The gene/protein map for NC_009921 is currently unavailable.
Definition Frankia sp. EAN1pec chromosome, complete genome.
Accession NC_009921
Length 8,982,042

Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 158312374

GI number: 158312374

Start: 600407

End: 601156

Strand: Direct

Name: fabG [C]

Synonym: Franean1_0515

Alternate gene names: 158312374

Gene position: 600407-601156 (Clockwise)

Preceding gene: 158312373

Following gene: 158312375

Centisome position: 6.68

GC content: 67.87

Gene sequence:

>750_bases
ATGGCGGCAAAGCTCGACGGCAAGGTCGCGATCATCACCGGAGCCGGTTCCGGTATCGGGCGCGCGAGCGCCCACCTTTT
CGCGGCGGAAGGCGCGAAGGTGGTCTGTGCGGACTTCAGCGGCAAGGAGAAGCGGACGGCCGACGAGATCGGGGCCGCCG
CCGTGGCGGTCCACGTCGACGTCGCGGTGGCCGCCGACGTCGAGAGGATGGTCGCCACAGCGGAGGACCGGTTCGGCAAG
CTCGACATCCTCTTCAACAACGCCGGCGTCGCCGGACCCAAGATGCTCATCACAGAACAGAAAGAGGAGGACTTCGACCG
CGTCGTCGCGGTGAACCTCAAGGGCGTGTTTCTCGGGATGAAGTACGGAATCCCGGCGATCCTCCGTAACGGTGGCGGCT
CCTTGATCAACACCGCGTCGGCGGCCGGGCTGGTCGGGTGGCGGAAGAACGCCGTCTACGGCGCGTCCAAGGGCGGCGTC
ATCCAGATGACCAAGGCGGTGGCGCTCGACTTCGCGGACCGGGGCGTCCGGGTCAACGCCATCTGCCCGGGCATGACCTG
GACCGGAATGGTCCCAGGATCAGACGATCTCCTGGAGCCTCCCGCCAGCGTGCCAGCGCCTCCTCAGCCGATGAGCCGGT
GGGGCCTGCCAAGCGAGCTCGCGACCGCCGCCCTCTTCCTCGCGAGCGACGACTCGTCGTTCGTCACCGGCGTCGCCCTT
CCTGTCGACGGGGGCTATGTCGTTGGCTGA

Upstream 100 bases:

>100_bases
ATGGCCTGGGCGTCCGAGGCCTGCCCGAGTCGAAGTTCGGGTAGCCCGTGCCCACTCGCGATGACCGGAACGCCCCATCT
GTCTGAAGGGAACTCAACCC

Downstream 100 bases:

>100_bases
CGCCCGGCCCTTCCGTTTCGCGGTCCAGACCACAACCGCGACGTCGGCCACCGAGTGGCGCGATCTCGCACGTCGGGTCG
AGGACCTCGGCTACTCGACC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MAAKLDGKVAIITGAGSGIGRASAHLFAAEGAKVVCADFSGKEKRTADEIGAAAVAVHVDVAVAADVERMVATAEDRFGK
LDILFNNAGVAGPKMLITEQKEEDFDRVVAVNLKGVFLGMKYGIPAILRNGGGSLINTASAAGLVGWRKNAVYGASKGGV
IQMTKAVALDFADRGVRVNAICPGMTWTGMVPGSDDLLEPPASVPAPPQPMSRWGLPSELATAALFLASDDSSFVTGVAL
PVDGGYVVG

Sequences:

>Translated_249_residues
MAAKLDGKVAIITGAGSGIGRASAHLFAAEGAKVVCADFSGKEKRTADEIGAAAVAVHVDVAVAADVERMVATAEDRFGK
LDILFNNAGVAGPKMLITEQKEEDFDRVVAVNLKGVFLGMKYGIPAILRNGGGSLINTASAAGLVGWRKNAVYGASKGGV
IQMTKAVALDFADRGVRVNAICPGMTWTGMVPGSDDLLEPPASVPAPPQPMSRWGLPSELATAALFLASDDSSFVTGVAL
PVDGGYVVG
>Mature_248_residues
AAKLDGKVAIITGAGSGIGRASAHLFAAEGAKVVCADFSGKEKRTADEIGAAAVAVHVDVAVAADVERMVATAEDRFGKL
DILFNNAGVAGPKMLITEQKEEDFDRVVAVNLKGVFLGMKYGIPAILRNGGGSLINTASAAGLVGWRKNAVYGASKGGVI
QMTKAVALDFADRGVRVNAICPGMTWTGMVPGSDDLLEPPASVPAPPQPMSRWGLPSELATAALFLASDDSSFVTGVALP
VDGGYVVG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI59889578, Length=226, Percent_Identity=36.7256637168142, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=34.1666666666667, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=32.4427480916031, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI66933014, Length=250, Percent_Identity=32.8, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI4758504, Length=254, Percent_Identity=36.2204724409449, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI31542939, Length=199, Percent_Identity=35.1758793969849, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=31.8548387096774, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=30.078125, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=30.6451612903226, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI4504505, Length=228, Percent_Identity=32.4561403508772, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI83715985, Length=253, Percent_Identity=33.9920948616601, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI10190704, Length=252, Percent_Identity=30.5555555555556, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI126723750, Length=251, Percent_Identity=29.4820717131474, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI5031737, Length=252, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI40807363, Length=216, Percent_Identity=33.7962962962963, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI224922801, Length=174, Percent_Identity=33.9080459770115, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI142976729, Length=204, Percent_Identity=30.8823529411765, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI210032110, Length=201, Percent_Identity=26.865671641791, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI33667109, Length=193, Percent_Identity=30.5699481865285, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI126723191, Length=187, Percent_Identity=31.0160427807487, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI25282469, Length=236, Percent_Identity=28.8135593220339, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI225579078, Length=207, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI209862901, Length=218, Percent_Identity=26.605504587156, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI19923983, Length=218, Percent_Identity=26.605504587156, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=35.2226720647773, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=36.2549800796813, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=34.5381526104418, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=33.6, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=31.2252964426877, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=32.6771653543307, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=31.2252964426877, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=31.7647058823529, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788459, Length=247, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=34.3629343629344, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789057, Length=268, Percent_Identity=28.7313432835821, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787820, Length=178, Percent_Identity=29.2134831460674, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=26.5873015873016, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367365, Length=243, Percent_Identity=30.8641975308642, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=35.5731225296443, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17559104, Length=256, Percent_Identity=35.546875, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71994600, Length=257, Percent_Identity=34.2412451361868, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=36.0323886639676, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71994604, Length=256, Percent_Identity=33.984375, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=35.3846153846154, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=32.8063241106719, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=31.4176245210728, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=31.9391634980989, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17551412, Length=272, Percent_Identity=29.0441176470588, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=31.2252964426877, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17562990, Length=260, Percent_Identity=32.3076923076923, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=29.5454545454545, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=31.9230769230769, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=31.2977099236641, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=30.1526717557252, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=30.4182509505703, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=33.7301587301587, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17562904, Length=260, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=32.3076923076923, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=31.203007518797, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=28.6290322580645, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17538486, Length=270, Percent_Identity=28.5185185185185, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17563726, Length=275, Percent_Identity=31.6363636363636, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17564282, Length=196, Percent_Identity=33.1632653061224, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=265, Percent_Identity=28.6792452830189, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17565030, Length=268, Percent_Identity=30.2238805970149, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193203117, Length=196, Percent_Identity=32.1428571428571, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17568967, Length=222, Percent_Identity=31.981981981982, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=32.1243523316062, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17536025, Length=255, Percent_Identity=32.5490196078431, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=29.5918367346939, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17536651, Length=255, Percent_Identity=30.1960784313725, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=249, Percent_Identity=28.9156626506024, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561272, Length=258, Percent_Identity=32.9457364341085, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71982365, Length=200, Percent_Identity=30.5, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=187, Percent_Identity=34.2245989304813, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=27.4900398406374, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=196, Percent_Identity=29.0816326530612, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639444, Length=246, Percent_Identity=38.2113821138211, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=35.8267716535433, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=38.2113821138211, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=35.4838709677419, Blast_Score=123, Evalue=9e-29,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=34.8, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17737361, Length=250, Percent_Identity=34.4, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=31.4741035856574, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18859837, Length=190, Percent_Identity=36.3157894736842, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24643142, Length=251, Percent_Identity=33.0677290836653, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24644337, Length=259, Percent_Identity=34.7490347490347, Blast_Score=97, Evalue=8e-21,
Organism=Drosophila melanogaster, GI281364892, Length=195, Percent_Identity=31.2820512820513, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24665247, Length=208, Percent_Identity=29.8076923076923, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221331216, Length=208, Percent_Identity=29.8076923076923, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24665243, Length=207, Percent_Identity=28.5024154589372, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221331218, Length=207, Percent_Identity=28.5024154589372, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21355631, Length=159, Percent_Identity=30.188679245283, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21358495, Length=195, Percent_Identity=26.1538461538462, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581726, Length=212, Percent_Identity=26.8867924528302, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21357673, Length=196, Percent_Identity=29.0816326530612, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25442; Mature: 25311

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MAAKLDGKVAIITGAGSGIGRASAHLFAAEGAKVVCADFSGKEKRTADEIGAAAVAVHVD
CCCCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHCCEEEEEEEE
VAVAADVERMVATAEDRFGKLDILFNNAGVAGPKMLITEQKEEDFDRVVAVNLKGVFLGM
EEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCCCEEEEEEEEEEEEEE
KYGIPAILRNGGGSLINTASAAGLVGWRKNAVYGASKGGVIQMTKAVALDFADRGVRVNA
CCCCCEEEECCCCCEEECCCCCCCCCCCCCEEECCCCCCEEEEEHEEEEECCCCCEEEEE
ICPGMTWTGMVPGSDDLLEPPASVPAPPQPMSRWGLPSELATAALFLASDDSSFVTGVAL
EECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHEEEEEECCCCCEEEEEEE
PVDGGYVVG
ECCCCEECC
>Mature Secondary Structure 
AAKLDGKVAIITGAGSGIGRASAHLFAAEGAKVVCADFSGKEKRTADEIGAAAVAVHVD
CCCCCCCEEEEEECCCCCCCCCEEEEEECCCEEEEECCCCCCCCCHHHHCCEEEEEEEE
VAVAADVERMVATAEDRFGKLDILFNNAGVAGPKMLITEQKEEDFDRVVAVNLKGVFLGM
EEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCCCEEEEEEEEEEEEEE
KYGIPAILRNGGGSLINTASAAGLVGWRKNAVYGASKGGVIQMTKAVALDFADRGVRVNA
CCCCCEEEECCCCCEEECCCCCCCCCCCCCEEECCCCCCEEEEEHEEEEECCCCCEEEEE
ICPGMTWTGMVPGSDDLLEPPASVPAPPQPMSRWGLPSELATAALFLASDDSSFVTGVAL
EECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHEEEEEECCCCCEEEEEEE
PVDGGYVVG
ECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]