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The map label for this gene is gor [H]

Identifier: 157963879

GI number: 157963879

Start: 4945269

End: 4946624

Strand: Direct

Name: gor [H]

Synonym: Spea_4068

Alternate gene names: 157963879

Gene position: 4945269-4946624 (Clockwise)

Preceding gene: 157963878

Following gene: 157963880

Centisome position: 95.57

GC content: 50.29

Gene sequence:

>1356_bases
ATGGCTCAACATTTTGATTATATCTGTCTTGGCGCAGGTAGCGGCGGCATTGCATCGGCTAACAGAGCAGCCATGCGCGG
CGCCAAAGTATTGCTTATCGAAGCAAAAGAGCTTGGCGGCACTTGTGTCAACGTAGGTTGCGTTCCTAAAAAAGTGATGT
GGTACGGCGCTCAAGTTGCTGAAGCCATGCACCTGTACGCTAAAGATTATGGCTTCGACGTAACCGTAAATAAGTTTGAC
TGGAGCACGCTGGTTGCTAGCCGCGAAGCCTATATCGACCGTATTCACGGATCTTACGATCGTGGCCTAGAAAGCAATGG
TGTCACCTTAGTGCGCGGCTATGGTCGCTTCGTCGATAGCCACACCATTGAAGTGAACGGCGAACACTACACTGCCGACA
ATATCTTAATCGCCACCGGCGGCGCGGCGACAATTCCGAACATTCCAGGTGCTGAACACGGTATCGATTCAGATGGTTTC
TTCGCGCTAGAAGCACAGCCTAAGCGTGTTGCCGTGGTTGGCGCGGGTTACATCGCCGTTGAAGTCGCAGGTGTATTACA
GGCGCTAGGCAGCGACACCCACCTATTTGTACGTAAACATGCACCACTGCGTAACTTCGACCCTATGCTAAGTGAAGCAC
TGATGGAGTCGATGGCGACTGATGGACCAACGCTACATACTCACAGCACCCCTGAGTCGGTCACCAAAAATGATGATGGC
AGCTTAACCCTTAAAATTGAAAATGGTGAAAGCTATGATGTTGATTGCCTTATCTGGGCGATCGGTCGACTTCCATCAAC
GGCTAATATCGGCCTTGAAAACACTAAGGTTGAACTCGATGCCAAGGGTTATGTGATCACCGACGAGCAGCAAAACACCA
CAGATGCTGGCATCTACTGTGTTGGCGATATTATGGCTGGCGGTGTAGAGCTAACGCCTGTAGCGGTTAAAGCCGGTCGC
CTACTGTCAGAGCGCTTATTCAATGGCATGACTGATGCCAAGATGGATTACAGCGTTATACCAACCGTGGTATTTAGTCA
CCCAGCAATTGGCACCATGGGTCTAACCCAACCAGAAGCTATTGCACAGTTCGGCGAAGAAAACGTAACCGTGTACACCT
CAGGTTTTACCTCTATGTACACAGCGGTAACTGCACACCGTCAGGCGTGTAAGATGAAGCTAGTGTGTGCGGGTGACAAC
CAAAAAGTAGTCGGTATTCACGGTATCGGTTACGGCATGGATGAAATTCTGCAAGGCTTCGGTGTAGCGATGAAGATGGG
CGCAACTAAGGCAGATTTTGATGCCGTCGTCGCGATTCACCCAACGGGTGCCGAAGAATTTGTTACCATGAGATAA

Upstream 100 bases:

>100_bases
ACCTTATTGAAACAATGAATGTGTTAAACATAATTACAGGTACAAAAGCCGCTATTTCTCTGCTTTTGTCCAACAGTTCG
CAACCTTATTGGAGATACAC

Downstream 100 bases:

>100_bases
TCTTCTGAATCAAAATAAAAAAAGCCGCTAAGTTAGCGGCTTTTTTGTATTCAAGGTTTGTCCCGTCCTGAGATAAGTTG
ACACATTGGAGACTTATCTA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MAQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKELGGTCVNVGCVPKKVMWYGAQVAEAMHLYAKDYGFDVTVNKFD
WSTLVASREAYIDRIHGSYDRGLESNGVTLVRGYGRFVDSHTIEVNGEHYTADNILIATGGAATIPNIPGAEHGIDSDGF
FALEAQPKRVAVVGAGYIAVEVAGVLQALGSDTHLFVRKHAPLRNFDPMLSEALMESMATDGPTLHTHSTPESVTKNDDG
SLTLKIENGESYDVDCLIWAIGRLPSTANIGLENTKVELDAKGYVITDEQQNTTDAGIYCVGDIMAGGVELTPVAVKAGR
LLSERLFNGMTDAKMDYSVIPTVVFSHPAIGTMGLTQPEAIAQFGEENVTVYTSGFTSMYTAVTAHRQACKMKLVCAGDN
QKVVGIHGIGYGMDEILQGFGVAMKMGATKADFDAVVAIHPTGAEEFVTMR

Sequences:

>Translated_451_residues
MAQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKELGGTCVNVGCVPKKVMWYGAQVAEAMHLYAKDYGFDVTVNKFD
WSTLVASREAYIDRIHGSYDRGLESNGVTLVRGYGRFVDSHTIEVNGEHYTADNILIATGGAATIPNIPGAEHGIDSDGF
FALEAQPKRVAVVGAGYIAVEVAGVLQALGSDTHLFVRKHAPLRNFDPMLSEALMESMATDGPTLHTHSTPESVTKNDDG
SLTLKIENGESYDVDCLIWAIGRLPSTANIGLENTKVELDAKGYVITDEQQNTTDAGIYCVGDIMAGGVELTPVAVKAGR
LLSERLFNGMTDAKMDYSVIPTVVFSHPAIGTMGLTQPEAIAQFGEENVTVYTSGFTSMYTAVTAHRQACKMKLVCAGDN
QKVVGIHGIGYGMDEILQGFGVAMKMGATKADFDAVVAIHPTGAEEFVTMR
>Mature_450_residues
AQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKELGGTCVNVGCVPKKVMWYGAQVAEAMHLYAKDYGFDVTVNKFDW
STLVASREAYIDRIHGSYDRGLESNGVTLVRGYGRFVDSHTIEVNGEHYTADNILIATGGAATIPNIPGAEHGIDSDGFF
ALEAQPKRVAVVGAGYIAVEVAGVLQALGSDTHLFVRKHAPLRNFDPMLSEALMESMATDGPTLHTHSTPESVTKNDDGS
LTLKIENGESYDVDCLIWAIGRLPSTANIGLENTKVELDAKGYVITDEQQNTTDAGIYCVGDIMAGGVELTPVAVKAGRL
LSERLFNGMTDAKMDYSVIPTVVFSHPAIGTMGLTQPEAIAQFGEENVTVYTSGFTSMYTAVTAHRQACKMKLVCAGDNQ
KVVGIHGIGYGMDEILQGFGVAMKMGATKADFDAVVAIHPTGAEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=51.0869565217391, Blast_Score=436, Evalue=1e-122,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=35.9477124183007, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI148277065, Length=432, Percent_Identity=37.037037037037, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI148277071, Length=432, Percent_Identity=37.037037037037, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI33519430, Length=432, Percent_Identity=37.037037037037, Blast_Score=254, Evalue=8e-68,
Organism=Homo sapiens, GI33519428, Length=432, Percent_Identity=37.037037037037, Blast_Score=254, Evalue=8e-68,
Organism=Homo sapiens, GI33519426, Length=432, Percent_Identity=37.037037037037, Blast_Score=254, Evalue=8e-68,
Organism=Homo sapiens, GI291045266, Length=458, Percent_Identity=33.6244541484716, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI291045268, Length=457, Percent_Identity=31.5098468271335, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=29.4372294372294, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=67.6274944567627, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI1786307, Length=453, Percent_Identity=27.5938189845475, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87082354, Length=468, Percent_Identity=25.6410256410256, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=21.6335540838852, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787114, Length=363, Percent_Identity=26.9972451790634, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=56.0975609756098, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=56.0975609756098, Blast_Score=449, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=35.1694915254237, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI71982272, Length=439, Percent_Identity=34.1685649202733, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI32565766, Length=465, Percent_Identity=28.3870967741935, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17559934, Length=194, Percent_Identity=25.2577319587629, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=49.4623655913978, Blast_Score=426, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=27.8969957081545, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=23.8900634249471, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=39.4904458598726, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=39.4904458598726, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=39.4904458598726, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=37.1308016877637, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=27.8260869565217, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48078; Mature: 47947

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKELGGTCVNVGCVPKKVMWYGAQVA
CCCCCCEEEEECCCCCCCCCCHHHHCCCEEEEEEEHHCCCEEEEECCCCHHHHHHHHHHH
EAMHLYAKDYGFDVTVNKFDWSTLVASREAYIDRIHGSYDRGLESNGVTLVRGYGRFVDS
HHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEEECCCCCCC
HTIEVNGEHYTADNILIATGGAATIPNIPGAEHGIDSDGFFALEAQPKRVAVVGAGYIAV
EEEEECCCEEECCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCHHHH
EVAGVLQALGSDTHLFVRKHAPLRNFDPMLSEALMESMATDGPTLHTHSTPESVTKNDDG
HHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCC
SLTLKIENGESYDVDCLIWAIGRLPSTANIGLENTKVELDAKGYVITDEQQNTTDAGIYC
EEEEEEECCCCCCCEEEEEEHHCCCCCCCCCCCCCEEEEECCCEEEECCCCCCCCCCEEE
VGDIMAGGVELTPVAVKAGRLLSERLFNGMTDAKMDYSVIPTVVFSHPAIGTMGLTQPEA
EEEHHCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCEECCCEEECCCCCCCCCCCCHHH
IAQFGEENVTVYTSGFTSMYTAVTAHRQACKMKLVCAGDNQKVVGIHGIGYGMDEILQGF
HHHCCCCCEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCCEEEEEEECCCCHHHHHHHC
GVAMKMGATKADFDAVVAIHPTGAEEFVTMR
CCEEECCCCCCCCCEEEEEECCCCHHEEECC
>Mature Secondary Structure 
AQHFDYICLGAGSGGIASANRAAMRGAKVLLIEAKELGGTCVNVGCVPKKVMWYGAQVA
CCCCCEEEEECCCCCCCCCCHHHHCCCEEEEEEEHHCCCEEEEECCCCHHHHHHHHHHH
EAMHLYAKDYGFDVTVNKFDWSTLVASREAYIDRIHGSYDRGLESNGVTLVRGYGRFVDS
HHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEEECCCCCCC
HTIEVNGEHYTADNILIATGGAATIPNIPGAEHGIDSDGFFALEAQPKRVAVVGAGYIAV
EEEEECCCEEECCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCHHHH
EVAGVLQALGSDTHLFVRKHAPLRNFDPMLSEALMESMATDGPTLHTHSTPESVTKNDDG
HHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCC
SLTLKIENGESYDVDCLIWAIGRLPSTANIGLENTKVELDAKGYVITDEQQNTTDAGIYC
EEEEEEECCCCCCCEEEEEEHHCCCCCCCCCCCCCEEEEECCCEEEECCCCCCCCCCEEE
VGDIMAGGVELTPVAVKAGRLLSERLFNGMTDAKMDYSVIPTVVFSHPAIGTMGLTQPEA
EEEHHCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCEECCCEEECCCCCCCCCCCCHHH
IAQFGEENVTVYTSGFTSMYTAVTAHRQACKMKLVCAGDNQKVVGIHGIGYGMDEILQGF
HHHCCCCCEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCCEEEEEEECCCCHHHHHHHC
GVAMKMGATKADFDAVVAIHPTGAEEFVTMR
CCEEECCCCCCCCCEEEEEECCCCHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]