The gene/protein map for NC_009921 is currently unavailable.
Definition Frankia sp. EAN1pec chromosome, complete genome.
Accession NC_009921
Length 8,982,042

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The map label for this gene is ephD [H]

Identifier: 158312280

GI number: 158312280

Start: 492279

End: 493022

Strand: Direct

Name: ephD [H]

Synonym: Franean1_0417

Alternate gene names: 158312280

Gene position: 492279-493022 (Clockwise)

Preceding gene: 158312279

Following gene: 158312281

Centisome position: 5.48

GC content: 69.62

Gene sequence:

>744_bases
ATGAAGGTGTTCGAGAACCGTGTCGCCGTCGTGACGGGCGCGGCGAGTGGCATCGGCCTGGCCGTCGCGCGGCGTCTTGC
CGCGATGGGTGTCCGGCTGGTGATGACGGATCTTGATGGTGGTGCGGTGGTGGCGGCCGGTGCGGCCGTCCGGAGCGATG
GCTGCGATGTCGAGGCAGTGCAGCTCGACGTCCGCGACCCCGGGGCGGTCGAGCGCGTGGCCGACCTGGCCATCGACCGG
TTCGGCGCGCTCCACGTCGCAGTGAACAATGCCGGGATCGTGAACCGGGGCCTCGCTTGGGAGCTTTCCCTCGAGGACTG
GCGCCGTGTGTTGGACGTGAACCTCCTCGGTGCCATCCACGGGGTGCGGTCGTTCGTGCCGAGGATCCTCGCAACCGGCG
AGGAGGGCCACGTCGTGAACGTGGCGTCGATGGCCGCCGTCCTCCCCCAGGAGCGCCTCGGGCCTTACACCGTCGCGAAG
CACGGTGTCCTCGGCCTCTCCGACGTCCTGCGTGCCGACCTCGCCGCGGTCGGAGCGCCGGTCGGTGTCAGCGTGGTCTT
TCCCGGCCGCATCCGCACGGGCATGAACCCGATCGGCACCGTCGAGCCTTCAACCGTCGCCGACCACGTCGTCGACGCGA
TCGAACGGCAACGACCCTACGTCTTCACCGACGACCACTCGGTCGGCGGCGTCGAGGCGCGTCTTCAGGCTATTCTCGCG
GCCCGCGCGGATGTCATCACCTGA

Upstream 100 bases:

>100_bases
GTCTTTCCTGCCAGCGAGGCCGCCAGCTATATCAACGGCGCGCAGGTACTCGCCGACGGAGGCCTCTTCAGAACCTTGTG
AGTCTCGGGATGGGGTAACC

Downstream 100 bases:

>100_bases
CGACCGCTCGGCGGCGCCAGCGCTCGACGGCCTGCGGGACGCCGGGCACCCAGTATCCTCGTGACCTGCCCGAACGGACC
CGTCGCCGAGTGGTCGGCTC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MKVFENRVAVVTGAASGIGLAVARRLAAMGVRLVMTDLDGGAVVAAGAAVRSDGCDVEAVQLDVRDPGAVERVADLAIDR
FGALHVAVNNAGIVNRGLAWELSLEDWRRVLDVNLLGAIHGVRSFVPRILATGEEGHVVNVASMAAVLPQERLGPYTVAK
HGVLGLSDVLRADLAAVGAPVGVSVVFPGRIRTGMNPIGTVEPSTVADHVVDAIERQRPYVFTDDHSVGGVEARLQAILA
ARADVIT

Sequences:

>Translated_247_residues
MKVFENRVAVVTGAASGIGLAVARRLAAMGVRLVMTDLDGGAVVAAGAAVRSDGCDVEAVQLDVRDPGAVERVADLAIDR
FGALHVAVNNAGIVNRGLAWELSLEDWRRVLDVNLLGAIHGVRSFVPRILATGEEGHVVNVASMAAVLPQERLGPYTVAK
HGVLGLSDVLRADLAAVGAPVGVSVVFPGRIRTGMNPIGTVEPSTVADHVVDAIERQRPYVFTDDHSVGGVEARLQAILA
ARADVIT
>Mature_247_residues
MKVFENRVAVVTGAASGIGLAVARRLAAMGVRLVMTDLDGGAVVAAGAAVRSDGCDVEAVQLDVRDPGAVERVADLAIDR
FGALHVAVNNAGIVNRGLAWELSLEDWRRVLDVNLLGAIHGVRSFVPRILATGEEGHVVNVASMAAVLPQERLGPYTVAK
HGVLGLSDVLRADLAAVGAPVGVSVVFPGRIRTGMNPIGTVEPSTVADHVVDAIERQRPYVFTDDHSVGGVEARLQAILA
ARADVIT

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=199, Percent_Identity=28.643216080402, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4758504, Length=220, Percent_Identity=33.1818181818182, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI31542939, Length=222, Percent_Identity=28.8288288288288, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI83715985, Length=184, Percent_Identity=35.3260869565217, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI32483357, Length=192, Percent_Identity=31.7708333333333, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40807363, Length=227, Percent_Identity=25.5506607929515, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7706318, Length=192, Percent_Identity=27.6041666666667, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI40548397, Length=224, Percent_Identity=31.25, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI214010158, Length=224, Percent_Identity=31.25, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI214010156, Length=224, Percent_Identity=31.25, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI22758144, Length=224, Percent_Identity=31.25, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI224922801, Length=165, Percent_Identity=30.9090909090909, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI5031737, Length=197, Percent_Identity=32.48730964467, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI210032110, Length=246, Percent_Identity=26.8292682926829, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI19743808, Length=198, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI157739938, Length=194, Percent_Identity=29.3814432989691, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=32.48730964467, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI44680136, Length=202, Percent_Identity=31.6831683168317, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI44680133, Length=202, Percent_Identity=31.6831683168317, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI17738292, Length=202, Percent_Identity=31.6831683168317, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI126723191, Length=173, Percent_Identity=31.7919075144509, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI142976729, Length=223, Percent_Identity=25.1121076233184, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4504503, Length=198, Percent_Identity=28.7878787878788, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI126723750, Length=195, Percent_Identity=30.2564102564103, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI150247226, Length=198, Percent_Identity=34.3434343434343, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI119392083, Length=193, Percent_Identity=30.5699481865285, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI109715829, Length=205, Percent_Identity=26.3414634146341, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI15277342, Length=227, Percent_Identity=29.0748898678414, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=194, Percent_Identity=32.4742268041237, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082160, Length=209, Percent_Identity=25.8373205741627, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789208, Length=190, Percent_Identity=28.4210526315789, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788459, Length=193, Percent_Identity=30.5699481865285, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082100, Length=229, Percent_Identity=27.5109170305677, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790717, Length=186, Percent_Identity=26.8817204301075, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787820, Length=184, Percent_Identity=28.804347826087, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789057, Length=232, Percent_Identity=24.5689655172414, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786701, Length=193, Percent_Identity=28.4974093264249, Blast_Score=61, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=213, Percent_Identity=30.0469483568075, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193203115, Length=224, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17508895, Length=231, Percent_Identity=25.974025974026, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=198, Percent_Identity=31.3131313131313, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=216, Percent_Identity=29.6296296296296, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17567345, Length=237, Percent_Identity=25.3164556962025, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=213, Percent_Identity=30.5164319248826, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI32563809, Length=197, Percent_Identity=30.9644670050761, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17507613, Length=197, Percent_Identity=30.9644670050761, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=230, Percent_Identity=26.9565217391304, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=189, Percent_Identity=31.2169312169312, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115534660, Length=196, Percent_Identity=30.6122448979592, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193210355, Length=243, Percent_Identity=26.3374485596708, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=193, Percent_Identity=27.979274611399, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=204, Percent_Identity=27.4509803921569, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=197, Percent_Identity=28.4263959390863, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=208, Percent_Identity=26.4423076923077, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=194, Percent_Identity=28.3505154639175, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21355319, Length=198, Percent_Identity=30.8080808080808, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI281364892, Length=219, Percent_Identity=27.8538812785388, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI23397609, Length=201, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI116007236, Length=206, Percent_Identity=27.6699029126214, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI116007234, Length=208, Percent_Identity=32.6923076923077, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24644339, Length=204, Percent_Identity=30.3921568627451, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28571387, Length=212, Percent_Identity=28.3018867924528, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581726, Length=222, Percent_Identity=25.6756756756757, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737361, Length=206, Percent_Identity=30.5825242718447, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21355631, Length=169, Percent_Identity=28.4023668639053, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI221510726, Length=225, Percent_Identity=25.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639444, Length=213, Percent_Identity=29.5774647887324, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007232, Length=194, Percent_Identity=32.9896907216495, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641232, Length=206, Percent_Identity=29.126213592233, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571526, Length=217, Percent_Identity=29.0322580645161, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI116007238, Length=193, Percent_Identity=27.979274611399, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24663911, Length=239, Percent_Identity=28.0334728033473, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648693, Length=219, Percent_Identity=28.7671232876712, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355889, Length=219, Percent_Identity=28.7671232876712, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281364494, Length=240, Percent_Identity=26.25, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI18859837, Length=174, Percent_Identity=31.0344827586207, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=203, Percent_Identity=30.0492610837438, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356301, Length=169, Percent_Identity=27.810650887574, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25725; Mature: 25725

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00061 ADH_SHORT ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MKVFENRVAVVTGAASGIGLAVARRLAAMGVRLVMTDLDGGAVVAAGAAVRSDGCDVEAV
CCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCEEEEECCEECCCCCCEEEE
QLDVRDPGAVERVADLAIDRFGALHVAVNNAGIVNRGLAWELSLEDWRRVLDVNLLGAIH
EEECCCCCHHHHHHHHHHHHCCEEEEEECCCCEEECCCEEEECHHHHHHHHHHHHHHHHH
GVRSFVPRILATGEEGHVVNVASMAAVLPQERLGPYTVAKHGVLGLSDVLRADLAAVGAP
HHHHHHHHHHCCCCCCCEEEHHHHHHHCCHHHCCCCHHHHCCCCCHHHHHHHHHHHHCCC
VGVSVVFPGRIRTGMNPIGTVEPSTVADHVVDAIERQRPYVFTDDHSVGGVEARLQAILA
CCEEEEECCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHH
ARADVIT
HHHHCCC
>Mature Secondary Structure
MKVFENRVAVVTGAASGIGLAVARRLAAMGVRLVMTDLDGGAVVAAGAAVRSDGCDVEAV
CCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEEECCCCEEEEECCEECCCCCCEEEE
QLDVRDPGAVERVADLAIDRFGALHVAVNNAGIVNRGLAWELSLEDWRRVLDVNLLGAIH
EEECCCCCHHHHHHHHHHHHCCEEEEEECCCCEEECCCEEEECHHHHHHHHHHHHHHHHH
GVRSFVPRILATGEEGHVVNVASMAAVLPQERLGPYTVAKHGVLGLSDVLRADLAAVGAP
HHHHHHHHHHCCCCCCCEEEHHHHHHHCCHHHCCCCHHHHCCCCCHHHHHHHHHHHHCCC
VGVSVVFPGRIRTGMNPIGTVEPSTVADHVVDAIERQRPYVFTDDHSVGGVEARLQAILA
CCEEEEECCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHH
ARADVIT
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]