Click here to switch to the map view.

The map label for this gene is caiB [H]

Identifier: 157963847

GI number: 157963847

Start: 4901099

End: 4902361

Strand: Reverse

Name: caiB [H]

Synonym: Spea_4036

Alternate gene names: 157963847

Gene position: 4902361-4901099 (Counterclockwise)

Preceding gene: 157963848

Following gene: 157963846

Centisome position: 94.74

GC content: 45.53

Gene sequence:

>1263_bases
ATGAATTTTGTTCGAAAATTAAGAGAGATGGGTATCATGTCAAATAAATTGTCCACACCTGCGTTCGGTCCTCTTGCTGG
TTTGAGAGTAGTATTTTCAGGTATTGAAATTGCGGGTCCATTCGCGGCGCAAATGCTTGCAGAGTGGGGCGCAGAGGTGA
TCTGGATTGAGAACGTGGCCTATGCGGATACTATCCGTGTACAGCCAAACTACCCAGAGCTATCACGTCGTAACCTTCAC
GCATTATCACTAAATATTTTTAAAGATGAAGGCCGTGATGCATTCCTGAAATTGATGGAAACCACTGACATCTTTATTGA
AGCCAGTAAAGGCCCAGCATTCGCTCGTCGTGGTATTACCGACGAAGTGTTATGGGAACAGAACAAAAAGTTAGTGATTG
CTCACTTATCTGGTTTCGGCCAGTACGGCACTGATGAGTATACTAATCTACCAGCCTACAACACGATTGCTCAGGCATTC
AGTGGCTACCTTATTCAGAATGGCGACGTTGATCAGCCAATGCCTGCTTTCCCGTACACAGCGGATTACTTCTCAGGTAT
GACGGCAACCACTTCGGCACTTGCGGCTCTATACCGTGTACGTGAAACCGGTGTAGGTGAAAGTATCGACGTGGCTATGT
ATGAAGTTATGCTACGCATGGGTCAGTACTTCATGATGGATCACTTCAACGGCGGCGAAGTTTGCCCACGTATGACCAAG
GGTAAAGACCCTTACTATGCAGGTTGTGGCCTATATAAGTGTGAAGATGGCTATATCGTGATGGAGCTTGTTGGCGGTAT
GCAAATCAAAGAGATGTTCAAGGATATGGATATCATGCACTTATATGGTGGTGAGGAGGTTCCTGAAGGTACCCAGCTCA
TTCATCGTATTGAATGTCCATTCGGCTATCAAGTTGAAGATGCATTAGACGAATACTTAGCGCACAAGAGTATCGAAGAG
GTGTTAGCACGCTTTGCTGAGCTAAACGTAGCGTGTGCGAAAGTGTTGACCATTCCAGAGCTCGACAGCAATCCACAGTA
TATTGCCCGTGAATCGATTACAGAGTGGAAGAACATCGACGGTAAGACCTATAGAGGTCCTAATGTGATGCCTAAGTTCA
AGAACAACCCAGGCCAAATTTGGCGTGGTATGCCAAAGCACGGTATGGATACTGCAGCAATCTTGGAAGATATCGGTTAC
TCACAAGAGCAAATTCAGAGCTTAAGCGAAAAAGGCTTAGCAAAAGTATCTGAGTGTAAGTGA

Upstream 100 bases:

>100_bases
CAGATCGACACTGCTACTCAAATCCTAACTTATTCGCCGTTCACCTCTGTTGCGTTAGAACAATCCCAATAATGACTGTC
TTCTCGGCACAGTAGCCGTG

Downstream 100 bases:

>100_bases
GGCTAGAAGAATGGATATCGTTGGTAGCAAAACATTAAGATGCATGTGGGAAGAGCGTGCTCGCAAATTCAGTAATAACA
CAGCGTTGGTTTATGAGGAT

Product: crotonobetainyl-CoA:carnitine CoA-transferase

Products: 4-(Trimethylammonio)But-2-Enoate; H2O; crotonobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MNFVRKLREMGIMSNKLSTPAFGPLAGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVAYADTIRVQPNYPELSRRNLH
ALSLNIFKDEGRDAFLKLMETTDIFIEASKGPAFARRGITDEVLWEQNKKLVIAHLSGFGQYGTDEYTNLPAYNTIAQAF
SGYLIQNGDVDQPMPAFPYTADYFSGMTATTSALAALYRVRETGVGESIDVAMYEVMLRMGQYFMMDHFNGGEVCPRMTK
GKDPYYAGCGLYKCEDGYIVMELVGGMQIKEMFKDMDIMHLYGGEEVPEGTQLIHRIECPFGYQVEDALDEYLAHKSIEE
VLARFAELNVACAKVLTIPELDSNPQYIARESITEWKNIDGKTYRGPNVMPKFKNNPGQIWRGMPKHGMDTAAILEDIGY
SQEQIQSLSEKGLAKVSECK

Sequences:

>Translated_420_residues
MNFVRKLREMGIMSNKLSTPAFGPLAGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVAYADTIRVQPNYPELSRRNLH
ALSLNIFKDEGRDAFLKLMETTDIFIEASKGPAFARRGITDEVLWEQNKKLVIAHLSGFGQYGTDEYTNLPAYNTIAQAF
SGYLIQNGDVDQPMPAFPYTADYFSGMTATTSALAALYRVRETGVGESIDVAMYEVMLRMGQYFMMDHFNGGEVCPRMTK
GKDPYYAGCGLYKCEDGYIVMELVGGMQIKEMFKDMDIMHLYGGEEVPEGTQLIHRIECPFGYQVEDALDEYLAHKSIEE
VLARFAELNVACAKVLTIPELDSNPQYIARESITEWKNIDGKTYRGPNVMPKFKNNPGQIWRGMPKHGMDTAAILEDIGY
SQEQIQSLSEKGLAKVSECK
>Mature_420_residues
MNFVRKLREMGIMSNKLSTPAFGPLAGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVAYADTIRVQPNYPELSRRNLH
ALSLNIFKDEGRDAFLKLMETTDIFIEASKGPAFARRGITDEVLWEQNKKLVIAHLSGFGQYGTDEYTNLPAYNTIAQAF
SGYLIQNGDVDQPMPAFPYTADYFSGMTATTSALAALYRVRETGVGESIDVAMYEVMLRMGQYFMMDHFNGGEVCPRMTK
GKDPYYAGCGLYKCEDGYIVMELVGGMQIKEMFKDMDIMHLYGGEEVPEGTQLIHRIECPFGYQVEDALDEYLAHKSIEE
VLARFAELNVACAKVLTIPELDSNPQYIARESITEWKNIDGKTYRGPNVMPKFKNNPGQIWRGMPKHGMDTAAILEDIGY
SQEQIQSLSEKGLAKVSECK

Specific function: Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl- CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl- CoA or L-

COG id: COG1804

COG function: function code C; Predicted acyl-CoA transferases/carnitine dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CaiB/BaiF CoA-transferase family [H]

Homologues:

Organism=Homo sapiens, GI42794625, Length=406, Percent_Identity=24.8768472906404, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI266456254, Length=395, Percent_Identity=25.3164556962025, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI300863128, Length=273, Percent_Identity=25.2747252747253, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI300863124, Length=273, Percent_Identity=25.2747252747253, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI266458397, Length=273, Percent_Identity=26.3736263736264, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI266458393, Length=241, Percent_Identity=27.3858921161826, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786222, Length=404, Percent_Identity=82.1782178217822, Blast_Score=689, Evalue=0.0,
Organism=Escherichia coli, GI87082093, Length=396, Percent_Identity=26.2626262626263, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788717, Length=414, Percent_Identity=24.6376811594203, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32564160, Length=347, Percent_Identity=23.9193083573487, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115535051, Length=339, Percent_Identity=22.4188790560472, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24648431, Length=408, Percent_Identity=23.2843137254902, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003673 [H]

Pfam domain/function: PF02515 CoA_transf_3 [H]

EC number: 2.8.3.- [C]

Molecular weight: Translated: 47086; Mature: 47086

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFVRKLREMGIMSNKLSTPAFGPLAGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVA
CCHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECEE
YADTIRVQPNYPELSRRNLHALSLNIFKDEGRDAFLKLMETTDIFIEASKGPAFARRGIT
EEEEEEECCCCCCHHHCCEEEEEEEEEECCCHHHHHHHHHHCEEEEECCCCCHHHHCCCC
DEVLWEQNKKLVIAHLSGFGQYGTDEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYT
HHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCC
ADYFSGMTATTSALAALYRVRETGVGESIDVAMYEVMLRMGQYFMMDHFNGGEVCPRMTK
HHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCC
GKDPYYAGCGLYKCEDGYIVMELVGGMQIKEMFKDMDIMHLYGGEEVPEGTQLIHRIECP
CCCCCEECCCEEEECCCEEEEHHHCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCC
FGYQVEDALDEYLAHKSIEEVLARFAELNVACAKVLTIPELDSNPQYIARESITEWKNID
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCC
GKTYRGPNVMPKFKNNPGQIWRGMPKHGMDTAAILEDIGYSQEQIQSLSEKGLAKVSECK
CCEECCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure
MNFVRKLREMGIMSNKLSTPAFGPLAGLRVVFSGIEIAGPFAAQMLAEWGAEVIWIENVA
CCHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECEE
YADTIRVQPNYPELSRRNLHALSLNIFKDEGRDAFLKLMETTDIFIEASKGPAFARRGIT
EEEEEEECCCCCCHHHCCEEEEEEEEEECCCHHHHHHHHHHCEEEEECCCCCHHHHCCCC
DEVLWEQNKKLVIAHLSGFGQYGTDEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYT
HHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCC
ADYFSGMTATTSALAALYRVRETGVGESIDVAMYEVMLRMGQYFMMDHFNGGEVCPRMTK
HHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCC
GKDPYYAGCGLYKCEDGYIVMELVGGMQIKEMFKDMDIMHLYGGEEVPEGTQLIHRIECP
CCCCCEECCCEEEECCCEEEEHHHCCHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHCCC
FGYQVEDALDEYLAHKSIEEVLARFAELNVACAKVLTIPELDSNPQYIARESITEWKNID
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCCC
GKTYRGPNVMPKFKNNPGQIWRGMPKHGMDTAAILEDIGYSQEQIQSLSEKGLAKVSECK
CCEECCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Carnitine; L-carnitinyl-CoA [C]

Specific reaction: L-Carnitine = 4-(Trimethylammonio)But-2-Enoate + H2O. L-carnitinyl-CoA = H2O + crotonobetainyl-CoA [C]

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA