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The map label for this gene is mhpC [C]

Identifier: 158312806

GI number: 158312806

Start: 1116154

End: 1117206

Strand: Direct

Name: mhpC [C]

Synonym: Franean1_0952

Alternate gene names: 158312806

Gene position: 1116154-1117206 (Clockwise)

Preceding gene: 158312805

Following gene: 158312807

Centisome position: 12.43

GC content: 75.02

Gene sequence:

>1053_bases
GTGGCGGTGACGGACGGCGGGCAAGCGGCGGGGCACAGGGCCGGCGCCGGGGACAGGACCGAGGCCGCGGCTCCGGCTCC
GGATGCGGGTGCGGCCGGGACCGCGGCCGCGCGGGCTTCCGGTGGGCCGGGGCGGCGGCTGTCCACCCGGTTCGTGACGG
TCCACGGTTACCGGCGGGCCTATCTCCGGGCCGGTCGTGGTCCGGCCCTGCTGCTGATCCACGGCATCGGGGACAATTCG
GGAACCTGGCGGGACCTCATCCCGGAGCTGGCGCGCGGCCGCACCGTCATCGCGCCGGATCTGCTGGGCCACGGCCGCTC
CGACAAGCCCCGGGGCGACTATTCGATCGCCGGCTACGCCTGCGGGATGCGCGACCTGCTGACCGTCCTGGGCGTCGAGC
GGGCGACGGTGGTCGGCCACTCGCTGGGCGGCGGAGTGGCGATGCAGTTCGCCTACCAGTTCCCCGAGCGGTGCGAGCGG
CTCGTCCTGGTGTCGACCGGGGGTGTGGGGCCGGACCTGCACCCGGTGCTGCGGGCGGCGACGGTGCCGGGCTCGGGCCA
TGCGCTGTCGCTGCTGACCAGAGCGCCCGTGCGCCGGGTCGGCTGGGCGGCCACCCGCGCGCTGCGGCTGCTGCACACCG
ACGTCGGGCGGGACGCGGACGACCTGATGCGCGTGTTCGCCTCGCTGGACGTCCCCACGGCCCGGCAGGCCTTCCTGCGC
ACCCTGCGCTCGGCGGTGGACGGCCACGGCCAGGCGATCACGATGCTGGACCGGTGCTACCTGGCGGCAGGCATGCCCTC
GCTGATCGTGTGGGGGGCGCACGACGCGGCGATCCCGGTGGAGCACGCGAGGATCGCCCACGAGGCGATGCCGGGCAGCC
GGCTGGAGATCTTCCCGGACGCGGGCCATTTCCCCCACCACGCGGACCCGGTGCGATTCCGGGCCGTTCTCGAGGATTTT
CTGGCGACCACCAGACCGGCCAGCCACTCCGCCCGCCAGTGGCGCACCCTGCTGCGTTCCCACGGCACGGCGGCACCCGC
ACAGGACGACTGA

Upstream 100 bases:

>100_bases
AGAAGAGCGGTTACGGAAAGGACCTGTCGGTCTACGGGCTGGAGGACTACACCCGTATCAAGCACGTGATGCACAACATC
GAGTTCTAGGGTCGGTGGCG

Downstream 100 bases:

>100_bases
TCCGCCGCCGGTCGCGCCCCGGGCGGCCGGTCGGTCCCGTGGCACCGGATGAAGGGATACCGCCACAGGTGACCTCCGCC
GCCCGGGCCGGCGCGATCCG

Product: alpha/beta hydrolase fold protein

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MAVTDGGQAAGHRAGAGDRTEAAAPAPDAGAAGTAAARASGGPGRRLSTRFVTVHGYRRAYLRAGRGPALLLIHGIGDNS
GTWRDLIPELARGRTVIAPDLLGHGRSDKPRGDYSIAGYACGMRDLLTVLGVERATVVGHSLGGGVAMQFAYQFPERCER
LVLVSTGGVGPDLHPVLRAATVPGSGHALSLLTRAPVRRVGWAATRALRLLHTDVGRDADDLMRVFASLDVPTARQAFLR
TLRSAVDGHGQAITMLDRCYLAAGMPSLIVWGAHDAAIPVEHARIAHEAMPGSRLEIFPDAGHFPHHADPVRFRAVLEDF
LATTRPASHSARQWRTLLRSHGTAAPAQDD

Sequences:

>Translated_350_residues
MAVTDGGQAAGHRAGAGDRTEAAAPAPDAGAAGTAAARASGGPGRRLSTRFVTVHGYRRAYLRAGRGPALLLIHGIGDNS
GTWRDLIPELARGRTVIAPDLLGHGRSDKPRGDYSIAGYACGMRDLLTVLGVERATVVGHSLGGGVAMQFAYQFPERCER
LVLVSTGGVGPDLHPVLRAATVPGSGHALSLLTRAPVRRVGWAATRALRLLHTDVGRDADDLMRVFASLDVPTARQAFLR
TLRSAVDGHGQAITMLDRCYLAAGMPSLIVWGAHDAAIPVEHARIAHEAMPGSRLEIFPDAGHFPHHADPVRFRAVLEDF
LATTRPASHSARQWRTLLRSHGTAAPAQDD
>Mature_349_residues
AVTDGGQAAGHRAGAGDRTEAAAPAPDAGAAGTAAARASGGPGRRLSTRFVTVHGYRRAYLRAGRGPALLLIHGIGDNSG
TWRDLIPELARGRTVIAPDLLGHGRSDKPRGDYSIAGYACGMRDLLTVLGVERATVVGHSLGGGVAMQFAYQFPERCERL
VLVSTGGVGPDLHPVLRAATVPGSGHALSLLTRAPVRRVGWAATRALRLLHTDVGRDADDLMRVFASLDVPTARQAFLRT
LRSAVDGHGQAITMLDRCYLAAGMPSLIVWGAHDAAIPVEHARIAHEAMPGSRLEIFPDAGHFPHHADPVRFRAVLEDFL
ATTRPASHSARQWRTLLRSHGTAAPAQDD

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

Organism=Homo sapiens, GI218777840, Length=279, Percent_Identity=25.4480286738351, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI13376164, Length=279, Percent_Identity=25.4480286738351, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI145611434, Length=260, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI23200012, Length=259, Percent_Identity=27.7992277992278, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI23200008, Length=259, Percent_Identity=27.7992277992278, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787244, Length=260, Percent_Identity=28.4615384615385, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789817, Length=253, Percent_Identity=28.0632411067194, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17554012, Length=295, Percent_Identity=23.0508474576271, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.- [C]

Molecular weight: Translated: 37013; Mature: 36881

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTDGGQAAGHRAGAGDRTEAAAPAPDAGAAGTAAARASGGPGRRLSTRFVTVHGYRRA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEEEEECHHHH
YLRAGRGPALLLIHGIGDNSGTWRDLIPELARGRTVIAPDLLGHGRSDKPRGDYSIAGYA
HHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCEEHHHH
CGMRDLLTVLGVERATVVGHSLGGGVAMQFAYQFPERCERLVLVSTGGVGPDLHPVLRAA
CCHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHH
TVPGSGHALSLLTRAPVRRVGWAATRALRLLHTDVGRDADDLMRVFASLDVPTARQAFLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHH
TLRSAVDGHGQAITMLDRCYLAAGMPSLIVWGAHDAAIPVEHARIAHEAMPGSRLEIFPD
HHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCEEECCC
AGHFPHHADPVRFRAVLEDFLATTRPASHSARQWRTLLRSHGTAAPAQDD
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AVTDGGQAAGHRAGAGDRTEAAAPAPDAGAAGTAAARASGGPGRRLSTRFVTVHGYRRA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEEEEECHHHH
YLRAGRGPALLLIHGIGDNSGTWRDLIPELARGRTVIAPDLLGHGRSDKPRGDYSIAGYA
HHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEEEEHHHHCCCCCCCCCCCCEEHHHH
CGMRDLLTVLGVERATVVGHSLGGGVAMQFAYQFPERCERLVLVSTGGVGPDLHPVLRAA
CCHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHH
TVPGSGHALSLLTRAPVRRVGWAATRALRLLHTDVGRDADDLMRVFASLDVPTARQAFLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHH
TLRSAVDGHGQAITMLDRCYLAAGMPSLIVWGAHDAAIPVEHARIAHEAMPGSRLEIFPD
HHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCEEECCC
AGHFPHHADPVRFRAVLEDFLATTRPASHSARQWRTLLRSHGTAAPAQDD
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]