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The map label for this gene is mutM [H]

Identifier: 157963915

GI number: 157963915

Start: 4991397

End: 4992212

Strand: Direct

Name: mutM [H]

Synonym: Spea_4104

Alternate gene names: 157963915

Gene position: 4991397-4992212 (Clockwise)

Preceding gene: 157963914

Following gene: 157963932

Centisome position: 96.46

GC content: 50.25

Gene sequence:

>816_bases
ATGCCAGAACTCCCCGAAGTTGAAGTGACTCGACAAGGCGTATCCCCCTATCTCATCGACAACACAGTTACCGACTTAAT
CGTGCGTAATCCATCACTCAGATGGCCTGTGCCTGAGATAGCCAAACAGATCATCGGCCAGACGATTCGCAATGTGCGCC
GCCGTGCTAAATACCTTCTTATCGATACCGATGCGGGCACCACCATTGTGCATCTGGGGATGTCGGGCAGCTTACGAATA
CTGCCTGCTACCACACCGGCAGAGAAACACGATCATATCGATCTGGTGCTAGCGAGTGGTAAAGCCCTGCGCTTTAACGA
CCCGAGACGCTTCGGTGCTTGGCTATGGTGTGAACTGCCTGAACAAGCCCATCCATTATTGTCAAAATTAGGCCCAGAAC
CTCTCACTGACGCTTTTAACGCTCCTTACCTATTAGAGAGTTTGGCCAATAAGAAGAAGGCCATAAAGCTGTGCTTAATG
GACAATCATATCGTGGTTGGCGTAGGTAATATTTACGCTAACGAGGCGCTGTTTGCCGCTGGTATTCATCCGCAAGCAGA
AGCAGGTAAAGTCGATGCCGAGCGTATCGAGATCTTAGTCAGTGAAGTAAAACAAATCTTGGCGGGCGCGATTAAACAGG
GCGGTACAACACTTAAGGACTTTACCAATGCCGATGGTAAACCGGGCTACTTTGCCCAGAAGCTACATGTTTACGGCCGC
GGCGGCAAAACCTGCACTCAGTGTGGCCACATGCTCAGTGAAATTAAACTCGGCCAACGGGCAACGGTTTTCTGTAGCTT
GTGCCAGCAAAGATAA

Upstream 100 bases:

>100_bases
TATCCTGCGCGCACAGGTCAACGCTCGCTAGCTCTAGTCCATAGCCCATAGCCATCATCAAGCTATTTATAACAATAAAA
AATAACAAGAGAGAGAAGAC

Downstream 100 bases:

>100_bases
CCGGCTAGCACATAGCAAGTAACAGCTGATAAGCAAGGTTATTTCTCTTCAATAATCTCGCTGATCTGCTGTCTTAGCCG
AGTCTTATACAGATAAAAAG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPELPEVEVTRQGVSPYLIDNTVTDLIVRNPSLRWPVPEIAKQIIGQTIRNVRRRAKYLLIDTDAGTTIVHLGMSGSLRI
LPATTPAEKHDHIDLVLASGKALRFNDPRRFGAWLWCELPEQAHPLLSKLGPEPLTDAFNAPYLLESLANKKKAIKLCLM
DNHIVVGVGNIYANEALFAAGIHPQAEAGKVDAERIEILVSEVKQILAGAIKQGGTTLKDFTNADGKPGYFAQKLHVYGR
GGKTCTQCGHMLSEIKLGQRATVFCSLCQQR

Sequences:

>Translated_271_residues
MPELPEVEVTRQGVSPYLIDNTVTDLIVRNPSLRWPVPEIAKQIIGQTIRNVRRRAKYLLIDTDAGTTIVHLGMSGSLRI
LPATTPAEKHDHIDLVLASGKALRFNDPRRFGAWLWCELPEQAHPLLSKLGPEPLTDAFNAPYLLESLANKKKAIKLCLM
DNHIVVGVGNIYANEALFAAGIHPQAEAGKVDAERIEILVSEVKQILAGAIKQGGTTLKDFTNADGKPGYFAQKLHVYGR
GGKTCTQCGHMLSEIKLGQRATVFCSLCQQR
>Mature_270_residues
PELPEVEVTRQGVSPYLIDNTVTDLIVRNPSLRWPVPEIAKQIIGQTIRNVRRRAKYLLIDTDAGTTIVHLGMSGSLRIL
PATTPAEKHDHIDLVLASGKALRFNDPRRFGAWLWCELPEQAHPLLSKLGPEPLTDAFNAPYLLESLANKKKAIKLCLMD
NHIVVGVGNIYANEALFAAGIHPQAEAGKVDAERIEILVSEVKQILAGAIKQGGTTLKDFTNADGKPGYFAQKLHVYGRG
GKTCTQCGHMLSEIKLGQRATVFCSLCQQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=270, Percent_Identity=55.9259259259259, Blast_Score=313, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 29763; Mature: 29632

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVTRQGVSPYLIDNTVTDLIVRNPSLRWPVPEIAKQIIGQTIRNVRRRAKYLL
CCCCCCCHHHHCCCCCEEECCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEE
IDTDAGTTIVHLGMSGSLRILPATTPAEKHDHIDLVLASGKALRFNDPRRFGAWLWCELP
EECCCCCEEEEECCCCCEEEEECCCCCCCCCCEEEEEECCCEEECCCCHHHCCEEEEECC
EQAHPLLSKLGPEPLTDAFNAPYLLESLANKKKAIKLCLMDNHIVVGVGNIYANEALFAA
HHHHHHHHHCCCCCCHHHCCCCHHHHHHHCHHHEEEEEEECCEEEEEECCHHHCCEEEEE
GIHPQAEAGKVDAERIEILVSEVKQILAGAIKQGGTTLKDFTNADGKPGYFAQKLHVYGR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCEEEEEEEEEC
GGKTCTQCGHMLSEIKLGQRATVFCSLCQQR
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PELPEVEVTRQGVSPYLIDNTVTDLIVRNPSLRWPVPEIAKQIIGQTIRNVRRRAKYLL
CCCCCCHHHHCCCCCEEECCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEE
IDTDAGTTIVHLGMSGSLRILPATTPAEKHDHIDLVLASGKALRFNDPRRFGAWLWCELP
EECCCCCEEEEECCCCCEEEEECCCCCCCCCCEEEEEECCCEEECCCCHHHCCEEEEECC
EQAHPLLSKLGPEPLTDAFNAPYLLESLANKKKAIKLCLMDNHIVVGVGNIYANEALFAA
HHHHHHHHHCCCCCCHHHCCCCHHHHHHHCHHHEEEEEEECCEEEEEECCHHHCCEEEEE
GIHPQAEAGKVDAERIEILVSEVKQILAGAIKQGGTTLKDFTNADGKPGYFAQKLHVYGR
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCEEEEEEEEEC
GGKTCTQCGHMLSEIKLGQRATVFCSLCQQR
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA