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The map label for this gene is ribBA [H]

Identifier: 158313560

GI number: 158313560

Start: 2060411

End: 2061745

Strand: Direct

Name: ribBA [H]

Synonym: Franean1_1724

Alternate gene names: 158313560

Gene position: 2060411-2061745 (Clockwise)

Preceding gene: 158313559

Following gene: 158313561

Centisome position: 22.94

GC content: 74.31

Gene sequence:

>1335_bases
GTGAGCTTCGCGACGATCGAGACCGCCATCGCCGAGATCGCCGCCGGCCGGCCGGTCGTCGTGGTCGACGACGCGGACCG
CGAGAACGAGGGCGACCTGATCTTCGCGGCCGAGGCGGCAACGCCGGAGCTGCTCGCCTTCATGGTCCGGCACACGGCGG
GGGTCGTCTGCGTACCGCTCGACCCCGCGGAGGTCGACCGGCTCGACCTCGACCAGATGGTCCCGCAGAACACCGACCGG
ATGGGCACCGCGTTCACGATCTCGGTGGACGCCCGCTCCGGCGTCACCACCGGGATCTCCGCCGCCGACCGTGCCCGGAC
CATCCGGCTGCTCGCCGACCCGGCCACCCAGCCCGGCGACCTGACCCGGCCCGGGCACATCTTCCCGCTGCGGGCGAAGG
AGGGCGGCGTGCTGCGCCGGCCCGGCCACACCGAGGCCGCCGTCGACCTCGCCCGGCTGGCGGGCCTGCGCCCGGCCGGG
GCGATCTGCGAGATCGTCAACGAGGACGGCTCCATGGCCCGGCTGCCGGAGCTGACCGCCTTCGCCCGGGAACACGGCCT
GGCCCTGATCTCGATCGCGGACCTCATCGCCTACCGCCGCCGGACGGAGAAGCAGGTCGTGCGGGTCGCCGAGGCCCGCA
TCCCGACCCGCTACGGCTCCTTCCGGGCCGTCGGATACCGGGGCACCCTGGACGGCGTCGAGCACATCGCGCTGATCCGC
GGCGAGGTCGGTGACGGGGAGAACGTCCTGGTCAGGGTGCACAGCGAATGCCTGACCGGGGACGTCTTCGGCTCCCAGCG
CTGCGACTGCGGCAACCAGCTCGACGCGGCGCTGCGCGCGGTGGCGGCCGAGGGCCGGGGTGTGGTGCTCTACGTGCGCG
GTCACGAGGGCCGCGGCATCGGCCTCATGCACAAGCTGCAGGCCTACCAGCTCCAGGACGCGGGGCACGACACCGTCGAC
GCGAACCTCGCCCTCGGGCTGCCGGCCGACGCCCGCGACTACGGCACCGGCGCCCAGATTCTGGTGGACCTGGGCGTGCG
CGGGCTGCGGCTGCTGTCCAACAACCCGACGAAGCGCGCGGGCCTGGAGGGCTACGGGCTGCGCATCGTCGAGCAGGTGG
GGCTGCCGGTGACCCACACCCCGGAGAACCTGCGCTACCTCACGACCAAGCGGGACCGGATGGGCCACGACCTGCCCGGC
CTCCCCGGCCTGCCTGATCTGCCGAAGGTCGTCGGCGGGGACGAGACCGCCGGCGCGCACGAGGCCCACCGCTGGCCGGT
GACGGCGGCCCCGGTCGCCGACCGCGCGGACCGGGCCTGCGAGGAGGCCCGATGA

Upstream 100 bases:

>100_bases
GACCACGAACCCGGTGACCACGAACCCGGCCGGCGACTCCTCGGCCGCCTCCCACCCGACGGCGCCCGCCTCCCACCCGA
CGGCATCCGCCGAGGCGTCG

Downstream 100 bases:

>100_bases
GCGGCGCCGGAGCACCCGCCGAGGAGCTGCCCGACGCCAGCGGGGTGCGCCTGGCGATCGTGGCCACCCGGTGGCATGTG
GAGATCACCGACGCGCTGCT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSFATIETAIAEIAAGRPVVVVDDADRENEGDLIFAAEAATPELLAFMVRHTAGVVCVPLDPAEVDRLDLDQMVPQNTDR
MGTAFTISVDARSGVTTGISAADRARTIRLLADPATQPGDLTRPGHIFPLRAKEGGVLRRPGHTEAAVDLARLAGLRPAG
AICEIVNEDGSMARLPELTAFAREHGLALISIADLIAYRRRTEKQVVRVAEARIPTRYGSFRAVGYRGTLDGVEHIALIR
GEVGDGENVLVRVHSECLTGDVFGSQRCDCGNQLDAALRAVAAEGRGVVLYVRGHEGRGIGLMHKLQAYQLQDAGHDTVD
ANLALGLPADARDYGTGAQILVDLGVRGLRLLSNNPTKRAGLEGYGLRIVEQVGLPVTHTPENLRYLTTKRDRMGHDLPG
LPGLPDLPKVVGGDETAGAHEAHRWPVTAAPVADRADRACEEAR

Sequences:

>Translated_444_residues
MSFATIETAIAEIAAGRPVVVVDDADRENEGDLIFAAEAATPELLAFMVRHTAGVVCVPLDPAEVDRLDLDQMVPQNTDR
MGTAFTISVDARSGVTTGISAADRARTIRLLADPATQPGDLTRPGHIFPLRAKEGGVLRRPGHTEAAVDLARLAGLRPAG
AICEIVNEDGSMARLPELTAFAREHGLALISIADLIAYRRRTEKQVVRVAEARIPTRYGSFRAVGYRGTLDGVEHIALIR
GEVGDGENVLVRVHSECLTGDVFGSQRCDCGNQLDAALRAVAAEGRGVVLYVRGHEGRGIGLMHKLQAYQLQDAGHDTVD
ANLALGLPADARDYGTGAQILVDLGVRGLRLLSNNPTKRAGLEGYGLRIVEQVGLPVTHTPENLRYLTTKRDRMGHDLPG
LPGLPDLPKVVGGDETAGAHEAHRWPVTAAPVADRADRACEEAR
>Mature_443_residues
SFATIETAIAEIAAGRPVVVVDDADRENEGDLIFAAEAATPELLAFMVRHTAGVVCVPLDPAEVDRLDLDQMVPQNTDRM
GTAFTISVDARSGVTTGISAADRARTIRLLADPATQPGDLTRPGHIFPLRAKEGGVLRRPGHTEAAVDLARLAGLRPAGA
ICEIVNEDGSMARLPELTAFAREHGLALISIADLIAYRRRTEKQVVRVAEARIPTRYGSFRAVGYRGTLDGVEHIALIRG
EVGDGENVLVRVHSECLTGDVFGSQRCDCGNQLDAALRAVAAEGRGVVLYVRGHEGRGIGLMHKLQAYQLQDAGHDTVDA
NLALGLPADARDYGTGAQILVDLGVRGLRLLSNNPTKRAGLEGYGLRIVEQVGLPVTHTPENLRYLTTKRDRMGHDLPGL
PGLPDLPKVVGGDETAGAHEAHRWPVTAAPVADRADRACEEAR

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=203, Percent_Identity=51.7241379310345, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=52.0618556701031, Blast_Score=191, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=49.7584541062802, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=46.7836257309941, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 47429; Mature: 47298

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFATIETAIAEIAAGRPVVVVDDADRENEGDLIFAAEAATPELLAFMVRHTAGVVCVPL
CCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEEEC
DPAEVDRLDLDQMVPQNTDRMGTAFTISVDARSGVTTGISAADRARTIRLLADPATQPGD
CHHHCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHEEEEEEECCCCCCCC
LTRPGHIFPLRAKEGGVLRRPGHTEAAVDLARLAGLRPAGAICEIVNEDGSMARLPELTA
CCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHCCCCCCHHHHEECCCCCEECCHHHHH
FAREHGLALISIADLIAYRRRTEKQVVRVAEARIPTRYGSFRAVGYRGTLDGVEHIALIR
HHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHEEEEEE
GEVGDGENVLVRVHSECLTGDVFGSQRCDCGNQLDAALRAVAAEGRGVVLYVRGHEGRGI
CCCCCCCEEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCC
GLMHKLQAYQLQDAGHDTVDANLALGLPADARDYGTGAQILVDLGVRGLRLLSNNPTKRA
HHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCEEEECCCCCHHC
GLEGYGLRIVEQVGLPVTHTPENLRYLTTKRDRMGHDLPGLPGLPDLPKVVGGDETAGAH
CCCCCCCHHHHHCCCCCEECCCCCEEEEECHHHCCCCCCCCCCCCCCCHHHCCCCCCCCC
EAHRWPVTAAPVADRADRACEEAR
CCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SFATIETAIAEIAAGRPVVVVDDADRENEGDLIFAAEAATPELLAFMVRHTAGVVCVPL
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCEEEEEC
DPAEVDRLDLDQMVPQNTDRMGTAFTISVDARSGVTTGISAADRARTIRLLADPATQPGD
CHHHCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHEEEEEEECCCCCCCC
LTRPGHIFPLRAKEGGVLRRPGHTEAAVDLARLAGLRPAGAICEIVNEDGSMARLPELTA
CCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHCCCCCCHHHHEECCCCCEECCHHHHH
FAREHGLALISIADLIAYRRRTEKQVVRVAEARIPTRYGSFRAVGYRGTLDGVEHIALIR
HHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHEEEEEE
GEVGDGENVLVRVHSECLTGDVFGSQRCDCGNQLDAALRAVAAEGRGVVLYVRGHEGRGI
CCCCCCCEEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCC
GLMHKLQAYQLQDAGHDTVDANLALGLPADARDYGTGAQILVDLGVRGLRLLSNNPTKRA
HHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCCCCEEEECCCCCHHC
GLEGYGLRIVEQVGLPVTHTPENLRYLTTKRDRMGHDLPGLPGLPDLPKVVGGDETAGAH
CCCCCCCHHHHHCCCCCEECCCCCEEEEECHHHCCCCCCCCCCCCCCCHHHCCCCCCCCC
EAHRWPVTAAPVADRADRACEEAR
CCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA