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The map label for this gene is pepA [H]

Identifier: 157962907

GI number: 157962907

Start: 3792760

End: 3794298

Strand: Reverse

Name: pepA [H]

Synonym: Spea_3090

Alternate gene names: 157962907

Gene position: 3794298-3792760 (Counterclockwise)

Preceding gene: 157962909

Following gene: 157962906

Centisome position: 73.33

GC content: 49.9

Gene sequence:

>1539_bases
ATGGGGTCAGTTAAGTTTGTTGATGAAATAGATCAAGGTGCCATTTTTGAAGGAAACGGCTGGGATGCGCTGGTGGTGGT
CACAGCCGATCTTGAATCACTGCAATTCGATGAGATTGTAATGTTAGCAAGTCATGGTCAAAAGATAGATAAGCGGGTTG
GTCAATCTCCTACGCTATTATTTGCTCCCGGAATGGCTGGTGGACGCCTGATTATAGCACCGGTAAAAAAGACGGATGAT
GACTATCAAGATGTTCGCGTCTTTGCTGACGCAGCAAGACAAGGTATCAAGCTGGCTAAAGAGGCTGGCGCCAAGCGTCC
TTTACTCATAGTCAATAACTTAGCTGAGCAACGTTATCAAAATGCAGCTCAAGTAGCAGCACTGGCGTGTGGCCAAGAGC
TTTGGCAGGCATTGGAGCTTAGAGAGGCGGGCGGTGGTGATGAGCCGTTAGAAGCCATTGGCCTGCTAAGCGACAAAAAG
AGCGCATTGGCACTTACTGCCATCGAAGCTGGTAGAGTACTGGCCCGTGATCTTTGTGGCACCGAGCCAGAGCGTATGTC
TGCTCCAGCCTTTGCCGACTACTGCTTGGATGCGCTGCAAGACTCAGATCTTACAATCAGCGTGGTCGAAGACCGAGACA
TTCTCGAGCGAGATTACCCACTATTAAGTGCGGTCGGCCGCTCATCATTCGCAGTATTGAGGCATCAACCTAGGGTGGTC
AAGCTTGAATATGTAGGCGAGGGTGAAATCGAGCGCACCTATATGTTTGCAGGTAAAGGTGTGGTCTATGACACAGGTGG
CGCTGACCTTAAAATTGCAGGCGGTATGGCGGGGATGAGCCGAGATAAAGGCGGCGCAGCGGCGGTTGCAGGACTAATGA
AGACCATCAGTATGTTAAAGCCTAAGGGCATTCGCATTGTCGCCGAGCTAGGTTTAGTCAGGAACAGTATCGGTAGCGAA
GCCTTTGTTACCGACGAGATCATCACAAGTCATGCGGGTAAGCGGGTGCGTATTGGTAATACTGATGCAGAAGGTCGTTT
AGTATTGGCAGATCTGCTTTCTCATTTACGTATAAAGGCTATCAACGCGGTTAAGCCACAGATGTTCTCGGTAGCGACAC
TAACAGGGCACGTGGTGCGTTGCTTTGGAGGATATACCGCAGTAGTTGAAAACAGCGTGGCTAAGCAGGAAAATGTTGCC
TCAGTGATGCAAGAGCAAGCATCGCTTTGGGGCGAGCCGATAGAGGTGAGTCAATTACGCCGAGATGATTTTAGCAAAAT
CGTCGATCCATCTGCGGCAGCCGATATGTTGTCATCTAATAATGCGCCATCATCTGTTACCGCTCGGGGGCATCAGTACC
CAGCAGCATTTTTGATTGAAGCATCGGGTCTTAGCGCCCATGGCTTAAATGCCGACAAGCCGATTGCTTATACCCATATC
GATATCGCCGGTAGTGCAACCGAAGGACACCCTCAATACGGTACGCCAACGGCAACACCTTTAGTCGGCTTGTTTCATTA
CATTACAGCGCCTAAGTGA

Upstream 100 bases:

>100_bases
AGTTTCCACAATACTTTTCATACTCGGTAAAGTCATTGGTAATCTCACCACAATGGGGGAATAATGCGCAGATAAAATTA
TAAATTAAGAAGGAAAGGTT

Downstream 100 bases:

>100_bases
GTAATGTAATAATGTGATTTAGACGGAGCTGTCTGCATACCCAATAAAACCAGCGCCTTAGCGCTGGTTTTTGTTTGTAT
CATCGAATCTAATCAACTAG

Product: peptidase M17 leucyl aminopeptidase domain-containing protein

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MGSVKFVDEIDQGAIFEGNGWDALVVVTADLESLQFDEIVMLASHGQKIDKRVGQSPTLLFAPGMAGGRLIIAPVKKTDD
DYQDVRVFADAARQGIKLAKEAGAKRPLLIVNNLAEQRYQNAAQVAALACGQELWQALELREAGGGDEPLEAIGLLSDKK
SALALTAIEAGRVLARDLCGTEPERMSAPAFADYCLDALQDSDLTISVVEDRDILERDYPLLSAVGRSSFAVLRHQPRVV
KLEYVGEGEIERTYMFAGKGVVYDTGGADLKIAGGMAGMSRDKGGAAAVAGLMKTISMLKPKGIRIVAELGLVRNSIGSE
AFVTDEIITSHAGKRVRIGNTDAEGRLVLADLLSHLRIKAINAVKPQMFSVATLTGHVVRCFGGYTAVVENSVAKQENVA
SVMQEQASLWGEPIEVSQLRRDDFSKIVDPSAAADMLSSNNAPSSVTARGHQYPAAFLIEASGLSAHGLNADKPIAYTHI
DIAGSATEGHPQYGTPTATPLVGLFHYITAPK

Sequences:

>Translated_512_residues
MGSVKFVDEIDQGAIFEGNGWDALVVVTADLESLQFDEIVMLASHGQKIDKRVGQSPTLLFAPGMAGGRLIIAPVKKTDD
DYQDVRVFADAARQGIKLAKEAGAKRPLLIVNNLAEQRYQNAAQVAALACGQELWQALELREAGGGDEPLEAIGLLSDKK
SALALTAIEAGRVLARDLCGTEPERMSAPAFADYCLDALQDSDLTISVVEDRDILERDYPLLSAVGRSSFAVLRHQPRVV
KLEYVGEGEIERTYMFAGKGVVYDTGGADLKIAGGMAGMSRDKGGAAAVAGLMKTISMLKPKGIRIVAELGLVRNSIGSE
AFVTDEIITSHAGKRVRIGNTDAEGRLVLADLLSHLRIKAINAVKPQMFSVATLTGHVVRCFGGYTAVVENSVAKQENVA
SVMQEQASLWGEPIEVSQLRRDDFSKIVDPSAAADMLSSNNAPSSVTARGHQYPAAFLIEASGLSAHGLNADKPIAYTHI
DIAGSATEGHPQYGTPTATPLVGLFHYITAPK
>Mature_511_residues
GSVKFVDEIDQGAIFEGNGWDALVVVTADLESLQFDEIVMLASHGQKIDKRVGQSPTLLFAPGMAGGRLIIAPVKKTDDD
YQDVRVFADAARQGIKLAKEAGAKRPLLIVNNLAEQRYQNAAQVAALACGQELWQALELREAGGGDEPLEAIGLLSDKKS
ALALTAIEAGRVLARDLCGTEPERMSAPAFADYCLDALQDSDLTISVVEDRDILERDYPLLSAVGRSSFAVLRHQPRVVK
LEYVGEGEIERTYMFAGKGVVYDTGGADLKIAGGMAGMSRDKGGAAAVAGLMKTISMLKPKGIRIVAELGLVRNSIGSEA
FVTDEIITSHAGKRVRIGNTDAEGRLVLADLLSHLRIKAINAVKPQMFSVATLTGHVVRCFGGYTAVVENSVAKQENVAS
VMQEQASLWGEPIEVSQLRRDDFSKIVDPSAAADMLSSNNAPSSVTARGHQYPAAFLIEASGLSAHGLNADKPIAYTHID
IAGSATEGHPQYGTPTATPLVGLFHYITAPK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI47155554, Length=306, Percent_Identity=32.3529411764706, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI41393561, Length=228, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87082123, Length=292, Percent_Identity=31.5068493150685, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790710, Length=249, Percent_Identity=30.1204819277108, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17565172, Length=450, Percent_Identity=43.1111111111111, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17556903, Length=237, Percent_Identity=33.7552742616034, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24646701, Length=466, Percent_Identity=43.7768240343348, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24646703, Length=466, Percent_Identity=43.7768240343348, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI21358201, Length=466, Percent_Identity=43.7768240343348, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI21357381, Length=350, Percent_Identity=30.8571428571429, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221379063, Length=349, Percent_Identity=30.945558739255, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221379062, Length=349, Percent_Identity=30.945558739255, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21355725, Length=210, Percent_Identity=27.6190476190476, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24661038, Length=210, Percent_Identity=28.0952380952381, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24662227, Length=221, Percent_Identity=25.3393665158371, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54509; Mature: 54378

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSVKFVDEIDQGAIFEGNGWDALVVVTADLESLQFDEIVMLASHGQKIDKRVGQSPTLL
CCCCCCHHHCCCCCEEECCCCCEEEEEEECCCCCCHHHEEEEHHCCHHHHHHCCCCCCEE
FAPGMAGGRLIIAPVKKTDDDYQDVRVFADAARQGIKLAKEAGAKRPLLIVNNLAEQRYQ
EECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
NAAQVAALACGQELWQALELREAGGGDEPLEAIGLLSDKKSALALTAIEAGRVLARDLCG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCC
TEPERMSAPAFADYCLDALQDSDLTISVVEDRDILERDYPLLSAVGRSSFAVLRHQPRVV
CCHHHCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHCCHHHHHHCCCHHHHHCCCCCEE
KLEYVGEGEIERTYMFAGKGVVYDTGGADLKIAGGMAGMSRDKGGAAAVAGLMKTISMLK
EEEECCCCCCEEEEEEECCCEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHC
PKGIRIVAELGLVRNSIGSEAFVTDEIITSHAGKRVRIGNTDAEGRLVLADLLSHLRIKA
CCCCEEHHHHHHHHHHCCCCCEEHHHHHHHCCCCEEEECCCCCCCCEEHHHHHHHHHHHH
INAVKPQMFSVATLTGHVVRCFGGYTAVVENSVAKQENVASVMQEQASLWGEPIEVSQLR
HHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RDDFSKIVDPSAAADMLSSNNAPSSVTARGHQYPAAFLIEASGLSAHGLNADKPIAYTHI
HHHHHHHCCCHHHHHHHHCCCCCCCEECCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEE
DIAGSATEGHPQYGTPTATPLVGLFHYITAPK
EEECCCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GSVKFVDEIDQGAIFEGNGWDALVVVTADLESLQFDEIVMLASHGQKIDKRVGQSPTLL
CCCCCHHHCCCCCEEECCCCCEEEEEEECCCCCCHHHEEEEHHCCHHHHHHCCCCCCEE
FAPGMAGGRLIIAPVKKTDDDYQDVRVFADAARQGIKLAKEAGAKRPLLIVNNLAEQRYQ
EECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
NAAQVAALACGQELWQALELREAGGGDEPLEAIGLLSDKKSALALTAIEAGRVLARDLCG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCC
TEPERMSAPAFADYCLDALQDSDLTISVVEDRDILERDYPLLSAVGRSSFAVLRHQPRVV
CCHHHCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHCCHHHHHHCCCHHHHHCCCCCEE
KLEYVGEGEIERTYMFAGKGVVYDTGGADLKIAGGMAGMSRDKGGAAAVAGLMKTISMLK
EEEECCCCCCEEEEEEECCCEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHC
PKGIRIVAELGLVRNSIGSEAFVTDEIITSHAGKRVRIGNTDAEGRLVLADLLSHLRIKA
CCCCEEHHHHHHHHHHCCCCCEEHHHHHHHCCCCEEEECCCCCCCCEEHHHHHHHHHHHH
INAVKPQMFSVATLTGHVVRCFGGYTAVVENSVAKQENVASVMQEQASLWGEPIEVSQLR
HHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RDDFSKIVDPSAAADMLSSNNAPSSVTARGHQYPAAFLIEASGLSAHGLNADKPIAYTHI
HHHHHHHCCCHHHHHHHHCCCCCCCEECCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEE
DIAGSATEGHPQYGTPTATPLVGLFHYITAPK
EEECCCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA