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The map label for this gene is mutM

Identifier: 158312992

GI number: 158312992

Start: 1360011

End: 1360886

Strand: Direct

Name: mutM

Synonym: Franean1_1140

Alternate gene names: 158312992

Gene position: 1360011-1360886 (Clockwise)

Preceding gene: 158312991

Following gene: 158312993

Centisome position: 15.14

GC content: 73.74

Gene sequence:

>876_bases
ATGCCTGAGCTGCCCGAGGTCGAGGTCGTCCGCCGGGGCCTCGAGCGCGGGGTGGTCGGCCGCACTGTCGCCGAGGTGGA
GGTCCATCACCTGCGGGCGGTCCGCCGCCATCTCGCCGGGGCCGACCACTTCGCCGCCTCGCTTGTCGGGCAGACGGTGG
CCACGGCGCGCCGGCGCGGCAAGTACCTGTGGCTCGGGCTCACGCCGTCTGAACCGGGCGGCCCGGCGGTCGGTGACGCG
CTGCTCGGTCATCTCGGGATGAGCGGCCAGCTCCTCGTGGTTCCGGCGGACAGCCCGGACCAGGTACACCTGCGGGTCCG
TTTCCGGTTCACCGACGAGGGCCGCGAGCTGCGCTTCGTGGACCAGCGGACGTTCGGTGGTCTTGCTGTGGTCTCGGGCG
GGGCGGAGCTGCCTGCCCCGATCGCCCACATCGCGCCCGACCCGCTCTCCGTCGACTTCGACCCGGAGCGTTTCGCCGAC
GCGCTGCGCCGCCGGCGCACCGGCCTCAAGCGCGCCCTGCTCGACCAGACGCTGATCAGCGGCGTGGGCAACATCTACGC
GGACGAGGGCTTGTGGGCCGCGCGCCTGCATTACGCCCGCCCGACCGAGACGGTGACCCGCGCCGAGGCGCTGCGGCTGC
TTGACGCGGTCCGCACGGTGATGACGGCGGCGCTGGCCGCCGGCGGTACCTCCTTCGACCGGCTCTACGTCTCGACCGAG
GGCGTCAGCGGGCTGTTCGAACGCTCGCTGGAGGTCTACGGACGCGGCGGCCAGGCGTGCTCCCGCTGCGCCTCGACCAT
CCGCCGGGACGCGTTCATGAACCGCTCGAGCTTCAGCTGCCCGGCGTGCCAGCCCCGGCCCCGCCGGGTCCGGTGA

Upstream 100 bases:

>100_bases
GGACGGAACGGGGCCGGCGAGCGATGCGGACGTGGACGTGGCGGTGAGGGGCGACGCGACGCCGGCGGCGCGGGACTCCC
GATGACTCTCGCCATTGGTG

Downstream 100 bases:

>100_bases
TACCCTTCGAACGCGCGTTCGAATCGCTTCGCGTCGGATCGGGAGCAAGCCGGTCCAGCACAGGTCGGTCCGGCACGGGT
CGGTCCAACACAGGTCGGTC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MPELPEVEVVRRGLERGVVGRTVAEVEVHHLRAVRRHLAGADHFAASLVGQTVATARRRGKYLWLGLTPSEPGGPAVGDA
LLGHLGMSGQLLVVPADSPDQVHLRVRFRFTDEGRELRFVDQRTFGGLAVVSGGAELPAPIAHIAPDPLSVDFDPERFAD
ALRRRRTGLKRALLDQTLISGVGNIYADEGLWAARLHYARPTETVTRAEALRLLDAVRTVMTAALAAGGTSFDRLYVSTE
GVSGLFERSLEVYGRGGQACSRCASTIRRDAFMNRSSFSCPACQPRPRRVR

Sequences:

>Translated_291_residues
MPELPEVEVVRRGLERGVVGRTVAEVEVHHLRAVRRHLAGADHFAASLVGQTVATARRRGKYLWLGLTPSEPGGPAVGDA
LLGHLGMSGQLLVVPADSPDQVHLRVRFRFTDEGRELRFVDQRTFGGLAVVSGGAELPAPIAHIAPDPLSVDFDPERFAD
ALRRRRTGLKRALLDQTLISGVGNIYADEGLWAARLHYARPTETVTRAEALRLLDAVRTVMTAALAAGGTSFDRLYVSTE
GVSGLFERSLEVYGRGGQACSRCASTIRRDAFMNRSSFSCPACQPRPRRVR
>Mature_290_residues
PELPEVEVVRRGLERGVVGRTVAEVEVHHLRAVRRHLAGADHFAASLVGQTVATARRRGKYLWLGLTPSEPGGPAVGDAL
LGHLGMSGQLLVVPADSPDQVHLRVRFRFTDEGRELRFVDQRTFGGLAVVSGGAELPAPIAHIAPDPLSVDFDPERFADA
LRRRRTGLKRALLDQTLISGVGNIYADEGLWAARLHYARPTETVTRAEALRLLDAVRTVMTAALAAGGTSFDRLYVSTEG
VSGLFERSLEVYGRGGQACSRCASTIRRDAFMNRSSFSCPACQPRPRRVR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=289, Percent_Identity=35.2941176470588, Blast_Score=155, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_FRASN (A8L594)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001505500.1
- ProteinModelPortal:   A8L594
- SMR:   A8L594
- GeneID:   5669553
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_1140
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- BioCyc:   FSP1855:FRANEAN1_1140-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31697; Mature: 31565

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 61-61 ACT_SITE 275-275 BINDING 103-103 BINDING 123-123 BINDING 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVVRRGLERGVVGRTVAEVEVHHLRAVRRHLAGADHFAASLVGQTVATARRRG
CCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
KYLWLGLTPSEPGGPAVGDALLGHLGMSGQLLVVPADSPDQVHLRVRFRFTDEGRELRFV
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEEECCCCCEEEEE
DQRTFGGLAVVSGGAELPAPIAHIAPDPLSVDFDPERFADALRRRRTGLKRALLDQTLIS
ECCCCCCEEEEECCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVGNIYADEGLWAARLHYARPTETVTRAEALRLLDAVRTVMTAALAAGGTSFDRLYVSTE
HHCCHHCCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
GVSGLFERSLEVYGRGGQACSRCASTIRRDAFMNRSSFSCPACQPRPRRVR
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVEVVRRGLERGVVGRTVAEVEVHHLRAVRRHLAGADHFAASLVGQTVATARRRG
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
KYLWLGLTPSEPGGPAVGDALLGHLGMSGQLLVVPADSPDQVHLRVRFRFTDEGRELRFV
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEEECCCCCEEEEE
DQRTFGGLAVVSGGAELPAPIAHIAPDPLSVDFDPERFADALRRRRTGLKRALLDQTLIS
ECCCCCCEEEEECCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVGNIYADEGLWAARLHYARPTETVTRAEALRLLDAVRTVMTAALAAGGTSFDRLYVSTE
HHCCHHCCCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
GVSGLFERSLEVYGRGGQACSRCASTIRRDAFMNRSSFSCPACQPRPRRVR
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA