALLDRSVTAGDEVAVDVRGRVSTMTVVRPPFVSASPR

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=374, Percent_Identity=31.0160427807487, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI257796258, Length=342, Percent_Identity=31.8713450292398, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI257796254, Length=371, Percent_Identity=27.4932614555256, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI24797151, Length=386, Percent_Identity=24.6113989637306, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI257796256, Length=324, Percent_Identity=28.7037037037037, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI197927446, Length=396, Percent_Identity=25, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI21361378, Length=396, Percent_Identity=25, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1789272, Length=376, Percent_Identity=35.6382978723404, Blast_Score=196, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17560118, Length=373, Percent_Identity=30.8310991957105, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71994045, Length=385, Percent_Identity=24.1558441558442, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71994052, Length=385, Percent_Identity=24.1558441558442, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320222, Length=383, Percent_Identity=29.5039164490862, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI20129441, Length=388, Percent_Identity=31.9587628865979, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_FRASN (A8LFB7)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001506126.1
- ProteinModelPortal:   A8LFB7
- SMR:   A8LFB7
- GeneID:   5670184
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_1782
- HOGENOM:   HBG299834
- OMA:   NDISKPP
- ProtClustDB:   PRK00389
- BioCyc:   FSP1855:FRANEAN1_1782-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 38655; Mature: 38524

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGELRRSPLHERHVELGAKTAAFGGWEMPIEYAGRGVLAEHAAVRGAVGIFDVSHLGKAR
CCCCCCCCHHHHHHHHCCCEECCCCCCCCHHHCCCCHHHHHHHHHCCHHEEEHHHCCCCC
VAGPGAAEFVNTCLTNDLRRVGPGQAQYTLCCDETGGVVDDLIAYYYAVDNVFLVPNAAN
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEECCCCC
TAEVVRRLAAQAPAGVAVTDLHTEFAVLAVQGPAAPEVLRKLGLPADGAYMSFADAEWKG
HHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEECCCCCCC
RPVIVCRSGYTGEAGFELLPRWADAVPLWDELLTVVTGLGGLPCGLGARDTLRTEMGYPL
CEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCC
HGQDLSLSISPVQARSGWAVGWDKPAFWGREALLAERAAGPARSLWGLRSNDRGIPRPHM
CCCCCEEEECCEECCCCEECCCCCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCC
RVSGPDGAELGEVTSGTFSPTLRQGIGLALLDRSVTAGDEVAVDVRGRVSTMTVVRPPFV
EECCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCCCCCEEEEEECCCEEEEEEECCCCC
SASPR
CCCCC
>Mature Secondary Structure 
GELRRSPLHERHVELGAKTAAFGGWEMPIEYAGRGVLAEHAAVRGAVGIFDVSHLGKAR
CCCCCCCHHHHHHHHCCCEECCCCCCCCHHHCCCCHHHHHHHHHCCHHEEEHHHCCCCC
VAGPGAAEFVNTCLTNDLRRVGPGQAQYTLCCDETGGVVDDLIAYYYAVDNVFLVPNAAN
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCEEEECCCCC
TAEVVRRLAAQAPAGVAVTDLHTEFAVLAVQGPAAPEVLRKLGLPADGAYMSFADAEWKG
HHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHCCCCCCCEEEECCCCCCC
RPVIVCRSGYTGEAGFELLPRWADAVPLWDELLTVVTGLGGLPCGLGARDTLRTEMGYPL
CEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCC
HGQDLSLSISPVQARSGWAVGWDKPAFWGREALLAERAAGPARSLWGLRSNDRGIPRPHM
CCCCCEEEECCEECCCCEECCCCCCCCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCC
RVSGPDGAELGEVTSGTFSPTLRQGIGLALLDRSVTAGDEVAVDVRGRVSTMTVVRPPFV
EECCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCCCCCEEEEEECCCEEEEEEECCCCC
SASPR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA