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The map label for this gene is menB [H]

Identifier: 157964036

GI number: 157964036

Start: 5137610

End: 5138512

Strand: Direct

Name: menB [H]

Synonym: Spea_4225

Alternate gene names: 157964036

Gene position: 5137610-5138512 (Clockwise)

Preceding gene: 157964035

Following gene: 157964037

Centisome position: 99.29

GC content: 48.06

Gene sequence:

>903_bases
ATGACACAACAAGTATCTGACATTTTTGATCCCGAATTGTGGGATGTTGTTCCAGGATTTGATTTCGAAGATGTTACCTA
CCACAGAGCCAAAGATCAGGGCACTGTACGTATTGCCATTAGTCGTCCAGACTGCTTAAATTCATTCCGCCCAAAGACTG
TCGATGAGCTTTATATCGCCCTAGACCATGCTCGTCAGTGGTCAGATGTAGGCTGCGTACTGTTAACCGGTAACGGTCCT
TCAGCCAAAGGCCAATGGTCTTTCAGTGCCGGTGGCGATCAGCGTATTCGTGGAAAAGATGGCTACAAGTATGAAGGTGC
TGAAGAAGGTACGCCGGATGTCGCTCGTATGGGGCGTTTACACATATTAGAAGTACAACGCCTAATCCGCTTTATGCCAA
AAGTGGTGATTGCTGTCGTTCCTGGTTGGGCTGTTGGCGGCGGCCATAGCTTACACGTGGTGTGTGACTTAACCCTAGCC
TCAAAAGAACACGCGGTATTTAAGCAAACCGACCCAGATGTTGGTAGTTTCGACTCTGGTTACGGTAGTGCTTACCTAGC
CAAGATGATTGGTCAAAAACGCGCTCGTGAAATCTTCTTCTTAGGTTTTAACTACACTGCTGAAGAAGCATTTGATATGG
GTATGGTTAACCGTGCTATACCGCATCAAGAATTGGAAGTTGAAGCATTAAAGTGGGCCAAAGAGATCAACTCTAAGTCA
CCGACTGCAATGCGCATGCTTAAATACGGCTTCAACCTCCCAGATGACGGCTTAGTGGGTCAGCAGCTATTTGCCGGTGA
AGCGACTCGCCTCGCTTATGGCACGGAAGAAGCGAGAGAAGGTCGTGACGCATTCCTTGAGAAGCGCGATCAAGACTTCT
CCTCTTTCCCGTGGCACTACTAA

Upstream 100 bases:

>100_bases
ACAGATCTCAGTTACTACATAAACTAGATTGACCTGAGATCTGATTAAGCCTAGCCTTTAGCGATTATTGTATTTCAGCG
ACATAAGAGGCTATAGGCTC

Downstream 100 bases:

>100_bases
TAGCAACCAGTATCGCTCCTAGCACTTAACTTGCTTATCTAAACCCATCAGTGAATTTCCTTTATTGATGGGTTTATCCT
GCTATATATAATCAAATTAT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTQQVSDIFDPELWDVVPGFDFEDVTYHRAKDQGTVRIAISRPDCLNSFRPKTVDELYIALDHARQWSDVGCVLLTGNGP
SAKGQWSFSAGGDQRIRGKDGYKYEGAEEGTPDVARMGRLHILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDLTLA
SKEHAVFKQTDPDVGSFDSGYGSAYLAKMIGQKRAREIFFLGFNYTAEEAFDMGMVNRAIPHQELEVEALKWAKEINSKS
PTAMRMLKYGFNLPDDGLVGQQLFAGEATRLAYGTEEAREGRDAFLEKRDQDFSSFPWHY

Sequences:

>Translated_300_residues
MTQQVSDIFDPELWDVVPGFDFEDVTYHRAKDQGTVRIAISRPDCLNSFRPKTVDELYIALDHARQWSDVGCVLLTGNGP
SAKGQWSFSAGGDQRIRGKDGYKYEGAEEGTPDVARMGRLHILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDLTLA
SKEHAVFKQTDPDVGSFDSGYGSAYLAKMIGQKRAREIFFLGFNYTAEEAFDMGMVNRAIPHQELEVEALKWAKEINSKS
PTAMRMLKYGFNLPDDGLVGQQLFAGEATRLAYGTEEAREGRDAFLEKRDQDFSSFPWHY
>Mature_299_residues
TQQVSDIFDPELWDVVPGFDFEDVTYHRAKDQGTVRIAISRPDCLNSFRPKTVDELYIALDHARQWSDVGCVLLTGNGPS
AKGQWSFSAGGDQRIRGKDGYKYEGAEEGTPDVARMGRLHILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDLTLAS
KEHAVFKQTDPDVGSFDSGYGSAYLAKMIGQKRAREIFFLGFNYTAEEAFDMGMVNRAIPHQELEVEALKWAKEINSKSP
TAMRMLKYGFNLPDDGLVGQQLFAGEATRLAYGTEEAREGRDAFLEKRDQDFSSFPWHY

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=286, Percent_Identity=28.6713286713287, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI31542718, Length=267, Percent_Identity=28.0898876404494, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI70995211, Length=254, Percent_Identity=28.3464566929134, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1788597, Length=290, Percent_Identity=45.5172413793103, Blast_Score=247, Evalue=8e-67,
Organism=Escherichia coli, GI87082183, Length=257, Percent_Identity=26.8482490272374, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787659, Length=271, Percent_Identity=27.3062730627306, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787660, Length=265, Percent_Identity=27.5471698113208, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI221142681, Length=270, Percent_Identity=25.9259259259259, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=266, Percent_Identity=27.4436090225564, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI25145438, Length=272, Percent_Identity=26.8382352941176, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540714, Length=223, Percent_Identity=26.457399103139, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129971, Length=264, Percent_Identity=26.5151515151515, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24653477, Length=264, Percent_Identity=26.5151515151515, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI19922422, Length=259, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24653139, Length=287, Percent_Identity=26.8292682926829, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 33595; Mature: 33464

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQVSDIFDPELWDVVPGFDFEDVTYHRAKDQGTVRIAISRPDCLNSFRPKTVDELYIA
CCCCHHHHCCCHHHHHCCCCCCCCCHHHHCCCCCEEEEEEECCHHHHCCCCCCHHHHHHH
LDHARQWSDVGCVLLTGNGPSAKGQWSFSAGGDQRIRGKDGYKYEGAEEGTPDVARMGRL
HHHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCEECCCCCCEECCCCCCCCHHHHHCCH
HILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDLTLASKEHAVFKQTDPDVGSFDSG
HHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEEEEEEEECCCCCCEEECCCCCCCCCCCC
YGSAYLAKMIGQKRAREIFFLGFNYTAEEAFDMGMVNRAIPHQELEVEALKWAKEINSKS
CCHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
PTAMRMLKYGFNLPDDGLVGQQLFAGEATRLAYGTEEAREGRDAFLEKRDQDFSSFPWHY
HHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TQQVSDIFDPELWDVVPGFDFEDVTYHRAKDQGTVRIAISRPDCLNSFRPKTVDELYIA
CCCHHHHCCCHHHHHCCCCCCCCCHHHHCCCCCEEEEEEECCHHHHCCCCCCHHHHHHH
LDHARQWSDVGCVLLTGNGPSAKGQWSFSAGGDQRIRGKDGYKYEGAEEGTPDVARMGRL
HHHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCEECCCCCCEECCCCCCCCHHHHHCCH
HILEVQRLIRFMPKVVIAVVPGWAVGGGHSLHVVCDLTLASKEHAVFKQTDPDVGSFDSG
HHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEEEEEEEECCCCCCEEECCCCCCCCCCCC
YGSAYLAKMIGQKRAREIFFLGFNYTAEEAFDMGMVNRAIPHQELEVEALKWAKEINSKS
CCHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
PTAMRMLKYGFNLPDDGLVGQQLFAGEATRLAYGTEEAREGRDAFLEKRDQDFSSFPWHY
HHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]