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The map label for this gene is basR [H]

Identifier: 157963391

GI number: 157963391

Start: 4367649

End: 4368323

Strand: Reverse

Name: basR [H]

Synonym: Spea_3577

Alternate gene names: 157963391

Gene position: 4368323-4367649 (Counterclockwise)

Preceding gene: 157963392

Following gene: 157963390

Centisome position: 84.42

GC content: 46.22

Gene sequence:

>675_bases
ATGTTGGTTCTCCTTGTCGAAGATAACCGCCTACTGGCTAAAAATATTATTCAGTATCTCGAGTTAAATGAGATTGAATG
TGACTATGCGGAGACTCTGGAACGGGCAGAGGAAAGAATATTTAGCAGTACCTTTGATGCGATCATTTTAGATCTTAATT
TACCCGATGGCGACGGCATTACAGCATGCCAGAGATGGAAAGAGCAATGCATTATGGCTCCAATCATTATGCTGACGGCT
AGGAGCAACTTACAAGATAGGCTTTCAGGTTTCGAGGCCGGAGCCGATGATTATCTGGTTAAGCCTTTTGCACTGGCGGA
GTTAGTCGCACGCCTTAAGGTTGTATCTCAGCGGCGTCCATCGCCAAAGCGGCTGACTATTGGCGATCTCGAGTTTGATT
TTGGTGCCCATCAGGTACATCGTCAGGGTCAGGACCTTGCTTTGTCACGAACAGGATGGCAGATCCTTTCATTTTTAGCT
CGAAGAAGCCCTGAAACCGTCGAACGGGAAGAGATAGAGCGATTACTGTGGCCAGATAGCCCTCCCGATAGCGACAGCTT
AAAAAGTCATATACACCTGCTTCGAAGGGTGGTTGATAAGCCATTCGAACAGCATCTTATTCATACGATTCGTGGTGTTG
GCTTATGCTTAAGAGTGGAAAATGATGAAGCCTAA

Upstream 100 bases:

>100_bases
TGGGGTGGAATACCACCTTGAATCTTTAAGAAATAAGTTGTCTGCCAGTAATAGGACCAATTTAGTTCATATCGCTCATC
AACTGGAAATTATATAGAAG

Downstream 100 bases:

>100_bases
GCTGAGTTTGAAGCGTGTATATCAGGTTTACGGCTTATGTTTTTTAGCTATCACCTTGGTTATAAACTTCCTTATTCCTC
TGTGTATGATGTGTGCGGGA

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MLVLLVEDNRLLAKNIIQYLELNEIECDYAETLERAEERIFSSTFDAIILDLNLPDGDGITACQRWKEQCIMAPIIMLTA
RSNLQDRLSGFEAGADDYLVKPFALAELVARLKVVSQRRPSPKRLTIGDLEFDFGAHQVHRQGQDLALSRTGWQILSFLA
RRSPETVEREEIERLLWPDSPPDSDSLKSHIHLLRRVVDKPFEQHLIHTIRGVGLCLRVENDEA

Sequences:

>Translated_224_residues
MLVLLVEDNRLLAKNIIQYLELNEIECDYAETLERAEERIFSSTFDAIILDLNLPDGDGITACQRWKEQCIMAPIIMLTA
RSNLQDRLSGFEAGADDYLVKPFALAELVARLKVVSQRRPSPKRLTIGDLEFDFGAHQVHRQGQDLALSRTGWQILSFLA
RRSPETVEREEIERLLWPDSPPDSDSLKSHIHLLRRVVDKPFEQHLIHTIRGVGLCLRVENDEA
>Mature_224_residues
MLVLLVEDNRLLAKNIIQYLELNEIECDYAETLERAEERIFSSTFDAIILDLNLPDGDGITACQRWKEQCIMAPIIMLTA
RSNLQDRLSGFEAGADDYLVKPFALAELVARLKVVSQRRPSPKRLTIGDLEFDFGAHQVHRQGQDLALSRTGWQILSFLA
RRSPETVEREEIERLLWPDSPPDSDSLKSHIHLLRRVVDKPFEQHLIHTIRGVGLCLRVENDEA

Specific function: Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=35.8407079646018, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=33.6363636363636, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=31.2775330396476, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=33.7899543378995, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=217, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1786599, Length=219, Percent_Identity=31.5068493150685, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=31.9634703196347, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=28.3261802575107, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=31.4410480349345, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=30.7017543859649, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=27.2321428571429, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=26.8722466960352, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25640; Mature: 25640

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLLVEDNRLLAKNIIQYLELNEIECDYAETLERAEERIFSSTFDAIILDLNLPDGDGI
CEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCH
TACQRWKEQCIMAPIIMLTARSNLQDRLSGFEAGADDYLVKPFALAELVARLKVVSQRRP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHCCC
SPKRLTIGDLEFDFGAHQVHRQGQDLALSRTGWQILSFLARRSPETVEREEIERLLWPDS
CCCEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
PPDSDSLKSHIHLLRRVVDKPFEQHLIHTIRGVGLCLRVENDEA
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCEEEEEECCCCC
>Mature Secondary Structure
MLVLLVEDNRLLAKNIIQYLELNEIECDYAETLERAEERIFSSTFDAIILDLNLPDGDGI
CEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCH
TACQRWKEQCIMAPIIMLTARSNLQDRLSGFEAGADDYLVKPFALAELVARLKVVSQRRP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHCCC
SPKRLTIGDLEFDFGAHQVHRQGQDLALSRTGWQILSFLARRSPETVEREEIERLLWPDS
CCCEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCC
PPDSDSLKSHIHLLRRVVDKPFEQHLIHTIRGVGLCLRVENDEA
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8282725; 7610040; 9278503 [H]