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The map label for this gene is caiC [H]

Identifier: 157961971

GI number: 157961971

Start: 2603184

End: 2605049

Strand: Direct

Name: caiC [H]

Synonym: Spea_2150

Alternate gene names: 157961971

Gene position: 2603184-2605049 (Clockwise)

Preceding gene: 157961970

Following gene: 157961972

Centisome position: 50.31

GC content: 43.94

Gene sequence:

>1866_bases
GTGAAAATTAAAAACCACAGTGGAGTGCCCTTGGCCTCCATGGAAGAGACTCAGGCAAAGAGTGACAAACGATCGAAAGC
GGCGCAACTTATTAAACCTTATGCAAAATATACAATCGCAGACAGGGTAGAACAACAAGCGCAGTCGCAACAGGATAAAA
CATTTCTTGTTTATAATGACCAGCACTTTAGTTACGCAGAAGTCGATCAACGTGCAAACCAAGTGGCCAACTTAGCTGCA
TCTCGAGGTCTAAATGCTGGAGATGTTTGTGCAATGGTGCTTGAAAATCGGCCCGAGTTTTTCTTTATTTGGTTTGGATT
GACCAAATTGGGCGTCATTGTCGCGTTTATTAATTCACAGGTTCACGGGGCTCCTTTATCCCACGCGATTAAAGAGACTG
AAGCAAGCGCCGTCATAGTCGGTGAAGAGTGTGCCCACTTAGTGAGTAAGACTATCAGTGATATTACAGATTGCTCGCTG
TTACAGGTGCCACTTTGGTTAGCTTCTGATGTCGAAAAAACTGCAGCCAACAAAGACCTTGAATGCTTTGATAGCAATTT
AGCCTTGAATTATATGGATTACAGTCGTGAATTTGATTCAAGGGTAGCCCGAAAAGATATTACCGCAGAAACGCCGAGTT
TACTTATTTTCACCTCTGGAACAACAGGCCTACCCAAAGCAGCCATATACAGCCATATGCGTTGGTTATGTTCTGGTGAT
GTGATGTCGGTGACAATCGATGCAACTGAATCTGATGTGTTTTACGTCTGCCTGCCTATGTATCATGGCGCAGCGGCAAC
GTCAGTGACTTCAACCGCTTTAGCGGCTGGCGCAAGTATTGTGGTTAGGCGAAAATTCAGTGTGCGTGAGTTTTGGCCGG
ATGTGCAGCAAAACGGGATTACCGTATGTCAGTACATCGGTGAGATCTGTCGCTATTTACTCAATTATGACGACAGTAAA
AATCAAGGCCAAGGAGTAAAAGATCATACTTTACGCTGCATGCTTGGCGCCGGTCTTAGTGCCGAGTCTTGGTTGAGTTG
GATTAACAAGTTTGGTGAGATGGACATTTATGAAGGTTGGGGCTCCACAGAGGCCAATACTAATTTAATTAATCTAGATA
ACTACATAGGTTCATGTGGCAGAGTAGCAGATTGGAGCAAGACCAATTTTCGCCTGGTTAAATTCAACACTGATTTAGAA
TGCCATGAAAAGGATGCCGATGGCTTGTATGTGCCTTGTAAAAGTGGTGAAGTCGGCGAGGCGATAGGCATGATCATTAA
TCATCCAGAGTTTGGCGGTGGCCGCTTTGAAGGCTATACCTCGAGTAATGCAACAGAGAAGAAGATCCTTGCTGATGTAT
TTACCCAGGGCGACGCATACTGGCGTTCAGGAGACTTATTACGTTTTGATGACAATGGCTATTTTTATTTTGTCGATAGA
ATAGGTGATACCTATCGCTGGAAAAGTGAGAACGTGTCCTCACAGGAAGTCGCAAATGAATTGAGTGGATTAGCAGGACT
TGAATTGATCAATATCTATGGTGTTCAAGTACCTGAGCATGAAGGCAGAGCCGGAATGGCAGCAATCGTTATGCAACAAG
GGAAAGATTTTGACCCTAATGCGTTTTATGCACTAACAGAGGCTAAGTTACCTCGTTACGCTGCGCCACAATTTGTCAGA
GTCAGCAGTGTTGCAGACATGACTTCAACCTTTAAGCTACGTAAGGTTGATTTGCAAAAACAAGGATATAACCCAATTGG
TTGTGACGATCCTATTTATATCCGCAATGATAAATTAGAGACTTATGTACGCTACTCCGATGAGGCGTTAACAGCAGTCG
GTTTACCGCCGTTTAAACAAGTGTGA

Upstream 100 bases:

>100_bases
AAGATACTCCGGCACCAAAGATCCGGGTGAAGTAGTGGTTTGAAGCTTACATGGACAGCGATTACATGCAAATTAACGTC
ACCATTGATAAGGACATGAT

Downstream 100 bases:

>100_bases
TCAGGAGGATAAATGGGACTATTAGGTAATGCAGCCATCGTAGGAGCTGCTCAGTACAAACCTGAAAAATATCAAACAGC
GCCACAGATGTTCCATTTGG

Product: long-chain-acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MKIKNHSGVPLASMEETQAKSDKRSKAAQLIKPYAKYTIADRVEQQAQSQQDKTFLVYNDQHFSYAEVDQRANQVANLAA
SRGLNAGDVCAMVLENRPEFFFIWFGLTKLGVIVAFINSQVHGAPLSHAIKETEASAVIVGEECAHLVSKTISDITDCSL
LQVPLWLASDVEKTAANKDLECFDSNLALNYMDYSREFDSRVARKDITAETPSLLIFTSGTTGLPKAAIYSHMRWLCSGD
VMSVTIDATESDVFYVCLPMYHGAAATSVTSTALAAGASIVVRRKFSVREFWPDVQQNGITVCQYIGEICRYLLNYDDSK
NQGQGVKDHTLRCMLGAGLSAESWLSWINKFGEMDIYEGWGSTEANTNLINLDNYIGSCGRVADWSKTNFRLVKFNTDLE
CHEKDADGLYVPCKSGEVGEAIGMIINHPEFGGGRFEGYTSSNATEKKILADVFTQGDAYWRSGDLLRFDDNGYFYFVDR
IGDTYRWKSENVSSQEVANELSGLAGLELINIYGVQVPEHEGRAGMAAIVMQQGKDFDPNAFYALTEAKLPRYAAPQFVR
VSSVADMTSTFKLRKVDLQKQGYNPIGCDDPIYIRNDKLETYVRYSDEALTAVGLPPFKQV

Sequences:

>Translated_621_residues
MKIKNHSGVPLASMEETQAKSDKRSKAAQLIKPYAKYTIADRVEQQAQSQQDKTFLVYNDQHFSYAEVDQRANQVANLAA
SRGLNAGDVCAMVLENRPEFFFIWFGLTKLGVIVAFINSQVHGAPLSHAIKETEASAVIVGEECAHLVSKTISDITDCSL
LQVPLWLASDVEKTAANKDLECFDSNLALNYMDYSREFDSRVARKDITAETPSLLIFTSGTTGLPKAAIYSHMRWLCSGD
VMSVTIDATESDVFYVCLPMYHGAAATSVTSTALAAGASIVVRRKFSVREFWPDVQQNGITVCQYIGEICRYLLNYDDSK
NQGQGVKDHTLRCMLGAGLSAESWLSWINKFGEMDIYEGWGSTEANTNLINLDNYIGSCGRVADWSKTNFRLVKFNTDLE
CHEKDADGLYVPCKSGEVGEAIGMIINHPEFGGGRFEGYTSSNATEKKILADVFTQGDAYWRSGDLLRFDDNGYFYFVDR
IGDTYRWKSENVSSQEVANELSGLAGLELINIYGVQVPEHEGRAGMAAIVMQQGKDFDPNAFYALTEAKLPRYAAPQFVR
VSSVADMTSTFKLRKVDLQKQGYNPIGCDDPIYIRNDKLETYVRYSDEALTAVGLPPFKQV
>Mature_621_residues
MKIKNHSGVPLASMEETQAKSDKRSKAAQLIKPYAKYTIADRVEQQAQSQQDKTFLVYNDQHFSYAEVDQRANQVANLAA
SRGLNAGDVCAMVLENRPEFFFIWFGLTKLGVIVAFINSQVHGAPLSHAIKETEASAVIVGEECAHLVSKTISDITDCSL
LQVPLWLASDVEKTAANKDLECFDSNLALNYMDYSREFDSRVARKDITAETPSLLIFTSGTTGLPKAAIYSHMRWLCSGD
VMSVTIDATESDVFYVCLPMYHGAAATSVTSTALAAGASIVVRRKFSVREFWPDVQQNGITVCQYIGEICRYLLNYDDSK
NQGQGVKDHTLRCMLGAGLSAESWLSWINKFGEMDIYEGWGSTEANTNLINLDNYIGSCGRVADWSKTNFRLVKFNTDLE
CHEKDADGLYVPCKSGEVGEAIGMIINHPEFGGGRFEGYTSSNATEKKILADVFTQGDAYWRSGDLLRFDDNGYFYFVDR
IGDTYRWKSENVSSQEVANELSGLAGLELINIYGVQVPEHEGRAGMAAIVMQQGKDFDPNAFYALTEAKLPRYAAPQFVR
VSSVADMTSTFKLRKVDLQKQGYNPIGCDDPIYIRNDKLETYVRYSDEALTAVGLPPFKQV

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=590, Percent_Identity=35.5932203389831, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI40807357, Length=595, Percent_Identity=35.4621848739496, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI62865631, Length=592, Percent_Identity=32.6013513513513, Blast_Score=338, Evalue=8e-93,
Organism=Homo sapiens, GI13325055, Length=592, Percent_Identity=32.6013513513513, Blast_Score=338, Evalue=8e-93,
Organism=Homo sapiens, GI38524616, Length=591, Percent_Identity=36.2098138747885, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI13325057, Length=595, Percent_Identity=33.2773109243697, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI13236579, Length=535, Percent_Identity=34.392523364486, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI227499621, Length=589, Percent_Identity=31.918505942275, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI221142682, Length=528, Percent_Identity=24.6212121212121, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788107, Length=572, Percent_Identity=19.4055944055944, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17551278, Length=568, Percent_Identity=39.7887323943662, Blast_Score=376, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI115534440, Length=569, Percent_Identity=35.3251318101933, Blast_Score=321, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6319515, Length=529, Percent_Identity=32.3251417769376, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6319264, Length=392, Percent_Identity=22.9591836734694, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI20130353, Length=570, Percent_Identity=37.5438596491228, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI28573631, Length=570, Percent_Identity=37.5438596491228, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24583465, Length=566, Percent_Identity=36.5724381625442, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24583463, Length=566, Percent_Identity=36.5724381625442, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI281364798, Length=566, Percent_Identity=36.5724381625442, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI45552801, Length=567, Percent_Identity=36.331569664903, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI45550496, Length=567, Percent_Identity=36.331569664903, Blast_Score=343, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 68960; Mature: 68960

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKNHSGVPLASMEETQAKSDKRSKAAQLIKPYAKYTIADRVEQQAQSQQDKTFLVYND
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
QHFSYAEVDQRANQVANLAASRGLNAGDVCAMVLENRPEFFFIWFGLTKLGVIVAFINSQ
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHCCC
VHGAPLSHAIKETEASAVIVGEECAHLVSKTISDITDCSLLQVPLWLASDVEKTAANKDL
CCCCCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCH
ECFDSNLALNYMDYSREFDSRVARKDITAETPSLLIFTSGTTGLPKAAIYSHMRWLCSGD
HHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
VMSVTIDATESDVFYVCLPMYHGAAATSVTSTALAAGASIVVRRKFSVREFWPDVQQNGI
EEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHCCCHHHCCC
TVCQYIGEICRYLLNYDDSKNQGQGVKDHTLRCMLGAGLSAESWLSWINKFGEMDIYEGW
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEEEECCCCCHHHHHHHHHHHCCCEEECCC
GSTEANTNLINLDNYIGSCGRVADWSKTNFRLVKFNTDLECHEKDADGLYVPCKSGEVGE
CCCCCCCCEEEEHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCHHH
AIGMIINHPEFGGGRFEGYTSSNATEKKILADVFTQGDAYWRSGDLLRFDDNGYFYFVDR
HHHHEECCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCEECCCCEEEEECCCEEEEEEC
IGDTYRWKSENVSSQEVANELSGLAGLELINIYGVQVPEHEGRAGMAAIVMQQGKDFDPN
CCCCEEECCCCCCHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCHHHHHHHCCCCCCCC
AFYALTEAKLPRYAAPQFVRVSSVADMTSTFKLRKVDLQKQGYNPIGCDDPIYIRNDKLE
CEEEEECCCCCCCCCCCEEEHHHHHHHHHHHEEEEEEHHHCCCCCCCCCCCEEEECCCEE
TYVRYSDEALTAVGLPPFKQV
EEEEECCCCEEEECCCCCCCC
>Mature Secondary Structure
MKIKNHSGVPLASMEETQAKSDKRSKAAQLIKPYAKYTIADRVEQQAQSQQDKTFLVYND
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
QHFSYAEVDQRANQVANLAASRGLNAGDVCAMVLENRPEFFFIWFGLTKLGVIVAFINSQ
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHCCC
VHGAPLSHAIKETEASAVIVGEECAHLVSKTISDITDCSLLQVPLWLASDVEKTAANKDL
CCCCCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCH
ECFDSNLALNYMDYSREFDSRVARKDITAETPSLLIFTSGTTGLPKAAIYSHMRWLCSGD
HHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCC
VMSVTIDATESDVFYVCLPMYHGAAATSVTSTALAAGASIVVRRKFSVREFWPDVQQNGI
EEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHCCCHHHCCC
TVCQYIGEICRYLLNYDDSKNQGQGVKDHTLRCMLGAGLSAESWLSWINKFGEMDIYEGW
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEEEECCCCCHHHHHHHHHHHCCCEEECCC
GSTEANTNLINLDNYIGSCGRVADWSKTNFRLVKFNTDLECHEKDADGLYVPCKSGEVGE
CCCCCCCCEEEEHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCHHH
AIGMIINHPEFGGGRFEGYTSSNATEKKILADVFTQGDAYWRSGDLLRFDDNGYFYFVDR
HHHHEECCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCEECCCCEEEEECCCEEEEEEC
IGDTYRWKSENVSSQEVANELSGLAGLELINIYGVQVPEHEGRAGMAAIVMQQGKDFDPN
CCCCEEECCCCCCHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCHHHHHHHCCCCCCCC
AFYALTEAKLPRYAAPQFVRVSSVADMTSTFKLRKVDLQKQGYNPIGCDDPIYIRNDKLE
CEEEEECCCCCCCCCCCEEEHHHHHHHHHHHEEEEEEHHHCCCCCCCCCCCEEEECCCEE
TYVRYSDEALTAVGLPPFKQV
EEEEECCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA