Click here to switch to the map view.

The map label for this gene is ftsI [H]

Identifier: 157963628

GI number: 157963628

Start: 4641505

End: 4643241

Strand: Reverse

Name: ftsI [H]

Synonym: Spea_3817

Alternate gene names: 157963628

Gene position: 4643241-4641505 (Counterclockwise)

Preceding gene: 157963629

Following gene: 157963627

Centisome position: 89.73

GC content: 47.21

Gene sequence:

>1737_bases
ATGAGCAAACAGGCGAAACGTAAACAAAAACCACAATTAATCCAATGGCGTTTATACGTCGTGGTGGCTTTTGTATGCCT
GATGTTTACAAGTTTGGTTGGCCGAGCCGCTTATATTCAAATCGTCGAGCCTGAAATGCTACGCCACCAAAGCGACATGC
GCACCTTGCGTACTACCAGTCGTGAAGTGCAGCGTGGCCTGATCACTGACCGCAATGGTGATATGCTAGCGGTGAGTGTG
CCGGTAAAAGCGGTTTACGCCGATCCTAAAGTAGTACATGACAAGAATGGTTTTGCCGATATGCGCCGTTGGCAAGCATT
AGCAGACGTATTGCATGAACCGAGAGAAGATATTCTTAAACGAGTTCAATCGAACCCTCGTAAGCGCTTTACCTACCTTA
AGCGCCAAGTGACTCCTGCCGTTGCTGATTATATTAAGCAGCTAAAACTCCCAGGTGTTTACCTTAAGCCTGAATCTCGT
CGCTATTATCCAACGGGTGAAATTACCGCGCAGCTGGTGGGGATCACCAATATCGATGACAAAGGTATTGAGGGCTTAGA
GAATACTTATAATGACTGGCTAACTGGCACGCCGAGTAAGCAAAAAGTACGTAAGTCTCGCGACGGCCACGTAGTCGAGC
GTCTCGATATGGTGCAAGAGGGTGAGAGCCCTAATGACTTGGTGCTAAGTATTGACCAACGTATTCAGCAACTGGCCTAT
CGCGAGCTAAAAAAGGCCACCGAGGTTAACCAAGCAACATCTGGTTCAATCGTGGTGCTTGATGTGCTTACTGGGGAAGT
GTTAGCGATGGCGAATACGCCCTCCTATAACCCGAACTCTCGTGAAAACCTACAAAGTTATCGCATGCGAAACCGTGCGT
TGACTGATGCTTATGAACCTGGCTCTACCATCAAACCATTTGTGGTTGCTGCTGCACTTGATGCCGGAACGATTAAGACA
GATCAAATTATTAAGACCAACCCTGGTCGCCTGCGTATCGGTGGTAAAATTGTCCGCGACGGGCGTAATTATGGTGACCT
TTCTCTGAGTGGTATTTTGGTGCATTCGAGTAACGTGGGTATGACCAAAATTGCCTTGTCTATGCCGGTACAGGAGTTAT
TAGGCGCCTACCAAACAATGGGTCTAGGTAACTATTCAGGTATTAATTTAGAGGGTGAAAGTGCGGGTCTTATTCACGAC
CGCCGTCGCTGGTCTGAATTTGAGCGTGCAACTTTATCATTTGGTTATGGCTTAATGGCCACACCACTGCAGTTGGCCAG
AATGTATGCCACTTTGGGTAATAAAGGCGTGCAGTATCCTGTTTCAATTTTGAAACTAAAACAAACGCCTGAAGGCACGC
AAGTCATTTCACCACAGGTAGCGCAAGATGTAATGGAGATGCTGGTGGGGGTTACTGAAAAAGGTGGCACCGCACGTAAG
GCACATATTGAAGGCTATCCTGTGGCAGGTAAAACCGGTACCGCGCGTAAAGCCGTCGCTGGTGGTTATGGTGAAGATTA
CGTAGCGCTATTTGCTGGTGTTGCACCAGTGCATAACCCTAGGTTAGCCATTGCTGTGGTAGTGAATGAGCCTAAAGGCG
ATCGTTATTATGGTGGCGATATCGCTGCACCGGTTTTTGCGTCAGTTATGTCAGGTGCTTTACAAATGTTAAATGTTGAG
CCTATTTCAAATCGTGAGAAGGTCCGTTTAGCTGCAAATTCTAGGAGTGTTGAATAA

Upstream 100 bases:

>100_bases
AGCAGTCTCGGTCGGAACATAGCCGAATTACTCGGATAGCGACTAAAGAACTGAATATGAAGCGTCCATTACCAAAAGAA
GAGGTTGTGGTAAGAGTCCC

Downstream 100 bases:

>100_bases
TGCTAATACGCGATCTATTAGCGCCATGGTTCCATTATTCGGGAGCCGAAGACTTCTTGGAGATCACTTTAGATAGCCGT
GCTGTGCAAGCAGGTTATCT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MSKQAKRKQKPQLIQWRLYVVVAFVCLMFTSLVGRAAYIQIVEPEMLRHQSDMRTLRTTSREVQRGLITDRNGDMLAVSV
PVKAVYADPKVVHDKNGFADMRRWQALADVLHEPREDILKRVQSNPRKRFTYLKRQVTPAVADYIKQLKLPGVYLKPESR
RYYPTGEITAQLVGITNIDDKGIEGLENTYNDWLTGTPSKQKVRKSRDGHVVERLDMVQEGESPNDLVLSIDQRIQQLAY
RELKKATEVNQATSGSIVVLDVLTGEVLAMANTPSYNPNSRENLQSYRMRNRALTDAYEPGSTIKPFVVAAALDAGTIKT
DQIIKTNPGRLRIGGKIVRDGRNYGDLSLSGILVHSSNVGMTKIALSMPVQELLGAYQTMGLGNYSGINLEGESAGLIHD
RRRWSEFERATLSFGYGLMATPLQLARMYATLGNKGVQYPVSILKLKQTPEGTQVISPQVAQDVMEMLVGVTEKGGTARK
AHIEGYPVAGKTGTARKAVAGGYGEDYVALFAGVAPVHNPRLAIAVVVNEPKGDRYYGGDIAAPVFASVMSGALQMLNVE
PISNREKVRLAANSRSVE

Sequences:

>Translated_578_residues
MSKQAKRKQKPQLIQWRLYVVVAFVCLMFTSLVGRAAYIQIVEPEMLRHQSDMRTLRTTSREVQRGLITDRNGDMLAVSV
PVKAVYADPKVVHDKNGFADMRRWQALADVLHEPREDILKRVQSNPRKRFTYLKRQVTPAVADYIKQLKLPGVYLKPESR
RYYPTGEITAQLVGITNIDDKGIEGLENTYNDWLTGTPSKQKVRKSRDGHVVERLDMVQEGESPNDLVLSIDQRIQQLAY
RELKKATEVNQATSGSIVVLDVLTGEVLAMANTPSYNPNSRENLQSYRMRNRALTDAYEPGSTIKPFVVAAALDAGTIKT
DQIIKTNPGRLRIGGKIVRDGRNYGDLSLSGILVHSSNVGMTKIALSMPVQELLGAYQTMGLGNYSGINLEGESAGLIHD
RRRWSEFERATLSFGYGLMATPLQLARMYATLGNKGVQYPVSILKLKQTPEGTQVISPQVAQDVMEMLVGVTEKGGTARK
AHIEGYPVAGKTGTARKAVAGGYGEDYVALFAGVAPVHNPRLAIAVVVNEPKGDRYYGGDIAAPVFASVMSGALQMLNVE
PISNREKVRLAANSRSVE
>Mature_577_residues
SKQAKRKQKPQLIQWRLYVVVAFVCLMFTSLVGRAAYIQIVEPEMLRHQSDMRTLRTTSREVQRGLITDRNGDMLAVSVP
VKAVYADPKVVHDKNGFADMRRWQALADVLHEPREDILKRVQSNPRKRFTYLKRQVTPAVADYIKQLKLPGVYLKPESRR
YYPTGEITAQLVGITNIDDKGIEGLENTYNDWLTGTPSKQKVRKSRDGHVVERLDMVQEGESPNDLVLSIDQRIQQLAYR
ELKKATEVNQATSGSIVVLDVLTGEVLAMANTPSYNPNSRENLQSYRMRNRALTDAYEPGSTIKPFVVAAALDAGTIKTD
QIIKTNPGRLRIGGKIVRDGRNYGDLSLSGILVHSSNVGMTKIALSMPVQELLGAYQTMGLGNYSGINLEGESAGLIHDR
RRWSEFERATLSFGYGLMATPLQLARMYATLGNKGVQYPVSILKLKQTPEGTQVISPQVAQDVMEMLVGVTEKGGTARKA
HIEGYPVAGKTGTARKAVAGGYGEDYVALFAGVAPVHNPRLAIAVVVNEPKGDRYYGGDIAAPVFASVMSGALQMLNVEP
ISNREKVRLAANSRSVE

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=567, Percent_Identity=47.9717813051146, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1786854, Length=590, Percent_Identity=27.6271186440678, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63845; Mature: 63714

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQAKRKQKPQLIQWRLYVVVAFVCLMFTSLVGRAAYIQIVEPEMLRHQSDMRTLRTTS
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHH
REVQRGLITDRNGDMLAVSVPVKAVYADPKVVHDKNGFADMRRWQALADVLHEPREDILK
HHHHHCCCCCCCCCEEEEECCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHH
RVQSNPRKRFTYLKRQVTPAVADYIKQLKLPGVYLKPESRRYYPTGEITAQLVGITNIDD
HHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEEECCCC
KGIEGLENTYNDWLTGTPSKQKVRKSRDGHVVERLDMVQEGESPNDLVLSIDQRIQQLAY
CCCCHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHH
RELKKATEVNQATSGSIVVLDVLTGEVLAMANTPSYNPNSRENLQSYRMRNRALTDAYEP
HHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GSTIKPFVVAAALDAGTIKTDQIIKTNPGRLRIGGKIVRDGRNYGDLSLSGILVHSSNVG
CCCCCHHHEEEECCCCCCCCCCEEECCCCEEEECCEEEECCCCCCCEEEEEEEEECCCCC
MTKIALSMPVQELLGAYQTMGLGNYSGINLEGESAGLIHDRRRWSEFERATLSFGYGLMA
HHHHHHHCCHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
TPLQLARMYATLGNKGVQYPVSILKLKQTPEGTQVISPQVAQDVMEMLVGVTEKGGTARK
HHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCCEECCHHHHHHHHHHHHCCCCCCCCCEE
AHIEGYPVAGKTGTARKAVAGGYGEDYVALFAGVAPVHNPRLAIAVVVNEPKGDRYYGGD
EECCCCCCCCCCCCCHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCC
IAAPVFASVMSGALQMLNVEPISNREKVRLAANSRSVE
HHHHHHHHHHHHHHHHEECCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
SKQAKRKQKPQLIQWRLYVVVAFVCLMFTSLVGRAAYIQIVEPEMLRHQSDMRTLRTTS
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHH
REVQRGLITDRNGDMLAVSVPVKAVYADPKVVHDKNGFADMRRWQALADVLHEPREDILK
HHHHHCCCCCCCCCEEEEECCEEEEECCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHH
RVQSNPRKRFTYLKRQVTPAVADYIKQLKLPGVYLKPESRRYYPTGEITAQLVGITNIDD
HHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEEECCCC
KGIEGLENTYNDWLTGTPSKQKVRKSRDGHVVERLDMVQEGESPNDLVLSIDQRIQQLAY
CCCCHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHH
RELKKATEVNQATSGSIVVLDVLTGEVLAMANTPSYNPNSRENLQSYRMRNRALTDAYEP
HHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
GSTIKPFVVAAALDAGTIKTDQIIKTNPGRLRIGGKIVRDGRNYGDLSLSGILVHSSNVG
CCCCCHHHEEEECCCCCCCCCCEEECCCCEEEECCEEEECCCCCCCEEEEEEEEECCCCC
MTKIALSMPVQELLGAYQTMGLGNYSGINLEGESAGLIHDRRRWSEFERATLSFGYGLMA
HHHHHHHCCHHHHHHHHHHCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
TPLQLARMYATLGNKGVQYPVSILKLKQTPEGTQVISPQVAQDVMEMLVGVTEKGGTARK
HHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCCEECCHHHHHHHHHHHHCCCCCCCCCEE
AHIEGYPVAGKTGTARKAVAGGYGEDYVALFAGVAPVHNPRLAIAVVVNEPKGDRYYGGD
EECCCCCCCCCCCCCHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCC
IAAPVFASVMSGALQMLNVEPISNREKVRLAANSRSVE
HHHHHHHHHHHHHHHHEECCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]