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The map label for this gene is caiT [H]

Identifier: 157963849

GI number: 157963849

Start: 4903734

End: 4905293

Strand: Reverse

Name: caiT [H]

Synonym: Spea_4038

Alternate gene names: 157963849

Gene position: 4905293-4903734 (Counterclockwise)

Preceding gene: 157963857

Following gene: 157963848

Centisome position: 94.8

GC content: 44.74

Gene sequence:

>1560_bases
ATGAACGATAAAACGATGGATGTAAATGCCACCGAAGTAAAAAAGAAGAAGGTCACGATTGACCCTGTTATCTTTTTCCC
TTCATTGCTTGCGGTCATATTACTGTCTTATTTGACGGTAAGAGACTTGGATGCCGCTAATTTAGCTATCAGCGAAGTCT
TCCACTATTTAACTCACTCTTGGGGATGGCTTTTTGAGTGGTACATGATCTTCATGGGAGCCGGTTGGGCCTGGTTGACC
TGGGGACCATATTCTAACAATCGCTTAGGTCAAGAAGCACCAGAATTTAGTACAGCAAGCTGGATATTCCTGATGTTTGC
TTCGTGTACCTCCGCAGCGGTGTTGTTCTGGGGCTCACTAGAAGTCTATTACTATGTTACTTACCCACCTTTTGATATTG
AGCCTTTGTCTATTCAAGCCAAAGAGCTAGGACTTGCATACAGTCTATTCCATTGGGGACCACTTCCTTGGATGGGTTAC
GGCTTCTTTACTGTTGCTTTGGGTTACTTCCTATTCGTTAAGAAGATGGATGTGGTTCGTCCAAGTGGCACTTTAGAGCC
TGTATTAGGTAAGCATCACAAAGGCTTTATCGGGATCTTTATCGATAACGTTTATGTTGTTGCATTGATCCTTGCTATGG
GTACCAGCTTAGGTTTGGCCACTCCGCTAGTAACTGAGTGTATTCAATGGTTATTTGGTATTCCACGTACCTCGGCAGTT
GACACTATCGTTATCTCTTCATGGATTGTATTCAACGCTATCTGTGTCGCTTTTGGTCTGACTAAAGGCATTAAGATCGC
CAGTGATTTAAGAAGTTATTTAAGCATCATCATGCTGGTTTGGGTATTCCTTATTGGCGCAACCAGTTTCACAGTGAACT
ATTTCACTGACTCTGTGGGCATCATGTTGGAACTACTTCCTCGCATGTTGTTCAACACGGCTTCAGTTAGTGAAGGCAGC
TTCCCGCAAGATTGGACCGTATTCTACTGGGCTTGGTGGGTCGTGTATGGCATCCAGATGTGTATCTTCTTAGCTAAGAT
CTCTCGTGGCCGTACCGTACGTGAACTTTGTTTAACTATGGTTGCTGGTTTGACTGCTTCTACCTGGTTCCTTTGGACCA
TCCTAGGTAGTAATACCATGAACTTGATGAATGAAAATCTCATCAATATGCCTCAACTGATTGAACAATATGGTGCTGCT
AGGGCCATTATCGAAACCTGGGCCGCATTACCGTTCAGCACTATCACTATGTGGGGCTTCTTCATCTTATGTTTCCTTGC
AACAGTGACCCTAGTTAACGCCTGTTCCTACACCTTAGCCATGTCGACCTGTAAAGGCGCCGACGCCGACAACGAGCCAC
CAATCTGGGTTCGTGTAGGTTGGTCTGTACTTGTGGGTGTTATCGGTATCGTTCTGTTATCACTCGGTGGCTTGAAGCCA
CTGCAAACGGCAATCATTGCCGGTGGTGCACCACTGATTATCGTCAACGTCATGATCATCATCTCTTTCTTGAAAGATGC
TCGTAAAAATAATTGGAAACCTGTCGGTGAAGAGGCTTAG

Upstream 100 bases:

>100_bases
TTGAATTTTGTTCTGAAAAATAAATAAAGTTGGTTCGATAGCTACTCAGTTTAAAACTTTAACTATTATCCTCCTAAAAC
AGAGAGGGAGAAGTATTGAT

Downstream 100 bases:

>100_bases
CCACACCTGGGATCCACAGTTGAAATTTAGAGGAATAAATAATGGATTTTAAATTAACCGACGAACAAGAGCTTTTTGTT
GCAGGTATTCGTGACCTGAT

Product: L-carnitine/gamma-butyrobetaine antiporter

Products: Proton [Cytoplasm]; L-carnitine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MNDKTMDVNATEVKKKKVTIDPVIFFPSLLAVILLSYLTVRDLDAANLAISEVFHYLTHSWGWLFEWYMIFMGAGWAWLT
WGPYSNNRLGQEAPEFSTASWIFLMFASCTSAAVLFWGSLEVYYYVTYPPFDIEPLSIQAKELGLAYSLFHWGPLPWMGY
GFFTVALGYFLFVKKMDVVRPSGTLEPVLGKHHKGFIGIFIDNVYVVALILAMGTSLGLATPLVTECIQWLFGIPRTSAV
DTIVISSWIVFNAICVAFGLTKGIKIASDLRSYLSIIMLVWVFLIGATSFTVNYFTDSVGIMLELLPRMLFNTASVSEGS
FPQDWTVFYWAWWVVYGIQMCIFLAKISRGRTVRELCLTMVAGLTASTWFLWTILGSNTMNLMNENLINMPQLIEQYGAA
RAIIETWAALPFSTITMWGFFILCFLATVTLVNACSYTLAMSTCKGADADNEPPIWVRVGWSVLVGVIGIVLLSLGGLKP
LQTAIIAGGAPLIIVNVMIIISFLKDARKNNWKPVGEEA

Sequences:

>Translated_519_residues
MNDKTMDVNATEVKKKKVTIDPVIFFPSLLAVILLSYLTVRDLDAANLAISEVFHYLTHSWGWLFEWYMIFMGAGWAWLT
WGPYSNNRLGQEAPEFSTASWIFLMFASCTSAAVLFWGSLEVYYYVTYPPFDIEPLSIQAKELGLAYSLFHWGPLPWMGY
GFFTVALGYFLFVKKMDVVRPSGTLEPVLGKHHKGFIGIFIDNVYVVALILAMGTSLGLATPLVTECIQWLFGIPRTSAV
DTIVISSWIVFNAICVAFGLTKGIKIASDLRSYLSIIMLVWVFLIGATSFTVNYFTDSVGIMLELLPRMLFNTASVSEGS
FPQDWTVFYWAWWVVYGIQMCIFLAKISRGRTVRELCLTMVAGLTASTWFLWTILGSNTMNLMNENLINMPQLIEQYGAA
RAIIETWAALPFSTITMWGFFILCFLATVTLVNACSYTLAMSTCKGADADNEPPIWVRVGWSVLVGVIGIVLLSLGGLKP
LQTAIIAGGAPLIIVNVMIIISFLKDARKNNWKPVGEEA
>Mature_519_residues
MNDKTMDVNATEVKKKKVTIDPVIFFPSLLAVILLSYLTVRDLDAANLAISEVFHYLTHSWGWLFEWYMIFMGAGWAWLT
WGPYSNNRLGQEAPEFSTASWIFLMFASCTSAAVLFWGSLEVYYYVTYPPFDIEPLSIQAKELGLAYSLFHWGPLPWMGY
GFFTVALGYFLFVKKMDVVRPSGTLEPVLGKHHKGFIGIFIDNVYVVALILAMGTSLGLATPLVTECIQWLFGIPRTSAV
DTIVISSWIVFNAICVAFGLTKGIKIASDLRSYLSIIMLVWVFLIGATSFTVNYFTDSVGIMLELLPRMLFNTASVSEGS
FPQDWTVFYWAWWVVYGIQMCIFLAKISRGRTVRELCLTMVAGLTASTWFLWTILGSNTMNLMNENLINMPQLIEQYGAA
RAIIETWAALPFSTITMWGFFILCFLATVTLVNACSYTLAMSTCKGADADNEPPIWVRVGWSVLVGVIGIVLLSLGGLKP
LQTAIIAGGAPLIIVNVMIIISFLKDARKNNWKPVGEEA

Specific function: Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786224, Length=501, Percent_Identity=69.2614770459082, Blast_Score=727, Evalue=0.0,
Organism=Escherichia coli, GI1788102, Length=443, Percent_Identity=26.1851015801354, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786506, Length=510, Percent_Identity=26.6666666666667, Blast_Score=173, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 57931; Mature: 57931

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKTMDVNATEVKKKKVTIDPVIFFPSLLAVILLSYLTVRDLDAANLAISEVFHYLTHS
CCCCEECCCHHHHHHHCEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WGWLFEWYMIFMGAGWAWLTWGPYSNNRLGQEAPEFSTASWIFLMFASCTSAAVLFWGSL
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECE
EVYYYVTYPPFDIEPLSIQAKELGLAYSLFHWGPLPWMGYGFFTVALGYFLFVKKMDVVR
EEEEEEEECCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PSGTLEPVLGKHHKGFIGIFIDNVYVVALILAMGTSLGLATPLVTECIQWLFGIPRTSAV
CCCCCCHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHH
DTIVISSWIVFNAICVAFGLTKGIKIASDLRSYLSIIMLVWVFLIGATSFTVNYFTDSVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHH
IMLELLPRMLFNTASVSEGSFPQDWTVFYWAWWVVYGIQMCIFLAKISRGRTVRELCLTM
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VAGLTASTWFLWTILGSNTMNLMNENLINMPQLIEQYGAARAIIETWAALPFSTITMWGF
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHH
FILCFLATVTLVNACSYTLAMSTCKGADADNEPPIWVRVGWSVLVGVIGIVLLSLGGLKP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCH
LQTAIIAGGAPLIIVNVMIIISFLKDARKNNWKPVGEEA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNDKTMDVNATEVKKKKVTIDPVIFFPSLLAVILLSYLTVRDLDAANLAISEVFHYLTHS
CCCCEECCCHHHHHHHCEEECHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WGWLFEWYMIFMGAGWAWLTWGPYSNNRLGQEAPEFSTASWIFLMFASCTSAAVLFWGSL
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECE
EVYYYVTYPPFDIEPLSIQAKELGLAYSLFHWGPLPWMGYGFFTVALGYFLFVKKMDVVR
EEEEEEEECCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PSGTLEPVLGKHHKGFIGIFIDNVYVVALILAMGTSLGLATPLVTECIQWLFGIPRTSAV
CCCCCCHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHH
DTIVISSWIVFNAICVAFGLTKGIKIASDLRSYLSIIMLVWVFLIGATSFTVNYFTDSVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHHHH
IMLELLPRMLFNTASVSEGSFPQDWTVFYWAWWVVYGIQMCIFLAKISRGRTVRELCLTM
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VAGLTASTWFLWTILGSNTMNLMNENLINMPQLIEQYGAARAIIETWAALPFSTITMWGF
HHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHH
FILCFLATVTLVNACSYTLAMSTCKGADADNEPPIWVRVGWSVLVGVIGIVLLSLGGLKP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCH
LQTAIIAGGAPLIIVNVMIIISFLKDARKNNWKPVGEEA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-carnitine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-carnitine [Periplasm] = Proton [Cytoplasm] + L-carnitine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA