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The map label for this gene is cvrA [H]

Identifier: 157964038

GI number: 157964038

Start: 5138920

End: 5140116

Strand: Reverse

Name: cvrA [H]

Synonym: Spea_4227

Alternate gene names: 157964038

Gene position: 5140116-5138920 (Counterclockwise)

Preceding gene: 157964045

Following gene: 157964034

Centisome position: 99.33

GC content: 44.95

Gene sequence:

>1197_bases
ATGACGACTGAAATGATCATGATTGGTATGTCTATTTTGATCTTAGTCGGAATTTTACTGCACCACCCCTCTAGAACCTT
AGGTATACCGTCACTACTGATCTTCATGGGCGTAGGACTTATGCTAGGTAATGGCGAATTTAACTTTGTTTATGATGATT
TAGAGAAAACGGCTTGGATAGGCGGTCTGGCATTAAACATAATTGTGTTTGTCGGCGGCATAAATACTTCCACCGACAAA
ATTAAAGTAGCTTATAAAGAGGGGGGCGTGCTGGCCTCCTTTGGAGTATTGTTTACCACGCTGATTTTTGCCGTCATCTT
GTATGGGCTGCTAGATTTCGATTTAATTACCTGTTTACTTTTTGCCGCCATAGTGTCGTCCACCGATGCGGCAGCCGTAT
TCTCCATTCTCGAATCTAAAAAGCTTAAGCTAAAAGAGCAAACTGATACCGTATTGGAGTTTGAGTCGGCTACCAACGAC
CCCGTGGCTATGCTGTTGGTGATCTTTTTAACTGATATGGCGCTTTCAAGTAGCAAGAGTGTGGTTACATCTGAAGTGGC
TATGGAGCTTGTCACGCAAATTGGCGTAGCAATGGTCGTCGGCTGGCTGGTGGCTAAAGTCGCGGTATCGCTACTTAATC
GCATTCATCTATCTGAGTTTGGTCTTATTCCTGTGTTCGTGTTGGCAAGCTTCGTGGTGGCAACCTATGGCGCCGAGATG
TTAGGGGGTAACATCTTGCTGGCCTCTTATATTGCAGGTGTAGTGATAGGTAATGGTATTAAGCGCGGGCAGTTAGTTAA
CCAACATTTCTTTAATAGCTTATCTTGGCTGGCTCAGGCACTGATGTTCATTGTGCTGGGCTTACAGATCTTCCCACAAT
CATTAGCAGCGGTATTTGTGAGTTCGTTATTACCAGCATTACTGTTAATTCTTGTTGCTAGACCATTGGCAGTACAGCTT
TGTTACCTGCCATTTGTTAAAGCCAGTTGGAAAAAGCGACTATTTATATCTGCAATTGGTTTAAAGGGGGCCACGCCCAT
CGTATTTGCTCTTATCCCTGCCGCAGCAGGAGTGCCTGGGGCACTTGAGATCGTGCATATGGTGTTCTTTATCGTATTGT
TTTCAGTATTTATTCAGGGAGGGGCGATAGCGCCCTTGGCGAACAAGCTCGGCCTGAATCGTTCCGATAAAGAGTGA

Upstream 100 bases:

>100_bases
GCTTGTGGGGCGAGTATTAGTCTCTCTTCATCGTAAAATATCCAATATGAATGCTTGCTAACCAATCTTATTTACACTAT
TCACGCAAAAGGTGCCCTAT

Downstream 100 bases:

>100_bases
TGAACTCCTTAAGCTGAAGCGGCTACTAAGGTATTTTTAGACTCGATACCTTTCCATACTTTCTCGTGGAAATAGAACAC
TACTGTATTGACTGCGGGTT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTTEMIMIGMSILILVGILLHHPSRTLGIPSLLIFMGVGLMLGNGEFNFVYDDLEKTAWIGGLALNIIVFVGGINTSTDK
IKVAYKEGGVLASFGVLFTTLIFAVILYGLLDFDLITCLLFAAIVSSTDAAAVFSILESKKLKLKEQTDTVLEFESATND
PVAMLLVIFLTDMALSSSKSVVTSEVAMELVTQIGVAMVVGWLVAKVAVSLLNRIHLSEFGLIPVFVLASFVVATYGAEM
LGGNILLASYIAGVVIGNGIKRGQLVNQHFFNSLSWLAQALMFIVLGLQIFPQSLAAVFVSSLLPALLLILVARPLAVQL
CYLPFVKASWKKRLFISAIGLKGATPIVFALIPAAAGVPGALEIVHMVFFIVLFSVFIQGGAIAPLANKLGLNRSDKE

Sequences:

>Translated_398_residues
MTTEMIMIGMSILILVGILLHHPSRTLGIPSLLIFMGVGLMLGNGEFNFVYDDLEKTAWIGGLALNIIVFVGGINTSTDK
IKVAYKEGGVLASFGVLFTTLIFAVILYGLLDFDLITCLLFAAIVSSTDAAAVFSILESKKLKLKEQTDTVLEFESATND
PVAMLLVIFLTDMALSSSKSVVTSEVAMELVTQIGVAMVVGWLVAKVAVSLLNRIHLSEFGLIPVFVLASFVVATYGAEM
LGGNILLASYIAGVVIGNGIKRGQLVNQHFFNSLSWLAQALMFIVLGLQIFPQSLAAVFVSSLLPALLLILVARPLAVQL
CYLPFVKASWKKRLFISAIGLKGATPIVFALIPAAAGVPGALEIVHMVFFIVLFSVFIQGGAIAPLANKLGLNRSDKE
>Mature_397_residues
TTEMIMIGMSILILVGILLHHPSRTLGIPSLLIFMGVGLMLGNGEFNFVYDDLEKTAWIGGLALNIIVFVGGINTSTDKI
KVAYKEGGVLASFGVLFTTLIFAVILYGLLDFDLITCLLFAAIVSSTDAAAVFSILESKKLKLKEQTDTVLEFESATNDP
VAMLLVIFLTDMALSSSKSVVTSEVAMELVTQIGVAMVVGWLVAKVAVSLLNRIHLSEFGLIPVFVLASFVVATYGAEML
GGNILLASYIAGVVIGNGIKRGQLVNQHFFNSLSWLAQALMFIVLGLQIFPQSLAAVFVSSLLPALLLILVARPLAVQLC
YLPFVKASWKKRLFISAIGLKGATPIVFALIPAAAGVPGALEIVHMVFFIVLFSVFIQGGAIAPLANKLGLNRSDKE

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=363, Percent_Identity=35.8126721763085, Blast_Score=181, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018421
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 42526; Mature: 42394

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEMIMIGMSILILVGILLHHPSRTLGIPSLLIFMGVGLMLGNGEFNFVYDDLEKTAWI
CCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHH
GGLALNIIVFVGGINTSTDKIKVAYKEGGVLASFGVLFTTLIFAVILYGLLDFDLITCLL
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAAIVSSTDAAAVFSILESKKLKLKEQTDTVLEFESATNDPVAMLLVIFLTDMALSSSKS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCCCH
VVTSEVAMELVTQIGVAMVVGWLVAKVAVSLLNRIHLSEFGLIPVFVLASFVVATYGAEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LGGNILLASYIAGVVIGNGIKRGQLVNQHFFNSLSWLAQALMFIVLGLQIFPQSLAAVFV
HCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLLPALLLILVARPLAVQLCYLPFVKASWKKRLFISAIGLKGATPIVFALIPAAAGVPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCH
ALEIVHMVFFIVLFSVFIQGGAIAPLANKLGLNRSDKE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
TTEMIMIGMSILILVGILLHHPSRTLGIPSLLIFMGVGLMLGNGEFNFVYDDLEKTAWI
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHH
GGLALNIIVFVGGINTSTDKIKVAYKEGGVLASFGVLFTTLIFAVILYGLLDFDLITCLL
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAAIVSSTDAAAVFSILESKKLKLKEQTDTVLEFESATNDPVAMLLVIFLTDMALSSSKS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCCCH
VVTSEVAMELVTQIGVAMVVGWLVAKVAVSLLNRIHLSEFGLIPVFVLASFVVATYGAEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LGGNILLASYIAGVVIGNGIKRGQLVNQHFFNSLSWLAQALMFIVLGLQIFPQSLAAVFV
HCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLLPALLLILVARPLAVQLCYLPFVKASWKKRLFISAIGLKGATPIVFALIPAAAGVPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCH
ALEIVHMVFFIVLFSVFIQGGAIAPLANKLGLNRSDKE
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA