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The map label for this gene is acsA [H]

Identifier: 158312922

GI number: 158312922

Start: 1259617

End: 1261638

Strand: Direct

Name: acsA [H]

Synonym: Franean1_1068

Alternate gene names: 158312922

Gene position: 1259617-1261638 (Clockwise)

Preceding gene: 158312921

Following gene: 158312923

Centisome position: 14.02

GC content: 72.01

Gene sequence:

>2022_bases
GTGACCGTTACAGGCATGGACGCAGGAAGCGGGACGGACGGCGGCGGCGGCGCCGGTGGAGCGCTCGAGGCCGAGCTGGA
GCGCCTGCAGACCGTGGAGCGCTTCGACCCGCCGCCGGGTTTCGCCCGTCGCCAGCCGTACGCCGCCGACGTGGCGGCGG
CCGCGGCCGACCCGCTGGCCTTCTGGGCGGGAAAGGCACGCGAGCTGCTGACCTGGCAGAAGCCCTTCACCCGCGTCCTC
GACGACGCGAACCCGCCGTTCTACAAGTGGTTCGACGACGGCGAGCTCAACGTCTCCGCCAACTGCCTGGACCGGCACGT
GGCGGCCGGCCTGGGCGGCCGGGTCGCCTACCACTGGCACGGCGAGGAGGGTGAGCGTCGGGCCGTCACCTACTCCGAGC
TGCTCGCCGACACCCAGCGGTTGGCGAACGGCCTGCGTTCCCTCGGCGTGGTCCCGGGCGACGTCGTCGGCATCTACCTG
CCGATGATCCCCGAGGTCGCGGTGGCCATGCTCGCCTGCGCCCGCATCGGCGCGGTGCACAACGTGGTCTTCGGCGGGTT
CGCGCCGTCCGCGGTGCGGGAGCGGATGGAGGTCTCCGACGCCAAGGTGCTGATCACCGTGGACGGGGCCCGCCGCAAGG
GCCGCACGGCGGCGGTCAAGGCCGGCGTGGACGCCGAGCTGGGCGACCTGCCGAAGCTGGAGCACGTCGTGGTCGTCCGC
TCCACCGGGCCGGTGGGCGGGGCCGAGACGGTGATGACGGCCGGCCGTGACGTCTGGTACCACGAGCTGCTCGCCGCCGC
CGACCCGCTGTGCCCGCCGGTGCCGCTCTCCGCCGAGCACCCGCTGTTCATCCTGTACAGCTCCGGGTCGACGGCGAAGC
CGAAGGGCATCCTGCACACCACCGGCGGCTACCTGCTCGGCGCGACCTACACCCACCGCACGGTCTTCGACATCGACCCG
GAGACCGACGTCTACTGGTGCTCCGCCGACGTCGGCTGGATCACCGGCCACTCCTACATCGTGTACGGCCCGCTGTCGAA
CGCCGTGACGAGCGTGATGTACGAGGGCGCGCCGGACTACCCGGACTACGACATCTGGTGGCGGCTGATCGCCGAGTACA
AGGTCACCGTCTTCTACACCGCGCCGACGGCCATCCGGGCGTGCATCAAGTGGGGAGCGCGGTACCCGGAGCGGCACGAC
CTGTCGTCGCTGCGGCTGCTCGGCTCGGTCGGCGAGCCGATCAACCCGAAGGCCTGGCTGTGGTACCACCAGATGATCGG
CGGTGGGCGCTGCCCGATCGTCGACACCTGGTGGCAGACCGAGACCGGCTCGATCCTGATCTCGCCGATCCCCGGGGTGA
CGTCGACGAAGCCGGGGTCGGCGACGACGCCGCTGCCCGGGATCAGCCCGGCGCTGCTGTCCGAGGACGGCGAGCCGGTC
ACCGAGGGCACCGGGGTCCTGGTGATCACCAGTCCGTGGCCGTCCATGCTGCGCACGCTCTACCGCGACGACGAGCGGTT
CGTGCAGACCTACTTCTCCCGGTTCGGCCCCCGCACCTACGTCGTGGGCGACGCCGCGCGGCTCGACGCGGACGGCTACT
TCTGGATCATCGGCCGGATCGACGACGTGATCAACGTGTCGGGGCACCGGCTGTCCACCGCCGAGGTGGAGTCCGCGATC
GTCGCGCACGAGGCCGTCGCCGAGGCGGCCGTGGTGGCCCAGTCGGACGAGGACACCGGCCAGGCGATCGTCGCGTTCGT
GACGCTGCGCGGCGAGCTGGTCGGCGACGACGCCATGGTCTCCCAGCTCCGGGACCACGTCGCTCACCGGATCGGCAAGC
TGGCCCGCCCGCGCCGCATCATCTGGGCCGACGACCTGCCCAAGACCCGGTCCGGCAAGATCATGCGCCGGCTGCTGCGG
GACGTCGCCGAGGGCCGCGAGCTCGGTGACGTCACGACCCTGCGCGACCCGGCGGTCATGTCCGCGCTCGCCGCGAAGGT
CGCCACCGCCCCCGACGAGTAG

Upstream 100 bases:

>100_bases
CGCGGCCCGGTGGCTCTGGGAGGCCGCCGGGCTTCGTGATACACCGGTGAAACCGTAGGTGACCGCGTTGTTCGGGCCTT
CGCCGATGCAGGAGGAACGC

Downstream 100 bases:

>100_bases
CCGCCGTCCCGCCCGTTCCCGCCGTCCGTCCCCGCCGCCCGTCCACCACGTGGTGGACGGGCGGCGGAGAGTGTGGAATA
TCCGTCTTGGGGGGATCGTG

Product: acetate--CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MTVTGMDAGSGTDGGGGAGGALEAELERLQTVERFDPPPGFARRQPYAADVAAAAADPLAFWAGKARELLTWQKPFTRVL
DDANPPFYKWFDDGELNVSANCLDRHVAAGLGGRVAYHWHGEEGERRAVTYSELLADTQRLANGLRSLGVVPGDVVGIYL
PMIPEVAVAMLACARIGAVHNVVFGGFAPSAVRERMEVSDAKVLITVDGARRKGRTAAVKAGVDAELGDLPKLEHVVVVR
STGPVGGAETVMTAGRDVWYHELLAAADPLCPPVPLSAEHPLFILYSSGSTAKPKGILHTTGGYLLGATYTHRTVFDIDP
ETDVYWCSADVGWITGHSYIVYGPLSNAVTSVMYEGAPDYPDYDIWWRLIAEYKVTVFYTAPTAIRACIKWGARYPERHD
LSSLRLLGSVGEPINPKAWLWYHQMIGGGRCPIVDTWWQTETGSILISPIPGVTSTKPGSATTPLPGISPALLSEDGEPV
TEGTGVLVITSPWPSMLRTLYRDDERFVQTYFSRFGPRTYVVGDAARLDADGYFWIIGRIDDVINVSGHRLSTAEVESAI
VAHEAVAEAAVVAQSDEDTGQAIVAFVTLRGELVGDDAMVSQLRDHVAHRIGKLARPRRIIWADDLPKTRSGKIMRRLLR
DVAEGRELGDVTTLRDPAVMSALAAKVATAPDE

Sequences:

>Translated_673_residues
MTVTGMDAGSGTDGGGGAGGALEAELERLQTVERFDPPPGFARRQPYAADVAAAAADPLAFWAGKARELLTWQKPFTRVL
DDANPPFYKWFDDGELNVSANCLDRHVAAGLGGRVAYHWHGEEGERRAVTYSELLADTQRLANGLRSLGVVPGDVVGIYL
PMIPEVAVAMLACARIGAVHNVVFGGFAPSAVRERMEVSDAKVLITVDGARRKGRTAAVKAGVDAELGDLPKLEHVVVVR
STGPVGGAETVMTAGRDVWYHELLAAADPLCPPVPLSAEHPLFILYSSGSTAKPKGILHTTGGYLLGATYTHRTVFDIDP
ETDVYWCSADVGWITGHSYIVYGPLSNAVTSVMYEGAPDYPDYDIWWRLIAEYKVTVFYTAPTAIRACIKWGARYPERHD
LSSLRLLGSVGEPINPKAWLWYHQMIGGGRCPIVDTWWQTETGSILISPIPGVTSTKPGSATTPLPGISPALLSEDGEPV
TEGTGVLVITSPWPSMLRTLYRDDERFVQTYFSRFGPRTYVVGDAARLDADGYFWIIGRIDDVINVSGHRLSTAEVESAI
VAHEAVAEAAVVAQSDEDTGQAIVAFVTLRGELVGDDAMVSQLRDHVAHRIGKLARPRRIIWADDLPKTRSGKIMRRLLR
DVAEGRELGDVTTLRDPAVMSALAAKVATAPDE
>Mature_672_residues
TVTGMDAGSGTDGGGGAGGALEAELERLQTVERFDPPPGFARRQPYAADVAAAAADPLAFWAGKARELLTWQKPFTRVLD
DANPPFYKWFDDGELNVSANCLDRHVAAGLGGRVAYHWHGEEGERRAVTYSELLADTQRLANGLRSLGVVPGDVVGIYLP
MIPEVAVAMLACARIGAVHNVVFGGFAPSAVRERMEVSDAKVLITVDGARRKGRTAAVKAGVDAELGDLPKLEHVVVVRS
TGPVGGAETVMTAGRDVWYHELLAAADPLCPPVPLSAEHPLFILYSSGSTAKPKGILHTTGGYLLGATYTHRTVFDIDPE
TDVYWCSADVGWITGHSYIVYGPLSNAVTSVMYEGAPDYPDYDIWWRLIAEYKVTVFYTAPTAIRACIKWGARYPERHDL
SSLRLLGSVGEPINPKAWLWYHQMIGGGRCPIVDTWWQTETGSILISPIPGVTSTKPGSATTPLPGISPALLSEDGEPVT
EGTGVLVITSPWPSMLRTLYRDDERFVQTYFSRFGPRTYVVGDAARLDADGYFWIIGRIDDVINVSGHRLSTAEVESAIV
AHEAVAEAAVVAQSDEDTGQAIVAFVTLRGELVGDDAMVSQLRDHVAHRIGKLARPRRIIWADDLPKTRSGKIMRRLLRD
VAEGRELGDVTTLRDPAVMSALAAKVATAPDE

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=694, Percent_Identity=44.8126801152738, Blast_Score=559, Evalue=1e-159,
Organism=Homo sapiens, GI253970489, Length=707, Percent_Identity=43.988684582744, Blast_Score=555, Evalue=1e-158,
Organism=Homo sapiens, GI28416953, Length=636, Percent_Identity=45.5974842767296, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI13375727, Length=627, Percent_Identity=35.4066985645933, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI38505220, Length=538, Percent_Identity=28.4386617100372, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI42544132, Length=558, Percent_Identity=27.9569892473118, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI122937307, Length=573, Percent_Identity=26.5270506108202, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI115511026, Length=570, Percent_Identity=26.3157894736842, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI31982927, Length=610, Percent_Identity=25.4098360655738, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI58082049, Length=565, Percent_Identity=25.1327433628319, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI157311624, Length=565, Percent_Identity=25.1327433628319, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI157311622, Length=565, Percent_Identity=25.1327433628319, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI195947378, Length=444, Percent_Identity=23.6486486486486, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI187761345, Length=393, Percent_Identity=25.9541984732824, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI187761343, Length=393, Percent_Identity=25.9541984732824, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI42544134, Length=366, Percent_Identity=25.4098360655738, Blast_Score=90, Evalue=7e-18,
Organism=Escherichia coli, GI1790505, Length=649, Percent_Identity=49.1525423728814, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1786529, Length=622, Percent_Identity=37.9421221864952, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI145693145, Length=545, Percent_Identity=23.8532110091743, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788107, Length=551, Percent_Identity=22.5045372050817, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1786810, Length=529, Percent_Identity=23.4404536862004, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71982997, Length=639, Percent_Identity=44.2879499217527, Blast_Score=481, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71983001, Length=639, Percent_Identity=44.2879499217527, Blast_Score=480, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17569507, Length=585, Percent_Identity=25.6410256410256, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17560308, Length=568, Percent_Identity=23.943661971831, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=361, Percent_Identity=23.8227146814404, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17560140, Length=121, Percent_Identity=33.0578512396694, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32563687, Length=526, Percent_Identity=20.532319391635, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=670, Percent_Identity=45.3731343283582, Blast_Score=556, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6319264, Length=661, Percent_Identity=43.267776096823, Blast_Score=526, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6319699, Length=372, Percent_Identity=21.7741935483871, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667955, Length=660, Percent_Identity=47.2727272727273, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI62472339, Length=553, Percent_Identity=51.5370705244123, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=51.9230769230769, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI21355225, Length=644, Percent_Identity=35.8695652173913, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI21355181, Length=531, Percent_Identity=22.9755178907721, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356947, Length=537, Percent_Identity=22.9050279329609, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24581924, Length=539, Percent_Identity=21.5213358070501, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648260, Length=550, Percent_Identity=23.2727272727273, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI18859661, Length=120, Percent_Identity=35, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72721; Mature: 72590

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTGMDAGSGTDGGGGAGGALEAELERLQTVERFDPPPGFARRQPYAADVAAAAADPLA
CEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHH
FWAGKARELLTWQKPFTRVLDDANPPFYKWFDDGELNVSANCLDRHVAAGLGGRVAYHWH
HHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEHHHHHHHHHHCCCCEEEEEEE
GEEGERRAVTYSELLADTQRLANGLRSLGVVPGDVVGIYLPMIPEVAVAMLACARIGAVH
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVVFGGFAPSAVRERMEVSDAKVLITVDGARRKGRTAAVKAGVDAELGDLPKLEHVVVVR
HHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEE
STGPVGGAETVMTAGRDVWYHELLAAADPLCPPVPLSAEHPLFILYSSGSTAKPKGILHT
CCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEE
TGGYLLGATYTHRTVFDIDPETDVYWCSADVGWITGHSYIVYGPLSNAVTSVMYEGAPDY
CCCEEEEEEEECCEEEECCCCCCEEEEECCCCEEECCCEEEEECHHHHHHHHHHCCCCCC
PDYDIWWRLIAEYKVTVFYTAPTAIRACIKWGARYPERHDLSSLRLLGSVGEPINPKAWL
CCHHHHHHHHHHEEEEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEE
WYHQMIGGGRCPIVDTWWQTETGSILISPIPGVTSTKPGSATTPLPGISPALLSEDGEPV
EEHHHHCCCCCCEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCC
TEGTGVLVITSPWPSMLRTLYRDDERFVQTYFSRFGPRTYVVGDAARLDADGYFWIIGRI
CCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHCCEEEEECCHHEECCCCEEEEEECC
DDVINVSGHRLSTAEVESAIVAHEAVAEAAVVAQSDEDTGQAIVAFVTLRGELVGDDAMV
CCHHCCCCCEEEHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEEECCCCCCCHHHH
SQLRDHVAHRIGKLARPRRIIWADDLPKTRSGKIMRRLLRDVAEGRELGDVTTLRDPAVM
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
SALAAKVATAPDE
HHHHHHHHCCCCC
>Mature Secondary Structure 
TVTGMDAGSGTDGGGGAGGALEAELERLQTVERFDPPPGFARRQPYAADVAAAAADPLA
EEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHH
FWAGKARELLTWQKPFTRVLDDANPPFYKWFDDGELNVSANCLDRHVAAGLGGRVAYHWH
HHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEHHHHHHHHHHCCCCEEEEEEE
GEEGERRAVTYSELLADTQRLANGLRSLGVVPGDVVGIYLPMIPEVAVAMLACARIGAVH
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVVFGGFAPSAVRERMEVSDAKVLITVDGARRKGRTAAVKAGVDAELGDLPKLEHVVVVR
HHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEE
STGPVGGAETVMTAGRDVWYHELLAAADPLCPPVPLSAEHPLFILYSSGSTAKPKGILHT
CCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEE
TGGYLLGATYTHRTVFDIDPETDVYWCSADVGWITGHSYIVYGPLSNAVTSVMYEGAPDY
CCCEEEEEEEECCEEEECCCCCCEEEEECCCCEEECCCEEEEECHHHHHHHHHHCCCCCC
PDYDIWWRLIAEYKVTVFYTAPTAIRACIKWGARYPERHDLSSLRLLGSVGEPINPKAWL
CCHHHHHHHHHHEEEEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEE
WYHQMIGGGRCPIVDTWWQTETGSILISPIPGVTSTKPGSATTPLPGISPALLSEDGEPV
EEHHHHCCCCCCEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCC
TEGTGVLVITSPWPSMLRTLYRDDERFVQTYFSRFGPRTYVVGDAARLDADGYFWIIGRI
CCCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHCCEEEEECCHHEECCCCEEEEEECC
DDVINVSGHRLSTAEVESAIVAHEAVAEAAVVAQSDEDTGQAIVAFVTLRGELVGDDAMV
CCHHCCCCCEEEHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEEECCCCCCCHHHH
SQLRDHVAHRIGKLARPRRIIWADDLPKTRSGKIMRRLLRDVAEGRELGDVTTLRDPAVM
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
SALAAKVATAPDE
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]