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The map label for this gene is ribE [H]

Identifier: 158313559

GI number: 158313559

Start: 2059626

End: 2060309

Strand: Direct

Name: ribE [H]

Synonym: Franean1_1723

Alternate gene names: 158313559

Gene position: 2059626-2060309 (Clockwise)

Preceding gene: 158313558

Following gene: 158313560

Centisome position: 22.93

GC content: 70.47

Gene sequence:

>684_bases
ATGTTCACCGGCATCGTCGAAGAACTCGGCGTGGTGACCGCCATCGAGCCGCGGCATGACGCCGCGTCGCTGACCGTCGA
GTGTCATGGCGTACTCGATGACGTGACGCACGGCGCTTCCGTCGCCGTGAACGGGGTCTGTCTCACGGTGACCTCGTTCG
TCCACCCCCCGGACGGCGCCGCCGGCGGGGACGTATCTGGGCCGGCCGGTTCCTCCGGGACGGCGGCCGGCGGCTTCACG
GCGGACGTGATGCTCGAGACGCTGCGCAGGTCCGCCCTCGGTGACCTCTCGGTCGGGGACCGGGTGAACCTTGAGCGCCC
CGTCCGCCTCTCCGACCGGCTCGGCGGGCATCTGGTGCAGGGGCACGTCGACGGTGTCGGCGTCGTCCTCGAGCGGGTGC
CGGCCGAGCACTGGGAGGTCGTCCGCGTCAGCCTGCCGCCGGGGCTGGACCGCTACCTCGTCGAGAAGGGCTCGGTGACC
GTGGACGGGGTCAGCCTGACCGTCGTCGACGTCCGCGCCGCGGCCGGCGGTGAACCGGCCAGTTTCTCCGTCAGCCTCAT
CCCGACCACCCTCGCCGTGACGACGCTGGGCACCCGCGCCGTCGGTGACAAGGTCAACATCGAGGTGGACGTCGTGGCCA
AGTATGTCGAGAAGCTCCACGCCGACCTGAACGGATCACACTGA

Upstream 100 bases:

>100_bases
CGCGTGGCCGTCCCGGCGTGGGTCGGCGCGGGCGCGTCGGCCCTGACCCGCGTCGCCTTCTGATGTCCCGGACGTGCCGG
GACCGGAGGTGCGGGGTCGG

Downstream 100 bases:

>100_bases
TGACCACGAACCCGGTGACCACGAACCCGGCCGGCGACTCCTCGGCCGCCTCCCACCCGACGGCGCCCGCCTCCCACCCG
ACGGCATCCGCCGAGGCGTC

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MFTGIVEELGVVTAIEPRHDAASLTVECHGVLDDVTHGASVAVNGVCLTVTSFVHPPDGAAGGDVSGPAGSSGTAAGGFT
ADVMLETLRRSALGDLSVGDRVNLERPVRLSDRLGGHLVQGHVDGVGVVLERVPAEHWEVVRVSLPPGLDRYLVEKGSVT
VDGVSLTVVDVRAAAGGEPASFSVSLIPTTLAVTTLGTRAVGDKVNIEVDVVAKYVEKLHADLNGSH

Sequences:

>Translated_227_residues
MFTGIVEELGVVTAIEPRHDAASLTVECHGVLDDVTHGASVAVNGVCLTVTSFVHPPDGAAGGDVSGPAGSSGTAAGGFT
ADVMLETLRRSALGDLSVGDRVNLERPVRLSDRLGGHLVQGHVDGVGVVLERVPAEHWEVVRVSLPPGLDRYLVEKGSVT
VDGVSLTVVDVRAAAGGEPASFSVSLIPTTLAVTTLGTRAVGDKVNIEVDVVAKYVEKLHADLNGSH
>Mature_227_residues
MFTGIVEELGVVTAIEPRHDAASLTVECHGVLDDVTHGASVAVNGVCLTVTSFVHPPDGAAGGDVSGPAGSSGTAAGGFT
ADVMLETLRRSALGDLSVGDRVNLERPVRLSDRLGGHLVQGHVDGVGVVLERVPAEHWEVVRVSLPPGLDRYLVEKGSVT
VDGVSLTVVDVRAAAGGEPASFSVSLIPTTLAVTTLGTRAVGDKVNIEVDVVAKYVEKLHADLNGSH

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=215, Percent_Identity=39.5348837209302, Blast_Score=120, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319733, Length=226, Percent_Identity=36.283185840708, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 23294; Mature: 23294

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00693 LUM_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGIVEELGVVTAIEPRHDAASLTVECHGVLDDVTHGASVAVNGVCLTVTSFVHPPDGA
CCCCHHHHCCEEEEECCCCCCEEEEEEEEECHHHHCCCCEEEECCEEEEEEEEECCCCCC
AGGDVSGPAGSSGTAAGGFTADVMLETLRRSALGDLSVGDRVNLERPVRLSDRLGGHLVQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCEEEE
GHVDGVGVVLERVPAEHWEVVRVSLPPGLDRYLVEKGSVTVDGVSLTVVDVRAAAGGEPA
ECCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHCCCCEEECCEEEEEEEEEECCCCCCC
SFSVSLIPTTLAVTTLGTRAVGDKVNIEVDVVAKYVEKLHADLNGSH
EEEEEECCCEEEHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFTGIVEELGVVTAIEPRHDAASLTVECHGVLDDVTHGASVAVNGVCLTVTSFVHPPDGA
CCCCHHHHCCEEEEECCCCCCEEEEEEEEECHHHHCCCCEEEECCEEEEEEEEECCCCCC
AGGDVSGPAGSSGTAAGGFTADVMLETLRRSALGDLSVGDRVNLERPVRLSDRLGGHLVQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCEEEE
GHVDGVGVVLERVPAEHWEVVRVSLPPGLDRYLVEKGSVTVDGVSLTVVDVRAAAGGEPA
ECCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHCCCCEEECCEEEEEEEEEECCCCCCC
SFSVSLIPTTLAVTTLGTRAVGDKVNIEVDVVAKYVEKLHADLNGSH
EEEEEECCCEEEHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]