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The map label for this gene is htrA [H]

Identifier: 158312720

GI number: 158312720

Start: 1012199

End: 1013230

Strand: Direct

Name: htrA [H]

Synonym: Franean1_0866

Alternate gene names: 158312720

Gene position: 1012199-1013230 (Clockwise)

Preceding gene: 158312719

Following gene: 158312721

Centisome position: 11.27

GC content: 73.93

Gene sequence:

>1032_bases
ATGGACGCAGGCGCCACCGCCAACCCGGGCCCCGAGGACCAGATCGCACTCCCCGACGGGACCGCGCCGTCCGATGATCG
TGGTGAGGCGGCGCTGGACGCATACTCCCGTGTGGTGACCCGGGTGGCCGAGCGGGTCGGGCCGAGCGTGGGAAGCCTGC
GGGTGCGCACCTCGCGCGGCGCCGGAGCCGGTTCCGCGGTGCTCTTCACCGAGGACGGGTTCCTGCTCACCTCCGCGCAT
GTCGTCGAGGGACGTCCAGGCACCGGCCGGGCCGGCGAGCCGGCTGGCACGGTGGAGTTCGTCGACGGGACCGAGCGTGC
CGTGGACCTGGTGGGAGCCGACCCGCTCTCGGACCTCGCCGTGCTGCGGGCCCGCGGCTCCACACCGCGCCCGGCCGAGC
TCGGCGACGCGGCGATGCTGCGGGTCGGCCAACTCGTCGTCGCCGTCGGCAATCCGCTGGGACTGACCGGGAGCGTCACC
GCCGGCGTGGTCAGCGCCCTGAACCGCTCGCTGCCGACCCGCTCCGGTTCGGCCGTGCGCGTCGTGGACGAGGTCATCCA
GACGGACGCCGCGCTGAACCCGGGAAACTCCGGCGGGGCACTGGTCACCGCCGACGGCCGCGTGGTCGGGGTGAACACCG
CCGTCGCCGGCGTCGGACTCGGCCTGGCCGTCCCCGTGAACGCCACCACCAGGCGCATCCTCGCGGCACTGATCCGGGAT
GGCCGAGTCCGCCGCGCCTACCTCGGTGTCGCCGGTGCCCGGGTGCCGCTCCCGCCGGCCCTGGCCGAGCGGACGGGGCA
ACGCCACGGCGTGCGCCTCGCGGAGGTGGTACAGGGTAGCCCAGCCGGGCAGGCCGGACTGTTCACCGACGATCTCGTCC
TGTCGATCGCCGGGACGCCTGTCGCCGGCCCGGGCGATCTCCAGCGACTGCTGACCGAGGACACCATCGGACAACCCGTC
GAAATGACAGTCTGGCGTCGCGGTGCCCTCGTGGACGTCATAGCCGTGCCCCGGGAACTCGTAACCCCGTAG

Upstream 100 bases:

>100_bases
GGGGTGGGGTGGTTATGCCGACGGCGGACGCCTCGGCGGCAGGATCCGCTCCTCGCTTGTGTTGATTGCAGTGCAACACT
GTAATCGCGAGGAGGATCGG

Downstream 100 bases:

>100_bases
GGCACCGACCCGGAGAAGCCGGCAGCGGAACGGGGCCTGGCGCCGGGGCGGCCGGCTGGCGGGCGGTGCGAGATCGACGG
TTCGGCCTCGGCGCGTGATC

Product: peptidase S1 and S6 chymotrypsin/Hap

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MDAGATANPGPEDQIALPDGTAPSDDRGEAALDAYSRVVTRVAERVGPSVGSLRVRTSRGAGAGSAVLFTEDGFLLTSAH
VVEGRPGTGRAGEPAGTVEFVDGTERAVDLVGADPLSDLAVLRARGSTPRPAELGDAAMLRVGQLVVAVGNPLGLTGSVT
AGVVSALNRSLPTRSGSAVRVVDEVIQTDAALNPGNSGGALVTADGRVVGVNTAVAGVGLGLAVPVNATTRRILAALIRD
GRVRRAYLGVAGARVPLPPALAERTGQRHGVRLAEVVQGSPAGQAGLFTDDLVLSIAGTPVAGPGDLQRLLTEDTIGQPV
EMTVWRRGALVDVIAVPRELVTP

Sequences:

>Translated_343_residues
MDAGATANPGPEDQIALPDGTAPSDDRGEAALDAYSRVVTRVAERVGPSVGSLRVRTSRGAGAGSAVLFTEDGFLLTSAH
VVEGRPGTGRAGEPAGTVEFVDGTERAVDLVGADPLSDLAVLRARGSTPRPAELGDAAMLRVGQLVVAVGNPLGLTGSVT
AGVVSALNRSLPTRSGSAVRVVDEVIQTDAALNPGNSGGALVTADGRVVGVNTAVAGVGLGLAVPVNATTRRILAALIRD
GRVRRAYLGVAGARVPLPPALAERTGQRHGVRLAEVVQGSPAGQAGLFTDDLVLSIAGTPVAGPGDLQRLLTEDTIGQPV
EMTVWRRGALVDVIAVPRELVTP
>Mature_343_residues
MDAGATANPGPEDQIALPDGTAPSDDRGEAALDAYSRVVTRVAERVGPSVGSLRVRTSRGAGAGSAVLFTEDGFLLTSAH
VVEGRPGTGRAGEPAGTVEFVDGTERAVDLVGADPLSDLAVLRARGSTPRPAELGDAAMLRVGQLVVAVGNPLGLTGSVT
AGVVSALNRSLPTRSGSAVRVVDEVIQTDAALNPGNSGGALVTADGRVVGVNTAVAGVGLGLAVPVNATTRRILAALIRD
GRVRRAYLGVAGARVPLPPALAERTGQRHGVRLAEVVQGSPAGQAGLFTDDLVLSIAGTPVAGPGDLQRLLTEDTIGQPV
EMTVWRRGALVDVIAVPRELVTP

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=333, Percent_Identity=26.4264264264264, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI22129776, Length=297, Percent_Identity=28.2828282828283, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI24308541, Length=308, Percent_Identity=29.2207792207792, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI7019477, Length=261, Percent_Identity=32.9501915708812, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1786356, Length=277, Percent_Identity=32.8519855595668, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1789629, Length=279, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1789630, Length=261, Percent_Identity=32.9501915708812, Blast_Score=114, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24646839, Length=272, Percent_Identity=31.6176470588235, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 34653; Mature: 34653

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAGATANPGPEDQIALPDGTAPSDDRGEAALDAYSRVVTRVAERVGPSVGSLRVRTSRG
CCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
AGAGSAVLFTEDGFLLTSAHVVEGRPGTGRAGEPAGTVEFVDGTERAVDLVGADPLSDLA
CCCCCEEEEECCCEEEEEEEEECCCCCCCCCCCCCCCEEEECCCCHHEEECCCCCHHHHH
VLRARGSTPRPAELGDAAMLRVGQLVVAVGNPLGLTGSVTAGVVSALNRSLPTRSGSAVR
HHHHCCCCCCCCCCCHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCHH
VVDEVIQTDAALNPGNSGGALVTADGRVVGVNTAVAGVGLGLAVPVNATTRRILAALIRD
HHHHHHHHCCCCCCCCCCCEEEEECCEEEEECHHHHHCCCCEEECCCHHHHHHHHHHHHC
GRVRRAYLGVAGARVPLPPALAERTGQRHGVRLAEVVQGSPAGQAGLFTDDLVLSIAGTP
CCEEEEEHCCCCCCCCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCEECCEEEEECCCC
VAGPGDLQRLLTEDTIGQPVEMTVWRRGALVDVIAVPRELVTP
CCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEHHHCCHHHCCC
>Mature Secondary Structure
MDAGATANPGPEDQIALPDGTAPSDDRGEAALDAYSRVVTRVAERVGPSVGSLRVRTSRG
CCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
AGAGSAVLFTEDGFLLTSAHVVEGRPGTGRAGEPAGTVEFVDGTERAVDLVGADPLSDLA
CCCCCEEEEECCCEEEEEEEEECCCCCCCCCCCCCCCEEEECCCCHHEEECCCCCHHHHH
VLRARGSTPRPAELGDAAMLRVGQLVVAVGNPLGLTGSVTAGVVSALNRSLPTRSGSAVR
HHHHCCCCCCCCCCCHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCHH
VVDEVIQTDAALNPGNSGGALVTADGRVVGVNTAVAGVGLGLAVPVNATTRRILAALIRD
HHHHHHHHCCCCCCCCCCCEEEEECCEEEEECHHHHHCCCCEEECCCHHHHHHHHHHHHC
GRVRRAYLGVAGARVPLPPALAERTGQRHGVRLAEVVQGSPAGQAGLFTDDLVLSIAGTP
CCEEEEEHCCCCCCCCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCCEECCEEEEECCCC
VAGPGDLQRLLTEDTIGQPVEMTVWRRGALVDVIAVPRELVTP
CCCHHHHHHHHHHHHCCCCEEEEEECCCCEEEHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 10692364; 11133960; 11555295 [H]