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The map label for this gene is crp [H]

Identifier: 158312955

GI number: 158312955

Start: 1314721

End: 1315461

Strand: Direct

Name: crp [H]

Synonym: Franean1_1101

Alternate gene names: 158312955

Gene position: 1314721-1315461 (Clockwise)

Preceding gene: 158312954

Following gene: 158312956

Centisome position: 14.64

GC content: 71.12

Gene sequence:

>741_bases
ATGAACGTGTCGGCTCCGGGATCTGCGGCACACGAGACCGCCGGGCGGCGCTACGTTCACCGCATGCACGACACTGAGGC
GGTCACGCTGCTGCGGGCGACCACGCTGCTGAAGGAGCTCGACGAGGAGGATCTGCTGCGGCTGGCCAGCCGGTCCGTGA
CCCGGCGTTTCCGCCGGGGTCAGGTGGTCTTCACCGAGGGGGAGCCGGCCGACACCCTCCTCGTCATCGCGTCCGGGCGA
CTCAAGATCCTCACCAAGGCCGACGACGGGCGCGACCACGTGCTCAACATCGCCGGTCCCCGGGAGACGCTGGGCGAGCT
CAACATCGTCGAGGCCGGGACGAGGTCCGCGAGCGTCGAGGCGCTCGAGCCGAGCACCGCGCTGGTGCTCGAGCGCAGCG
CCGTGTGGGAGCTCGTCCGGGAGCGCCCGGCTGTCGCCGAGCAGCTCATCCGTGCGCTGGTGGCGCACGTGCGCCGGCTC
ACCGGGGCGAACGCGGACCTGGTCTTCCTCGATCTCCCGCGCCGGGTCGCGAAGCTGCTGCTGATGCGGATGCGCGAGGC
CGGCCGGCCGGTCATCGAGCTGGGCCTGACGCAGACCGAGATCGCGTCGCTGCTGGGCGGCTCGCGCCAGTCGGTCAACC
AGGCACTGCGTGAGTTCGAGCGGCGGGCGTGGATCCTGTCCGAAGGTCAGACGATCACCATCATGCAGGTCGACCGCCTC
CGCCGGTTCGCGGGCGACTGA

Upstream 100 bases:

>100_bases
GCGTGACGTGGTGCGTTGCTGGAGTCGGCAGCGGGTGTCGGCCTGACGTGCCGGCCGCGAGGGGTATTACCGGGCGTGTT
TGCATGATCACGATTTTGCG

Downstream 100 bases:

>100_bases
CCGCTGCGGCGGGCGCGCATGGCACTCGCCACACTTACTACGTGTCCAGCGTGTTACATCGTATGGTGGGACGCTGGCGG
CGAACCCGTCCCCGTCGCGC

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MNVSAPGSAAHETAGRRYVHRMHDTEAVTLLRATTLLKELDEEDLLRLASRSVTRRFRRGQVVFTEGEPADTLLVIASGR
LKILTKADDGRDHVLNIAGPRETLGELNIVEAGTRSASVEALEPSTALVLERSAVWELVRERPAVAEQLIRALVAHVRRL
TGANADLVFLDLPRRVAKLLLMRMREAGRPVIELGLTQTEIASLLGGSRQSVNQALREFERRAWILSEGQTITIMQVDRL
RRFAGD

Sequences:

>Translated_246_residues
MNVSAPGSAAHETAGRRYVHRMHDTEAVTLLRATTLLKELDEEDLLRLASRSVTRRFRRGQVVFTEGEPADTLLVIASGR
LKILTKADDGRDHVLNIAGPRETLGELNIVEAGTRSASVEALEPSTALVLERSAVWELVRERPAVAEQLIRALVAHVRRL
TGANADLVFLDLPRRVAKLLLMRMREAGRPVIELGLTQTEIASLLGGSRQSVNQALREFERRAWILSEGQTITIMQVDRL
RRFAGD
>Mature_246_residues
MNVSAPGSAAHETAGRRYVHRMHDTEAVTLLRATTLLKELDEEDLLRLASRSVTRRFRRGQVVFTEGEPADTLLVIASGR
LKILTKADDGRDHVLNIAGPRETLGELNIVEAGTRSASVEALEPSTALVLERSAVWELVRERPAVAEQLIRALVAHVRRL
TGANADLVFLDLPRRVAKLLLMRMREAGRPVIELGLTQTEIASLLGGSRQSVNQALREFERRAWILSEGQTITIMQVDRL
RRFAGD

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=193, Percent_Identity=25.9067357512953, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27324; Mature: 27324

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSAPGSAAHETAGRRYVHRMHDTEAVTLLRATTLLKELDEEDLLRLASRSVTRRFRRG
CCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
QVVFTEGEPADTLLVIASGRLKILTKADDGRDHVLNIAGPRETLGELNIVEAGTRSASVE
CEEEECCCCCCEEEEEECCCEEEEEECCCCCCCEEECCCCHHHHCCCEEEECCCCCCCCE
ALEPSTALVLERSAVWELVRERPAVAEQLIRALVAHVRRLTGANADLVFLDLPRRVAKLL
EECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHH
LMRMREAGRPVIELGLTQTEIASLLGGSRQSVNQALREFERRAWILSEGQTITIMQVDRL
HHHHHHHCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEHHHH
RRFAGD
HHHHCC
>Mature Secondary Structure
MNVSAPGSAAHETAGRRYVHRMHDTEAVTLLRATTLLKELDEEDLLRLASRSVTRRFRRG
CCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
QVVFTEGEPADTLLVIASGRLKILTKADDGRDHVLNIAGPRETLGELNIVEAGTRSASVE
CEEEECCCCCCEEEEEECCCEEEEEECCCCCCCEEECCCCHHHHCCCEEEECCCCCCCCE
ALEPSTALVLERSAVWELVRERPAVAEQLIRALVAHVRRLTGANADLVFLDLPRRVAKLL
EECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHH
LMRMREAGRPVIELGLTQTEIASLLGGSRQSVNQALREFERRAWILSEGQTITIMQVDRL
HHHHHHHCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCEEEEEEHHHH
RRFAGD
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]