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The map label for this gene is mutT2 [H]

Identifier: 158312717

GI number: 158312717

Start: 1008519

End: 1008980

Strand: Direct

Name: mutT2 [H]

Synonym: Franean1_0863

Alternate gene names: 158312717

Gene position: 1008519-1008980 (Clockwise)

Preceding gene: 158312715

Following gene: 158312718

Centisome position: 11.23

GC content: 72.08

Gene sequence:

>462_bases
GTGGATGTGTGGCTGGTGGATGTGTGGACGGAGGTGGGGTCGGTGGAAGAGGGGCGGCTCGTGGTCGCTGTCGCGTTGAT
CGACGGTGATCGCAGGGTGCTCGCCGCGCGGCGGGTCTCGCCGCCGGCGCTCGCGGGCATGTGGGAGTTCCCGGGCGGCA
AGGTCGAGCCTGGTGAGGACGAGCTCGCGGCGCTGCGCCGGGAGTGCCGCGAGGAACTGGATGTGGAGATCGAGGTCGGG
CGCCTCTTCGGGGAGATCGCGCTGCCACGTCCGGGGTGGCGGATGCGGTTGTGGCTCGGGCGCGTCGCCGCGGGCGAGCC
GTTTGCCGCCGAGCATGACGACCTGCGTTGGCTGGGTGTGGGCGAGCTTGACGACGTCCCGTGGCTCCCGGCGGACGCGC
CGCTGGTCGATGCTCTCCGGGCGGAGCTTGCGGAGCCGGTGGAGGGTTCTGTGGGGTCGTGA

Upstream 100 bases:

>100_bases
ACTCGCTCAGTCGCCACGCTTCTGACGGCGGGGCCCGGGAGCGGCCGGCGGTAGATCGGCAGTGGCCAGGTGGCTGAGTG
GCCAGGTGGCTGAGTGGCTG

Downstream 100 bases:

>100_bases
CGGTCCGCCGCGCGCGGCCCGCGGCTGTGAGTCCGTACCATGGGAGTTGGACCGCGGCGGGGTAGACGTCGTTTCCCGGG
CGGGTACCGCCCTCCGGGGC

Product: NUDIX hydrolase

Products: CMP; diphosphate [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MDVWLVDVWTEVGSVEEGRLVVAVALIDGDRRVLAARRVSPPALAGMWEFPGGKVEPGEDELAALRRECREELDVEIEVG
RLFGEIALPRPGWRMRLWLGRVAAGEPFAAEHDDLRWLGVGELDDVPWLPADAPLVDALRAELAEPVEGSVGS

Sequences:

>Translated_153_residues
MDVWLVDVWTEVGSVEEGRLVVAVALIDGDRRVLAARRVSPPALAGMWEFPGGKVEPGEDELAALRRECREELDVEIEVG
RLFGEIALPRPGWRMRLWLGRVAAGEPFAAEHDDLRWLGVGELDDVPWLPADAPLVDALRAELAEPVEGSVGS
>Mature_153_residues
MDVWLVDVWTEVGSVEEGRLVVAVALIDGDRRVLAARRVSPPALAGMWEFPGGKVEPGEDELAALRRECREELDVEIEVG
RLFGEIALPRPGWRMRLWLGRVAAGEPFAAEHDDLRWLGVGELDDVPWLPADAPLVDALRAELAEPVEGSVGS

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=122, Percent_Identity=39.344262295082, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 16785; Mature: 16785

Theoretical pI: Translated: 4.12; Mature: 4.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVWLVDVWTEVGSVEEGRLVVAVALIDGDRRVLAARRVSPPALAGMWEFPGGKVEPGED
CCEEEEEEEHHCCCCCCCCEEEEEEEECCCCEEEEECCCCCCHHCCEEECCCCCCCCCHH
ELAALRRECREELDVEIEVGRLFGEIALPRPGWRMRLWLGRVAAGEPFAAEHDDLRWLGV
HHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEC
GELDDVPWLPADAPLVDALRAELAEPVEGSVGS
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDVWLVDVWTEVGSVEEGRLVVAVALIDGDRRVLAARRVSPPALAGMWEFPGGKVEPGED
CCEEEEEEEHHCCCCCCCCEEEEEEEECCCCEEEEECCCCCCHHCCEEECCCCCCCCCHH
ELAALRRECREELDVEIEVGRLFGEIALPRPGWRMRLWLGRVAAGEPFAAEHDDLRWLGV
HHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEC
GELDDVPWLPADAPLVDALRAELAEPVEGSVGS
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; H2O [C]

Specific reaction: CTP + H2O = CMP + diphosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]