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The map label for this gene is maeB [C]

Identifier: 158312834

GI number: 158312834

Start: 1144172

End: 1145566

Strand: Direct

Name: maeB [C]

Synonym: Franean1_0980

Alternate gene names: 158312834

Gene position: 1144172-1145566 (Clockwise)

Preceding gene: 158312832

Following gene: 158312836

Centisome position: 12.74

GC content: 72.47

Gene sequence:

>1395_bases
GTGCCCGCCGCCCCGCGAACGCCCGATCTTCGCCGGGGCCCCGGGAACGTCCAGCCACGTCCGGTCAGTGACACCGTTCG
CCGGACGGAACCGCCGTGGCTTGTCCGAGGAGCCCCTTTCGTGACCGCAACCACAGACCACACGACCCTCGACTCGTCCC
TCGCGGCCCCGACCGATGGGCCCGTCTCGCCCGCGGCACCGGTGACGTCGCCGGGGTTCGACGGGCCGAGCCCGCGCCCG
TCCGACGACGACCCCGCCTTCGCGCTGCACCGGGGCGGGAAGATCGGAATCGGGCTGACCGCACCTCTGAACAACCGCGA
GGACCTCTCGCTCGCCTACACCCCCGGCGTGGCCCGGGTGTGCACGGCGATCGCCGAGACGCCGGCCCTGGCCGACGAGT
ACACCTGGCGTTCCAACACCGTGATCGTGGTGACCGACGGAACGGCCGTCCTGGGCCTCGGTGACATCGGCCCCGCGGCC
GCCCTGCCGGTCATGGAGGGCAAGGCCGCCCTCTTCAAGCACTTCGGCGGGGTCGACGCCGTGCCGATCTGCCTCGACTG
CACCGACGTCGAGGAGATCGTCGACACGGTCGCCCGCCTCGCCCCGGGCTTCGGTGGCGTCAACCTCGAGGACATCTCGG
CCCCCCGGTGCTTCGCGATCGAGTCGATGCTCCAGGACCGCGTCGACATCCCCGTCTTCCACGACGACCAGCACGGCACC
GCGATCGTCGCGCTCGCCGCGCTGGAGAACGCCGCCCGGCTGACCGGGCGGACCCTCGGCGACCTGCGGGCCGTCGTGTC
AGGCGCCGGCGCCGCCGGTGTGGCCGTCACCCGCATCCTGCTCGCCGCCGGCATCGGTGACATCGCCGTCGGCGACAGTC
GCGGCATGATCTACCCTGGTCGGGACGGCCTGACGACGGTCAAGGCCGCCCTCGCCGCCGAGACGAACAAGGCCGGCCTG
CGCGGCTCGATCAACGAGGCACTTGCCGGGGCGGACGTCTACCTCGGCCTCTCCGCGGGCAAGGTGCCCGAGGAGGCCGT
CGCCACGATGGCACCGGAGGCGATCGTCTTCGCGATGGCGAACCCGGACCCGGAGATCGACCCCGAGATCGCCCACAAGT
ACGCCCGGATCGTGGCGACCGGCCGCAGCGACTACCCGAACCAGATCAACAACGTGCTGGCCTTCCCGGGCGTCTTCCGG
GGCGCGCTGGACGTGCGTGCCAGCCGGGTCACCGAGGGCATGAAGCTCGCGGCCGCCCGGGCTCTCGCCGACGTGATCGC
CGACGAGCTGGCCGATGACAACATCATCCCGAGCGTCTTCGATGAGCGCGTCGCGCCCGCGGTCTCGACCGCGGTTGCCG
CGGCAGCCCGCGCCGACGGAGTCGCACGCCGCTAG

Upstream 100 bases:

>100_bases
GCCCGGAGCCTCGCGCGTGCCATATTGGAAGCAGCGCCGGGCCACCCCCGTCGCAGGCATGTGGCAGTCCAGCCATCTCA
CACGTCGAGGTGGCGCAGCA

Downstream 100 bases:

>100_bases
CACCTCCGCCGCGGCAGGGCTCGGGTCGTCCGGAGCGCTGCGGGCAGGGAAAGACAGAGCCGAACGCGACCGCCGCGGAA
CCTCAGGGTTCCGCGGCGGT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MPAAPRTPDLRRGPGNVQPRPVSDTVRRTEPPWLVRGAPFVTATTDHTTLDSSLAAPTDGPVSPAAPVTSPGFDGPSPRP
SDDDPAFALHRGGKIGIGLTAPLNNREDLSLAYTPGVARVCTAIAETPALADEYTWRSNTVIVVTDGTAVLGLGDIGPAA
ALPVMEGKAALFKHFGGVDAVPICLDCTDVEEIVDTVARLAPGFGGVNLEDISAPRCFAIESMLQDRVDIPVFHDDQHGT
AIVALAALENAARLTGRTLGDLRAVVSGAGAAGVAVTRILLAAGIGDIAVGDSRGMIYPGRDGLTTVKAALAAETNKAGL
RGSINEALAGADVYLGLSAGKVPEEAVATMAPEAIVFAMANPDPEIDPEIAHKYARIVATGRSDYPNQINNVLAFPGVFR
GALDVRASRVTEGMKLAAARALADVIADELADDNIIPSVFDERVAPAVSTAVAAAARADGVARR

Sequences:

>Translated_464_residues
MPAAPRTPDLRRGPGNVQPRPVSDTVRRTEPPWLVRGAPFVTATTDHTTLDSSLAAPTDGPVSPAAPVTSPGFDGPSPRP
SDDDPAFALHRGGKIGIGLTAPLNNREDLSLAYTPGVARVCTAIAETPALADEYTWRSNTVIVVTDGTAVLGLGDIGPAA
ALPVMEGKAALFKHFGGVDAVPICLDCTDVEEIVDTVARLAPGFGGVNLEDISAPRCFAIESMLQDRVDIPVFHDDQHGT
AIVALAALENAARLTGRTLGDLRAVVSGAGAAGVAVTRILLAAGIGDIAVGDSRGMIYPGRDGLTTVKAALAAETNKAGL
RGSINEALAGADVYLGLSAGKVPEEAVATMAPEAIVFAMANPDPEIDPEIAHKYARIVATGRSDYPNQINNVLAFPGVFR
GALDVRASRVTEGMKLAAARALADVIADELADDNIIPSVFDERVAPAVSTAVAAAARADGVARR
>Mature_463_residues
PAAPRTPDLRRGPGNVQPRPVSDTVRRTEPPWLVRGAPFVTATTDHTTLDSSLAAPTDGPVSPAAPVTSPGFDGPSPRPS
DDDPAFALHRGGKIGIGLTAPLNNREDLSLAYTPGVARVCTAIAETPALADEYTWRSNTVIVVTDGTAVLGLGDIGPAAA
LPVMEGKAALFKHFGGVDAVPICLDCTDVEEIVDTVARLAPGFGGVNLEDISAPRCFAIESMLQDRVDIPVFHDDQHGTA
IVALAALENAARLTGRTLGDLRAVVSGAGAAGVAVTRILLAAGIGDIAVGDSRGMIYPGRDGLTTVKAALAAETNKAGLR
GSINEALAGADVYLGLSAGKVPEEAVATMAPEAIVFAMANPDPEIDPEIAHKYARIVATGRSDYPNQINNVLAFPGVFRG
ALDVRASRVTEGMKLAAARALADVIADELADDNIIPSVFDERVAPAVSTAVAAAARADGVARR

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=361, Percent_Identity=27.1468144044321, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI62420882, Length=371, Percent_Identity=25.6064690026954, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI62420880, Length=371, Percent_Identity=25.6064690026954, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI239049447, Length=371, Percent_Identity=25.6064690026954, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1788806, Length=394, Percent_Identity=48.4771573604061, Blast_Score=331, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI17537199, Length=410, Percent_Identity=24.6341463414634, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322823, Length=346, Percent_Identity=25.7225433526012, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646388, Length=382, Percent_Identity=29.3193717277487, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646386, Length=382, Percent_Identity=29.3193717277487, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281363505, Length=419, Percent_Identity=26.7303102625298, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI78707236, Length=419, Percent_Identity=26.7303102625298, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281363503, Length=419, Percent_Identity=26.7303102625298, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI78707232, Length=419, Percent_Identity=26.7303102625298, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 47751; Mature: 47620

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAPRTPDLRRGPGNVQPRPVSDTVRRTEPPWLVRGAPFVTATTDHTTLDSSLAAPTDG
CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCC
PVSPAAPVTSPGFDGPSPRPSDDDPAFALHRGGKIGIGLTAPLNNREDLSLAYTPGVARV
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCCCCCCEEEECCCHHHH
CTAIAETPALADEYTWRSNTVIVVTDGTAVLGLGDIGPAAALPVMEGKAALFKHFGGVDA
HHHHHHCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCHHCCCCCCCHHHHHHHCCCCCC
VPICLDCTDVEEIVDTVARLAPGFGGVNLEDISAPRCFAIESMLQDRVDIPVFHDDQHGT
EEEEEECCCHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCEEECCCCCC
AIVALAALENAARLTGRTLGDLRAVVSGAGAAGVAVTRILLAAGIGDIAVGDSRGMIYPG
EEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCEEECC
RDGLTTVKAALAAETNKAGLRGSINEALAGADVYLGLSAGKVPEEAVATMAPEAIVFAMA
CCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEECCCCCCCHHHHHHCCCCEEEEEEC
NPDPEIDPEIAHKYARIVATGRSDYPNQINNVLAFPGVFRGALDVRASRVTEGMKLAAAR
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ALADVIADELADDNIIPSVFDERVAPAVSTAVAAAARADGVARR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PAAPRTPDLRRGPGNVQPRPVSDTVRRTEPPWLVRGAPFVTATTDHTTLDSSLAAPTDG
CCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEECCCEEEECCCCCCCCCCCCCCCCC
PVSPAAPVTSPGFDGPSPRPSDDDPAFALHRGGKIGIGLTAPLNNREDLSLAYTPGVARV
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCCCCCCCCEEEECCCHHHH
CTAIAETPALADEYTWRSNTVIVVTDGTAVLGLGDIGPAAALPVMEGKAALFKHFGGVDA
HHHHHHCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCHHCCCCCCCHHHHHHHCCCCCC
VPICLDCTDVEEIVDTVARLAPGFGGVNLEDISAPRCFAIESMLQDRVDIPVFHDDQHGT
EEEEEECCCHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCEEECCCCCC
AIVALAALENAARLTGRTLGDLRAVVSGAGAAGVAVTRILLAAGIGDIAVGDSRGMIYPG
EEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEECCCCCEEECC
RDGLTTVKAALAAETNKAGLRGSINEALAGADVYLGLSAGKVPEEAVATMAPEAIVFAMA
CCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEECCCCCCCHHHHHHCCCCEEEEEEC
NPDPEIDPEIAHKYARIVATGRSDYPNQINNVLAFPGVFRGALDVRASRVTEGMKLAAAR
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ALADVIADELADDNIIPSVFDERVAPAVSTAVAAAARADGVARR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]