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The map label for this gene is murC [H]

Identifier: 157963621

GI number: 157963621

Start: 4632424

End: 4633893

Strand: Reverse

Name: murC [H]

Synonym: Spea_3810

Alternate gene names: 157963621

Gene position: 4633893-4632424 (Counterclockwise)

Preceding gene: 157963622

Following gene: 157963620

Centisome position: 89.55

GC content: 48.78

Gene sequence:

>1470_bases
ATGAGTAACAAAGCAGAGAAGTATTCGCAGCTAAGAACCATGATCCCTGAGATGCGCAGGGTTAAGCACATCTATTTCGT
TGGAATAGGTGGTGCTGGTATGGGCGGCATAGCGGAAGTGCTTGTTAATGAGGGTTACAAATTAAGTGGCTCAGATATCG
CGCAAAGTGCGGTCACTGAGCGATTAGCTCAACTTGGCGTGACTATCTATATTGGCCACGATGCAAGTCAGGTAAAAGAT
GTCGATGTGGTTGTGGTGTCTACGGCGATTAGCGCCGATAACCCAGAGCTAGTTGCAGCAAAAGAGCTTAGGATCCCTGT
AGTACGCCGCGCCGAGATGCTGGCTGAGCTGATGCGTTATCGTCACGGTGTTGCCGTTGCGGGAACTCACGGTAAAACCA
CTACGACAAGTTTAATTGCCAGCGTTTATGGTCAGGCTGAGCGTGACCCAACATTTGTGATTGGCGGCTTGTTAAATAGT
GCGGGTACTAACGCAAGACTAGGTCATAGCCGTTATCTTATTGCCGAGGCGGATGAGAGCGATGCGAGCTTCTTGCATCT
GCAGCCGATGGTGAGTGTGGTGACCAATATTGAAGCTGACCATATGGATACCTATGAAGGCGATCTAGAGAAGCTTAAGA
CGACCTTCGTCGATTTCCTGCATAACTTGCCATTCTATGGCGTCGCAGTTGTGTGTATCGACGATCCTATCGTACGTGAG
CTTATTCCGCGTATCGGTCGTCGTATAGTGACTTACGGTTTCAGTGAAGATGCAGATGTTCGTGCATTAGATTTCAAGCA
AACAGGTTATAGCTGTGAGTTTACCGTACGCCGCGCTGGTATGGATGATCTGCAGCTGTCAGTTAATTTACCCGGTGAAC
ATAACGTACTTAACTCATTGGCTGCGATTGCTGTAGCAACTGAAGATGAGATTGAAGACGAGGCGATTATTACCGCCTTA
GCCGACTTCCAGGGTATTGGTCGCCGCTTTCAACAGATTGGTGAATTCACAACGGCCAAAGGTGAGATTAAGTTGGTCGA
TGACTATGGTCATCACCCAAGCGAAGTCGCGGCAACGATTAAGGCTGCCAGATTAGGCTGGCCTGAGCGTCGCTTAGTCA
TGATCTATCAGCCACACCGCTATAGTCGAACCCGTGACCTATATGAAGACTTTGTGGAAGTCTTATCGCAAGTGGACTGC
TTGTTGATGCTTGATGTTTATGCCGCAGGTGAAGCGCCAATCCCTGGTGCCGATAGTCGAGCATTATGTCGTTCGATTAG
AGTGCGTGGCCAAGTCGAGCCTGTGTTCGTGGCGAGTACCGAACAACTAGAAACTGTATTGCCAGAGATCTTACAAGATG
GCGACCTACTGTTGACCCAAGGGGCTGGCAGTATTGGCTTGTTGTCTCGCAGTCTAGCCGAGTCAAACCTTGGTTTTGAT
TCTGCGGTTACAGATGAAAAAAATGCGTAA

Upstream 100 bases:

>100_bases
GAATTATGCAATATGGGCCAGCGTGCTCGAGACGTAGCCATTTTAGATGCGACAGAGCGAGTAGCTAATGTCTGTATTCG
ATTAGCTGAGAAGGGTTGAG

Downstream 100 bases:

>100_bases
TTTAGAGCGATATAGCTTAAGTTACACATCAAATTTTGACGCTTGGAATAAGGGCTATATAATGGCCGATTTTCCGGGGT
TATGGTTGCAAAAGGAAGCC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MSNKAEKYSQLRTMIPEMRRVKHIYFVGIGGAGMGGIAEVLVNEGYKLSGSDIAQSAVTERLAQLGVTIYIGHDASQVKD
VDVVVVSTAISADNPELVAAKELRIPVVRRAEMLAELMRYRHGVAVAGTHGKTTTTSLIASVYGQAERDPTFVIGGLLNS
AGTNARLGHSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYEGDLEKLKTTFVDFLHNLPFYGVAVVCIDDPIVRE
LIPRIGRRIVTYGFSEDADVRALDFKQTGYSCEFTVRRAGMDDLQLSVNLPGEHNVLNSLAAIAVATEDEIEDEAIITAL
ADFQGIGRRFQQIGEFTTAKGEIKLVDDYGHHPSEVAATIKAARLGWPERRLVMIYQPHRYSRTRDLYEDFVEVLSQVDC
LLMLDVYAAGEAPIPGADSRALCRSIRVRGQVEPVFVASTEQLETVLPEILQDGDLLLTQGAGSIGLLSRSLAESNLGFD
SAVTDEKNA

Sequences:

>Translated_489_residues
MSNKAEKYSQLRTMIPEMRRVKHIYFVGIGGAGMGGIAEVLVNEGYKLSGSDIAQSAVTERLAQLGVTIYIGHDASQVKD
VDVVVVSTAISADNPELVAAKELRIPVVRRAEMLAELMRYRHGVAVAGTHGKTTTTSLIASVYGQAERDPTFVIGGLLNS
AGTNARLGHSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYEGDLEKLKTTFVDFLHNLPFYGVAVVCIDDPIVRE
LIPRIGRRIVTYGFSEDADVRALDFKQTGYSCEFTVRRAGMDDLQLSVNLPGEHNVLNSLAAIAVATEDEIEDEAIITAL
ADFQGIGRRFQQIGEFTTAKGEIKLVDDYGHHPSEVAATIKAARLGWPERRLVMIYQPHRYSRTRDLYEDFVEVLSQVDC
LLMLDVYAAGEAPIPGADSRALCRSIRVRGQVEPVFVASTEQLETVLPEILQDGDLLLTQGAGSIGLLSRSLAESNLGFD
SAVTDEKNA
>Mature_488_residues
SNKAEKYSQLRTMIPEMRRVKHIYFVGIGGAGMGGIAEVLVNEGYKLSGSDIAQSAVTERLAQLGVTIYIGHDASQVKDV
DVVVVSTAISADNPELVAAKELRIPVVRRAEMLAELMRYRHGVAVAGTHGKTTTTSLIASVYGQAERDPTFVIGGLLNSA
GTNARLGHSRYLIAEADESDASFLHLQPMVSVVTNIEADHMDTYEGDLEKLKTTFVDFLHNLPFYGVAVVCIDDPIVREL
IPRIGRRIVTYGFSEDADVRALDFKQTGYSCEFTVRRAGMDDLQLSVNLPGEHNVLNSLAAIAVATEDEIEDEAIITALA
DFQGIGRRFQQIGEFTTAKGEIKLVDDYGHHPSEVAATIKAARLGWPERRLVMIYQPHRYSRTRDLYEDFVEVLSQVDCL
LMLDVYAAGEAPIPGADSRALCRSIRVRGQVEPVFVASTEQLETVLPEILQDGDLLLTQGAGSIGLLSRSLAESNLGFDS
AVTDEKNA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=479, Percent_Identity=63.8830897703549, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI1790680, Length=463, Percent_Identity=27.8617710583153, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53402; Mature: 53271

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKAEKYSQLRTMIPEMRRVKHIYFVGIGGAGMGGIAEVLVNEGYKLSGSDIAQSAVTE
CCCHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHCCCCEECCHHHHHHHHHH
RLAQLGVTIYIGHDASQVKDVDVVVVSTAISADNPELVAAKELRIPVVRRAEMLAELMRY
HHHHCCEEEEECCCHHHCCCCEEEEEEEEECCCCCCEEEHHHCCCHHHHHHHHHHHHHHH
RHGVAVAGTHGKTTTTSLIASVYGQAERDPTFVIGGLLNSAGTNARLGHSRYLIAEADES
HCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCCCCEEEEEECCCC
DASFLHLQPMVSVVTNIEADHMDTYEGDLEKLKTTFVDFLHNLPFYGVAVVCIDDPIVRE
CCCEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHH
LIPRIGRRIVTYGFSEDADVRALDFKQTGYSCEFTVRRAGMDDLQLSVNLPGEHNVLNSL
HHHHHCCEEEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHH
AAIAVATEDEIEDEAIITALADFQGIGRRFQQIGEFTTAKGEIKLVDDYGHHPSEVAATI
HHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
KAARLGWPERRLVMIYQPHRYSRTRDLYEDFVEVLSQVDCLLMLDVYAAGEAPIPGADSR
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHEEEEHHHCCCCCCCCCCHH
ALCRSIRVRGQVEPVFVASTEQLETVLPEILQDGDLLLTQGAGSIGLLSRSLAESNLGFD
HHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCC
SAVTDEKNA
CCCCCCCCC
>Mature Secondary Structure 
SNKAEKYSQLRTMIPEMRRVKHIYFVGIGGAGMGGIAEVLVNEGYKLSGSDIAQSAVTE
CCHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHHHHHCCCCEECCHHHHHHHHHH
RLAQLGVTIYIGHDASQVKDVDVVVVSTAISADNPELVAAKELRIPVVRRAEMLAELMRY
HHHHCCEEEEECCCHHHCCCCEEEEEEEEECCCCCCEEEHHHCCCHHHHHHHHHHHHHHH
RHGVAVAGTHGKTTTTSLIASVYGQAERDPTFVIGGLLNSAGTNARLGHSRYLIAEADES
HCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCCCCEEEEEECCCC
DASFLHLQPMVSVVTNIEADHMDTYEGDLEKLKTTFVDFLHNLPFYGVAVVCIDDPIVRE
CCCEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHH
LIPRIGRRIVTYGFSEDADVRALDFKQTGYSCEFTVRRAGMDDLQLSVNLPGEHNVLNSL
HHHHHCCEEEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHH
AAIAVATEDEIEDEAIITALADFQGIGRRFQQIGEFTTAKGEIKLVDDYGHHPSEVAATI
HHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
KAARLGWPERRLVMIYQPHRYSRTRDLYEDFVEVLSQVDCLLMLDVYAAGEAPIPGADSR
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHEEEEHHHCCCCCCCCCCHH
ALCRSIRVRGQVEPVFVASTEQLETVLPEILQDGDLLLTQGAGSIGLLSRSLAESNLGFD
HHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCC
SAVTDEKNA
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA