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The map label for this gene is dxr [H]

Identifier: 158313020

GI number: 158313020

Start: 1391425

End: 1392720

Strand: Direct

Name: dxr [H]

Synonym: Franean1_1168

Alternate gene names: 158313020

Gene position: 1391425-1392720 (Clockwise)

Preceding gene: 158313019

Following gene: 158313021

Centisome position: 15.49

GC content: 71.68

Gene sequence:

>1296_bases
ATGAACCGAACAGGCCTCGGTCGAAGCGTCGAAGGGCCTGCGAGAATAGGCAGCGTGGCGGAGGCTTCGGTCCAGCGTGA
GGTTGTTCTGCTCGGGTCCACCGGCTCGATCGGGACTCAGGCGATAGATGTCGTACGCCGCAACCCGGACAGGTTCCGGG
TGGTGGCGCTGATGGGAGGCGGGTCGCGGGTCGACCTGCTCGCGGCGCAGGCGCTCGACCTGGGGGTCGAGGCGGTCGGT
GTGGCCGCGGCCTCGTCGGCGCAGGACCTTCAGCTCGCGTTCTTCGCGGAGGCGTCCAAGCGCGGCTACCGCCGTGGCGA
GTTCGCCGTCCCGAAGATCCTCGCGGGGCCGGACGCGGCCGTCGAGATCGCGTCCTGGCCGGCGGACATCGTCCTCAACG
GGGTGTCCGGCTCGGTCGGGCTCGCGCCGACGCTGGCGGCTCTCAAGGCCGGCGCGACGGTGGGGCTGGCGAACAAGGAG
TCGCTGGTCGCGGGTGGTCCGCTGGTGCTCGACGCGCTCGGCGGCAACCCGGACCGGCTCGTCCCAGTGGATTCCGAGCA
CTCGGCGCTCGCGCAGTGCCTGCGCGGGGGTCGGCGTGAGGAAGTCCACAAGCTGGTGCTGACCGCCAGCGGCGGGCCCT
TCCGTGGCCGGAGCAGGGACGACCTGGCCGGGGTCACCCGGGAGCAGGCACTGGCCCATCCGACCTGGGCGATGGGGCCG
CTGGTCACGATCAACTCGGCGACGCTGATGAACAAGGGCCTCGAGCTGATCGAGGCCCACCTGTTCTTCGGTGTGCCGTA
TGACGACATCGAGGTCGTCGTCCACCCGCAGTCGCTGGTCCACTCGATGGTCGAGTTCAACGACGGGTCGACCATCGCCC
AGGTGTCGCCGCCGGACATGCGGCTCCCGATCGCGCTGGCCCTGGGCTGGCCGGACCGGGTGCCGCTGGCCCAGCCGCCG
ATGGACTGGACGCGCGCCCAGTCGCTGACCTTCGAGCCCCTGGACACCGTCGCGTTCCCCGCGGTGGACCTCGCCCGGAC
GGCGGGCCGCCTCGGCGGGACCGCGCCGGCCGTGTTCAACGCGGCGAACGAGGAGGCCGTCGCGGCCTTCCTCGCCGGGC
AGTTGCCGTTCGTCCGTATCGTCGACCTGGTGGCCGAGGTGGTGCAGGCACACGAGGTGATCGCCCGTCCGACGCTGGAC
GAGGTGTTCGCCGTCGAACGTGAGGCCCGCGCCGCCGCGAACCGCCTGATCGAGAAGGCCGGCGGGCATCCCGTGGCGGC
CGGAGGACATGGTTGA

Upstream 100 bases:

>100_bases
GGGTACGGACAGGGGCGGGCAGGTCACGCCCGGATGCTCCGGGTGTTGACCAGTCGTAGGCGCGGCTACACCCATTGCGC
ACCTTCGGGCCTCACCTGTC

Downstream 100 bases:

>100_bases
TGGCAACTCTGGGCATCGTCGCCTTCGTCCTCGCCCTGTTCGTCTCGGTCGTCCTGCACGAGGCGGGGCACTTCGTCACC
GCCCGCTACTTCGGGATGAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNRTGLGRSVEGPARIGSVAEASVQREVVLLGSTGSIGTQAIDVVRRNPDRFRVVALMGGGSRVDLLAAQALDLGVEAVG
VAAASSAQDLQLAFFAEASKRGYRRGEFAVPKILAGPDAAVEIASWPADIVLNGVSGSVGLAPTLAALKAGATVGLANKE
SLVAGGPLVLDALGGNPDRLVPVDSEHSALAQCLRGGRREEVHKLVLTASGGPFRGRSRDDLAGVTREQALAHPTWAMGP
LVTINSATLMNKGLELIEAHLFFGVPYDDIEVVVHPQSLVHSMVEFNDGSTIAQVSPPDMRLPIALALGWPDRVPLAQPP
MDWTRAQSLTFEPLDTVAFPAVDLARTAGRLGGTAPAVFNAANEEAVAAFLAGQLPFVRIVDLVAEVVQAHEVIARPTLD
EVFAVEREARAAANRLIEKAGGHPVAAGGHG

Sequences:

>Translated_431_residues
MNRTGLGRSVEGPARIGSVAEASVQREVVLLGSTGSIGTQAIDVVRRNPDRFRVVALMGGGSRVDLLAAQALDLGVEAVG
VAAASSAQDLQLAFFAEASKRGYRRGEFAVPKILAGPDAAVEIASWPADIVLNGVSGSVGLAPTLAALKAGATVGLANKE
SLVAGGPLVLDALGGNPDRLVPVDSEHSALAQCLRGGRREEVHKLVLTASGGPFRGRSRDDLAGVTREQALAHPTWAMGP
LVTINSATLMNKGLELIEAHLFFGVPYDDIEVVVHPQSLVHSMVEFNDGSTIAQVSPPDMRLPIALALGWPDRVPLAQPP
MDWTRAQSLTFEPLDTVAFPAVDLARTAGRLGGTAPAVFNAANEEAVAAFLAGQLPFVRIVDLVAEVVQAHEVIARPTLD
EVFAVEREARAAANRLIEKAGGHPVAAGGHG
>Mature_431_residues
MNRTGLGRSVEGPARIGSVAEASVQREVVLLGSTGSIGTQAIDVVRRNPDRFRVVALMGGGSRVDLLAAQALDLGVEAVG
VAAASSAQDLQLAFFAEASKRGYRRGEFAVPKILAGPDAAVEIASWPADIVLNGVSGSVGLAPTLAALKAGATVGLANKE
SLVAGGPLVLDALGGNPDRLVPVDSEHSALAQCLRGGRREEVHKLVLTASGGPFRGRSRDDLAGVTREQALAHPTWAMGP
LVTINSATLMNKGLELIEAHLFFGVPYDDIEVVVHPQSLVHSMVEFNDGSTIAQVSPPDMRLPIALALGWPDRVPLAQPP
MDWTRAQSLTFEPLDTVAFPAVDLARTAGRLGGTAPAVFNAANEEAVAAFLAGQLPFVRIVDLVAEVVQAHEVIARPTLD
EVFAVEREARAAANRLIEKAGGHPVAAGGHG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=401, Percent_Identity=40.1496259351621, Blast_Score=270, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 44834; Mature: 44834

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTGLGRSVEGPARIGSVAEASVQREVVLLGSTGSIGTQAIDVVRRNPDRFRVVALMGG
CCCCCCCCCCCCHHHHCHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECC
GSRVDLLAAQALDLGVEAVGVAAASSAQDLQLAFFAEASKRGYRRGEFAVPKILAGPDAA
CCEEHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEEHHHHCCCCCCCCCCCEEECCCCCE
VEIASWPADIVLNGVSGSVGLAPTLAALKAGATVGLANKESLVAGGPLVLDALGGNPDRL
EEEECCCCEEEEECCCCCCCCHHHHHHHHCCCEEECCCCCCEEECCCEEEEECCCCCCCE
VPVDSEHSALAQCLRGGRREEVHKLVLTASGGPFRGRSRDDLAGVTREQALAHPTWAMGP
EECCCCHHHHHHHHHCCCHHHEEEEEEEECCCCCCCCCCHHHHCCCHHHHHCCCCCCCCC
LVTINSATLMNKGLELIEAHLFFGVPYDDIEVVVHPQSLVHSMVEFNDGSTIAQVSPPDM
EEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCC
RLPIALALGWPDRVPLAQPPMDWTRAQSLTFEPLDTVAFPAVDLARTAGRLGGTAPAVFN
EEEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHCHHHHHHHHHHCCCCCCHHEE
AANEEAVAAFLAGQLPFVRIVDLVAEVVQAHEVIARPTLDEVFAVEREARAAANRLIEKA
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GGHPVAAGGHG
CCCCCCCCCCC
>Mature Secondary Structure
MNRTGLGRSVEGPARIGSVAEASVQREVVLLGSTGSIGTQAIDVVRRNPDRFRVVALMGG
CCCCCCCCCCCCHHHHCHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECC
GSRVDLLAAQALDLGVEAVGVAAASSAQDLQLAFFAEASKRGYRRGEFAVPKILAGPDAA
CCEEHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEEHHHHCCCCCCCCCCCEEECCCCCE
VEIASWPADIVLNGVSGSVGLAPTLAALKAGATVGLANKESLVAGGPLVLDALGGNPDRL
EEEECCCCEEEEECCCCCCCCHHHHHHHHCCCEEECCCCCCEEECCCEEEEECCCCCCCE
VPVDSEHSALAQCLRGGRREEVHKLVLTASGGPFRGRSRDDLAGVTREQALAHPTWAMGP
EECCCCHHHHHHHHHCCCHHHEEEEEEEECCCCCCCCCCHHHHCCCHHHHHCCCCCCCCC
LVTINSATLMNKGLELIEAHLFFGVPYDDIEVVVHPQSLVHSMVEFNDGSTIAQVSPPDM
EEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCC
RLPIALALGWPDRVPLAQPPMDWTRAQSLTFEPLDTVAFPAVDLARTAGRLGGTAPAVFN
EEEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHCHHHHHHHHHHCCCCCCHHEE
AANEEAVAAFLAGQLPFVRIVDLVAEVVQAHEVIARPTLDEVFAVEREARAAANRLIEKA
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GGHPVAAGGHG
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA