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The map label for this gene is pth [H]

Identifier: 158312638

GI number: 158312638

Start: 907956

End: 908543

Strand: Direct

Name: pth [H]

Synonym: Franean1_0782

Alternate gene names: 158312638

Gene position: 907956-908543 (Clockwise)

Preceding gene: 158312637

Following gene: 158312639

Centisome position: 10.11

GC content: 70.75

Gene sequence:

>588_bases
ATGGAAGCCCCTGCCGATGACGGGCCCTGGCTCGTCGTCGGCCTAGGCAACCCAGGCGCGAGCTATGCCGGGAACCGGCA
CAACGTCGGTTTCATGGTGGTGGACCTGTTGGCCGAGCGCACCGGCGCCCGGCTGCGGTCCCACCGCTCGCGGGCCGAGA
TCGACCAGGTGCGGCTCGCTGGGCGCTCGGTCGTTCTCGCCAGGCCGCGGACGTTCATGAACGTCTCGGGGCCGCCGGTG
GCCGCTGTCCGGGCGTTCTACAAGATCGACGTCTCCCGGGTGATCGTCGTCCACGACGAGCTGGACATCCCGTTCGACGC
CATCCGGCTCAAGCGCGGCGGCGGGGACAACGGGCACAACGGGCTGCGCTCGATCACCTCGTCGCTGGGCTCGCGTGACT
ACCTGCGGGTCCGGGTTGGCATCGGCCGGCCACCCGGGCGGATGGATCCGGCGGATTTCGTCCTGCGCGACTTCAGCCCG
GTCGAGCGCAAGGCGCTCCCGCTGATCGTCGACAACGCGGCGGACGCCGTCGAGTCGCTGCTCCAGGAGGAACTCGCGGC
CGCGCAGAACCGCTTCCACGCCGGCTGA

Upstream 100 bases:

>100_bases
CGGTCGCCCAGATGGAAGCCGATCTCGGCGAGACCGCTGAGGGCGCTGAGGGCGCGGCTGCCGACTCGGCTGCCTCGGCC
TGATCTGTTCCGGCGAGCGG

Downstream 100 bases:

>100_bases
CGCGCACCCGCGAGGGAACACACCGCCACCGCGTTCGCCCGCGGGTGCGCGAGCGCGCTGGTGCAGGCGGTATCGGTGAT
GTTCCGCTGTGCGGATCCGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MEAPADDGPWLVVGLGNPGASYAGNRHNVGFMVVDLLAERTGARLRSHRSRAEIDQVRLAGRSVVLARPRTFMNVSGPPV
AAVRAFYKIDVSRVIVVHDELDIPFDAIRLKRGGGDNGHNGLRSITSSLGSRDYLRVRVGIGRPPGRMDPADFVLRDFSP
VERKALPLIVDNAADAVESLLQEELAAAQNRFHAG

Sequences:

>Translated_195_residues
MEAPADDGPWLVVGLGNPGASYAGNRHNVGFMVVDLLAERTGARLRSHRSRAEIDQVRLAGRSVVLARPRTFMNVSGPPV
AAVRAFYKIDVSRVIVVHDELDIPFDAIRLKRGGGDNGHNGLRSITSSLGSRDYLRVRVGIGRPPGRMDPADFVLRDFSP
VERKALPLIVDNAADAVESLLQEELAAAQNRFHAG
>Mature_195_residues
MEAPADDGPWLVVGLGNPGASYAGNRHNVGFMVVDLLAERTGARLRSHRSRAEIDQVRLAGRSVVLARPRTFMNVSGPPV
AAVRAFYKIDVSRVIVVHDELDIPFDAIRLKRGGGDNGHNGLRSITSSLGSRDYLRVRVGIGRPPGRMDPADFVLRDFSP
VERKALPLIVDNAADAVESLLQEELAAAQNRFHAG

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=177, Percent_Identity=41.2429378531073, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1787455, Length=186, Percent_Identity=44.0860215053763, Blast_Score=124, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6321983, Length=173, Percent_Identity=33.5260115606936, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21153; Mature: 21153

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAPADDGPWLVVGLGNPGASYAGNRHNVGFMVVDLLAERTGARLRSHRSRAEIDQVRLA
CCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRSVVLARPRTFMNVSGPPVAAVRAFYKIDVSRVIVVHDELDIPFDAIRLKRGGGDNGHN
CCEEEEECCCEEEECCCCCHHHHHHHHHCCEEEEEEEECCCCCCHHHEEEECCCCCCCHH
GLRSITSSLGSRDYLRVRVGIGRPPGRMDPADFVLRDFSPVERKALPLIVDNAADAVESL
HHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCHHHCCCCEEECCHHHHHHHH
LQEELAAAQNRFHAG
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MEAPADDGPWLVVGLGNPGASYAGNRHNVGFMVVDLLAERTGARLRSHRSRAEIDQVRLA
CCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRSVVLARPRTFMNVSGPPVAAVRAFYKIDVSRVIVVHDELDIPFDAIRLKRGGGDNGHN
CCEEEEECCCEEEECCCCCHHHHHHHHHCCEEEEEEEECCCCCCHHHEEEECCCCCCCHH
GLRSITSSLGSRDYLRVRVGIGRPPGRMDPADFVLRDFSPVERKALPLIVDNAADAVESL
HHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCHHHCCCCEEECCHHHHHHHH
LQEELAAAQNRFHAG
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA