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The map label for this gene is cpxA [H]

Identifier: 157963745

GI number: 157963745

Start: 4782070

End: 4783446

Strand: Direct

Name: cpxA [H]

Synonym: Spea_3934

Alternate gene names: 157963745

Gene position: 4782070-4783446 (Clockwise)

Preceding gene: 157963744

Following gene: 157963747

Centisome position: 92.41

GC content: 48.58

Gene sequence:

>1377_bases
ATGCAGCTAACAAAAACCCCCAACAATATATTCGTCAAGCTACTGCTGGGTTTTTGGCTGTGTAGCTCCTTGATCATAGC
CCTTATCGGCATGCTGCCGTTATTACAGCAAAACCATGATCAATCTGCGATTCCAGCTCCGTTAGAACGTTTACTGGAAA
AAAGTGCCAAACGCATCAGCCAAAACCCACAAATTCTTAATTCAGACAAGCTCACCCATTGGAGTCGCTTTAAAGAATTC
AAAGGTCGCCCTGCCCGCATCTACTTAGTCGACGAATACGGTAAGGTGCTCAATAGCCATAAGTCATCACGTTCACTGAG
GCGCTTTATGCTGATGGCCGATGAAGCGGGCCATCCAATTAAACATCAATTTAGGGATGAGCTGATTTTCGGCCCTTATA
ACTTTGAGATAAAAGGTAAGCCTTACAGCCTATACGGCCGCTTACCAGAACATCATCCAAGGCCTTGGTTCTTCTTCTTT
ATCGACAATAAGATCCTCACATTGAGCATTGCCATTATCTTATCTGGCCTGCTCTGCGGACTATTTGCCTGGCATCTCGG
TAAGCCGTTGCGCTCACTAAAGCGCAGCGCCGATGCACTCGCAGCTGGCGACTTAAGCAGCCGTGTTGATATGGCAACAG
CCCTGCGTAACGACGAAGTTGGCCAATTAGCTCAAGCCTTTAATGGCATGGCTAACTCGGTTGAAGATATGGTTAACAGC
CAGCAGAGGTTGATTAGCGATATCTCTCATGAGCTGCGCACCCCGCTAACAAGGCTCAAGCTCTCTTTGGCACTGAGTCG
TAAGAAGGGGCAAGAAACACCAGAGATGAAGCGAATTGAGTATGAAGCCGATCAACTCGAGCAGATGATTGCCGAGCTGT
TAGAGCTGTCTAGGGTGAAGCTCAATGCCAACGAGAATAAACGCAGTCTTGAGCTGGCCGAAACCTTAAGCCAAGTCTTG
GACGATGCCGATTTCGAAGCGCAGCAACAGCAAAAGCAGCTGCATATCGATATCGATGAATCTATCGTGATACCGCTTTA
CCCTAGGCCCTTATCTAGAGCGGTAGAGAACCTGCTCAGAAATGCGATTCGTTACGCCAATACCCAAGTCTCAATTCAAG
CCATGGCCAGTGCCAGTGCCAGCGGCGTGCAGATTGAGATTATCGATGATGGCCCAGGCATTAGCGACGAAGCCGACTTA
GAAGCGATATTCAAGCCTTTCTATCGACCACAATCGGCGCGAGAACGGGAGTCTGGCGGCTGGGGGTTAGGTTTGGCGAT
TGCCAAGGCGGCAATTCAAGCCCATCAAGGCAAGATCACCGCAGTCAATCAACAACCTAGCGGATTAAAGATCAACATTC
ACTTGCCTCAAAAGTAA

Upstream 100 bases:

>100_bases
CATGCACCTTTCTAACCTGCGTAAGAAGATGCCAGAGCGTGATGATGGCCGCCCTCGAGTGAAAACTATTCGTGGTAAAG
GCTACATTTGGTTACCTTAA

Downstream 100 bases:

>100_bases
GCGCTCTGCCAGCATCTAAGCTGCGTTTGCCGCAGGCTCAAGCCGGGCAAGCCAGCTGGCATAGTCCGCCAGCTTTGGAA
TGCGCTTATCTGAGTGCCCC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MQLTKTPNNIFVKLLLGFWLCSSLIIALIGMLPLLQQNHDQSAIPAPLERLLEKSAKRISQNPQILNSDKLTHWSRFKEF
KGRPARIYLVDEYGKVLNSHKSSRSLRRFMLMADEAGHPIKHQFRDELIFGPYNFEIKGKPYSLYGRLPEHHPRPWFFFF
IDNKILTLSIAIILSGLLCGLFAWHLGKPLRSLKRSADALAAGDLSSRVDMATALRNDEVGQLAQAFNGMANSVEDMVNS
QQRLISDISHELRTPLTRLKLSLALSRKKGQETPEMKRIEYEADQLEQMIAELLELSRVKLNANENKRSLELAETLSQVL
DDADFEAQQQQKQLHIDIDESIVIPLYPRPLSRAVENLLRNAIRYANTQVSIQAMASASASGVQIEIIDDGPGISDEADL
EAIFKPFYRPQSARERESGGWGLGLAIAKAAIQAHQGKITAVNQQPSGLKINIHLPQK

Sequences:

>Translated_458_residues
MQLTKTPNNIFVKLLLGFWLCSSLIIALIGMLPLLQQNHDQSAIPAPLERLLEKSAKRISQNPQILNSDKLTHWSRFKEF
KGRPARIYLVDEYGKVLNSHKSSRSLRRFMLMADEAGHPIKHQFRDELIFGPYNFEIKGKPYSLYGRLPEHHPRPWFFFF
IDNKILTLSIAIILSGLLCGLFAWHLGKPLRSLKRSADALAAGDLSSRVDMATALRNDEVGQLAQAFNGMANSVEDMVNS
QQRLISDISHELRTPLTRLKLSLALSRKKGQETPEMKRIEYEADQLEQMIAELLELSRVKLNANENKRSLELAETLSQVL
DDADFEAQQQQKQLHIDIDESIVIPLYPRPLSRAVENLLRNAIRYANTQVSIQAMASASASGVQIEIIDDGPGISDEADL
EAIFKPFYRPQSARERESGGWGLGLAIAKAAIQAHQGKITAVNQQPSGLKINIHLPQK
>Mature_458_residues
MQLTKTPNNIFVKLLLGFWLCSSLIIALIGMLPLLQQNHDQSAIPAPLERLLEKSAKRISQNPQILNSDKLTHWSRFKEF
KGRPARIYLVDEYGKVLNSHKSSRSLRRFMLMADEAGHPIKHQFRDELIFGPYNFEIKGKPYSLYGRLPEHHPRPWFFFF
IDNKILTLSIAIILSGLLCGLFAWHLGKPLRSLKRSADALAAGDLSSRVDMATALRNDEVGQLAQAFNGMANSVEDMVNS
QQRLISDISHELRTPLTRLKLSLALSRKKGQETPEMKRIEYEADQLEQMIAELLELSRVKLNANENKRSLELAETLSQVL
DDADFEAQQQQKQLHIDIDESIVIPLYPRPLSRAVENLLRNAIRYANTQVSIQAMASASASGVQIEIIDDGPGISDEADL
EAIFKPFYRPQSARERESGGWGLGLAIAKAAIQAHQGKITAVNQQPSGLKINIHLPQK

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=381, Percent_Identity=40.4199475065617, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1787894, Length=327, Percent_Identity=31.1926605504587, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1786783, Length=330, Percent_Identity=31.5151515151515, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788393, Length=271, Percent_Identity=33.210332103321, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789808, Length=240, Percent_Identity=29.1666666666667, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=30.8333333333333, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=25.6637168141593, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=24.7457627118644, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=28.4403669724771, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790551, Length=300, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788279, Length=285, Percent_Identity=25.2631578947368, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI145693157, Length=261, Percent_Identity=25.2873563218391, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=24, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789149, Length=354, Percent_Identity=23.728813559322, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789403, Length=274, Percent_Identity=27.7372262773723, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51564; Mature: 51564

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTKTPNNIFVKLLLGFWLCSSLIIALIGMLPLLQQNHDQSAIPAPLERLLEKSAKRIS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
QNPQILNSDKLTHWSRFKEFKGRPARIYLVDEYGKVLNSHKSSRSLRRFMLMADEAGHPI
CCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHCCHHHHHHHHHHHHHCCCCCCH
KHQFRDELIFGPYNFEIKGKPYSLYGRLPEHHPRPWFFFFIDNKILTLSIAIILSGLLCG
HHHHHHCEEECCEEEEECCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
LFAWHLGKPLRSLKRSADALAAGDLSSRVDMATALRNDEVGQLAQAFNGMANSVEDMVNS
HHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QQRLISDISHELRTPLTRLKLSLALSRKKGQETPEMKRIEYEADQLEQMIAELLELSRVK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHEE
LNANENKRSLELAETLSQVLDDADFEAQQQQKQLHIDIDESIVIPLYPRPLSRAVENLLR
ECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEECCCCEEEEECCCHHHHHHHHHHH
NAIRYANTQVSIQAMASASASGVQIEIIDDGPGISDEADLEAIFKPFYRPQSARERESGG
HHHHHCCCCEEEHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHCCCC
WGLGLAIAKAAIQAHQGKITAVNQQPSGLKINIHLPQK
CHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCC
>Mature Secondary Structure
MQLTKTPNNIFVKLLLGFWLCSSLIIALIGMLPLLQQNHDQSAIPAPLERLLEKSAKRIS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHC
QNPQILNSDKLTHWSRFKEFKGRPARIYLVDEYGKVLNSHKSSRSLRRFMLMADEAGHPI
CCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHCCHHHHHHHHHHHHHCCCCCCH
KHQFRDELIFGPYNFEIKGKPYSLYGRLPEHHPRPWFFFFIDNKILTLSIAIILSGLLCG
HHHHHHCEEECCEEEEECCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
LFAWHLGKPLRSLKRSADALAAGDLSSRVDMATALRNDEVGQLAQAFNGMANSVEDMVNS
HHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
QQRLISDISHELRTPLTRLKLSLALSRKKGQETPEMKRIEYEADQLEQMIAELLELSRVK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHEE
LNANENKRSLELAETLSQVLDDADFEAQQQQKQLHIDIDESIVIPLYPRPLSRAVENLLR
ECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEECCCCEEEEECCCHHHHHHHHHHH
NAIRYANTQVSIQAMASASASGVQIEIIDDGPGISDEADLEAIFKPFYRPQSARERESGG
HHHHHCCCCEEEHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHCCCC
WGLGLAIAKAAIQAHQGKITAVNQQPSGLKINIHLPQK
CHHHHHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]