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The map label for this gene is pyrG [H]

Identifier: 158313590

GI number: 158313590

Start: 2104159

End: 2106117

Strand: Direct

Name: pyrG [H]

Synonym: Franean1_1754

Alternate gene names: 158313590

Gene position: 2104159-2106117 (Clockwise)

Preceding gene: 158313589

Following gene: 158313591

Centisome position: 23.43

GC content: 72.43

Gene sequence:

>1959_bases
GTGGCGCAGGCGCATGTGACCAAGCACGTGTTCGTGACGGGAGGTGTGGCGTCCAGTCTCGGTAAGGGACTGACGGCGTC
CAGCCTCGGCCGTCTGCTCAAGGCCCGCGGTCTGCGGGTCACGATGCAGAAGCTCGACCCGTATCTGAATGTTGATCCGG
GAACGATGAACCCGTTCCAGCACGGCGAGGTGTTCGTCACCAACGACGGCGCCGAGACCGACCTGGACATCGGGCACTAC
GAACGCTTCCTCGACGTCGACCTCGACGGCAGCGCGAACGTGACCACCGGGCAGGTGTACTCGGCGGTCATCGCCCGCGA
GCGGCGCGGCGGGTACCTCGGTGAGACGGTGCAGGTCGTCCCGCACATCACCGACGAGATCAAGGGCCGGATCCGCCGGC
TGGCCACCGATTCGGTGGACGTGGTGATCACCGAGGTGGGTGGCACCGTCGGCGACATCGAGTCGCTGCCCTACCTGGAG
GCGATCCGCCAGGTCCGGCACGAGGTCGGCCGGGACAACGCGCTGACGGTGCACGTCAGCCTCGTCCCGTACCTCGCGCC
GTCGGGTGAGCTGAAGACCAAGCCGACCCAGCACTCGGTCGCGGCGCTGCGCAGCATCGGCCTGCAGCCGGACGCGGTGG
TCTGCCGCTCCGACCGGCCGTTGCCCGACGCGCTCAAGCGCAAGATCGCCATGATGTGCGACGTCGACGACGAGGCGGTC
GTCGGCGCACCGGACGCCGGCTCGATCTATGACATCCCGAAGGTGCTGCACAAGGAGGGCCTCGACGCCTACGTCGTGCG
CCGGCTCGGCCTCAGCTTCCGGGACGTCGACTGGACGGAGTGGGACACCCTGCTCCGCCGTGTGCACCATCCCTCGAACA
CCGCCACGGTGGCGATCGTCGGCAAGTACGTCGACCTGCCCGACGCCTACCTGTCGGTGACCGAGGCGCTGCGCGCCGGC
GCGTTCGCCGTCGACGCCCGCGCGGACATCCGCTGGATCGGGTCGGACGAGTTCACCTCGCCCGCCGCCGCCGCGCACGC
GCTGGAAGGCGTGGACGGGATCATCGTCCCGGGCGGGTTCGGGATCCGCGGCATCGAGGGCAAGATCGAGGCGCTGCGGC
ACGCCCGCGAACACGGCATTCCCACGCTGGGGATCTGCCTGGGCCTGCAGTGCATGGTGATCGAGGCCGGCCGTTCGCTG
GCCGGGCTGGCCGGGTCGAACTCCACCGAGTTCGACCCGGAGACCGCCCACCCGGTGATCTCCACGATGGCCGACCAGCA
CGACGTGGTCGCCGGCAAACGGGATATGGGCGGCACGATGCGGCTCGGCCTGTACCCGTGCGCGCTGGGCGCGGGGACCG
TCGCCCGCCGGGAGTACGGCGAGCCGGAGGTGCTCGAGCGCCACCGGCACCGCTACGAGGTCAACAACTCCTACCGGGAG
CGGCTGACCGCCGCCGGGCTGGTGTTCTCCGGCACCTCGCCGGACGGCCGCCTGGTCGAGGTCGTCGAGCTGCCGGCCGA
CGTCCACCCGTTCTACGTGGGGACGCAGGCGCACCCGGAGTTCCGGTCGCGGCCGACGCGCGCGCACCCGCTGTTCCGCG
GGCTCGCCGCCGCTGCCGTGGCCCACGCCGACCGGCGCCGGGGCCGGCTGCCCGTCGACATCCCGGACGGTGGTGTCGCG
GGCGGTGGTGTCGCGGGCGGCGGGCCCGCCGATGGTGACATGATCGGGTCGGGTGACGGTGACGCGGCCGGTGCGCGGGC
GGGCAACGGTGCCCGGTCGGCAGGTGGGCGGGCCCGCCGGGGCCGCGCGGAGCAGAGCGCGGCGGCCGGCGCCGGCACGA
CCGCCGGTGTCAGCGGTGCCGCGGGTACCGGTGGTGCCGTGGGTGCGGCATTGCCCGGTGGGTCCACGGGGCCGGCCGCG
GCGGCCGGTGTGAGCGACGGAGAGCTGGTTTCCCCATGA

Upstream 100 bases:

>100_bases
CGGCGGCGGGGCGGGGCGTCGGCCTGCTCGGCACGGTGTTACCGTGAAGACCCGTGGAGGCGCCGGGGCCGGACCGGCGG
CGTGACCACGGGGGTTCCGC

Downstream 100 bases:

>100_bases
GCGGTACCGCGCACACCTACGAGGTGGCGGACAGCTCCGTCGCCTACCGCGGGCGGGTCATCGCCGTTCGCCGTGACATG
GTGCGGATGCCCGACGGCGA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MAQAHVTKHVFVTGGVASSLGKGLTASSLGRLLKARGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTNDGAETDLDIGHY
ERFLDVDLDGSANVTTGQVYSAVIARERRGGYLGETVQVVPHITDEIKGRIRRLATDSVDVVITEVGGTVGDIESLPYLE
AIRQVRHEVGRDNALTVHVSLVPYLAPSGELKTKPTQHSVAALRSIGLQPDAVVCRSDRPLPDALKRKIAMMCDVDDEAV
VGAPDAGSIYDIPKVLHKEGLDAYVVRRLGLSFRDVDWTEWDTLLRRVHHPSNTATVAIVGKYVDLPDAYLSVTEALRAG
AFAVDARADIRWIGSDEFTSPAAAAHALEGVDGIIVPGGFGIRGIEGKIEALRHAREHGIPTLGICLGLQCMVIEAGRSL
AGLAGSNSTEFDPETAHPVISTMADQHDVVAGKRDMGGTMRLGLYPCALGAGTVARREYGEPEVLERHRHRYEVNNSYRE
RLTAAGLVFSGTSPDGRLVEVVELPADVHPFYVGTQAHPEFRSRPTRAHPLFRGLAAAAVAHADRRRGRLPVDIPDGGVA
GGGVAGGGPADGDMIGSGDGDAAGARAGNGARSAGGRARRGRAEQSAAAGAGTTAGVSGAAGTGGAVGAALPGGSTGPAA
AAGVSDGELVSP

Sequences:

>Translated_652_residues
MAQAHVTKHVFVTGGVASSLGKGLTASSLGRLLKARGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTNDGAETDLDIGHY
ERFLDVDLDGSANVTTGQVYSAVIARERRGGYLGETVQVVPHITDEIKGRIRRLATDSVDVVITEVGGTVGDIESLPYLE
AIRQVRHEVGRDNALTVHVSLVPYLAPSGELKTKPTQHSVAALRSIGLQPDAVVCRSDRPLPDALKRKIAMMCDVDDEAV
VGAPDAGSIYDIPKVLHKEGLDAYVVRRLGLSFRDVDWTEWDTLLRRVHHPSNTATVAIVGKYVDLPDAYLSVTEALRAG
AFAVDARADIRWIGSDEFTSPAAAAHALEGVDGIIVPGGFGIRGIEGKIEALRHAREHGIPTLGICLGLQCMVIEAGRSL
AGLAGSNSTEFDPETAHPVISTMADQHDVVAGKRDMGGTMRLGLYPCALGAGTVARREYGEPEVLERHRHRYEVNNSYRE
RLTAAGLVFSGTSPDGRLVEVVELPADVHPFYVGTQAHPEFRSRPTRAHPLFRGLAAAAVAHADRRRGRLPVDIPDGGVA
GGGVAGGGPADGDMIGSGDGDAAGARAGNGARSAGGRARRGRAEQSAAAGAGTTAGVSGAAGTGGAVGAALPGGSTGPAA
AAGVSDGELVSP
>Mature_651_residues
AQAHVTKHVFVTGGVASSLGKGLTASSLGRLLKARGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTNDGAETDLDIGHYE
RFLDVDLDGSANVTTGQVYSAVIARERRGGYLGETVQVVPHITDEIKGRIRRLATDSVDVVITEVGGTVGDIESLPYLEA
IRQVRHEVGRDNALTVHVSLVPYLAPSGELKTKPTQHSVAALRSIGLQPDAVVCRSDRPLPDALKRKIAMMCDVDDEAVV
GAPDAGSIYDIPKVLHKEGLDAYVVRRLGLSFRDVDWTEWDTLLRRVHHPSNTATVAIVGKYVDLPDAYLSVTEALRAGA
FAVDARADIRWIGSDEFTSPAAAAHALEGVDGIIVPGGFGIRGIEGKIEALRHAREHGIPTLGICLGLQCMVIEAGRSLA
GLAGSNSTEFDPETAHPVISTMADQHDVVAGKRDMGGTMRLGLYPCALGAGTVARREYGEPEVLERHRHRYEVNNSYRER
LTAAGLVFSGTSPDGRLVEVVELPADVHPFYVGTQAHPEFRSRPTRAHPLFRGLAAAAVAHADRRRGRLPVDIPDGGVAG
GGVAGGGPADGDMIGSGDGDAAGARAGNGARSAGGRARRGRAEQSAAAGAGTTAGVSGAAGTGGAVGAALPGGSTGPAAA
AGVSDGELVSP

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=554, Percent_Identity=46.2093862815885, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI28559085, Length=558, Percent_Identity=43.7275985663082, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI28559083, Length=558, Percent_Identity=43.7275985663082, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI221316689, Length=558, Percent_Identity=43.7275985663082, Blast_Score=470, Evalue=1e-132,
Organism=Escherichia coli, GI1789142, Length=546, Percent_Identity=50.5494505494505, Blast_Score=553, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI25148299, Length=601, Percent_Identity=37.4376039933444, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322563, Length=570, Percent_Identity=44.7368421052632, Blast_Score=456, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319432, Length=566, Percent_Identity=43.4628975265018, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24664469, Length=554, Percent_Identity=46.3898916967509, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI21357815, Length=500, Percent_Identity=45, Blast_Score=402, Evalue=1e-112,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 68083; Mature: 67952

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQAHVTKHVFVTGGVASSLGKGLTASSLGRLLKARGLRVTMQKLDPYLNVDPGTMNPFQ
CCCCCEEEEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEHHHCCCCEECCCCCCCCCC
HGEVFVTNDGAETDLDIGHYERFLDVDLDGSANVTTGQVYSAVIARERRGGYLGETVQVV
CCEEEEECCCCCCCCCHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHH
PHITDEIKGRIRRLATDSVDVVITEVGGTVGDIESLPYLEAIRQVRHEVGRDNALTVHVS
HHHHHHHHHHHHHHHCCCEEEEEEECCCCHHCHHCCHHHHHHHHHHHHHCCCCEEEEEEE
LVPYLAPSGELKTKPTQHSVAALRSIGLQPDAVVCRSDRPLPDALKRKIAMMCDVDDEAV
EEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCE
VGAPDAGSIYDIPKVLHKEGLDAYVVRRLGLSFRDVDWTEWDTLLRRVHHPSNTATVAIV
ECCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
GKYVDLPDAYLSVTEALRAGAFAVDARADIRWIGSDEFTSPAAAAHALEGVDGIIVPGGF
EEECCCCHHHHHHHHHHHCCCEEEECCCCEEECCCCCCCCHHHHHHHHHCCCEEEECCCC
GIRGIEGKIEALRHAREHGIPTLGICLGLQCMVIEAGRSLAGLAGSNSTEFDPETAHPVI
CCCCCCHHHHHHHHHHHHCCCEEHHHHCCEEEEEECCCCCEECCCCCCCCCCCCHHHHHH
STMADQHDVVAGKRDMGGTMRLGLYPCALGAGTVARREYGEPEVLERHRHRYEVNNSYRE
HHHCCCHHHHCCCCCCCCEEEEEEEEHHCCCCHHHHHHCCCHHHHHHHHHHHHCCHHHHH
RLTAAGLVFSGTSPDGRLVEVVELPADVHPFYVGTQAHPEFRSRPTRAHPLFRGLAAAAV
HHHHHCEEEECCCCCCCEEEEEECCCCCCCEEECCCCCHHHHCCCCHHHHHHHHHHHHHH
AHADRRRGRLPVDIPDGGVAGGGVAGGGPADGDMIGSGDGDAAGARAGNGARSAGGRARR
HHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHC
GRAEQSAAAGAGTTAGVSGAAGTGGAVGAALPGGSTGPAAAAGVSDGELVSP
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCC
>Mature Secondary Structure 
AQAHVTKHVFVTGGVASSLGKGLTASSLGRLLKARGLRVTMQKLDPYLNVDPGTMNPFQ
CCCCEEEEEEEECCHHHHHCCCCCHHHHHHHHHHCCCEEEHHHCCCCEECCCCCCCCCC
HGEVFVTNDGAETDLDIGHYERFLDVDLDGSANVTTGQVYSAVIARERRGGYLGETVQVV
CCEEEEECCCCCCCCCHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHH
PHITDEIKGRIRRLATDSVDVVITEVGGTVGDIESLPYLEAIRQVRHEVGRDNALTVHVS
HHHHHHHHHHHHHHHCCCEEEEEEECCCCHHCHHCCHHHHHHHHHHHHHCCCCEEEEEEE
LVPYLAPSGELKTKPTQHSVAALRSIGLQPDAVVCRSDRPLPDALKRKIAMMCDVDDEAV
EEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCE
VGAPDAGSIYDIPKVLHKEGLDAYVVRRLGLSFRDVDWTEWDTLLRRVHHPSNTATVAIV
ECCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
GKYVDLPDAYLSVTEALRAGAFAVDARADIRWIGSDEFTSPAAAAHALEGVDGIIVPGGF
EEECCCCHHHHHHHHHHHCCCEEEECCCCEEECCCCCCCCHHHHHHHHHCCCEEEECCCC
GIRGIEGKIEALRHAREHGIPTLGICLGLQCMVIEAGRSLAGLAGSNSTEFDPETAHPVI
CCCCCCHHHHHHHHHHHHCCCEEHHHHCCEEEEEECCCCCEECCCCCCCCCCCCHHHHHH
STMADQHDVVAGKRDMGGTMRLGLYPCALGAGTVARREYGEPEVLERHRHRYEVNNSYRE
HHHCCCHHHHCCCCCCCCEEEEEEEEHHCCCCHHHHHHCCCHHHHHHHHHHHHCCHHHHH
RLTAAGLVFSGTSPDGRLVEVVELPADVHPFYVGTQAHPEFRSRPTRAHPLFRGLAAAAV
HHHHHCEEEECCCCCCCEEEEEECCCCCCCEEECCCCCHHHHCCCCHHHHHHHHHHHHHH
AHADRRRGRLPVDIPDGGVAGGGVAGGGPADGDMIGSGDGDAAGARAGNGARSAGGRARR
HHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCHHC
GRAEQSAAAGAGTTAGVSGAAGTGGAVGAALPGGSTGPAAAAGVSDGELVSP
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA