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The map label for this gene is adk [H]

Identifier: 158312695

GI number: 158312695

Start: 983116

End: 983772

Strand: Direct

Name: adk [H]

Synonym: Franean1_0839

Alternate gene names: 158312695

Gene position: 983116-983772 (Clockwise)

Preceding gene: 158312693

Following gene: 158312697

Centisome position: 10.95

GC content: 68.04

Gene sequence:

>657_bases
GTGCGCAAGTTCGTGATCATGGGCGTGCAGGGCAGCGGGAAGGGGACCCAGGCGAAGCTGATGGCCGACGAGCTCGACCT
GGTCCACATCAGCGTGGGCGACGTGTTCCGCTGGAACGTGCAGAACCACACCAAGATCGGCGCGCAGGTGCGGCGGATCG
TGGCCAGCGGGCACCTGGTGGGCGACGACCTCGTCGAGTCGGTGGTCCGCACCCGGCTCACCGAGCACGACTGGAACTAC
GGGTTCATCATCGACGGGTTCCCGCGCAACGCCAGGCAGGCGGAGTTCTTCCTGGAGAGCTACGACATAGACGGCGTCAT
CTACCTCGACCTGCCGGACGAGGAGGTGGTGCGCCGGGTGCTGGCTCGCCGGCTGTGCTCGCGATGTGGTCTCGACTACA
ACCTGATCGCGAGCCGGCCGCAGATCGAGGACACCTGTGACGTCTGTGGGGGCGCGCTGGTGACGCGCTCCGACGACAAC
CCCGAGGCCCTCGCGGTGCGGCTCTCGGAGTACCACGCGAAGACCCGGCCGGTGATGGAGATCTTCCAGCGCAAGGAGCA
GGTCGCCGTGGTCGACGCGCGGCGCTCCGTCCTGGAGGTACAGGCGGAGATCCGCGACCAGTTCGCCCTGCCGTCACCGC
GCGCCATGGCACGGTGA

Upstream 100 bases:

>100_bases
CACGCCATCGGCAGCCAGATCAGGGCTCCCCGCCGCACGGGTCGTCGGCTGGGTGGGGAGCCGCCCGACCACAGGCCGTC
GAAGCACGCGGGGAGGCACC

Downstream 100 bases:

>100_bases
CGGCCTCGCCCGGCGGATCCACTCCGGCCCGGTGATGATCCGCCGGTCCGGCGATAATCCCCCGGTCCGGCGGAGTCACT
GCTTCTGGAAGACGACCGCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRKFVIMGVQGSGKGTQAKLMADELDLVHISVGDVFRWNVQNHTKIGAQVRRIVASGHLVGDDLVESVVRTRLTEHDWNY
GFIIDGFPRNARQAEFFLESYDIDGVIYLDLPDEEVVRRVLARRLCSRCGLDYNLIASRPQIEDTCDVCGGALVTRSDDN
PEALAVRLSEYHAKTRPVMEIFQRKEQVAVVDARRSVLEVQAEIRDQFALPSPRAMAR

Sequences:

>Translated_218_residues
MRKFVIMGVQGSGKGTQAKLMADELDLVHISVGDVFRWNVQNHTKIGAQVRRIVASGHLVGDDLVESVVRTRLTEHDWNY
GFIIDGFPRNARQAEFFLESYDIDGVIYLDLPDEEVVRRVLARRLCSRCGLDYNLIASRPQIEDTCDVCGGALVTRSDDN
PEALAVRLSEYHAKTRPVMEIFQRKEQVAVVDARRSVLEVQAEIRDQFALPSPRAMAR
>Mature_218_residues
MRKFVIMGVQGSGKGTQAKLMADELDLVHISVGDVFRWNVQNHTKIGAQVRRIVASGHLVGDDLVESVVRTRLTEHDWNY
GFIIDGFPRNARQAEFFLESYDIDGVIYLDLPDEEVVRRVLARRLCSRCGLDYNLIASRPQIEDTCDVCGGALVTRSDDN
PEALAVRLSEYHAKTRPVMEIFQRKEQVAVVDARRSVLEVQAEIRDQFALPSPRAMAR

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=210, Percent_Identity=31.9047619047619, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4502013, Length=210, Percent_Identity=31.9047619047619, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI19923437, Length=185, Percent_Identity=37.8378378378378, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI310110345, Length=181, Percent_Identity=33.7016574585635, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI53832003, Length=181, Percent_Identity=33.7016574585635, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI8051579, Length=181, Percent_Identity=33.7016574585635, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI53832001, Length=181, Percent_Identity=33.7016574585635, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI4502011, Length=201, Percent_Identity=27.363184079602, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1786680, Length=208, Percent_Identity=35.0961538461538, Blast_Score=141, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17552384, Length=210, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=197, Percent_Identity=29.4416243654822, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17537943, Length=221, Percent_Identity=23.9819004524887, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=33.8028169014084, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=29.7979797979798, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322828, Length=205, Percent_Identity=25.3658536585366, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI22026816, Length=209, Percent_Identity=34.9282296650718, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17737899, Length=192, Percent_Identity=36.9791666666667, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24645822, Length=192, Percent_Identity=36.9791666666667, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17647141, Length=201, Percent_Identity=27.8606965174129, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24663208, Length=201, Percent_Identity=27.8606965174129, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI221459597, Length=208, Percent_Identity=25, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356893, Length=208, Percent_Identity=25, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24641; Mature: 24641

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFVIMGVQGSGKGTQAKLMADELDLVHISVGDVFRWNVQNHTKIGAQVRRIVASGHLV
CCEEEEEEECCCCCCCEEEEECCCCCEEEEEECCEEEECCCCCHHHHHHHHHHHHCCCCC
GDDLVESVVRTRLTEHDWNYGFIIDGFPRNARQAEFFLESYDIDGVIYLDLPDEEVVRRV
CHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHH
LARRLCSRCGLDYNLIASRPQIEDTCDVCGGALVTRSDDNPEALAVRLSEYHAKTRPVME
HHHHHHHHCCCCEEEECCCCCCCHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCHHHH
IFQRKEQVAVVDARRSVLEVQAEIRDQFALPSPRAMAR
HHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCCCHHCCC
>Mature Secondary Structure
MRKFVIMGVQGSGKGTQAKLMADELDLVHISVGDVFRWNVQNHTKIGAQVRRIVASGHLV
CCEEEEEEECCCCCCCEEEEECCCCCEEEEEECCEEEECCCCCHHHHHHHHHHHHCCCCC
GDDLVESVVRTRLTEHDWNYGFIIDGFPRNARQAEFFLESYDIDGVIYLDLPDEEVVRRV
CHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHH
LARRLCSRCGLDYNLIASRPQIEDTCDVCGGALVTRSDDNPEALAVRLSEYHAKTRPVME
HHHHHHHHCCCCEEEECCCCCCCHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCHHHH
IFQRKEQVAVVDARRSVLEVQAEIRDQFALPSPRAMAR
HHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA